entity-type-manager.php

<?php

// node, block, block_content, user, view, fiel, taxonomy_term, menu, menu_link_content, migration, ...
$storage = 'block';
$service = \Drupal::service('entity_type.manager')->getStorage($storage);

// LOAD
// One entity
$entity = $service->load($id);

// More entities.
// We'll get all ids.
$ids = $service->getQuery()
  ->condition('theme', 'bartik')
  ->condition('region', 'header')
  ->execute();

// We'll get all complete entities.
$entities = $service->loadMultiple($ids);

// CREATE
// We can also create an entity.
$service = \Drupal::service('entity_type.manager')->getStorage('node');
$node = $service->create(array('type' => 'page', 'title' => 'About Us'));
$node->save();

// SAVE
$entity->title->value = 'Yes we can!';
$entity->save();

// DELETE
// Delete a single entity.
$entity = \Drupal::entityTypeManager()->getStorage('node')->load(22);
$entity->delete();

// Delete multiple entities at once.
\Drupal::entityTypeManager()->getStorage($entity_type)->delete([$id1, $id2]);

// TRANSLATION
$translation = $node->getTranslation('es');

// English title
print $node->title->value;

// Spanish title
print $translation->title->value;