urls.py

...
url(r'^v1/tiles/(?P<tile_user>([^/]+))/(?P<tile_layer>([^/]+))/(?P<tile_zoom>(\d+))/(?P<tile_column>(\d+))/(?P<tile_row>(\d+))\.(?P<tile_format>([a-z]+))$', TileManager.as_view(), name='tile_manager'),
...

views.py

from django.http import HttpResponse, HttpResponseServerError
from ModestMaps.Core import Coordinate
from TileStache import getTile, parseConfigfile
from TileStache.Core import KnownUnknown
from django.contrib.auth.models import User
from django.views.generic import View
from django.contrib.sites.models import Site

#include my custom permission mixin see Django docs on several ways to do this
from utils import APIPermissionMixin

class TileManager(APIPermissionMixin, View):
    """
    Returns tiles
    """
    def get(self, request, *args, **kwargs):
        try:
            #the mixin already checked that the layers and users exist

            user = User.objects.get(username__exact=kwargs['tile_user'])
            config = parseConfigfile(user.get_profile().tile_config_file)
            layer = config.layers[kwargs['tile_layer']]
            coord = Coordinate(int(kwargs['tile_row']), int(kwargs['tile_column']), int(kwargs['tile_zoom']))
            tile_mimetype, tile_content = getTile(layer, coord, kwargs['tile_format'], ignore_cached=False)

            return HttpResponse(mimetype=tile_mimetype, content=tile_content)

        except KnownUnknown, e:
            return HttpResponseServerError(str(e))