ll_methods.md

In order to estimate transduction efficiency from sc-RNA-Seq data, we use the following model: We assume that a non-transduced cell expresses NeoR such that an expected fraction $\mu^\text{R}$ of its UMIs maps to this gene. For each individual cell $j$, the actual expression strength of the gene varies around this expectation with some coefficient of variation, which we denote $\alpha^R$.