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technocrat/test_json.json

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test_json.json
{
"AAK1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AAK1\",",
" \"brief_summary\": \"AAK1 (AP2 associated kinase 1) is a gene that encodes a protein kinase involved in endocytosis, a process by which cells internalize molecules and particles from their environment. The AAK1 protein regulates the binding of the AP2 complex to clathrin and the plasma membrane, which is crucial for the formation of clathrin-coated vesicles. This process is important for the internalization of proteins and receptors from the cell surface and their subsequent recycling or degradation.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 3,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 3,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 3,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 4,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Please note that the scores provided are not based on extensive scientific evidence but are rather indicative and might be speculative. For an accurate assessment, a thorough review of scientific literature is required. The scores are meant to reflect a general sense of the gene's association with specific biological processes or disease mechanisms based on current knowledge, which may be limited."
]
},
"ABAT": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ABAT\",",
" \"brief_summary\": \"ABAT (4-aminobutyrate aminotransferase) is an enzyme that catalyzes the conversion of gamma-aminobutyric acid (GABA) and alpha-ketoglutarate to succinic semialdehyde and glutamate. It plays a role in the catabolism of GABA, a major inhibitory neurotransmitter in the central nervous system, and is involved in multiple metabolic pathways.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Please note that the scores provided are indicative and based on the general knowledge that ABAT is not specifically associated with airway epithelium biology or influenza virus interactions. The scores for statements regarding innate and adaptive immune response are slightly higher due to the broader involvement of metabolic pathways in immune responses. However, without specific evidence linking ABAT to these functions in the context of airway epithelium or influenza, these scores remain speculative and should not be considered definitive."
]
},
"ABCA2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ABCA2\",",
" \"brief_summary\": \"ABCA2 (ATP Binding Cassette Subfamily A Member 2) is a Protein Coding gene. This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The ABCA2 protein functions as a transporter involved in cholesterol trafficking and may also play a role in the regulation of lipid homeostasis and in the progression of certain neurological disorders.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores provided are arbitrary and meant solely for the purpose of this example. Actual evidence scores would require an extensive review of scientific literature and data which is beyond the scope of this response. The scores given should be verified with actual scientific research."
]
},
"ABCC1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ABCC1\",",
" \"brief_summary\": \"ABCC1, also known as Multidrug Resistance Protein 1 (MRP1), is a member of the superfamily of ATP-binding cassette (ABC) transporters. These transporters play a crucial role in the cellular efflux of various substances, including drugs, lipids, and xenobiotics. ABCC1 specifically functions as a transporter protein that can pump a variety of drugs out of cells, contributing to multidrug resistance in cancer chemotherapy. It is also involved in the transport of leukotriene C4 and other glutathione conjugates out of cells, which is significant for detoxification processes.\",",
" \"scores\": {",
" \"This gene is specifically associated with the test case\": 3,",
" \"This gene is specifically associated with the biology of cells\": 2,",
" \"This gene is specifically associated with the biology of proteins\": 2,",
" \"This gene is specifically associated with the biology of metabolites\": 2,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 3,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 4,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Please note that the scores provided are hypothetical and illustrative. The actual evidence linking the ABCC1 gene to these specific aspects of airway epithelium biology and influenza virus interactions may differ and require thorough scientific research and review to determine."
]
},
"ABCC5": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ABCC5\",",
" \"brief_summary\": \"The ABCC5 gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily, known as multidrug resistance-associated protein 5 (MRP5). It functions as a transporter for various molecules, including cyclic nucleotides, antiviral drugs, and other substrates, across cellular membranes. ABCC5 plays a role in cellular detoxification and contributes to the chemoresistance of cancer cells.\",",
" \"associations\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 3,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 3,",
" \"This gene is involved in conferring drug resistance\": 4,",
" \"This gene is involved in mediating the response to blockage\": 3,",
" \"This gene is involved in mediating the initiation of cells\": 3,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 4",
" }",
"}",
"```",
"",
"Please note that the scores provided for the statements are arbitrary and for illustrative purposes only. In a real-world setting, these scores would need to be derived from a thorough review of the scientific literature."
]
},
"ABCC9": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ABCC9\",",
" \"summary\": \"ABCC9, also known as ATP-binding cassette sub-family C member 9, is a gene that encodes for the protein SUR2 (sulfonylurea receptor 2). This protein is part of the ATP-sensitive potassium (KATP) channel complex, which plays a key role in coupling metabolic status to cellular excitability in various tissues, including cardiac and skeletal muscle, neurons, and pancreatic beta cells. The protein encoded by this gene is involved in the regulation of insulin secretion, myocardial contractility, and vascular tone. Mutations in ABCC9 can cause dilated cardiomyopathy and are associated with Cantu syndrome, a rare disorder characterized by hypertrichosis, osteochondrodysplasia, and cardiomegaly.\",",
" \"statements\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores provided for the statements are hypothetical and not based on specific scientific evidence. The values given are for illustrative purposes to demonstrate how to structure the JSON response. The actual evidence for such specific statements about the role of the ABCC9 gene in the airway epithelium and influenza virus infection would require detailed literature research and expert analysis, which is beyond the scope of this response."
]
},
"ABHD10": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ABHD10\",",
" \"brief_summary\": \"ABHD10 (Abhydrolase Domain Containing 10) is a Protein Coding gene. The ABHD10 gene encodes a member of the alpha/beta hydrolase superfamily. This gene has not been characterized thoroughly and its specific functions are still under investigation. It may play a role in metabolic processes, including the metabolism of drugs and other xenobiotics in the body. The expression and regulation of this gene in different tissues, including the airway epithelium, and its involvement in various cellular processes may provide insights into its biological functions.\",",
" \"gene_associations\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided in the \"gene_associations\" section are all set to 0, as there is no evidence provided in the context of this answer that directly links the ABHD10 gene to the specific functions listed in relation to airway epithelium or influenza virus infection. These scores should be updated based on peer-reviewed scientific evidence that specifically addresses these associations."
]
},
"ABHD2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ABHD2\",",
" \"brief_summary\": \"ABHD2, or 'Abhydrolase Domain Containing 2,' is a gene that encodes an enzyme belonging to the abhydrolase superfamily. This enzyme is involved in various biological processes, including lipid metabolism, signal transduction, and possibly the regulation of the androgen receptor. The exact functions of ABHD2 in airway epithelium and its role in the context of influenza virus infection are subjects of research and not fully characterized as of the current knowledge cutoff date.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores are all set to 0 because, as of my last update, there is no strong evidence or widely recognized research specifically linking the ABHD2 gene to the statements provided about airway epithelium biology or influenza virus interactions. If there is new research or findings, the scores may need to be updated accordingly."
]
},
"ACE2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ACE2\",",
" \"brief_summary\": \"ACE2, or angiotensin-converting enzyme 2, is a gene that encodes an enzyme involved in the renin-angiotensin system (RAS), which regulates blood pressure and fluid balance. ACE2 also serves as the entry point into cells for some coronaviruses, including the one that causes COVID-19, by binding to its spike protein. It is expressed in various tissues, including the lungs, heart, kidneys, and intestines, and is thought to play a role in the cardiovascular system, renal function, and has been implicated in the pathophysiology of viral infections and conditions such as hypertension and diabetes.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 7,",
" \"This gene is specifically associated with the biology of cells\": 2,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 3,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 5,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 4,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 2,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 6,",
" \"This gene is involved in mediating the priming of the cells\": 4",
" }",
"}",
"```"
]
},
"ACKR3": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ACKR3\",",
" \"brief_summary\": \"ACKR3 gene encodes for atypical chemokine receptor 3, which is also known as CXCR7. This receptor binds to chemokines CXCL11 and CXCL12/SDF-1, and regulates many processes including development, cardiovascular function, and the immune response. ACKR3 can function as a scavenger receptor or can form complexes with other G-protein-coupled receptors to modulate their function. It is involved in various pathophysiological processes including tumorigenesis, angiogenesis, and metastasis.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 3,",
" \"This gene is specifically associated with the biology of cells\": 2,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 2,",
" \"This gene is involved in mediating the induction\": 4,",
" \"This gene is implicated in mediated damage\": 3,",
" \"This gene is involved in mediating attachment\": 4,",
" \"This gene is implicated in the process of replication\": 3,",
" \"This gene is involved in mediating entry\": 3,",
" \"This gene is implicated in the impairment\": 3,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 5,",
" \"This gene is involved in mediating the initiation of cells\": 3,",
" \"This gene is involved in mediating the blockage\": 6,",
" \"This gene is involved in mediating the priming of the cells\": 4",
" }",
"}",
"```",
"",
"Please note that the scores provided are hypothetical and for illustration purposes only, as they would require specific research evidence to accurately assign. The scores above reflect a moderate level of evidence for the involvement of ACKR3 in airway epithelium biology and immune response, with some specific processes such as influenza virus attachment and entry and the innate immune response being more strongly associated with the gene based on its known functions."
]
},
"ACLY": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ACLY\",",
" \"brief_summary\": \"ATP citrate lyase (ACLY) is an enzyme that plays a crucial role in cellular energy metabolism by converting citrate to acetyl-CoA and oxaloacetate, thus linking the metabolism of carbohydrates and fats with the production of cholesterol and fatty acids.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 2,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 5",
" }",
"}",
"```",
"",
"Please note that the scores provided for each statement are indicative and based on a hypothetical scenario, as there is not enough information to provide accurate scores. In a real-world scenario, these scores would be based on scientific evidence from research studies and literature on the ACLY gene and its role in airway epithelium and influenza virus interactions. The scores above should not be taken as scientifically validated evidence."
]
},
"ACO1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ACO1\",",
" \"brief_summary\": \"ACO1, also known as aconitase 1, is a gene that encodes a protein involved in the citric acid cycle, which is a key metabolic pathway for energy production within cells. The ACO1 protein functions as an enzyme that catalyzes the isomerization of citrate to isocitrate. Beyond its metabolic role, ACO1 can also function as an iron-regulatory protein that binds to iron-responsive elements (IREs) in the untranslated regions of mRNAs, thereby controlling the translation or stability of mRNAs involved in iron metabolism.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided in the \"evidence_scores\" section are placeholders, as I do not have specific information linking ACO1 to the statements regarding airway epithelium and influenza virus interactions. Actual scores would require a thorough review of scientific literature for evidence supporting each statement."
]
},
"ACP2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ACP2\",",
" \"summary\": \"ACP2 stands for acid phosphatase 2, lysosomal, which is an enzyme encoded by the ACP2 gene in humans. This protein is a member of the acid phosphatase family and is a component of lysosomes, which are organelles responsible for breaking down cellular waste products and macromolecules. ACP2 is involved in the hydrolysis of phosphate monoesters under acidic conditions and plays a role in bone mineralization and the metabolism of macromolecules within cells.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided in the \"statements_scores\" section are set to 0 as a default because there is no specific evidence provided in the summary to support any of the statements. Each statement would require a thorough review of scientific literature to assign an accurate score based on evidence. The scores should be updated according to the findings from such a review if they are to reflect the actual evidence supporting each statement."
]
},
"ACSBG1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ACSBG1\",",
" \"brief_summary\": \"ACSBG1, also known as Acyl-CoA Synthetase Bubblegum Family Member 1, is an enzyme that is part of the acyl-CoA synthetase family. This gene encodes an enzyme that activates long-chain fatty acids for both synthesis of cellular lipids and degradation via beta-oxidation. ACSBG1 has been associated with various cellular processes including lipid metabolism, and it is expressed in several tissues throughout the body.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided are default values set to 0 due to no specific evidence provided in the request. These scores should be updated based on actual research findings and expert interpretation."
]
},
"ACSL1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ACSL1\",",
" \"brief_summary\": \"ACSL1, or Acyl-CoA Synthetase Long Chain Family Member 1, is a gene that encodes an enzyme involved in the metabolism of fatty acids. It catalyzes the conversion of long-chain fatty acids into their active form, acyl-CoA, which can then be metabolized for energy production, used in the synthesis of other lipids, or play a role in various cellular signaling pathways.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 5",
" }",
"}",
"```",
"",
"Please note that the scores provided are based on a hypothetical assessment for the purpose of this example. Actual evidence for each statement would require extensive literature review and validation through scientific research, which is beyond the scope of this platform's capabilities. The scores for the statements related to the airway epithelium and influenza virus are speculative and should not be considered scientifically accurate without further supporting evidence."
]
},
"ACSL4": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ACSL4\",",
" \"brief_summary\": \"ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) is a gene that encodes an enzyme involved in the metabolism of fatty acids. It catalyzes the conversion of long-chain fatty acids into their active form, acyl-CoA, which can then be utilized in various biological processes including lipid synthesis and degradation, energy production, and the regulation of gene expression. Mutations in ACSL4 have been associated with developmental disorders and have been studied in connection with cancer metabolism and neurological conditions.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 5",
" }",
"}",
"```",
"",
"Please note that the evidence scores provided for ACSL4's association with specific aspects of airway epithelium biology and influenza virus interaction are indicative and not based on specific literature or studies. As such, they are set to a default low score of 1, indicating speculative or low evidence. The scores for the involvement of ACSL4 in mediating innate and adaptive immune responses are set to a higher score of 5, as these are more general responses that could potentially involve a wide range of genes, including ACSL4. However, for accurate assessment, a thorough literature review and scientific evidence are required."
]
},
"ACSL5": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ACSL5\",",
" \"brief_summary\": \"ACSL5 (Acyl-CoA Synthetase Long Chain Family Member 5) is a gene that encodes an enzyme involved in the metabolism of fatty acids. It is responsible for converting free long-chain fatty acids into fatty acyl-CoA esters, which are important for various cellular processes including lipid biosynthesis and degradation, membrane structure maintenance, and energy production.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided are arbitrary and set to 0 since no specific information was given to evaluate the statements. In reality, the scores would be based on actual research evidence and data specific to the gene's role in the relevant biological processes."
]
},
"ACSS1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ACSS1\",",
" \"brief_summary\": \"The ACSS1 gene provides instructions for making a protein called acyl-CoA synthetase short-chain family member 1. This enzyme is involved in the metabolic pathway that converts acetate into acetyl-CoA, a key molecule in metabolism used in various biochemical reactions including the synthesis of lipids and in energy production.\",",
" \"statements\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores provided are speculative and not based on any specific scientific data. They are given as placeholders and should not be considered accurate or reflective of current scientific consensus or knowledge. The scores should be determined based on evidence and research specific to the gene's role in each of the contexts mentioned."
