Created
April 7, 2019 13:21
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A routine showing how to calculate quantiles.
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library(survival) | |
library(Hmisc) | |
# 1. a weibull random number generator, see http://statwonk.com/weibull.html | |
rweibull_cens <- function(n, shape, scale) { | |
# will happen to see the death time first or censoring? | |
rweibull(n, shape = shape, scale = scale) -> a_random_death_time | |
rweibull(n, shape = shape, scale = scale) -> a_random_censor_time | |
pmin(a_random_censor_time, a_random_death_time) -> observed_time | |
(observed_time == a_random_death_time) -> censor | |
data.frame(time = observed_time, censor = censor, stringsAsFactors = FALSE) | |
} | |
# 2. generate sample data | |
rweibull_cens(1e3, 1, 500) -> d | |
# 3. calculate a single median 0.5 quantile (percentile/100) | |
(survival:::quantile.survfit( | |
survfit(Surv(time, censor) ~ 1, data = d), | |
probs = 0.5 | |
) -> single_estimate) | |
# 4. calculate 1,000 of them and visualize a distribution | |
hist(Hmisc::bootkm(Surv(d$time, d$censor), B = 1e3), breaks = 25, col = "orange", | |
xlab = "Time until half convert", main = "Time until half convert (median failure time)") | |
abline(v = single_estimate, col = "black", lwd = 2, lty = 2) |
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