SQLA + pyodbc

freetds.conf

[db_name]
	host = 1.1.1.1
	port = 1433
	tds version = 8.0
	client charset = UTF-8

gistfile1.txt

apt-get install unixodbc unixodbc-dev freetds-dev tdsodbc

odbcinst.ini

[FreeTDS]
Description=FreeTDS Driver
Driver=/usr/lib/x86_64-linux-gnu/odbc/libtdsodbc.so
Setup=/usr/lib/x86_64-linux-gnu/odbc/libtdsS.so

pyodbc_sa.py

from urllib import quote_plus
from sqlalchemy import create_engine


engine = create_engine(
    'mssql+pyodbc:///?odbc_connect=' +
    quote_plus(
        'DRIVER=FreeTDS;'
        'SERVER=1.1.1.1;'
        'PORT=1433;'
        'DATABASE=db_name;'
        'UID=db_user;'
        'PWD=db_password;'
        'TDS_Version=8.0;'
    )
)