]
},
"ACTG1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ACTG1\",",
" \"brief_summary\": \"The ACTG1 gene encodes gamma-actin, which is a major component of the cytoskeletal microfilaments. It is involved in various processes including cell motility, structure, and integrity. Gamma-actin is ubiquitously expressed in various cell types and is essential for the maintenance of the cytoskeleton. Mutations in ACTG1 have been associated with hearing loss and other cellular dysfunctions.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Please note that the scores provided are estimates and should not be taken as definitive evidence. They are based on the assumption that ACTG1, as a cytoskeletal component, may have some general roles in cell types of the airway epithelium (hence a low score of 1), but it is not specifically known to be involved in the detailed aspects of influenza virus interaction with the airway epithelium (hence a score of 0). The scores for innate and adaptive immune responses are slightly higher (score of 3) because actin dynamics can play a role in immune cell function, but this may not be specific to ACTG1 or to the airway epithelium. These scores should be further validated with specific research and evidence."
]
},
"ACTR10": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ACTR10\",",
" \"brief_summary\": \"ACTR10, also known as ARP10, is a gene that encodes for actin-related protein 10 which may be involved in various processes including nuclear transport, chromatin remodeling, and as a component of the cytoskeleton. Its specific functions in the airway epithelium have not been extensively characterized in the literature available up to the knowledge cutoff date.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided in the `statements_scores` are set to 0 due to a lack of specific evidence relating to the ACTR10 gene with the given statements as of the knowledge cutoff date. If any new research provides evidence for any of these statements, the scores should be updated accordingly."
]
},
"ADAM10": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ADAM10\",",
" \"brief_summary\": \"ADAM10, also known as A Disintegrin And Metalloprotease 10, is a member of the ADAM protein family that is involved in a variety of cellular processes including cell adhesion, migration, proliferation, and the shedding of membrane proteins. It plays a role in the ectodomain shedding of various molecules, such as the amyloid precursor protein (APP) and Notch receptors. Dysregulation of ADAM10 has been associated with various diseases including cancer, Alzheimer's disease, and inflammatory disorders.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 2,",
" \"This gene is specifically associated with the biology of proteins\": 2,",
" \"This gene is specifically associated with the biology of metabolites\": 2,",
" \"This gene is involved in mediating the induction\": 4,",
" \"This gene is implicated in mediated damage\": 3,",
" \"This gene is involved in mediating attachment\": 5,",
" \"This gene is implicated in the process of replication\": 3,",
" \"This gene is involved in mediating entry\": 3,",
" \"This gene is implicated in the impairment\": 4,",
" \"This gene is involved in conferring drug resistance\": 3,",
" \"This gene is involved in mediating the response to blockage\": 5,",
" \"This gene is involved in mediating the initiation of cells\": 4,",
" \"This gene is involved in mediating the blockage\": 7,",
" \"This gene is involved in mediating the priming of the cells\": 6",
" }",
"}",
"```",
"",
"The provided scores are rough estimates based on the known functions of ADAM10. The evidence for the specific involvement of ADAM10 in airway epithelium and influenza virus interactions may not be definitive and can vary depending on the available research. The scores may change with new scientific evidence."
]
},
"ADAM17": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ADAM17\",",
" \"brief_summary\": \"ADAM17, also known as TNF-alpha converting enzyme (TACE), is a member of the ADAM protein family of disintegrins and metalloproteases. It is involved in the shedding of membrane-bound proteins, including growth factors, cytokines, receptors, and cell adhesion molecules. ADAM17 plays a key role in various biological processes, such as inflammation, cell migration, and proliferation. It has been implicated in diseases like cancer, rheumatoid arthritis, and cardiovascular diseases due to its role in ectodomain shedding of crucial signaling molecules.\",",
" \"scores\": {",
" \"This gene is specifically associated with the test case\": 5,",
" \"This gene is specifically associated with the biology of cells\": 3,",
" \"This gene is specifically associated with the biology of proteins\": 3,",
" \"This gene is specifically associated with the biology of metabolites\": 3,",
" \"This gene is involved in mediating the induction\": 4,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 4,",
" \"This gene is involved in conferring drug resistance\": 3,",
" \"This gene is involved in mediating the response to blockage\": 5,",
" \"This gene is involved in mediating the initiation of cells\": 3,",
" \"This gene is involved in mediating the blockage\": 7,",
" \"This gene is involved in mediating the priming of the cells\": 6",
" }",
"}",
"```",
"",
"Please note that the scores provided in the \"scores\" section are hypothetical and based on a general understanding of the gene function. They do not reflect specific experimental evidence and should not be used as a definitive guide to the functions of ADAM17 in the context of influenza virus infection or airway epithelium biology. Actual scores would require thorough research and evidence from scientific literature."
]
},
"ADAM28": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ADAM28\",",
" \"brief_summary\": \"ADAM28, also known as disintegrin and metalloproteinase domain-containing protein 28, is a protein that in humans is encoded by the ADAM28 gene. This gene belongs to the ADAM family, which is characterized by a disintegrin and metalloproteinase domain. These proteins are involved in a variety of processes including cell adhesion, cell fusion, and the shedding of membrane proteins. The specific functions of ADAM28 in the airway epithelium or in response to influenza virus infection are less well characterized compared to other members of the ADAM family.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided above are placeholders (all set to 0) because without specific scientific evidence or references, it's not possible to accurately assign scores to these statements. To provide accurate scores, one would need to review relevant scientific literature for evidence of ADAM28's role in these specific aspects of airway epithelium biology and response to influenza virus infection."
]
},
"ADAM8": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ADAM8\",",
" \"brief_summary\": \"ADAM8, also known as a disintegrin and metalloprotease domain 8, is a member of the ADAM protein family that is involved in various biological processes, including cell-cell and cell-matrix interactions, proteolysis of membrane proteins, and signal transduction. It has been implicated in inflammatory responses, bone development, nervous system development, and cancer.\",",
" \"statements\": {",
" \"This gene is specifically associated with the test case\": 6,",
" \"This gene is specifically associated with the biology of cells\": 3,",
" \"This gene is specifically associated with the biology of proteins\": 3,",
" \"This gene is specifically associated with the biology of metabolites\": 3,",
" \"This gene is involved in mediating the induction\": 5,",
" \"This gene is implicated in mediated damage\": 4,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 5,",
" \"This gene is involved in conferring drug resistance\": 3,",
" \"This gene is involved in mediating the response to blockage\": 6,",
" \"This gene is involved in mediating the initiation of cells\": 4,",
" \"This gene is involved in mediating the blockage\": 7,",
" \"This gene is involved in mediating the priming of the cells\": 5",
" }",
"}",
"```",
"Please note that the scores provided for each statement are for illustrative purposes and represent a hypothetical scenario. Actual evidence may vary, and these scores should not be used as a definitive source without consulting current scientific literature and databases."
]
},
"ADAR": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ADAR\",",
" \"summary\": \"ADAR (Adenosine Deaminase, RNA Specific) is a gene that encodes a protein responsible for editing adenosine to inosine in double-stranded RNA (dsRNA) substrates, which is a form of post-transcriptional modification. This editing can alter the coding sequence of mRNAs and affect their function. ADAR activity is involved in various cellular processes including RNA editing, innate immune response, and may play a role in the development of cancer and neurological disorders.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 3,",
" \"This gene is involved in mediating the response to blockage\": 4,",
" \"This gene is involved in mediating the initiation of cells\": 3,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 4",
" }",
"}",
"```",
"",
"Please note that the scores provided here are not based on specific scientific evidence but are hypothetical values meant to illustrate how one might represent the level of evidence for these statements in JSON format. Actual scores would require a thorough review of the scientific literature."
]
},
"ADGB": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ADGB\",",
" \"brief_summary\": \"ADGB, also known as adhesion G protein-coupled receptor B, is a gene that encodes a protein which may be involved in cell adhesion. This gene is a member of the adhesion GPCR family and has been implicated in various biological processes. However, its specific role in the airway epithelium and response to influenza virus infection requires further investigation.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the evidence scores have been set to 0, as there is no specific evidence provided in the brief summary or from the information available up to the knowledge cutoff date that directly associates the ADGB gene with the specific statements listed. If there is research or data that links ADGB with these roles in airway epithelium or influenza virus infection, the scores should be adjusted accordingly based on the strength of the evidence."
]
},
"ADGRA3": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ADGRA3\",",
" \"brief_summary\": \"The gene ADGRA3 encodes a member of the adhesion G protein-coupled receptor (GPCR) family. These receptors play roles in various biological processes including cell-cell interaction, cell adhesion, and signal transduction. The specific functions of ADGRA3 in the airway epithelium or its role in influenza virus infection and immune response are not well characterized in the current scientific literature.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided above are all set to 0, as there is no specific evidence provided in the prompt that links ADGRA3 to the statements listed. If there is scientific evidence to support any of these claims, the corresponding scores should be adjusted accordingly based on the strength of that evidence."
]
},
"ADGRG1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ADGRG1\",",
" \"brief_summary\": \"The ADGRG1 gene, also known as GPR56, encodes a member of the adhesion G protein-coupled receptor (GPCR) family. These receptors are characterized by an extended extracellular region with a variety of domain structures. The encoded protein is involved in several biological processes, which may include cell adhesion and signal transduction. It plays a role in the development of the nervous system and other bodily systems and has been studied in the context of cancer and neurological diseases.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 5,",
" \"This gene is specifically associated with the biology of cells\": 4,",
" \"This gene is specifically associated with the biology of proteins\": 2,",
" \"This gene is specifically associated with the biology of metabolites\": 3,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 2,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 6,",
" \"This gene is involved in mediating the priming of the cells\": 5",
" }",
"}",
"```",
"",
"Please note that the scores provided in the \"evidence_scores\" section are hypothetical and illustrative. They do not reflect any actual research data or consensus within the scientific community, as the actual scores would depend on the available scientific literature and findings related to the ADGRG1 gene and its role in the context of influenza virus infection and airway epithelium biology. To obtain accurate scores, a comprehensive review of the scientific literature would be necessary."
]
},
"ADGRL2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ADGRL2\",",
" \"brief_summary\": \"ADGRL2 (Adhesion G Protein-Coupled Receptor L2) is a Protein Coding gene. Diseases associated with ADGRL2 include Attention Deficit-Hyperactivity Disorder and Schizophrenia. Its related pathways are GPCRs, Other and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is ADGRL3.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided here are set to 0 due to the lack of specific evidence available up to my knowledge cutoff date. If there is research available that associates ADGRL2 with any of the mentioned statements, the scores would need to be updated accordingly based on that evidence."
]
},
"ADH1C": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ADH1C\",",
" \"brief_summary\": \"ADH1C, or alcohol dehydrogenase 1C, is a member of the alcohol dehydrogenase family, which metabolizes various substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. It plays a role in metabolizing alcohol within the liver and has been studied in the context of alcohol metabolism and associated disorders, but it is not primarily known for its role in airway epithelium biology.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores assigned to each statement are hypothetical and based on general knowledge that ADH1C is predominantly known for its role in alcohol metabolism. The actual evidence for these statements might differ, and specific literature searches would be needed to provide accurate scores. The scores of 0 indicate low to no evidence, while scores of 1 or 2 indicate a very weak association, which is not well established or is speculative based on the known functions of ADH1C. The scores might be higher if there is direct evidence supporting these statements in scientific literature."
]
},
"ADH5": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ADH5\",",
" \"brief_summary\": \"ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide) is a gene that encodes for a member of the alcohol dehydrogenase family, which is involved in the metabolism of various substrates, including ethanol and retinol. The ADH5 gene product is also known as glutathione-dependent formaldehyde dehydrogenase, which is involved in the detoxification of formaldehyde, a potent irritant, and a byproduct of cellular metabolism as well as environmental exposure.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores provided are illustrative and based on hypothetical evaluation. For specific research-based evidence scores on the association of ADH5 with the given statements, scientific literature and experimental data need to be reviewed."
]
},
"ADH6": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ADH6\",",
" \"brief_summary\": \"The ADH6 gene encodes a member of the alcohol dehydrogenase family, which is involved in the metabolism of alcohols in the liver and other tissues. This enzyme class is responsible for the conversion of alcohols into aldehydes or ketones. ADH6 has a different enzymatic activity profile compared to other alcohol dehydrogenase family members and is expressed less widely in the body.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided above are based on the lack of specific evidence connecting the ADH6 gene to airway epithelium biology or influenza virus infection mechanisms. The scores may change as new research emerges, so it is essential to consult the latest scientific literature for the most current information. If there is evidence for any of these statements, the respective scores should be adjusted accordingly."
]
},
"ADH7": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ADH7\",",
" \"summary\": \"ADH7, also known as alcohol dehydrogenase 7, is a member of the alcohol dehydrogenase family. It encodes a class IV alcohol dehydrogenase, which is responsible for the metabolism of ethanol and other alcohols in the body. This enzyme is also involved in the metabolism of retinol to retinoic acid, which plays a role in the regulation of gene transcription. ADH7 is expressed in several tissues, including the gastrointestinal tract, but its expression and specific role in the airway epithelium are less well characterized.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 1",
" }",
"}",
"```",
"",
"Please note that the scores provided for the statements are hypothetical and are based on a general understanding of the gene's function. Specific research would need to be conducted to provide accurate scores for these statements."
]
},
"ADI1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ADI1\",",
" \"summary\": \"The ADI1 gene encodes a protein that is involved in the metabolism of methionine and is part of the S-adenosylmethionine (SAM) cycle. This protein, known as acireductone dioxygenase 1, plays a role in the methionine salvage pathway, which recycles methionine from S-adenosylhomocysteine. The activity of ADI1 is crucial for maintaining cellular methionine levels and for various methylation reactions that are critical for normal cellular function.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided are filled with the value '0' by default and do not represent any actual analysis or evidence. These scores would need to be updated with actual values based on research and evidence related to the ADI1 gene and its roles in the contexts mentioned. The summary provided is a brief description of the ADI1 gene's general biological function without specific reference to its role in airway epithelium or influenza infection, as there is no strong evidence to suggest a specific link to these areas at the time of my knowledge cutoff."
]
},
"ADM": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ADM\",",
" \"summary\": \"The ADM gene encodes adrenomedullin, a peptide hormone that is involved in various physiological processes including vasodilation, angiogenesis, antimicrobial activity, and regulation of hormonal secretion. It is expressed in a wide variety of tissues, including cardiovascular, central nervous system, and possibly the respiratory tract, where it may play a role in the local physiology and response to injury or infection.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 3,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 3,",
" \"This gene is involved in conferring drug resistance\": 3,",
" \"This gene is involved in mediating the response to blockage\": 4,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 4",
" }",
"}",
"```",
"Please note that the scores provided are hypothetical and for illustrative purposes. Actual evidence scores would depend on a detailed review of scientific literature and experimental data, which is beyond the scope of this AI's knowledge."
]
},
"AFAP1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AFAP1\",",
" \"brief_summary\": \"The gene AFAP1 encodes the protein actin filament-associated protein 1, which is known to play a role in the organization of the actin cytoskeleton. It is involved in cross-linking actin filaments and may be involved in the establishment and maintenance of cell morphology and signaling pathways linked to actin dynamics. The protein encoded by AFAP1 is also implicated in cancer cell motility and invasiveness, but its role in airway epithelium biology and influenza virus interactions has not been as clearly defined.\",",
" \"scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores given are hypothetical and indicate a low level of evidence (score of 0) for the statements listed, as there is no specific information provided that links AFAP1 to those exact biological processes or its role in influenza virus interactions in the airway epithelium. These scores should be updated based on the results from scientific studies and available literature that could provide evidence for each statement."
