Prevent monitors from going to sleep by regularly moving the mouse

nosleep.py

# Run `pip install mouse` first
from mouse import move, get_position
from time import sleep

# This will move the mouse in squares.
# You can change the size of the square (default 200px) and the
# movement duration (default 2s), the programm will sleep for 20s.

# You can change the square implementation or introduce some randomness
# to the above values to make it difficult to be detected.
while True:
  move(get_position()[0] + 200, get_position()[1], duration=2)
  sleep(20)
  move(get_position()[0], get_position()[1] + 200, duration=2)
  sleep(20)
  move(get_position()[0] - 200, get_position()[1], duration=2)
  sleep(20)
  move(get_position()[0], get_position()[1] - 200, duration=2)
  sleep(20)

Another implementation using the autopy library:

from autopy.mouse import smooth_move, location
from time import sleep

while True:
	smooth_move(location()[0] + 200, location()[1], duration=2)
	sleep(20)
	smooth_move(location()[0], location()[1] + 200, duration=2)
	sleep(20)
	smooth_move(location()[0] - 200, location()[1], duration=2)
	sleep(20)
	smooth_move(location()[0], location()[1] - 200, duration=2)
	sleep(20)