Libvirt configuration to boot from a real harddrive with VGA Passthrough on 00:07.0 + 00:07.1 with audio attached to PulseAudio of user id 1000 and support for a PS/2 mouse shared with the host (Use Ctrl_L + Ctrl_R to switch). With looking-glass IVSHM configured (17M is enough for fullhd, but round to nearest power of 2).

realboot.xml

<domain type='kvm' xmlns:qemu='http://libvirt.org/schemas/domain/qemu/1.0'>
  <name>win10</name>
  <uuid>3716c67d-59b9-42f4-8ac4-f0ada39ef48a</uuid>
  <memory unit='KiB'>16588800</memory>
  <currentMemory unit='KiB'>4194304</currentMemory>
  <memoryBacking>
    <hugepages/>
  </memoryBacking>
  <vcpu placement='static'>8</vcpu>
  <iothreads>2</iothreads>
  <cputune>
    <vcpupin vcpu='0' cpuset='0'/>
    <vcpupin vcpu='1' cpuset='1'/>
    <vcpupin vcpu='2' cpuset='2'/>
    <vcpupin vcpu='3' cpuset='3'/>
    <vcpupin vcpu='4' cpuset='4'/>
    <vcpupin vcpu='5' cpuset='5'/>
    <vcpupin vcpu='6' cpuset='6'/>
    <vcpupin vcpu='7' cpuset='7'/>
    <emulatorpin cpuset='0-1'/>
  </cputune>
  <os>
    <type arch='x86_64' machine='pc-i440fx-2.11'>hvm</type>
    <loader readonly='yes' type='pflash'>/usr/share/edk2/ovmf/OVMF_CODE.fd</loader>
    <nvram>/var/lib/libvirt/qemu/nvram/win10_VARS.fd</nvram>
    <boot dev='hd'/>
    <bootmenu enable='yes'/>
  </os>
  <features>
    <acpi/>
    <apic/>
    <hyperv>
      <relaxed state='on'/>
      <vapic state='on'/>
      <spinlocks state='on' retries='8191'/>
      <vendor_id state='on' value='1234567890ab'/>
    </hyperv>
    <kvm>
      <hidden state='on'/>
    </kvm>
    <vmport state='off'/>
  </features>
  <cpu mode='host-passthrough' check='none'>
    <topology sockets='1' cores='4' threads='2'/>
  </cpu>
  <clock offset='localtime'>
    <timer name='rtc' tickpolicy='catchup'/>
    <timer name='pit' tickpolicy='delay'/>
    <timer name='hpet' present='no'/>
    <timer name='hypervclock' present='yes'/>
  </clock>
  <on_poweroff>destroy</on_poweroff>
  <on_reboot>restart</on_reboot>
  <on_crash>destroy</on_crash>
  <pm>
    <suspend-to-mem enabled='no'/>
    <suspend-to-disk enabled='no'/>
  </pm>
  <devices>
    <emulator>/usr/bin/qemu-kvm</emulator>
    <disk type='block' device='disk'>
      <driver name='qemu' type='raw' cache='none'/>
      <source dev='/dev/sda'/>
      <target dev='sdb' bus='sata'/>
      <address type='drive' controller='0' bus='0' target='0' unit='1'/>
    </disk>
    <disk type='file' device='cdrom'>
      <driver name='qemu' type='raw'/>
      <source file='/var/lib/libvirt/images/W10.PRO.X64.es-es.ISO'/>
      <target dev='sdd' bus='sata'/>
      <readonly/>
      <address type='drive' controller='0' bus='0' target='0' unit='3'/>
    </disk>
    <disk type='file' device='cdrom'>
      <driver name='qemu' type='raw'/>
      <source file='/var/lib/libvirt/images/virtio-win-0.1.141.iso'/>
      <target dev='sde' bus='sata'/>
      <readonly/>
      <address type='drive' controller='0' bus='0' target='0' unit='4'/>
    </disk>
    <controller type='usb' index='0' model='nec-xhci'>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x05' function='0x0'/>
    </controller>
    <controller type='pci' index='0' model='pci-root'/>
    <controller type='pci' index='1' model='pci-bridge'>
      <model name='pci-bridge'/>
      <target chassisNr='1'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x0b' function='0x0'/>
    </controller>
    <controller type='pci' index='2' model='pci-bridge'>
      <model name='pci-bridge'/>
      <target chassisNr='2'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x0c' function='0x0'/>
    </controller>
    <controller type='pci' index='3' model='pci-bridge'>
      <model name='pci-bridge'/>
      <target chassisNr='3'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x0d' function='0x0'/>
    </controller>
    <controller type='pci' index='4' model='pci-bridge'>