]
},
"AFF1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AFF1\",",
" \"summary\": \"AFF1, also known as AF4 or MLLT2, is a gene that encodes a member of the AF4/LAF4/FMR2 (ALF) family of transcription factors. It is involved in transcriptional activation as part of the RNA polymerase II complex and plays a role in the elongation of nascent transcripts. AFF1 is also known for its involvement in chromosomal translocations associated with acute lymphoblastic leukemia, where it is frequently fused with the MLL (mixed lineage leukemia) gene.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```"
]
},
"AGAP3": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AGAP3\",",
" \"brief_summary\": \"AGAP3 (ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 3) is a gene that encodes a protein belonging to the ArfGAP family, which is involved in GTPase-activating protein activity for ADP ribosylation factor (a small GTP-binding protein). The protein encoded by AGAP3 may be involved in cytoskeletal organization and dynamics, but its specific functions in various biological processes, including those in the airway epithelium, are still being explored and are not fully understood.\",",
" \"statements\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided are hypothetical and are set to 0, indicating low evidence because there is no specific information provided about AGAP3's role in airway epithelium biology or its involvement in influenza virus infection and immune response in the context of this request. Actual evidence may vary, and the scores should be adjusted based on detailed scientific research and evidence available from credible sources."
]
},
"AGBL2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AGBL2\",",
" \"brief_summary\": \"ATP/GTP Binding Protein Like 2 (AGBL2) is a gene that encodes a protein involved in the metabolism of cytosolic carboxypeptidases, which play a role in the post-translational modification of tubulin. The exact functions of AGBL2 in the airway epithelium are not well-characterized, but it may be involved in cellular processes that affect the structure and function of cilia and microtubules.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 2,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided are illustrative and not based on specific scientific evidence. Actual scores would require a thorough review of the scientific literature. In the absence of specific data, most scores have been set to 0, indicating low evidence, and some have been given low positive scores to reflect potential but not well-established associations with airway epithelium biology, particularly related to ciliated cells due to the role of AGBL2 in microtubule modification which can be important for cilia function."
]
},
"AGL": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AGL\",",
" \"brief_summary\": \"AGL (Amylo-Alpha-1, 6-Glucosidase, 4-Alpha-Glucanotransferase) is a gene that encodes the glycogen debranching enzyme. This enzyme is involved in glycogen metabolism and is responsible for the degradation of glycogen. Mutations in AGL are associated with glycogen storage disease type III, which affects the liver, cardiac muscle, and in some cases, skeletal muscle, leading to a range of symptoms including hepatomegaly, hypoglycemia, and muscle weakness.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 1,",
" \"This gene is involved in mediating the priming of the cells\": 1",
" }",
"}",
"```",
"Please note that the evidence scores assigned to the statements are set to 0, indicating low or no evidence of direct association with the specific biological aspects of the airway epithelium or influenza virus infection, based on the general knowledge of the AGL gene's function in glycogen metabolism. Scores of 1 are provided for the last two statements as there may be some indirect involvement of glycogen metabolism in immune responses, but this is not specific to the AGL gene or its known primary functions. The exact scores may vary based on the latest research findings which are beyond my knowledge cutoff date."
]
},
"AGO2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AGO2\",",
" \"brief_summary\": \"AGO2, also known as Argonaute 2, is a protein-coding gene that plays a crucial role in RNA silencing processes, such as RNA interference (RNAi) and microRNA (miRNA) regulation. It is a part of the RNA-induced silencing complex (RISC), where it interacts with miRNAs and siRNAs to regulate gene expression by cleaving mRNA molecules whose sequence is complementary to the bound siRNA or miRNA. AGO2 is involved in various cellular processes including development, differentiation, and maintenance of cell type identity.\"",
"}",
"",
"{",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 2,",
" \"This gene is involved in mediating the induction\": 3,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 3,",
" \"This gene is implicated in the process of replication\": 3,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 4,",
" \"This gene is involved in mediating the response to blockage\": 5,",
" \"This gene is involved in mediating the initiation of cells\": 4,",
" \"This gene is involved in mediating the blockage\": 7,",
" \"This gene is involved in mediating the priming of the cells\": 6",
"}",
"```",
"",
"Please note that the scores provided are not based on extensive scientific evidence or research but are rather educated guesses based on AGO2's general role in RNA silencing and potential implications in viral infection responses. Actual scores might vary and would require thorough literature research and expertise in the field to accurately determine."
]
},
"AGPS": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AGPS\",",
" \"brief_summary\": \"The AGPS gene encodes for alkylglycerone phosphate synthase, an enzyme involved in the biosynthesis of ether lipids. These lipids are crucial components of cell membranes and have roles in various cellular processes including signal transduction, cell differentiation, and membrane fluidity.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 1",
" }",
"}",
"```",
"",
"Please note that the scores provided here are hypothetical and not based on specific scientific evidence. Actual scores would depend on the results of scientific research which might not be available or conclusive for the AGPS gene in relation to the statements provided. The scores above are given as an example of how evidence could be quantified in a JSON format, assuming a general knowledge about the AGPS gene and its functions."
]
},
"AGRN": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AGRN\",",
" \"summary\": \"The AGRN gene provides instructions for making a protein called agrin, which plays a key role in the development and maintenance of the neuromuscular junction (the connection between nerve cells and muscle cells). Agrin is located in the synaptic basal lamina, a part of the muscle cell membrane that is involved in signal transmission between nerves and muscles. Mutations in this gene may be involved in various neuromuscular conditions and congenital myasthenic syndrome.\",",
" \"statements\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores provided for the statements are hypothetical and do not reflect actual scientific evidence. For accurate scores, a detailed literature review and scientific research would be required. The summary provided for the AGRN gene is also simplified and may not encompass all aspects of its function or related disorders."
]
},
"AHCYL2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AHCYL2\",",
" \"summary\": \"The AHCYL2 gene encodes a protein that is involved in the regulation of ion transport and may play a role in the development of epithelial tissues. It is a member of the adenosylhomocysteinase-like (AHCY) family and has been studied for its potential role in various cellular processes, such as signal transduction and enzyme regulation. However, specific functions in airway epithelium and response to influenza virus are not well-characterized in the literature as of the knowledge cutoff date.\",",
" \"statements\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores provided are a rough estimate based on general knowledge about gene functions and the typical roles of epithelial cells in the airway. These scores are not based on specific scientific evidence for the AHCYL2 gene and should be taken as hypothetical. For accurate and evidence-based information, a thorough review of the current scientific literature is recommended."
]
},
"AHNAK": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AHNAK\",",
" \"brief_summary\": \"AHNAK is a large protein that has been implicated in various cellular processes, including cell migration, differentiation, and signal transduction. It is found in many tissues and cell types and has been associated with several diseases, including cancer. AHNAK is known to interact with various proteins and contribute to the architecture of the cell, but its precise biological functions are still being investigated.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 2,",
" \"This gene is specifically associated with the biology of proteins\": 2,",
" \"This gene is specifically associated with the biology of metabolites\": 2,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 2,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 4",
" }",
"}",
"```",
"",
"Please note that the scores provided are estimates based on the summary information and the gene's general functions. The actual scores could vary based on specific experimental evidence, which may not be available from the provided summary. These scores should thus be validated by further research and scientific evidence."
]
},
"AHNAK2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AHNAK2\",",
" \"brief_summary\": \"AHNAK Nucleoprotein 2 (AHNAK2) is a protein-coding gene that encodes a large scaffold protein. AHNAK2 is known to be involved in various cellular processes including signal transduction, cell migration, and the organization of the actin cytoskeleton. It may also play a role in pathology such as cancer progression. However, the specific functions of AHNAK2 in the airway epithelium and its role in influenza virus interactions within the airway epithelium are less well characterized.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the evidence scores provided above are not based on a thorough scientific evaluation but are rather indicative of the potential relevance of the AHNAK2 gene in the context given. For accurate assessments, extensive literature reviews and experimental data would be necessary."
]
},
"AHR": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AHR\",",
" \"brief_summary\": \"The gene AHR encodes the aryl hydrocarbon receptor, which is involved in the regulation of biological responses to planar aromatic (aryl) hydrocarbons. This receptor is a transcription factor that can be activated by binding of various ligands, including environmental pollutants, such as dioxins, and natural compounds, such as indoles. Upon activation, AHR translocates to the nucleus, where it influences the expression of multiple genes, including those involved in xenobiotic metabolism. AHR is also involved in developmental processes, immune system function, and cell cycle regulation.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 5,",
" \"This gene is specifically associated with the biology of cells\": 3,",
" \"This gene is specifically associated with the biology of proteins\": 3,",
" \"This gene is specifically associated with the biology of metabolites\": 3,",
" \"This gene is involved in mediating the induction\": 4,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 3,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 4,",
" \"This gene is involved in conferring drug resistance\": 4,",
" \"This gene is involved in mediating the response to blockage\": 5,",
" \"This gene is involved in mediating the initiation of cells\": 3,",
" \"This gene is involved in mediating the blockage\": 7,",
" \"This gene is involved in mediating the priming of the cells\": 5",
" }",
"}",
"```",
"",
"Please note that the evidence scores provided are arbitrary and not based on specific scientific literature. In reality, these scores would need to be determined by a thorough review of the available research. The provided scores are for the sake of example only."
]
},
"AHSA1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AHSA1\",",
" \"brief_summary\": \"The AHSA1 gene encodes a protein known as activator of HSP90 ATPase activity 1. This protein functions as a co-chaperone that interacts with the ATPase domain of the heat shock protein 90 (HSP90) and can stimulate its activity. Through its role in the HSP90 chaperone machinery, AHSA1 is involved in the folding, stabilization, and activation of a wide range of client proteins, many of which are involved in signal transduction, cell cycle control, and transcriptional regulation. Dysregulation of AHSA1 has been implicated in various cancers, and it may also play a role in neurodegenerative diseases due to its involvement in protein quality control mechanisms.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 5",
" }",
"}",
"```",
"",
"Please note that the scores provided for the statements are hypothetical and used as an example. The actual evidence supporting these statements may vary and would require detailed literature review and research to accurately assess."
]
},
"AIDA": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AIDA\",",
" \"summary\": \"The gene AIDA (axoneme-associated protein) is not a widely recognized gene in the context of airway epithelium biology or influenza virus infection. Due to limited information, a specific summary for this gene in relation to airway epithelium and influenza cannot be provided. If AIDA refers to a different gene or if it is an acronym used within a specific study or context, additional information would be required to provide an accurate summary and assessment.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores are set to 0 for all statements due to the lack of information on the gene AIDA in the context of airway epithelium biology and influenza virus infection. If AIDA is an acronym or refers to a specific gene of interest in a particular study, then the scores and summary could change with more specific information."
]
},
"AK1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AK1\",",
" \"brief_summary\": \"AK1, or Adenylate Kinase 1, is a gene that encodes an enzyme involved in the nucleotide metabolism pathway. This enzyme catalyzes the transfer of phosphate from ATP to AMP to generate ADP. It plays a crucial role in maintaining the balance of cellular energy economy and is ubiquitously found in cytoplasmic compartments of various tissues.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 3,",
" \"This gene is involved in mediating the initiation of cells\": 3,",
" \"This gene is involved in mediating the blockage\": 4,",
" \"This gene is involved in mediating the priming of the cells\": 4",
" }",
"}",
"```",
"",
"**Note:** The scores provided in the \"evidence_scores\" are speculative and not based on specific scientific evidence. They are meant to serve as an illustrative example and do not represent factual information. For accurate evidence-based scores, one would need to consult scientific literature and databases specific to gene function and disease association."
]
},
"AK4": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AK4\",",
" \"summary\": \"AK4, or adenylate kinase 4, is a gene that encodes for an enzyme involved in the cellular energy homeostasis by catalyzing the conversion of ATP and AMP to two molecules of ADP. This enzyme is localized in the mitochondrial matrix and plays a role in the adenine nucleotide metabolism within the cell.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"Please note that the scores provided for the statements regarding the gene AK4 are speculative and based on the general biological role of AK4. There may be limited or no direct evidence regarding AK4's specific role in airway epithelium biology or its involvement in influenza virus infection dynamics, which is reflected in the low scores for these statements. The scores related to innate and adaptive immune responses are slightly higher due to the general involvement of energy metabolism in these processes, but specific evidence linking AK4 to these functions in the context of influenza infection would be necessary for a definitive score."
]
},
"AK7": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AK7\",",
" \"summary\": \"The AK7 gene encodes adenylate kinase 7, an enzyme that plays a role in cellular energy homeostasis by catalyzing the reversible transfer of phosphate between ATP and AMP. This process is crucial for maintaining an adequate supply of ATP, which is the primary energy currency in cells. AK7 is expressed in various tissues, and its precise biological functions, particularly in the context of specific cell types like those in the airway epithelium, are still being investigated.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Note: The scores have been set to 0 as no specific evidence has been provided in the prompt regarding AK7's role in the context of airway epithelium or influenza virus infection. More detailed research and peer-reviewed studies would be required to give accurate scores for these statements."
]
},
"AK8": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AK8\",",
" \"brief_summary\": \"Adenylate kinase 8 (AK8) is a member of the adenylate kinase family of enzymes involved in regulating the cellular adenine nucleotide composition and in the energy metabolism of cells. The specific functions and processes that AK8 is involved in are not fully characterized, but it is known to have nucleoside diphosphate kinase activity and may play a role in nucleotide metabolism and energy homeostasis.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided are placeholders and reflect a lack of information specific to the gene AK8 in relation to airway epithelium biology and influenza virus interactions. It is important to consult the latest research literature or databases for up-to-date evidence and information on the role of AK8 in these contexts. The provided scores should be replaced with actual evidence scores based on scientific research."
]
},
"AK9": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AK9\",",
" \"brief_summary\": \"Adenylate kinase 9 (AK9) is a nucleoside monophosphate (NMP) kinase that is involved in the regulation of cellular energy metabolism by catalyzing the reversible transfer of the terminal phosphate group between ATP and AMP. This enzyme is found in various tissues and plays a role in the homeostasis of cellular adenine nucleotide ratios.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided are default values (0) indicating a lack of specific evidence linking the gene AK9 to the listed statements, particularly in the context of airway epithelium biology or influenza virus interactions. This does not necessarily mean that the gene has no role in those processes, but rather that there is no widely accepted evidence available as of the knowledge cutoff date or that such evidence was not provided in the response. These scores can be updated with actual values if specific research or evidence becomes available that supports any of these statements."
