IAM Policy that allows API Calls, but restricts all Console actions(including View) if the user doesn't have MFA enabled. the only thing the user can do is change his own password and assign MFA.

MFAPolicy

{
    "Version": "2012-10-17",
    "Statement": [
        {
            "Sid": "AllowManageOwnVirtualMFADevice1",
            "Effect": "Allow",
            "Action": [
                "iam:CreateVirtualMFADevice",
                "iam:DeleteVirtualMFADevice"
            ],
            "Resource": "arn:aws:iam::*:mfa/${aws:username}"
        },
        {
            "Sid": "AllowViewAccountInfo",
            "Effect": "Allow",
            "Action": [
                "iam:GetAccountPasswordPolicy",
                "iam:GetAccountSummary",
                "iam:ListVirtualMFADevices",
                "iam:CreateVirtualMFADevice",
                "iam:EnableMFADevice"
            ],
            "Resource": "*"
        },
        {
            "Sid": "AllowManageOwnPasswords",
            "Effect": "Allow",
            "Action": [
                "iam:ChangePassword",
                "iam:GetUser"
            ],
            "Resource": "arn:aws:iam::*:user/${aws:username}"
        },
        {
            "Sid": "AllowManageOwnAccessKeys",
            "Effect": "Allow",
            "Action": [
                "iam:CreateAccessKey",
                "iam:DeleteAccessKey",
                "iam:ListAccessKeys",
                "iam:UpdateAccessKey"
            ],
            "Resource": "arn:aws:iam::*:user/${aws:username}"
        },
        {
            "Sid": "AllowManageOwnSigningCertificates",
            "Effect": "Allow",
            "Action": [
                "iam:DeleteSigningCertificate",
                "iam:ListSigningCertificates",
                "iam:UpdateSigningCertificate",
                "iam:UploadSigningCertificate"
            ],
            "Resource": "arn:aws:iam::*:user/${aws:username}"
        },
        {
            "Sid": "AllowManageOwnSSHPublicKeys",
            "Effect": "Allow",
            "Action": [
                "iam:DeleteSSHPublicKey",
                "iam:GetSSHPublicKey",
                "iam:ListSSHPublicKeys",
                "iam:UpdateSSHPublicKey",
                "iam:UploadSSHPublicKey"
            ],
            "Resource": "arn:aws:iam::*:user/${aws:username}"
        },
        {
            "Sid": "AllowManageOwnGitCredentials",
            "Effect": "Allow",
            "Action": [
                "iam:CreateServiceSpecificCredential",
                "iam:DeleteServiceSpecificCredential",
                "iam:ListServiceSpecificCredentials",
                "iam:ResetServiceSpecificCredential",
                "iam:UpdateServiceSpecificCredential"
            ],
            "Resource": "arn:aws:iam::*:user/${aws:username}"
        },
        {
            "Sid": "AllowManageOwnVirtualMFADevice",
            "Effect": "Allow",
            "Action": [
                "iam:CreateVirtualMFADevice",
                "iam:DeleteVirtualMFADevice"
            ],
            "Resource": "arn:aws:iam::*:mfa/${aws:username}"
        },
        {
            "Sid": "AllowManageOwnUserMFA",
            "Effect": "Allow",
            "Action": [
                "iam:DeactivateMFADevice",
                "iam:EnableMFADevice",
                "iam:ListMFADevices",
                "iam:ResyncMFADevice",
                "iam:CreateVirtualMFADevice",
                "iam:EnableMFADevice"
            ],
            "Resource": "arn:aws:iam::*:user/${aws:username}"
        },
        {
            "Sid": "DenyAllExceptListedIfNoMFA",
            "Effect": "Deny",
            "NotAction": [
                "iam:GetUser",
                "iam:ListMFADevices",
                "iam:ListVirtualMFADevices",
                "iam:ResyncMFADevice",
                "sts:GetSessionToken",
                "iam:CreateVirtualMFADevice",
                "iam:EnableMFADevice",
                "iam:DeleteVirtualMFADevice"
            ],
            "Resource": "*",
            "Condition": {
                "Bool": {
                    "aws:MultiFactorAuthPresent": "false"
                }
            }
        }
    ]
}