The idea here is to asynchronously process chunk of data by pushing it into a multiprocessing pool queue. Each process in pool will work on the task, and return the result. Note, it is important to create the Pool inside the __main__ block. That is

read_boost

import pandas as pd
import multiprocessing as mp

LARGE_FILE = "D:\\my_large_file.txt"
CHUNKSIZE = 100000 # processing 100,000 rows at a time

def process_frame(df):
        # process data frame
        return len(df)

if __name__ == '__main__':
        reader = pd.read_table(LARGE_FILE, chunksize=CHUNKSIZE)
        pool = mp.Pool(4) # use 4 processes

        funclist = []
        for df in reader:
                # process each data frame
                f = pool.apply_async(process_frame,[df])
                funclist.append(f)

        result = 0
        for f in funclist:
                result += f.get(timeout=10) # timeout in 10 seconds

        print "There are %d rows of data"%(result)

read_file

import pandas as pd

LARGE_FILE = "D:\\my_large_file.txt"
CHUNKSIZE = 100000 # processing 100,000 rows at a time

def process_frame(df):
        # process data frame
        return len(df)

if __name__ == '__main__':
        reader = pd.read_table(LARGE_FILE, chunksize=CHUNKSIZE)

        result = 0
        for df in reader:
                # process each data frame
                result += process_frame(df)

        print "There are %d rows of data"%(result)