]
},
"AKAP12": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AKAP12\",",
" \"summary\": \"The AKAP12 gene encodes A-kinase anchoring protein 12, which is a member of the A-kinase anchoring protein (AKAP) family. AKAP12 is involved in the scaffolding of protein kinase A (PKA) and other signaling enzymes to specific locations within the cell. It is implicated in various cellular processes, including the regulation of cell growth, cell motility, and angiogenesis. AKAP12 may also play a role in the regulation of the cytoskeleton architecture and in the maintenance of cellular integrity.\",",
" \"associations\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 2,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores provided are hypothetical and not based on specific scientific evidence. In reality, the level of association between AKAP12 and the attributes mentioned would need to be determined by a thorough review of the scientific literature. The scores should be interpreted with caution and are for illustrative purposes only."
]
},
"AKAP14": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AKAP14\",",
" \"brief_summary\": \"The gene AKAP14 (A-Kinase Anchoring Protein 14) is not a standard gene symbol and does not correspond to a known gene in current genomic databases. It is possible that AKAP14 is a misnomer, a gene symbol that has been updated, or a gene that is not widely recognized. Therefore, a brief summary is not available as it is not a standard gene identifier. If you are referring to a gene within the A-kinase anchoring protein (AKAP) family, please provide the correct gene symbol for accurate information.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided are all set to 0 due to the lack of information on the gene \"AKAP14,\" as it is not recognized in genomic databases. If you have more specific information or an updated gene symbol, please provide it for a more accurate assessment."
]
},
"AKAP6": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AKAP6\",",
" \"brief_summary\": \"AKAP6, also known as A-kinase anchor protein 6, is a member of the A-kinase anchor protein (AKAP) family. AKAPs are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining it to discrete locations within the cell. This particular AKAP is expressed in various tissues, with a high level of expression in cardiac and skeletal muscle. It plays a critical role in the regulation of cardiac myocyte function by anchoring PKA in close proximity to its substrates.\"",
"",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 1,",
" \"This gene is involved in mediating the priming of the cells\": 1",
" }",
"}",
"```",
"",
"Please note that the scores provided for the statements are illustrative and reflect a general lack of evidence connecting AKAP6 to airway epithelium biology or influenza virus interactions. The scores of '1' for the last two statements suggest a very low level of evidence that AKAP6 may play a role in immune responses, based on its broader biological functions, but not specifically tied to the airway epithelium or influenza virus infection. More specific research would be required to accurately score these statements."
]
},
"AKAP9": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AKAP9\",",
" \"brief_summary\": \"The gene AKAP9 encodes the A-kinase anchor protein 9, which is involved in the targeting of protein kinase A to specific locations within the cell. This can include various cellular structures such as the centrosome and the Golgi apparatus. AKAP9 plays a role in the regulation of various cellular processes by anchoring protein kinase A to specific subcellular compartments, facilitating the phosphorylation of target substrates in close proximity to these locations.\",",
" \"statements\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores provided in the \"statements\" section are hypothetical and are primarily for illustrative purposes. The actual evidence for the relationship between AKAP9 and the specific aspects of airway epithelium biology and response to influenza virus would require detailed scientific research and literature review to determine accurate scores. The scores of \"1\" indicate very low evidence, whereas \"2\" suggests a slightly higher but still low level of evidence."
]
},
"AKIRIN2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AKIRIN2\",",
" \"brief_summary\": \"AKIRIN2 is a gene that encodes a nuclear protein involved in the regulation of innate immune responses and developmental processes. It functions as a core component of the BAF60c-BAF250a complex that facilitates chromatin remodeling, which is essential for the expression of specific genes during the immune response. AKIRIN2 has been implicated in various biological functions, including embryonic development, muscle differentiation, and the regulation of cytokine expression.\"",
"",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 6,",
" \"This gene is involved in mediating the priming of the cells\": 4",
"}",
"```",
"",
"Please note that the scores provided are illustrative and may not represent actual research findings. For accurate assessments, one would need to review the current scientific literature on the gene in question. The scores have been set to 0 for statements related to specific cell types within the airway epithelium and influenza virus interactions, due to the lack of information provided on these specific aspects in the summary. The scores for general immune response involvement are arbitrarily assigned to indicate that there may be some evidence linking AKIRIN2 to these broader immune processes, but exact scores would require detailed literature review."
]
},
"AKR1B1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AKR1B1\",",
" \"brief_summary\": \"The AKR1B1 gene encodes a member of the aldo-keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes are involved in the reduction of aldehydes and ketones to their corresponding alcohols by using NADH and/or NADPH as cofactors. The AKR1B1 protein is also known as aldose reductase, and it is implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol, which contributes to osmotic and oxidative stress in tissues. Additionally, AKR1B1 has a role in detoxifying aldehydes formed by lipid peroxidation, and it is expressed in various tissues, including the eye, kidney, and nerve tissues.\",",
" \"scores\": {",
" \"This gene is specifically associated with the test case\": 3,",
" \"This gene is specifically associated with the biology of cells\": 2,",
" \"This gene is specifically associated with the biology of proteins\": 2,",
" \"This gene is specifically associated with the biology of metabolites\": 2,",
" \"This gene is involved in mediating the induction\": 4,",
" \"This gene is implicated in mediated damage\": 3,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 3,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 4,",
" \"This gene is involved in mediating the initiation of cells\": 3,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```"
]
},
"AKR1B10": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AKR1B10\",",
" \"brief_summary\": \"AKR1B10 (Aldo-Keto Reductase Family 1 Member B10) is an enzyme that in humans is encoded by the AKR1B10 gene. It is primarily involved in the detoxification of aldehydes and ketones, and it is implicated in various physiological and pathological processes such as carbohydrate metabolism and cancer development. AKR1B10 is often upregulated in certain types of cancer, including hepatocellular carcinoma and lung cancer, suggesting a potential role in tumor progression and chemoresistance.\",",
" \"scores\": {",
" \"This gene is specifically associated with the test case\": 3,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 2,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 4,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Please note that the scores are an educated guess, based on the known functions of the AKR1B10 gene and its involvement in metabolic processes and cancer development. Direct evidence linking AKR1B10 to specific airway epithelium cell types or to influenza virus infection processes at a molecular level may not be well-established, and therefore the scores may reflect a low to moderate level of evidence. The scores should be interpreted with caution and are subject to change as new research emerges."
]
},
"AKR1C2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AKR1C2\",",
" \"brief_summary\": \"The AKR1C2 gene encodes a member of the aldo/keto reductase superfamily, which is involved in the metabolism of steroid hormones and prostaglandins, as well as the reduction of aldehydes and ketones. This enzyme is expressed in a variety of tissues and plays a role in the inactivation and elimination of various endogenous and exogenous compounds.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores are speculative and based on the general biological functions of the AKR1C2 gene. The actual evidence for each statement may vary, and I have assigned low scores (0-2) due to the lack of direct evidence or widely known association of AKR1C2 with the specific statements provided. More detailed research and up-to-date scientific literature reviews would be required to provide accurate scores."
]
},
"AKR1C3": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AKR1C3\",",
" \"brief_summary\": \"AKR1C3, also known as Aldo-Keto Reductase Family 1 Member C3, is an enzyme that in humans is encoded by the AKR1C3 gene. It is involved in the metabolism of steroids, prostaglandins, and lipids. This enzyme also plays a role in the development of certain types of cancer and is a target for cancer therapy research.\",",
" \"statements_score\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"**Note:** The scores are set to 0 for all statements as there is no specific evidence provided in the question that links AKR1C3 to the biology of the airway epithelium or its involvement in influenza virus infection and its effects on the airway epithelium. To assign accurate scores, detailed scientific research or evidence needs to be reviewed. As such, the scores are placeholders and should not be considered a scientific assessment."
]
},
"AKR7A2": {
"data-turbo_1": [
"Here is the requested information in JSON format:",
"",
"```json",
"{",
" \"gene_name\": \"AKR7A2\",",
" \"brief_summary\": \"The AKR7A2 gene encodes a member of the aldo-keto reductase superfamily, which is involved in the detoxification of aldehydes and ketones. This enzyme is expressed in a variety of tissues, including the liver and has been shown to have a role in the metabolism of various toxins and carcinogens.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 3,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 4",
" }",
"}",
"```",
"",
"Please note that the scores are illustrative and not based on specific scientific evidence. They represent a hypothetical assessment of the gene's roles in various biological processes related to the airway epithelium and influenza virus infection. For accurate and evidence-based evaluations, detailed literature review and experimental data would be required."
]
},
"ALCAM": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ALCAM\",",
" \"summary\": \"ALCAM (Activated Leukocyte Cell Adhesion Molecule) is a protein-coding gene that plays a role in various cellular processes, including cell adhesion, migration, and signaling. It is a member of the immunoglobulin superfamily and is implicated in the development and maintenance of the immune system. ALCAM is also involved in the interactions between cells and the extracellular matrix, and may be relevant in cancer metastasis, immune responses, and neural development.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 2,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 4",
" }",
"}",
"```",
"",
"Please note that the scores assigned above are hypothetical and not based on specific scientific evidence. They are illustrative and meant to show how the JSON format could be used to convey such information. Actual evidence scores would need to be determined by a thorough review of the scientific literature."
]
},
"ALDH1A1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ALDH1A1\",",
" \"brief_summary\": \"ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) is a gene that encodes an enzyme involved in the oxidation of aldehydes to their corresponding carboxylic acids. It is important for the detoxification of alcohol-derived acetaldehyde and plays a role in the metabolism of vitamin A (retinoic acid synthesis). ALDH1A1 is expressed in various tissues, and its dysregulation has been associated with certain cancers and other diseases.\",",
" \"scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 1",
" }",
"}",
"```",
"",
"Please note that the scores provided are based on general knowledge and are not specific to the latest research literature. The scores are subjective assessments meant to reflect the degree of association based on current understanding, which may change as new research becomes available. The scores of 1 or 2 suggest a very low level of evidence or a speculative association, while scores of 0 indicate no known association based on the provided context."
]
},
"ALDH1L1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ALDH1L1\",",
" \"summary\": \"The gene ALDH1L1 encodes for the enzyme aldehyde dehydrogenase 1 family member L1, which is important in folate metabolism. It acts as a cytoplasmic enzyme involved in the reversible conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2, playing a role in the regulation of cell growth and proliferation. ALDH1L1 is also known as a marker of astrocytes in the central nervous system.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores provided are not based on specific scientific evidence but are a hypothetical representation intended to illustrate how the JSON format can be used to convey such information. Actual evidence for these statements should be sourced from scientific literature and databases."
]
},
"ALDH3A1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ALDH3A1\",",
" \"brief_summary\": \"ALDH3A1, or aldehyde dehydrogenase 3 family member A1, is an enzyme that belongs to the ALDH superfamily. It is involved in the oxidation of aldehydes to their corresponding carboxylic acids, playing a crucial role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. ALDH3A1 is expressed in various tissues and has been studied for its role in oxidative stress response and in the metabolism of bioactive molecules.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 3,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 3,",
" \"This gene is involved in conferring drug resistance\": 4,",
" \"This gene is involved in mediating the response to blockage\": 3,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 4",
" }",
"}",
"```",
"",
"Please note that the scores provided for the statements are not based on specific scientific evidence but are rather arbitrary values meant to give a general sense of potential association. For accurate and evidence-based information, it would be necessary to consult scientific literature and databases."
]
},
"ALDH3A2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ALDH3A2\",",
" \"brief_summary\": \"ALDH3A2, or Aldehyde Dehydrogenase 3 Family Member A2, is an enzyme that in humans is encoded by the ALDH3A2 gene. It is part of the aldehyde dehydrogenase family, which is responsible for the detoxification of aldehydes in the body. Mutations in this gene are associated with Sj\u00f6gren-Larsson syndrome, a neurocutaneous disorder characterized by ichthyosis, spasticity, and intellectual disability.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the provided scores are set to '0' by default, as there is no specific evidence provided in the question context that directly links ALDH3A2 to the statements regarding airway epithelium biology or influenza virus interaction. Further research and specific scientific evidence would be required to accurately score these statements."
]
},
"ALDH3B1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ALDH3B1\",",
" \"brief_summary\": \"The ALDH3B1 gene encodes a member of the aldehyde dehydrogenase family of proteins which are responsible for oxidizing aldehydes to their corresponding carboxylic acids. These enzymes play a key role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. ALDH3B1 is expressed in a variety of tissues and may be involved in general cellular metabolism or other specific physiological processes, but its specific functions in the airway epithelium are not well-documented in the literature as of the knowledge cutoff date.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores provided are based on a hypothetical assessment due to the lack of specific evidence in the literature (as of the knowledge cutoff date) about the involvement of ALDH3B1 in the detailed aspects of airway epithelium biology and influenza virus pathology. The scores of 1 indicate a low level of evidence while scores of 2 indicate a slightly higher, but still low, level of evidence. The scores should be interpreted as expert guesses rather than based on specific experimental data. For accurate information, consulting the latest research and reviews on ALDH3B1's role in these processes is recommended."
]
},
"ALDH5A1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ALDH5A1\",",
" \"brief_summary\": \"ALDH5A1, also known as succinate-semialdehyde dehydrogenase, is an enzyme that is involved in the degradation of the neurotransmitter gamma-aminobutyric acid (GABA) into succinate within the GABA shunt. This enzyme plays a crucial role in the GABAergic neurotransmission by maintaining the balance of GABA levels in the central nervous system. Mutations in the ALDH5A1 gene can lead to a rare autosomal recessive disorder known as succinic semialdehyde dehydrogenase deficiency, which can result in a range of neurological symptoms.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the evidence scores provided are based on the assumption that there is no known direct association between the ALDH5A1 gene and the specific statements related to airway epithelium biology and influenza virus infection. As such, they have been scored as 0, implying low evidence. If there is new evidence or research findings that indicate a connection, these scores would need to be updated accordingly."
]
},
"ALDH7A1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ALDH7A1\",",
" \"summary\": \"ALDH7A1, also known as Antiquitin, is a gene that encodes for the enzyme aldehyde dehydrogenase 7 family member A1. This enzyme is involved in the metabolism of aldehydes in the body, including the conversion of the neurotransmitter gamma-aminobutyric acid (GABA) to succinate in the brain. Mutations in this gene are associated with pyridoxine-dependent epilepsy, a rare condition that requires lifelong treatment with vitamin B6 (pyridoxine). The gene is expressed in various tissues, including the liver, kidney, muscle, and brain.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 1",
" }",
"}",
"```",
"",
"The scores provided for each statement reflect the evidence available as of my knowledge cutoff date in early 2023. Since ALDH7A1 is not directly associated with airway epithelium biology, influenza virus interaction with the airway epithelium, or the immune response specifically in the airway epithelium, the scores for these statements are low. However, given that aldehyde dehydrogenases can have roles in broader metabolic processes which might indirectly affect immune responses, very low scores are provided for the statements regarding general immune response mediation. It is important to note that new research could change these scores, and a thorough review of current literature would be required for the most accurate assessment."
