gistfile1.txt

var requirejs = require("requirejs");


requirejs.config({
    nodeRequire: require,
    baseUrl: "./"
});

requirejs(["./app/path2"],function(p2) {
	console.warn("ok1");
});


var config = {
  baseUrl: "./app/",
  name: "./start",
  out: "out.js"
};

requirejs.optimize(config, function (buildResponse) {
  console.warn("success!");

	  
	requirejs.config({
	    nodeRequire: require,
	    baseUrl: "./"
	});


	requirejs(["./app/path2"],function(p2) {
		console.warn("I should be shown!");
	});

});

This may not work:

//For the non-optimize() calls, use the context: config to create a new context for the code to run in, 
//that is separate from the default context used by requirejs for builds. And then, since the build 
//overrides are in effect, a special flag needs to be added to the callback function to tell requirejs 
//to just execute it:

var appRequire = requirejs.config({
    nodeRequire: require,
    baseUrl: "./"
    context: 'appRequire'
});

function appCallback(p2) {
    console.warn("I should be shown!");
}
appCallback.__requireJsBuild = true;

appRequire((["./app/path2"], appCallback);