Replace all the occurrence of the pattern in a file sed -i 's/lorem=.*/lorem=REPLACED/g' /path/to/the/config.ini Before lorem=ipsum dolor=sit amet=consectetur adipiscing=elit Morbi=luctus tempor=odio lorem=ipsum #lorem=ipsum dolor=sit After lorem=REPLACED dolor=sit amet=consectetur adipiscing=elit Morbi=luctus tempor=odio lorem=REPLACED #lorem=REPLACED dolor=sit Replace whole lines sed -i "/lorem=/c\lorem=REPLACED" /path/to/the/config.ini Before lorem=ipsum dolor=sit amet=consectetur adipiscing=elit Morbi=luctus tempor=odio lorem=ipsum #lorem=ipsum dolor=sit After lorem=REPLACED dolor=sit amet=consectetur adipiscing=elit Morbi=luctus tempor=odio lorem=REPLACED lorem=REPLACED dolor=sit