OK. I think everyone's expressed interest, so I haven't untagged them yet.
OTOH, I'm not going to pay for Twitter Blue (more characters).
Question here:
Conversation starters were:
PJeffcock: "...Covid ain’t going down because there is no biological pressure to do so. Those troughs are just getting higher. Humanity is allowing it to evolve to complete vaccine escape..."
mononockle: "By now it's complete immune escape"
sourcejedi: "I don't think T-Cell epitopes are going anywhere."
mononockle: "The T cells are, tho."
Citations provided for these concerns:
T-cell harm (8 month study so we don’t know how long it persists for)
https://www.nature.com/articles/s41392-022-00919-x
Cite 1 starts with an abstract (no separate conclusion at the end). It appears to me focused on "the strongest association with LC among the 28 analytes measured. Combinations of the inflammatory mediators IFN-β, PTX3, IFN-γ, IFN-λ2/3 and IL-6 associated with LC with 78.5–81.6% accuracy".
I assume this is not cited as evidence of complete immune escape, from vaccine or infection, correct? We know the labs can test that. It takes a while for T-Cells, but it would be a very publishable result.
This leaves us with concern "The T-Cells are [going], tho" (informal).
Again, obviously the overwhelmingly majority have T-Cells, they have memory T-Cells against Sars-Cov-2, this is still true of the sub-population represented in the Nature letter, your concern is more technical than that.
Are you relating this to some of the specific figures / results in the Nature letter? Which? What are the effects of these values?
Is it likely to cause "those troughs are just getting higher", or is that a separate concern?
Are these concerns on a greater, lesser, or similar level of importance as "evolve to complete vaccine escape" which includes T-Cell immunity? Do people who work on the specific details share your assessment?