]
},
"ALDH9A1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ALDH9A1\",",
" \"brief_summary\": \"ALDH9A1, also known as aldehyde dehydrogenase 9 family member A1, is an enzyme that in humans is encoded by the ALDH9A1 gene. This enzyme is part of the aldehyde dehydrogenase family, which plays a crucial role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. ALDH9A1 has been implicated in various metabolic pathways, including the metabolism of gamma-aminobutyric acid (GABA), and may have a role in other physiological and pathological processes.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 1",
" }",
"}",
"```",
"",
"Please note that the evidence scores provided above are illustrative and not based on specific scientific literature. They are intended to show a hypothetical example of how one might score the evidence for each statement. The actual scores might differ based on current research findings."
]
},
"ALKBH7": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ALKBH7\",",
" \"brief_summary\": \"ALKBH7, also known as AlkB homolog 7, is a mitochondrial protein that is part of the AlkB family of dioxygenases. It is involved in various cellular processes including mitochondrial homeostasis and apoptosis. ALKBH7 has been shown to participate in the regulation of lipid metabolism and may play a role in the pathogenesis of diseases such as obesity and cancer. However, its specific functions are not yet fully understood.\",",
" \"scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided above are based on the lack of evidence or information specifically linking the ALKBH7 gene to airway epithelium biology or influenza virus interaction with the airway epithelium as of my knowledge cutoff date. If new research emerges that provides evidence for such associations, the scores would need to be updated accordingly."
]
},
"ALOX15": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ALOX15\",",
" \"brief_summary\": \"The ALOX15 gene encodes for arachidonate 15-lipoxygenase, an enzyme that is involved in the metabolism of fatty acids to produce bioactive lipid mediators. These lipid mediators are involved in various physiological and pathophysiological processes, including inflammation, immunity, and cell signaling. The ALOX15 enzyme is known to be expressed in a variety of cell types and tissues, and its activities have been linked to diseases such as atherosclerosis, asthma, and cancer.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 3,",
" \"This gene is specifically associated with the biology of cells\": 2,",
" \"This gene is specifically associated with the biology of proteins\": 2,",
" \"This gene is specifically associated with the biology of metabolites\": 2,",
" \"This gene is involved in mediating the induction\": 4,",
" \"This gene is implicated in mediated damage\": 3,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 4,",
" \"This gene is involved in conferring drug resistance\": 3,",
" \"This gene is involved in mediating the response to blockage\": 5,",
" \"This gene is involved in mediating the initiation of cells\": 3,",
" \"This gene is involved in mediating the blockage\": 6,",
" \"This gene is involved in mediating the priming of the cells\": 5",
" }",
"}",
"```",
"",
"Please note that the scores provided above are not based on specific research data but rather are indicative of the potential relevance of the ALOX15 gene in the context of the airway epithelium and influenza virus infection. These scores should be used as a general guide and would need to be substantiated with detailed scientific evidence from research studies."
]
},
"ALPK1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ALPK1\",",
" \"brief_summary\": \"The gene ALPK1 encodes the alpha-kinase 1 protein, which is a member of the alpha-kinase family. This family of proteins is characterized by the unique alpha-kinase domain and is involved in various cellular processes. ALPK1 has been implicated in the regulation of several biological functions, including the phosphorylation of proteins involved in inflammation and immune responses. However, the specific roles of ALPK1 in the airway epithelium and its response to influenza virus infection are less well-characterized and may require further research.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 3,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 3,",
" \"This gene is involved in mediating the response to blockage\": 5,",
" \"This gene is involved in mediating the initiation of cells\": 4,",
" \"This gene is involved in mediating the blockage\": 6,",
" \"This gene is involved in mediating the priming of the cells\": 5",
" }",
"}",
"```",
"",
"Please note that the provided evidence scores are hypothetical and should be interpreted with caution. In a real-world scenario, these scores would be based on the current scientific literature, and as such, they could vary depending on the latest research and evidence available. The scores above are given as placeholders and are not based on actual scientific evidence."
]
},
"ALPL": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ALPL\",",
" \"brief_summary\": \"The ALPL gene provides instructions for making an enzyme called alkaline phosphatase. This enzyme is involved in the breakdown of certain compounds in the body, including molecules that contain phosphates, and is particularly important in the development and maintenance of bones and teeth.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"Please note that the scores provided above are arbitrary since there is no specific evidence provided in the question to associate the ALPL gene with airway epithelium biology or influenza virus interactions. The scores may differ based on future research findings or specific experimental data."
]
},
"ALS2CL": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ALS2CL\",",
" \"brief_summary\": \"ALS2CL (ALS2 C-terminal like) is a gene that encodes a protein which may be involved in endosomal trafficking. The specific biological processes and functions of the ALS2CL protein are not well characterized in the context of airway epithelium or influenza virus infection.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores are set to 0 because there is no specific evidence provided in the prompt, nor is there widely known evidence suggesting that ALS2CL is specifically associated with the airway epithelium or influenza virus interactions. More research would be needed to assign accurate scores to these statements."
]
},
"AMBRA1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AMBRA1\",",
" \"brief_summary\": \"The gene AMBRA1, which stands for Autophagy and Beclin 1 Regulator 1, is involved in the regulation of autophagy, a cellular degradation process that is important for cellular homeostasis and survival. AMBRA1 is a positive regulator of the BECN1-dependent program of autophagy and plays a role in the development of the nervous system and autophagic cell death during development.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores above are set to 0 due to a lack of specific evidence provided in the prompt regarding the role of AMBRA1 in the context of airway epithelium and influenza virus infection. If there is any recent scientific literature that has found a connection between AMBRA1 and the provided statements, the scores should be updated accordingly to reflect the strength of the evidence."
]
},
"AMD1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AMD1\",",
" \"brief_summary\": \"AMD1 (Adenosylmethionine Decarboxylase 1) is a gene that codes for an enzyme involved in the biosynthesis of polyamines, which are organic compounds that play critical roles in cell growth, proliferation, and differentiation. The enzyme catalyzed by this gene is responsible for the decarboxylation of S-adenosylmethionine (SAM) to produce decarboxylated S-adenosylmethionine (dcSAM), which is a key propylamine donor in the synthesis of polyamines. Polyamines are essential for a wide range of cellular functions, and dysregulation of polyamine metabolism can be involved in various diseases, including cancer.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the evidence scores are all set to 0 because, based on my knowledge cutoff in 2023, there is no specific evidence linking the AMD1 gene to the biology of the airway epithelium or its response to influenza virus infection. These scores should be updated according to the latest research data available."
]
},
"AMOT": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AMOT\",",
" \"summary\": \"The gene AMOT (angiomotin) is known to encode proteins involved in the regulation of endothelial cell migration and tube formation. Angiomotin proteins are part of the motin family and play a role in angiogenesis and the Hippo signaling pathway, which is important for controlling organ size and suppressing tumors. AMOT has also been implicated in the regulation of tight junction assembly and maintaining cell polarity, which are key processes in epithelial cells, including those in the airway epithelium.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 1,",
" \"This gene is involved in mediating the priming of the cells\": 1",
" }",
"}",
"```",
"",
"Please note that the scores provided in the JSON object for the various statements regarding AMOT and its association with airway epithelium and influenza virus interaction reflect a hypothetical assessment and are not based on specific scientific evidence. The actual scores may vary depending on the current research and understanding of AMOT's function in these contexts. The score of 1 is arbitrarily chosen to indicate low evidence due to the lack of specific information provided about these associations in the prompt."
]
},
"AMOTL2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AMOTL2\",",
" \"summary\": \"AMOTL2, or Angiomotin Like 2, is a gene that encodes for a protein which is a member of the motin family of angiomotins. It is involved in angiogenesis and endothelial cell migration. The protein may participate in the formation and stabilization of adherens junctions and in the establishment of cell polarity. It is also implicated in the regulation of the actin cytoskeleton and in the control of cell shape.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 1,",
" \"This gene is involved in mediating the priming of the cells\": 1",
" }",
"}",
"```",
"",
"Please note that the scores provided here are not based on extensive scientific evidence and are for demonstrative purposes only. In reality, the association and evidence of AMOTL2's role in airway epithelium biology and response to influenza virus would require a thorough review of the scientific literature. Each statement may have a different level of evidence, and the scores could vary widely based on the latest research findings."
]
},
"AMZ2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AMZ2\",",
" \"brief_summary\": \"The gene AMZ2 (Archaeal Metalloprotease Family Protein 2) encodes a protein that is part of the metzincin superfamily of metalloproteases. These enzymes play a role in a variety of cellular processes, including cell signaling, growth, and development. The specific function of AMZ2 in humans is not well characterized.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the evidence scores are set to 0 for all statements because there is no specific information provided that links AMZ2 to those aspects of airway epithelium biology or to influenza virus infection responses. These scores may change with future research and evidence. It's important to consult current scientific literature for the most up-to-date and accurate information."
]
},
"ANAPC11": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANAPC11\",",
" \"brief_summary\": \"ANAPC11 (Anaphase Promoting Complex Subunit 11) is a gene that encodes a protein which is a component of the anaphase-promoting complex (APC/C), a large E3 ubiquitin ligase that regulates various processes in cell cycle progression. The APC/C is responsible for the ubiquitination and subsequent degradation of target proteins, particularly those that need to be removed for the cell to progress from metaphase to anaphase during mitosis. This is crucial for proper cell division and maintenance of genomic stability.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Note that the scores provided are based on the lack of specific evidence linking ANAPC11 directly to the functions and processes related to the airway epithelium or influenza virus infection, as described in the statements. If new research provides evidence for any of these roles, the scores would need to be updated accordingly."
]
},
"ANAPC15": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANAPC15\",",
" \"summary\": \"ANAPC15 stands for 'Anaphase Promoting Complex Subunit 15'. It is a gene that encodes a protein that is part of the anaphase-promoting complex (APC), which is a key regulator of the cell cycle. The APC is responsible for triggering the transition from metaphase to anaphase during cell division, and it is involved in the ubiquitination and subsequent degradation of specific cell cycle proteins. ANAPC15 is one of the subunits of this complex and plays a role in its function, although the precise biological details may vary among species.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the evidence scores provided are all set to \"0\", which represents low or no evidence, as the specific relationship between the ANAPC15 gene and each of the listed statements about airway epithelium biology and influenza virus interactions is not provided within the scope of this response. To provide accurate scores, detailed literature review and research would be necessary to establish the involvement of ANAPC15 in these processes."
]
},
"ANAPC16": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANAPC16\",",
" \"brief_summary\": \"ANAPC16, also known as Anaphase Promoting Complex Subunit 16, is a component of the anaphase-promoting complex/cyclosome (APC/C), which is a highly conserved protein complex that functions as an E3 ubiquitin ligase and regulates various cell cycle processes, including the metaphase-anaphase transition and exit from mitosis. It is involved in the ubiquitination and subsequent degradation of specific cell cycle proteins, contributing to cell cycle regulation and maintaining genomic stability.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided are based on the lack of specific evidence associating ANAPC16 with the airway epithelium or influenza virus infection processes as of my knowledge cutoff date in 2023. The gene's primary function is related to cell cycle regulation, but there is no information provided that links it directly to the airway epithelium or influenza virus. If more specific research has been conducted since that time, the scores may need to be updated accordingly."
]
},
"ANAPC4": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANAPC4\",",
" \"brief_summary\": \"ANAPC4, also known as Anaphase Promoting Complex Subunit 4, is a component of the anaphase-promoting complex (APC/C), which is a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex functions by mediating the ubiquitination and subsequent degradation of target proteins, including cyclins and other cell cycle regulators.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided above are based on the general knowledge of the ANAPC4 gene function as a part of the anaphase-promoting complex and not on a detailed analysis of its role in airway epithelium biology or influenza virus infection. Therefore, all scores are set to 0, indicating a lack of evidence for these specific statements as of my last update. Research may reveal more information regarding the involvement of ANAPC4 in these processes, so it's important to consult the latest scientific literature for up-to-date evidence."
]
},
"ANG": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANG\",",
" \"brief_summary\": \"The ANG gene encodes angiogenin, a member of the ribonuclease A superfamily with roles in angiogenesis and inflammation. It is involved in the formation of new blood vessels and has been implicated in cancer progression and other diseases. Angiogenin interacts with endothelial cells and has ribonucleolytic activity that contributes to its function.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 3,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 4",
" }",
"}",
"```",
"Please note that the scores provided are arbitrary and for illustrative purposes only. Actual evidence may vary, and these scores should be determined by a thorough review of the scientific literature."
]
},
"ANGPTL4": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANGPTL4\",",
" \"brief_summary\": \"ANGPTL4 (Angiopoietin-like 4) is a protein-coding gene that plays a role in various biological processes, including lipid metabolism, angiogenesis, and wound healing. It is involved in the regulation of triglyceride metabolism by inhibiting lipoprotein lipase activity. ANGPTL4 is also known to modulate vascular permeability and is associated with cancer progression and metastasis.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 5",
" }",
"}",
"```",
"",
"Please note that the scores provided for each statement are illustrative and based on hypothetical assessments. Actual evidence may vary, and it is recommended to consult scientific literature or databases for up-to-date and accurate information on the gene ANGPTL4 and its association with specific cellular functions and disease mechanisms."
]
},
"ANKFN1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANKFN1\",",
" \"brief_summary\": \"ANKFN1 (Ankyrin Repeat And Fibronectin Type III Domain Containing 1) is a protein-coding gene that contains ankyrin repeats and fibronectin type III domains. The function of this gene has not been fully characterized, but ankyrin repeats are known to be important in protein-protein interactions, and fibronectin type III domains are involved in the binding of fibronectin to integrins and other extracellular matrix proteins. The role of ANKFN1 in specific tissues or cellular processes is not well-documented in the literature as of the knowledge cutoff date.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the provided evidence scores are based on the lack of specific documented association of the ANKFN1 gene with the statements listed, as of the knowledge cutoff date. If new research has been published that provides evidence for any of these associations, the scores should be updated accordingly."
]
},
"ANKFY1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANKFY1\",",
" \"brief_summary\": \"ANKFY1 (Ankyrin Repeat And FYVE Domain Containing 1) is a Protein Coding gene. Diseases associated with ANKFY1 include Retinitis Pigmentosa and Cone-Rod Dystrophy. Its molecular function is related to Rab GTPase binding and it is involved in the biological process of endosome to lysosome transport. The protein encoded by ANKFY1 has a role in endocytic trafficking and is characterized by ankyrin repeats and a FYVE domain, which is involved in the interaction with phosphatidylinositol 3-phosphate, found in endosomal membranes.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores provided are hypothetical and for illustrative purposes only. The actual evidence supporting these statements would require thorough literature research and may not be represented accurately in the scores above."
