Simple script to get optimal cookies per second from cookie clicker: http://orteil.dashnet.org/cookieclicker/ Although it doesn't factor in upgrades or wrinklers. Does nothing that you can't do manually. (except for speed)

gistfile1.js

//to clear all purchases:
Game.ObjectsById.forEach(function(o){for(var i=0;i<200;i++){o.sell()}})

var mostProfitable = -1;
var price = -1;
var interval = -1;

function determineBest(){
	price = -1;
	Game.ObjectsById.forEach(function(o){
		var ppcps = o.price/o.cps();
		if(ppcps < price || price == -1){
			price = ppcps;
			mostProfitable = o.id;
		}
	});
	var thing = Game.ObjectsById[mostProfitable];
	thing.buy();
	if(thing.price > Game.cookies){ //the most profitable is too pricy, wait before trying again
		interval = setTimeout(determineBest,10000);
	}else{//it is buyable! Buy more, as fast as possible!
		interval = setTimeout(determineBest,10);
	}
}
interval = setTimeout(determineBest,0)