Filippo Valsorda has a solution for OS X that incorporates iTerm 2, tmux, and mosh.
His solution uses a single window/tab to connect to a remote shell. The shell survives disconnects (e.g., connection failure, IP changes, laptop reboots) and supports scrollback with a touchpad, copy-paste, and colors.
Caveats are that you must build mosh from source, scrolling is less fluid than native, and click-drag is relayed, so you must hold Option to select.
iTerm In the Terminal Profile settings, Enable xterm mouse reporting and set Report Terminal Type to xterm-256color.