]
},
"ANKIB1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANKIB1\",",
" \"summary\": \"ANKIB1, or Ankyrin repeat and IBR domain-containing protein 1, is a gene that encodes a protein with ankyrin repeat and IBR (in between RING fingers) domains. The protein may be involved in protein-protein interactions and could have a role in the regulation of various cellular processes, although its specific function in airway epithelium biology remains unclear without further context or research data.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Note: The scores provided are all set to 0 as this is a hypothetical exercise and there is no specific evidence given in the prompt to suggest that ANKIB1 is associated with the functions or processes mentioned. More detailed and context-specific scientific research would be needed to accurately score these statements."
]
},
"ANKLE2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANKLE2\",",
" \"brief_summary\": \"ANKLE2, also known as ankyrin repeat and LEM domain-containing protein 2, is a gene that encodes a protein with roles in various cellular processes including cell cycle regulation, DNA damage response, and maintenance of nuclear envelope integrity. It is involved in mitotic spindle assembly and has been implicated in neurodevelopmental disorders.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"The scores provided are all zeroes, indicating a lack of evidence in the literature that the gene ANKLE2 is specifically associated with the statements listed, particularly regarding airway epithelium and influenza virus interactions. If new research provides evidence for any of these associations, the scores would need to be updated accordingly."
]
},
"ANKRD17": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANKRD17\",",
" \"brief_summary\": \"ANKRD17, also known as Ankyrin Repeat Domain 17, is a gene that encodes a protein which is believed to be involved in various cellular processes such as transcription regulation and cell cycle control. The protein contains ankyrin repeats, which are known to mediate protein-protein interactions. The exact functions of ANKRD17 within airway epithelium and its role in respiratory diseases or viral infections like influenza remain to be fully elucidated.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 2,",
" \"This gene is specifically associated with the biology of proteins\": 2,",
" \"This gene is specifically associated with the biology of metabolites\": 2,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 2,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the evidence scores provided are hypothetical and not based on specific scientific data. The actual evidence for the association of ANKRD17 with the statements provided may vary, and it is important to consult the latest research for accurate information."
]
},
"ANKRD28": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANKRD28\",",
" \"brief_summary\": \"ANKRD28 (Ankyrin Repeat Domain 28) is a Protein Coding gene. Diseases associated with ANKRD28 include Pertussis and Whooping Cough. Among its related pathways are Innate Immune System and Interleukin-11 Signaling Pathway. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is ANKRD44.\",",
" \"scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided are based on the lack of specific evidence relating ANKRD28 to the detailed statements about airway epithelium and influenza virus interactions. If more recent or specific research has been published that provides evidence for any of these statements, the scores may need to be updated accordingly. As of my last update, there was no direct evidence to suggest that ANKRD28 is involved in these specific aspects of airway epithelium biology or influenza virus interactions."
]
},
"ANKRD36C": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANKRD36C\",",
" \"summary\": \"ANKRD36C (Ankyrin Repeat Domain 36C) is a protein-coding gene that belongs to the ankyrin repeat family. Ankyrin repeats are a common protein domain involved in protein-protein interactions. The specific functions of ANKRD36C are not well characterized, and its role in various biological processes and diseases remains to be elucidated.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided above are set to 0 due to a lack of specific information or evidence linking the ANKRD36C gene to the statements provided. These scores would need to be updated as new research becomes available that might support or refute these associations."
]
},
"ANKRD37": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANKRD37\",",
" \"summary\": \"ANKRD37 (Ankyrin Repeat Domain 37) is a Protein Coding gene. The ANKRD37 gene encodes a protein that contains ankyrin repeats, which are known to be important in protein-protein interactions. The specific functions of ANKRD37 are not well characterized, but ankyrin repeat-containing proteins are generally involved in various cellular processes, including signal transduction, cell cycle regulation, and the regulation of transcriptional activity.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```"
]
},
"ANKRD65": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANKRD65\",",
" \"brief_summary\": \"ANKRD65, or Ankyrin Repeat Domain 65, is a protein-coding gene with currently limited characterization. The function of this gene is not well understood, and its role in various biological processes and pathways remains to be elucidated through future research.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores have been set to 0 due to the lack of evidence or specific associations of ANKRD65 with the statements provided, as of my knowledge cutoff date in 2023. More research may be needed to provide accurate scores for these statements."
]
},
"ANKRD66": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANKRD66\",",
" \"brief_summary\": \"ANKRD66, also known as Ankyrin Repeat Domain 66, is a protein-coding gene. The specific functions of this gene in the airway epithelium or its role in relation to influenza virus and immune responses are not well-documented in the scientific literature as of the last knowledge update.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note: The scores provided are based on the lack of specific information about ANKRD66 being associated with the listed statements in the scientific literature as of the last knowledge update. If there has been recent research providing new insights into the role of ANKRD66, these scores may not accurately reflect the current state of knowledge."
]
},
"ANKUB1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANKUB1\",",
" \"brief_summary\": \"ANKUB1, which stands for Ankyrin repeat and ubiquitin domain containing 1, is a protein-coding gene that may play a role in various cellular processes, including protein modification and degradation pathways. The specific functions of ANKUB1 in the airway epithelium or in response to viral infections such as influenza are not well characterized, and relevant literature is limited as of the current knowledge cutoff date.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 1,",
" \"This gene is involved in mediating the priming of the cells\": 1",
" }",
"}",
"```",
"",
"Please note that the scores provided are hypothetical and do not necessarily reflect actual evidence since detailed information about the gene ANKUB1 is limited. The scores are intended to demonstrate the JSON format you requested. For accurate information, further scientific research and evidence are needed."
]
},
"ANLN": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANLN\",",
" \"brief_summary\": \"The ANLN gene encodes Anillin, actin binding protein, which plays a crucial role in cytokinesis during cell division. It is involved in the organization and stabilization of the contractile ring that forms between dividing cells. Anillin interacts with actin filaments, myosin, and other proteins to coordinate the final stages of cell division. It has also been implicated in various cellular processes including cell migration, and its dysregulation is associated with certain forms of cancer.\",",
" \"gene_association_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 3,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 4,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Please note that the scores provided above are hypothetical and are meant to serve as an example of how one might score the association of the ANLN gene with various statements related to airway epithelium biology and influenza virus infection. Actual scores would require a thorough review of the scientific literature. The scores I assigned are conservative estimates and should not be taken as authoritative without proper scientific backing."
]
},
"ANOS1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANOS1\",",
" \"brief_summary\": \"ANOS1, formerly known as KAL1, is a gene that encodes a protein involved in the migration of the gonadotropin-releasing hormone (GnRH) and olfactory neurons during embryonic development. Mutations in this gene are associated with Kallmann syndrome, a condition characterized by hypogonadotropic hypogonadism and anosmia (the inability to perceive odors).\"",
"}",
"```",
"",
"```json",
"{",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
"}",
"```",
"",
"Please note that the scores above are based on the known functions of ANOS1 as associated with Kallmann syndrome and neuronal migration, not airway epithelium or influenza virus infection. Therefore, they have been rated with a score of 0. This does not imply that the gene has absolutely no role in those areas, but rather that there is no well-established evidence linking ANOS1 to those specific functions or processes as of my knowledge cutoff date."
]
},
"ANTXR1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANTXR1\",",
" \"brief_summary\": \"ANTXR1, also known as anthrax toxin receptor 1, is a protein encoded by the ANTXR1 gene in humans. It is a type I transmembrane protein and a receptor for anthrax toxin. The ANTXR1 protein plays a role in endothelial cell migration and angiogenesis and is involved in interactions with extracellular matrix proteins and integrins. Mutations in this gene have been associated with juvenile hyaline fibromatosis and infantile systemic hyalinosis.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note: The scores provided are hypothetical and based on the information given. There's no specific evidence provided in the question that links the ANTXR1 gene to the specific statements about airway epithelium or influenza virus infection, hence all scores are set to zero. To obtain accurate scores, a thorough literature search and scientific evidence would be required."
]
},
"ANTXR2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ANTXR2\",",
" \"brief_summary\": \"ANTXR2, also known as capillary morphogenesis gene 2 (CMG2), is a protein that in humans is encoded by the ANTXR2 gene. It is a type I transmembrane protein and acts as a receptor for anthrax toxin. ANTXR2 is involved in various cellular processes, including endothelial cell proliferation and capillary tube formation. Mutations in the ANTXR2 gene can lead to hyaline fibromatosis syndrome, which is characterized by abnormal growth of fibrous tissue and can manifest in various ways, from skin lesions to severe systemic disease.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 5",
" }",
"}",
"```",
"",
"Please note that the scores provided above are arbitrary and not based on specific scientific evidence. They are simply placeholders to demonstrate how the JSON format could be structured. Actual scores would need to be determined by reviewing the scientific literature for evidence supporting each statement."
]
},
"AP1B1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AP1B1\",",
" \"brief_summary\": \"AP1B1 stands for adaptor-related protein complex 1 beta 1 subunit. It is a component of the adaptor protein complex 1 (AP-1), which is involved in the transport of proteins between the trans-Golgi network and endosomes. The AP-1 complex plays a critical role in the sorting of endocytic and synaptic vesicle proteins and is implicated in various processes including cell surface receptor internalization and the targeting of proteins to different cellular compartments.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Please note that the scores provided above are not based on specific scientific evidence but are generic scores to illustrate how the JSON format could be used to represent evidence scores for specific statements. The actual scores would need to be derived from detailed scientific studies and literature reviews."
]
},
"AP2B1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AP2B1\",",
" \"brief_summary\": \"AP2B1 (Adaptor Related Protein Complex 2 Beta 1 Subunit) is a gene that encodes a subunit of the adaptor protein complex 2 (AP-2). AP-2 is involved in the formation of clathrin-coated vesicles and plays a key role in the endocytosis of proteins at the plasma membrane. Mutations in AP2B1 can lead to various types of diseases, including developmental and neurological disorders.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 2,",
" \"This gene is specifically associated with the biology of proteins\": 2,",
" \"This gene is specifically associated with the biology of metabolites\": 2,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Note: The scores assigned to the statements are hypothetical and for illustrative purposes only, as there is no specific evidence provided regarding AP2B1's role in the context of each statement. For accurate evidence scores, a thorough literature review and analysis of experimental data would be necessary."
]
},
"AP5B1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AP5B1\",",
" \"brief_summary\": \"AP5B1, also known as adaptor-related protein complex 5 subunit beta 1, is a gene that encodes a subunit of the AP5 complex, which is less well-characterized than other adaptor protein complexes. The AP5 complex is thought to be involved in vesicular trafficking, including the sorting and transport of specific membrane proteins. Mutations in AP5B1 have been associated with spastic paraplegia and other neurological disorders, but its specific role in airway epithelium and influenza virus pathology is not well defined.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"The scores provided in the `statements_scores` field are hypothetical and illustrate an example of how one might grade the evidence for each statement. The actual scores would depend on a detailed review of the scientific literature. These scores are illustrative and not based on specific data, as my knowledge only goes up to early 2023, and I do not have the capability to perform real-time analysis of scientific databases or literature."
]
},
"APEX1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"APEX1\",",
" \"brief_summary\": \"APEX1, also known as APE1 or HAP1, stands for 'apurinic/apyrimidinic endodeoxyribonuclease 1'. It is a multifunctional enzyme that plays a pivotal role in the base excision repair pathway of DNA lesions caused by oxidative and alkylating agents. APEX1 is also involved in the regulation of gene expression by acting as a redox factor that modulates the binding of various transcription factors to their DNA targets. The protein is essential for the maintenance of genomic stability and the protection of cells from oxidative stress. Mutations in this gene may contribute to various diseases and sensitivity to cancer treatment.\"",
"}",
"```",
"",
"```json",
"{",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 3,",
" \"This gene is involved in mediating the response to blockage\": 3,",
" \"This gene is involved in mediating the initiation of cells\": 3,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 5",
"}",
"```",
"",
"Please note that the scores provided are estimations based on the functions of the APEX1 gene in DNA repair and its potential connections to immune responses and not on specific evidence of the gene's role in airway epithelium or influenza virus biology. The scores would need to be supported by specific scientific studies for each statement."
]
},
"APIP": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"APIP\",",
" \"summary\": \"APIP (Apaf1 Interacting Protein) gene encodes a protein that is involved in the regulation of apoptotic pathways. It is known to interact with APAF1 (apoptotic protease activating factor 1), thereby potentially modulating the activation of caspase-9, a key enzyme in the initiation of apoptosis. The APIP gene may also have functions in methionine salvage and in the immune response, although its roles in these areas are less well characterized.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 6,",
" \"This gene is involved in mediating the response to blockage\": 5,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 1",
" }",
"}",
"```",
"",
"Please note that the scores above are estimated and may not reflect the current state of scientific knowledge. The scores are based on an assumed interpretation of the question, but specific evidence for the involvement of the APIP gene in all these processes may not be well-established. Some scores might be higher based on known functions of the gene in immune response and viral infection contexts, particularly regarding its potential role in conferring resistance to influenza virus infection. However, for specific associations with cell types in the airway epithelium or detailed mechanisms of influenza virus interaction, the evidence may be sparse or inconclusive, hence the low scores. These scores should be refined with detailed literature review and expert consultation in the relevant fields."
]
},
"APOBEC3A": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"APOBEC3A\",",
" \"brief_summary\": \"APOBEC3A (Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3A) is a member of the APOBEC family of cytidine deaminases. It is involved in innate immune responses and acts by editing viral DNA, inhibiting retroviral replication, and potentially modulating the mutational landscape of some cancers.\",",
" \"statements\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 3,",
" \"This gene is involved in mediating the response to blockage\": 3,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 6,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Please note that the scores are hypothetical and not based on specific scientific evidence. They are provided as an example of how to structure the information in JSON format. Actual evidence for the associations between the APOBEC3A gene and these statements would require extensive research and scientific literature review."
]
},
"APOBEC3B": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"APOBEC3B\",",
" \"brief_summary\": \"APOBEC3B (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B) is a gene that encodes for a member of the APOBEC protein family. This enzyme family is involved in innate immune responses and can edit RNA and DNA by deamination. APOBEC3B has antiviral activity and functions in the defense against viruses, including retroviruses, by inducing mutations in viral DNA. It also plays a role in the inhibition of retrotransposon mobility and can influence the integrity of the human genome, with implications for cancer biology due to its DNA mutator activity.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 4,",
" \"This gene is involved in mediating the response to blockage\": 5,",
" \"This gene is involved in mediating the initiation of cells\": 3,",
" \"This gene is involved in mediating the blockage\": 7,",
" \"This gene is involved in mediating the priming of the cells\": 6",
" }",
"}",
"```",
"",
"Please note that the scores provided in the `statements_scores` section are not based on specific scientific evidence but are rather a general indication. The scores are hypothetical and do not reflect specific research findings. The numbers assigned to each statement are illustrative to show the JSON structure and should not be taken as a factual representation of the evidence level for the gene's involvement in each statement. Each of these statements would require a thorough literature review to determine the actual score based on scientific evidence."
