Access joysticks/game controllers from Python in Linux via the joystick driver. See https://www.panda3d.org/forums/viewtopic.php?f=8&t=16767

n64_joy.py

# Released by rdb under the Unlicense (unlicense.org)
# Modified for N64 controller from https://gist.github.com/rdb/8864666

import os, struct, array
from fcntl import ioctl

# Iterate over the joystick devices.
print('Available devices:')

for fn in os.listdir('/dev/input'):
    if fn.startswith('js'):
        print('  /dev/input/%s' % (fn))

# We'll store the states here.
axis_states = {}
button_states = {}

# These constants were borrowed from linux/input.h
axis_names = {
    0x00 : 'x',
    0x01 : 'y',
    0x02 : 'z',
    0x03 : 'rx',
    0x04 : 'ry',
    0x05 : 'rz',
}

button_names = {
    0x120 : 'C-Up',
    0x121 : 'C-Right',
    0x122 : 'C-Down',
    0x123 : 'C-Left',
    #
    # ignore so we don't unintentionally register two hits
    #
    0x124 : 'A', 
    0x125 : 'B',
    
    0x126 : 'L',
    0x127 : 'R',
    
    0x128 : 'A',
    0x129 : 'B',    
    0x12a : 'Z (trigger)',
    
    0x12b : 'Start',
    0x12c : 'Up',
    0x12d : 'Right',
    0x12e : 'Down',
    0x12f : 'Left', 
}

axis_map = []
button_map = []

# Open the joystick device.
fn = '/dev/input/js0'
print('Opening %s...' % fn)
jsdev = open(fn, 'rb')

# Get the device name.
#buf = bytearray(63)
buf = array.array('c', ['\0'] * 64)
ioctl(jsdev, 0x80006a13 + (0x10000 * len(buf)), buf) # JSIOCGNAME(len)
js_name = buf.tostring()
print('Device name: %s' % js_name)

# Get number of axes and buttons.
buf = array.array('B', [0])
ioctl(jsdev, 0x80016a11, buf) # JSIOCGAXES
num_axes = buf[0]

buf = array.array('B', [0])
ioctl(jsdev, 0x80016a12, buf) # JSIOCGBUTTONS
num_buttons = buf[0]

# Get the axis map.
buf = array.array('B', [0] * 0x40)
ioctl(jsdev, 0x80406a32, buf) # JSIOCGAXMAP

for axis in buf[:num_axes]:
    axis_name = axis_names.get(axis, 'unknown(0x%02x)' % axis)
    axis_map.append(axis_name)
    axis_states[axis_name] = 0.0

# Get the button map.
buf = array.array('H', [0] * 200)
ioctl(jsdev, 0x80406a34, buf) # JSIOCGBTNMAP

for btn in buf[:num_buttons]:
    btn_name = button_names.get(btn, 'unknown(0x%03x)' % btn)
    button_map.append(btn_name)
    button_states[btn_name] = 0

print '%d axes found: %s' % (num_axes, ', '.join(axis_map))
print '%d buttons found: %s' % (num_buttons, ', '.join(button_map))

# Main event loop
while True:
    evbuf = jsdev.read(8)
    if evbuf:
        time, value, type, number = struct.unpack('IhBB', evbuf)

        if type & 0x80:
             print "(initial)",

        if type & 0x01:
            button = button_map[number]
            if button:
                button_states[button] = value
                if value:
                    print "%s pressed" % (button)
                else:
                    print "%s released" % (button)

        if type & 0x02:
            axis = axis_map[number]
            if axis:
                fvalue = value / 32767.0
                axis_states[axis] = fvalue
                print "%s: %.3f" % (axis, fvalue)