      <model name='pci-bridge'/>
      <target chassisNr='4'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x0e' function='0x0'/>
    </controller>
    <controller type='pci' index='5' model='pci-bridge'>
      <model name='pci-bridge'/>
      <target chassisNr='5'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x0f' function='0x0'/>
    </controller>
    <controller type='sata' index='0'>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x06' function='0x0'/>
    </controller>
    <controller type='virtio-serial' index='0'>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x07' function='0x0'/>
    </controller>
    <controller type='scsi' index='0' model='virtio-scsi'>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x15' function='0x0'/>
    </controller>
    <interface type='network'>
      <mac address='52:54:00:64:38:c5'/>
      <source network='trustednet1'/>
      <model type='virtio'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x03' function='0x0'/>
    </interface>
    <interface type='direct'>
      <mac address='52:54:00:37:08:d4'/>
      <source dev='enp5s0' mode='bridge'/>
      <model type='virtio'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x10' function='0x0'/>
    </interface>
    <serial type='pty'>
      <target type='isa-serial' port='0'>
        <model name='isa-serial'/>
      </target>
    </serial>
    <console type='pty'>
      <target type='serial' port='0'/>
    </console>
    <channel type='spicevmc'>
      <target type='virtio' name='com.redhat.spice.0'/>
      <address type='virtio-serial' controller='0' bus='0' port='1'/>
    </channel>
    <input type='tablet' bus='usb'>
      <address type='usb' bus='0' port='1'/>
    </input>
    <input type='mouse' bus='ps2'/>
    <input type='keyboard' bus='ps2'/>
    <input type='keyboard' bus='virtio'>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x12' function='0x0'/>
    </input>
    <input type='tablet' bus='virtio'>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x13' function='0x0'/>
    </input>
    <graphics type='spice' autoport='yes' listen='127.0.0.1'>
      <listen type='address' address='127.0.0.1'/>
      <image compression='off'/>
      <gl enable='no'/>
    </graphics>
    <sound model='ich9'>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x04' function='0x0'/>
    </sound>
    <video>
      <model type='qxl' ram='65536' vram='65536' vgamem='16384' heads='1' primary='yes'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x02' function='0x0'/>
    </video>
    <hostdev mode='subsystem' type='pci' managed='yes'>
      <source>
        <address domain='0x0000' bus='0x07' slot='0x00' function='0x0'/>
      </source>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x09' function='0x0'/>
    </hostdev>
    <hostdev mode='subsystem' type='pci' managed='yes'>
      <source>
        <address domain='0x0000' bus='0x07' slot='0x00' function='0x1'/>
      </source>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x0a' function='0x0'/>
    </hostdev>
    <redirdev bus='usb' type='spicevmc'>
      <address type='usb' bus='0' port='2'/>
    </redirdev>
    <redirdev bus='usb' type='spicevmc'>
      <address type='usb' bus='0' port='3'/>
    </redirdev>
    <memballoon model='virtio'>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x08' function='0x0'/>
    </memballoon>
    <shmem name='looking-glass'>
      <model type='ivshmem-plain'/>
      <size unit='M'>32</size>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x11' function='0x0'/>
    </shmem>
  </devices>
  <qemu:commandline>
    <qemu:arg value='-object'/>
    <qemu:arg value='input-linux,id=kbd1,evdev=/dev/input/by-path/platform-i8042-serio-0-event-kbd,grab_all=on,repeat=on'/>
    <qemu:env name='QEMU_AUDIO_DRV' value='pa'/>
    <qemu:env name='QEMU_PA_SERVER' value='/run/user/1000/pulse/native'/>
  </qemu:commandline>
</domain>