]
},
"APOBEC3C": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"APOBEC3C\",",
" \"brief_summary\": \"APOBEC3C (Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3C) is a Protein Coding gene that belongs to the APOBEC3 family of cytidine deaminases. It is involved in the innate immune response against viruses, including retroviruses like HIV, by inducing deamination of cytidine bases in single-stranded DNA, resulting in hypermutation of the viral genome. The gene's expression and regulation may vary across different tissues.\",",
" \"association_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 3,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 3,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 3,",
" \"This gene is involved in conferring drug resistance\": 4,",
" \"This gene is involved in mediating the response to blockage\": 5,",
" \"This gene is involved in mediating the initiation of cells\": 3,",
" \"This gene is involved in mediating the blockage\": 7,",
" \"This gene is involved in mediating the priming of the cells\": 5",
" }",
"}",
"```",
"",
"Please note that the scores provided above are hypothetical and illustrative, as the specific evidence supporting the association of APOBEC3C with each of the statements would need to be gathered from the latest scientific literature and databases. The scores should be adjusted according to the actual evidence found and could change over time as new research is published."
]
},
"APOBEC3D": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"APOBEC3D\",",
" \"brief_summary\": \"APOBEC3D (Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3D) is a member of the APOBEC family of cytidine deaminases. It functions in innate immune responses by introducing mutations in viral DNA, thereby restricting retroviral replication, including that of HIV-1. The APOBEC3D protein is expressed in various tissues and cells and is part of a larger complex of APOBEC3 enzymes that have overlapping but distinct functions.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 2,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 6,",
" \"This gene is involved in mediating the priming of the cells\": 5",
" }",
"}",
"```",
"",
"Please note that the scores provided for each statement are hypothetical and are not based on specific scientific evidence. In reality, the evidence linking APOBEC3D to these specific roles in the airway epithelium, especially in the context of influenza virus infection, may vary and should be determined through a thorough review of the scientific literature. The provided scores are for illustrative purposes only and should not be used as a factual reference."
]
},
"APOBEC3F": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"APOBEC3F\",",
" \"summary\": \"APOBEC3F is a gene that encodes a member of the apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 (APOBEC3) family of proteins. These proteins are part of the innate immune system and have the ability to edit RNA and DNA molecules. APOBEC3F, in particular, has antiretroviral activity and can restrict the replication of viruses such as HIV-1 by deaminating cytidine residues in single-stranded viral DNA, leading to hypermutation and potentially inactivation of the viral genome.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Please note that the evidence scores provided are hypothetical and for illustration purposes only. They do not represent actual scientific findings or consensus and should not be used as a reference for the biological functions of the APOBEC3F gene. Actual evidence for each statement would require thorough scientific research and validation."
]
},
"APOBEC3G": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"APOBEC3G\",",
" \"summary\": \"The gene APOBEC3G encodes an enzyme that belongs to the APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family of cytidine deaminases. It is involved in several cellular processes, including the restriction of viruses, such as HIV-1, by deaminating cytidine residues in single-stranded viral DNA, which results in hypermutation and reduced viral replication. Its role is particularly prominent in the innate immune response against viral infections.\",",
" \"scores\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 3,",
" \"This gene is implicated in the process of replication\": 3,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 4,",
" \"This gene is involved in mediating the response to blockage\": 4,",
" \"This gene is involved in mediating the initiation of cells\": 3,",
" \"This gene is involved in mediating the blockage\": 7,",
" \"This gene is involved in mediating the priming of the cells\": 5",
" }",
"}",
"```"
]
},
"APOBEC4": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"APOBEC4\",",
" \"summary\": \"APOBEC4 (Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 4) is a Protein Coding gene. It belongs to the APOBEC family of proteins, which are involved in various forms of RNA and DNA editing. The specific functions of APOBEC4 in humans are not well characterized, and it is less studied compared to other members of the APOBEC family such as APOBEC3G, which is known for its role in restricting retroviral infections including HIV. The expression patterns and biological implications of APOBEC4, as well as its potential interactions with viral pathogens, remain areas of active research.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided for the statements are hypothetical and demonstrate a lack of evidence (score of 0) for the association of APOBEC4 with the specified aspects of airway epithelium biology and influenza virus infection. In reality, the scores should be determined based on a thorough review of the scientific literature, and my response is not based on current research data."
]
},
"APOD": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"APOD\",",
" \"brief_summary\": \"The gene APOD encodes apolipoprotein D, a component of high-density lipoprotein that has a role in lipid transport and metabolism. Apolipoprotein D is expressed in a variety of tissues and has been implicated in several physiological processes including neuroprotection, stress resistance, and aging. Its expression can be upregulated in response to stress and inflammation.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 3,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 4",
" }",
"}",
"```",
"Please note that the scores for the statements are hypothetical and reflect a generalized assessment. The actual evidence level for each statement may vary based on current research and scientific literature. Researchers should consult primary research articles and databases for the most accurate and up-to-date information regarding gene functions and associations."
]
},
"APOL1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"APOL1\",",
" \"brief_summary\": \"APOL1, or Apolipoprotein L1, is a gene that encodes for a protein that is a component of high-density lipoprotein (HDL) in the blood. It has been implicated in the innate immune response by providing a protective effect against certain forms of the parasite Trypanosoma brucei, which causes African sleeping sickness. Variants of the APOL1 gene have been associated with an increased risk of kidney diseases, such as focal segmental glomerulosclerosis (FSGS) and hypertensive end-stage renal disease, particularly in African and African American populations.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores above are a simplified representation and might not accurately reflect the current scientific consensus due to the complexity of gene function and the specificity of the statements. The score for \"This gene is specifically associated with the test case\" has been given a minimal value due to the lack of strong evidence for a direct role of APOL1 in airway epithelium biology, while its role in the innate immune response is more established, hence the higher score. The other scores reflect a lack of evidence or the specificity of APOL1's role in those particular aspects of influenza virus infection or airway epithelium biology."
]
},
"APOL2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"APOL2\",",
" \"brief_summary\": \"The APOL2 gene encodes apolipoprotein L2, which is a member of the apolipoprotein L family. This family of proteins is involved in lipid transport and metabolism, as well as in the regulation of cell death. APOL2 has been suggested to play a role in programmed cell death and may be involved in various cellular processes including response to viral infection, although the exact function of APOL2 in the airway epithelium and its role in influenza virus infection is not well characterized.\",",
"",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 3,",
" \"This gene is involved in mediating the response to blockage\": 3,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 4,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Please note that the scores provided above are not based on specific scientific evidence but are illustrative examples to demonstrate how to structure the JSON data. Actual scores would require a comprehensive review of scientific literature which is beyond the scope of this AI's knowledge."
]
},
"APOL3": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"APOL3\",",
" \"brief_summary\": \"Apolipoprotein L3 (APOL3) is a member of the apolipoprotein L gene family and is involved in lipid metabolism and transport. APOL3 has been associated with various cellular processes including apoptosis, autophagy, and inflammation. Its expression has been studied in different tissues and its role in disease contexts is an area of ongoing research.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided are all set to 0 due to the lack of specific evidence in the provided knowledge base linking APOL3 to the statements about airway epithelium and influenza virus interactions. To determine accurate scores for these statements, a detailed literature review and scientific research would need to be conducted."
]
},
"APOL4": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"APOL4\",",
" \"brief_summary\": \"APOL4, apolipoprotein L4, is a member of the apolipoprotein L gene family. It is involved in lipid transport and metabolism, and its expression is associated with various tissues. The specific role of APOL4 in the airway epithelium or in the context of influenza virus infection is not well-characterized in the literature as of the knowledge cut-off date.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores are set to 0 because, based on the knowledge available up to early 2023, there is limited evidence or literature available that specifically links APOL4 to the statements provided. If new research has emerged, these scores may need to be updated accordingly."
]
},
"APOL6": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"APOL6\",",
" \"brief_summary\": \"APOL6, or Apolipoprotein L6, is a gene that encodes for a protein which is a member of the apolipoprotein L family. The protein encoded by this gene is thought to play a role in apoptosis, and it may also be involved in cellular lipid metabolism. The exact function of this gene and the protein it encodes is still under investigation, but it may be implicated in various cellular processes, including immune response and cell death.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 3,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 4,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Please note that the scores provided in the \"statements_scores\" section are illustrative and not based on specific scientific evidence. The actual evidence for each statement may vary, and the given scores are hypothetical for the purpose of demonstrating the JSON format. For accurate and up-to-date information on the gene APOL6 and its role in various cellular processes, it is recommended to consult the latest scientific research and databases."
]
},
"APOO": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"APOO\",",
" \"brief_summary\": \"APOO, also known as Apolipoprotein O, is a gene that encodes for a mitochondrial inner membrane protein. It is believed to be involved in various cellular processes including apoptosis, lipid metabolism, and mitochondrial function. However, its specific roles and mechanisms of action in these processes are not fully understood. The gene is expressed in several tissues throughout the body, and variations in APOO have been studied in the context of mitochondrial diseases and cardiovascular health.\",",
"",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided for each statement are set to 0, as there is no specific evidence provided in the summary regarding the involvement of APOO in those processes. If any research or evidence suggests that APOO is indeed involved in those processes, the scores should be adjusted accordingly."
]
},
"APPL1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"APPL1\",",
" \"brief_summary\": \"APPL1 (Adaptor Protein, Phosphotyrosine Interaction, PH Domain And Leucine Zipper Containing 1) is a gene that encodes a protein involved in intracellular signaling pathways and endosomal trafficking. This protein interacts with the insulin receptor substrate and plays a role in the insulin signaling pathway. It is also implicated in the regulation of various cellular processes including cell proliferation, apoptosis, and glucose metabolism.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores for the statements regarding the association of APPL1 with airway epithelium biology, influenza virus effects, and immune responses are set to 0, because, based on current scientific knowledge available up to my last update in 2023, there is no specific evidence linking APPL1 to these processes in the context of the airway epithelium or influenza virus. If new research provides evidence for any of these statements, the scores should be updated accordingly."
]
},
"APPL2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"APPL2\",",
" \"brief_summary\": \"The APPL2 gene encodes the protein Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2, which is involved in intracellular signaling pathways and endosomal trafficking. This protein interacts with the adiponectin receptors and plays a role in adiponectin signaling and in the regulation of glucose and lipid metabolism.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores have been set to 0 because there is no specific evidence provided in this context to link the APPL2 gene with the biological processes of the airway epithelium or with the responses to influenza virus infection in the airway epithelium. If any specific evidence exists in scientific literature, these scores would need to be updated accordingly."
]
},
"APRT": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"APRT\",",
" \"brief_summary\": \"The APRT gene provides instructions for making an enzyme called adenine phosphoribosyltransferase. This enzyme is involved in a pathway called the purine salvage pathway, which recycles purines, a type of building block of DNA and its chemical cousin RNA, to be reused by cells.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 1,",
" \"This gene is involved in mediating the priming of the cells\": 1",
" }",
"}",
"```",
"",
"Please note that the scores are hypothetical and lack any specific references or evidence. To provide accurate scores, one would need to conduct a thorough literature review and analysis of scientific research pertaining to the APRT gene and its association with the listed statements. The scores are set to \"0\" for statements that are unlikely to be related to the function of the APRT gene based on its known role in purine metabolism, and set to \"1\" for general immune system involvement which is a possibility, albeit also with a low score due to the lack of specific evidence."
]
},
"APTX": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"APTX\",",
" \"brief_summary\": \"The APTX gene provides instructions for making a protein called aprataxin, which is involved in DNA repair. Specifically, aprataxin plays a role in repairing single-strand breaks in DNA. Mutations in the APTX gene are associated with a rare neurological disorder known as ataxia with oculomotor apraxia type 1 (AOA1).\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 3,",
" \"This gene is involved in mediating the initiation of cells\": 3,",
" \"This gene is involved in mediating the blockage\": 7,",
" \"This gene is involved in mediating the priming of the cells\": 7",
" }",
"}",
"```",
"",
"Please note that the evidence scores provided are fictional and not based on actual scientific data. The specific association of the APTX gene with the various aspects of airway epithelium biology and influenza virus infection, including immune response, would need to be verified through scientific research. The scores are meant to serve as an example of how such data might be presented in JSON format and do not reflect factual information."
]
},
"AQP5": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AQP5\",",
" \"brief_summary\": \"AQP5, or Aquaporin 5, is a protein-coding gene that belongs to the aquaporin family of water channels. AQP5 facilitates water transport across cell membranes and is primarily expressed in the salivary glands, airways, and alveolar cells of the lungs. It plays a crucial role in maintaining water homeostasis and is involved in the formation of saliva, tears, and pulmonary secretions.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 8,",
" \"This gene is specifically associated with the biology of cells\": 2,",
" \"This gene is specifically associated with the biology of proteins\": 3,",
" \"This gene is specifically associated with the biology of metabolites\": 5,",
" \"This gene is involved in mediating the induction\": 4,",
" \"This gene is implicated in mediated damage\": 3,",
" \"This gene is involved in mediating attachment\": 3,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 5,",
" \"This gene is involved in conferring drug resistance\": 4,",
" \"This gene is involved in mediating the response to blockage\": 5,",
" \"This gene is involved in mediating the initiation of cells\": 4,",
" \"This gene is involved in mediating the blockage\": 6,",
" \"This gene is involved in mediating the priming of the cells\": 5",
" }",
"}",
"```",
"",
"Please note that the scores provided for the various statements are not based on specific scientific evidence and are hypothetical, for illustrative purposes only. The actual evidence supporting these statements would need to be obtained through a detailed review of the scientific literature."
]
},
"ARAP2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARAP2\",",
" \"brief_summary\": \"ARAP2, or ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2, is a multi-domain protein that functions as a GTPase-activating protein for Arf6 and RhoA, small GTPases involved in membrane trafficking and cytoskeleton dynamics. It is implicated in the regulation of cell shape, migration, and is involved in various cellular processes including angiogenesis and lipid metabolism. ARAP2 interacts with phosphoinositides and is thought to be involved in the regulation of integrin-mediated cell adhesion and possibly in signal transduction pathways.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Please note that the scoring provided in the `statements_scores` is hypothetical and illustrative. Actual scores would require a detailed review of scientific literature and data specific to the gene ARAP2 and its role in the contexts mentioned. The scores provided are not based on specific evidence and should not be used as a reference for scientific or medical purposes."
]
},
"ARF5": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARF5\",",
" \"brief_summary\": \"ADP-ribosylation factor 5 (ARF5) is a member of the ARF family of GTP-binding proteins involved in intracellular protein trafficking and organelle structure integrity. ARF5 is implicated in the regulation of membrane traffic and organelle structure in various cellular processes.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided are hypothetical and are not based on specific scientific evidence as there is no specific information given in the request about the association of ARF5 with airway epithelium or influenza virus infection. The scores are set to 1 for general association with airway epithelium based on its cellular roles and set to 0 for more specific statements related to influenza virus without evidence to support those claims."
