http://sridharkatakam.com/use-full-width-template-homepage-genesis/

front-page.php

<?php

//* Force full width content layout
add_filter( 'genesis_pre_get_option_site_layout', '__genesis_return_full_width_content' );

remove_action( 'genesis_loop', 'genesis_do_loop' );
add_action( 'genesis_loop', 'custom_do_loop' );

function custom_do_loop() { ?>

	<p>My page content goes here</p>

<?php }

//* Run the Genesis loop
genesis();