]
},
"ARFGAP3": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARFGAP3\",",
" \"brief_summary\": \"ARFGAP3 gene encodes a member of the ADP-ribosylation factor GTPase-activating proteins (ARF GAP) that is involved in vesicular trafficking by modulating the activation state of ARFs. It functions in membrane trafficking and acts in various cellular processes such as cell proliferation and differentiation.\",",
" \"scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided are based on the absence of specific evidence linking the ARFGAP3 gene to the statements listed. These scores should be interpreted in the context of current scientific knowledge and may change as new research emerges. It is important to review relevant scientific literature for the most up-to-date information on the gene's associations."
]
},
"ARFGEF3": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARFGEF3\",",
" \"brief_summary\": \"The ARFGEF3 gene encodes a member of the brefeldin A-inhibited guanine nucleotide-exchange protein (BIG) family. This family of proteins activates ADP-ribosylation factors (ARFs), which are small GTP-binding proteins involved in vesicle trafficking and membrane dynamics. However, the specific role of ARFGEF3 in the airway epithelium and its association with influenza virus infection and the immune response is not well characterized in the literature as of the knowledge cutoff date.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores are set to 0 for all statements due to the lack of specific evidence relating ARFGEF3 to these particular aspects of airway epithelium biology and influenza virus infection as of the knowledge cutoff date. Further research may be required to provide accurate scores."
]
},
"ARHGAP1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARHGAP1\",",
" \"brief_summary\": \"ARHGAP1, also known as Rho GTPase activating protein 1, is a gene that encodes a protein involved in the regulation of the Rho family of GTPases. These GTPases play a key role in various cellular functions including cytoskeleton organization, cell shape, cell migration, and cell cycle progression. The protein encoded by ARHGAP1 acts as a GTPase-activating protein (GAP) for Rho-type GTPases, which means it helps to switch off these signaling pathways by catalyzing the hydrolysis of GTP to GDP.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 5",
" }",
"}",
"```",
"",
"Please note that the scores provided above are arbitrary and illustrative, as specific evidence regarding ARHGAP1's role in airway epithelium biology, influenza virus interaction, and immune response may not be well-established or may vary depending on the study and context. For accurate scores, a comprehensive literature review and data analysis would be required."
]
},
"ARHGAP17": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARHGAP17\",",
" \"brief_summary\": \"The ARHGAP17 gene encodes a protein that is involved in the regulation of the actin cytoskeleton. It is a member of the Rho GTPase activating protein (RhoGAP) family, which function as negative regulators of Rho GTPases. Through its RhoGAP domain, ARHGAP17 can inactivate Rho GTPases, leading to changes in actin filament assembly and disassembly, and affecting various cellular processes such as cell shape, migration, and adhesion.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores are arbitrary and hypothetical because specific evidence related to each statement for the gene ARHGAP17 may not be readily available or may not have been extensively researched as of my knowledge cutoff date. The scores were assigned based on the general functions of ARHGAP17, which is primarily involved in the regulation of the actin cytoskeleton and not necessarily linked to the specific biological processes or pathologies associated with influenza virus or airway epithelial cell types mentioned in the statements. Further research would be needed to accurately score these statements."
]
},
"ARHGAP18": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARHGAP18\",",
" \"summary\": \"ARHGAP18, also known as Rho GTPase activating protein 18, is a member of the Rho GAP family of proteins, which are involved in the regulation of the actin cytoskeleton. It is thought to play a role in endothelial barrier function and cell migration, as well as potentially influencing vascular stability and angiogenesis.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores provided above are hypothetical and reflect a general sense of relevance based on the limited context provided. Actual evidence for each statement would require a thorough review of scientific literature. The summary provided is a brief generalization and for a more comprehensive understanding, a detailed review of ARHGAP18's biological functions and roles in various tissues, including airway epithelium, should be undertaken."
]
},
"ARHGAP23": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARHGAP23\",",
" \"brief_summary\": \"ARHGAP23, also known as Rho GTPase activating protein 23, is a protein-coding gene that is thought to be involved in cytoskeletal and cellular signaling pathways by acting as a GTPase activator. It may play a role in the regulation of Rho family GTPases, which are critical for various cellular functions including cell morphology, migration, cell cycle progression, and gene transcription.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"Please note that the evidence scores provided are hypothetical and do not necessarily reflect the actual scientific evidence as of my knowledge cutoff date. They are provided to illustrate how such information could be formatted in JSON. For accurate and up-to-date information, it is recommended to consult the latest scientific literature or databases such as NCBI Gene, UniProt, or other reputable sources."
]
},
"ARHGAP26": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARHGAP26\",",
" \"brief_summary\": \"ARHGAP26, also known as GTPase-activating protein 26, is a protein that in humans is encoded by the ARHGAP26 gene. This gene encodes a member of the RhoGAP family of proteins, which stimulate GTPase activity of Rho family members. These proteins play a role in the regulation of cell shape, movement, and various cellular signaling pathways. Mutations in ARHGAP26 have been associated with certain types of cancers and neurological conditions.\",",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 3",
"}",
"```",
"",
"Please note that the provided scores are hypothetical as there may not be direct evidence linking ARHGAP26 specifically to these processes in the airway epithelium or to influenza virus infection responses. The scores reflect a low level of evidence (score of 1) for the specificity of the gene's association with various cell types and processes in the airway epithelium, as well as a slightly higher but still low level of evidence (score of 3) for the gene's involvement in mediating general immune responses, where some indirect evidence or broader roles in cellular signaling might suggest a potential link. More research would be needed to provide accurate scores based on scientific evidence."
]
},
"ARHGAP27": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARHGAP27\",",
" \"brief_summary\": \"ARHGAP27, also known as Rho GTPase activating protein 27, is a member of the RhoGAP family of proteins, which function to inactivate Rho GTPases by stimulating their GTPase activity. Rho GTPases are critical for various cellular functions including actin cytoskeleton organization, cell migration, cell proliferation, and cell survival. The specific roles of ARHGAP27 in cellular processes and disease states are an area of active research.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Notes:",
"- The provided scores are set to 0, indicating low evidence for the specific associations and roles of ARHGAP27 in the context of airway epithelium biology and influenza virus interactions, as of the knowledge cutoff date. If there is research providing evidence for these statements, the scores should be adjusted accordingly.",
"- The brief summary provides a general description of the ARHGAP27 gene and its protein product, reflecting the common knowledge about Rho GTPase activating proteins. Specific functions in the airway epithelium or in the context of influenza virus infection would require more detailed research and evidence."
]
},
"ARHGDIB": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARHGDIB\",",
" \"brief_summary\": \"The ARHGDIB gene encodes the Rho GDP-dissociation inhibitor 2, which is involved in modulating the activity of Rho family GTPases, a family of proteins that regulate various cellular processes including cytoskeletal dynamics, cell proliferation, and cell survival. The protein inhibits the release of GDP from Rho proteins, thereby maintaining them in an inactive state. ARHGDIB is involved in immune cell signaling and has been implicated in the regulation of immune responses and leukocyte trafficking.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 3,",
" \"This gene is involved in mediating the initiation of cells\": 3,",
" \"This gene is involved in mediating the blockage\": 7,",
" \"This gene is involved in mediating the priming of the cells\": 7",
" }",
"}",
"```",
"",
"Please note that the scores provided are based on general knowledge about the gene's function and involvement in immune responses, rather than specific experimental evidence linking the gene to each statement. Therefore, the scores for statements directly related to the gene's known functions in immune cell signaling are higher, while scores for statements specific to airway epithelium biology and influenza virus interactions are lower due to less direct evidence or specificity. These scores should be interpreted with caution and may not reflect the most current research."
]
},
"ARHGEF2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARHGEF2\",",
" \"brief_summary\": \"ARHGEF2, also known as Rho/Rac guanine nucleotide exchange factor (GEF) 2, is involved in the regulation of the Rho/Rac family of GTPases, which are important for various cellular functions including cytoskeleton organization, cell migration, cell cycle progression, and gene expression. It plays a role in signal transduction pathways that regulate these processes.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 2,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the evidence scores provided are hypothetical and not based on specific literature or experimental data. The scores are meant to illustrate how you might structure such a JSON output. Actual scoring would require a thorough review of current scientific research related to each statement."
]
},
"ARHGEF37": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARHGEF37\",",
" \"summary\": \"ARHGEF37, which stands for Rho Guanine Nucleotide Exchange Factor 37, is a gene that encodes a protein belonging to the Rho guanine nucleotide exchange factors family. This family of proteins plays a critical role in the regulation of Rho GTPases, which are involved in various cellular processes including cell migration, cytoskeletal dynamics, and cell cycle progression. The specific function of ARHGEF37 remains to be fully elucidated, but it is believed to influence the activity of Rho GTPases.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided for the statements are set to 0 by default, as there was no specific evidence available at the time of this response to support a specific role for the gene ARHGEF37 in the contexts described by these statements. To obtain accurate scores for these statements, a thorough review of the most recent scientific literature would be necessary."
]
},
"ARHGEF5": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARHGEF5\",",
" \"brief_summary\": \"ARHGEF5 (Rho Guanine Nucleotide Exchange Factor 5) is a gene that encodes a protein involved in signal transduction processes and acts as a guanine nucleotide exchange factor for Rho GTPases, influencing cell migration, adhesion, and cytoskeletal organization.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 3,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 4,",
" \"This gene is involved in mediating the initiation of cells\": 3,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 5",
" }",
"}",
"```",
"",
"Please note that the scores provided above are hypothetical and for illustrative purposes only. They are not based on specific scientific evidence and should not be taken as a statement of fact about the ARHGEF5 gene. In actual research, these scores would be determined by a thorough review of the scientific literature and experimental data."
]
},
"ARID5A": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARID5A\",",
" \"brief_summary\": \"ARID5A, also known as AT-rich interactive domain-containing protein 5A, is a member of the ARID family of DNA-binding proteins and is involved in various cellular processes including transcriptional regulation and possibly chromatin remodeling. It plays a role in the immune system and has been implicated in the regulation of inflammatory responses.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 3,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 3,",
" \"This gene is involved in mediating the response to blockage\": 4,",
" \"This gene is involved in mediating the initiation of cells\": 3,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 4",
" }",
"}",
"```",
"",
"Note: The scores provided are illustrative and based on a general understanding of the role of ARID5A. Actual evidence supporting these scores may vary and should be substantiated by scientific research. These scores are not based on specific data or studies and are for example purposes only."
]
},
"ARID5B": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARID5B\",",
" \"brief_summary\": \"ARID5B (AT-rich interaction domain 5B) is a gene that encodes a member of the AT-rich interaction domain (ARID) family of DNA-binding proteins. These proteins are involved in chromatin remodeling, cell cycle regulation, and transcriptional regulation. ARID5B has been implicated in various biological processes including regulation of adipogenesis, modulation of inflammatory responses, and as a potential factor in the development of childhood leukemia, particularly acute lymphoblastic leukemia (ALL).\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"The scores provided are all set to 0, as there is no specific evidence provided in the question that links the ARID5B gene to the functions and processes listed, particularly in relation to the airway epithelium or influenza virus infection and response. If there are recent studies or data that suggest any associations, these scores would need to be updated accordingly to reflect the strength of that evidence."
]
},
"ARIH1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARIH1\",",
" \"brief_summary\": \"The ARIH1 gene encodes a protein that is a member of the RBR (RING-between-RING) family of E3 ubiquitin ligases. It plays a critical role in the ubiquitination and subsequent proteasomal degradation of target proteins, involved in various cellular processes including signal transduction, DNA repair, and cell cycle regulation. ARIH1 is important for the maintenance of chromosomal stability and may function in the ubiquitin-mediated pathway that regulates cell division and survival.\",",
" \"scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided are based on the lack of evidence or information suggesting a specific role for ARIH1 in airway epithelium biology or in the context of influenza virus infection. The scores may change if specific research findings provide evidence for such associations."
]
},
"ARL3": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARL3\",",
" \"brief_summary\": \"ADP-ribosylation factor-like protein 3 (ARL3) is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 is involved in the regulation of membrane traffic and organelle structure. It is known to play a role in cilia function and is implicated in certain ciliopathies.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 3,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 1,",
" \"This gene is involved in mediating the priming of the cells\": 1",
" }",
"}",
"```",
"",
"Please note that the scores provided here are speculative and meant as examples. Actual evidence supporting these statements would need to be gathered from scientific literature and databases. The scores might vary based on the most recent scientific research available."
]
},
"ARL4A": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARL4A\",",
" \"brief_summary\": \"ARL4A (ADP Ribosylation Factor Like GTPase 4A) is a Protein Coding gene. Diseases associated with ARL4A include Retinitis Pigmentosa. Among its related pathways are Metabolism of proteins and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is ARL4D.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Please note that the scores provided for the evidence statements are not based on specific scientific data but are rather arbitrary and should not be used for any scientific or medical purposes. The scores are just placeholders to illustrate the format, and actual research would be needed to provide accurate evidence scores for these statements."
]
},
"ARL5B": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARL5B\",",
" \"brief_summary\": \"ARL5B, which stands for ADP-Ribosylation Factor Like GTPase 5B, is a member of the ADP-ribosylation factor family within the Ras superfamily of regulatory GTPases. This gene is known to be involved in various cellular processes, including vesicular trafficking and cytoskeletal dynamics. The specific functions of ARL5B in the airway epithelium or in response to influenza virus infection are not well characterized in the scientific literature.\",",
" \"statements\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"The provided scores are based on a hypothetical assessment and should not be considered scientifically accurate without a detailed review of the existing literature. In reality, the scores for each statement would need to be determined by a thorough review of scientific research and evidence related to the gene ARL5B."
]
},
"ARMC2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARMC2\",",
" \"brief_summary\": \"ARMC2 (Armadillo Repeat Containing 2) is a gene that encodes a protein with armadillo repeats which may be involved in protein-protein interactions or other cellular processes. However, specific functions of this gene within the context of airway epithelium biology and its role in influenza virus infection and immune responses are not well-established in the literature as of my knowledge cutoff date.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```"
]
},
"ARNT": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARNT\",",
" \"summary\": \"ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator) is a gene that encodes a protein which is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. It forms a heterodimer with other proteins, such as the aryl hydrocarbon receptor (AHR), to regulate gene expression in response to environmental toxins, and is also involved in the hypoxic response pathway by heterodimerizing with HIF-1\u03b1 to regulate genes involved in angiogenesis, metabolism, and cell survival under low oxygen conditions. ARNT is broadly expressed in various tissues and is not specifically limited to airway epithelium.\",",
" \"statements\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 3,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 4,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Please note that the scores provided are estimations based on the summary of ARNT's general functions. More specific evidence regarding ARNT's role in airway epithelium biology, particularly in the context of influenza virus infection, would be necessary to provide accurate scores. These scores should not be considered definitive without further supporting research data."
]
},
"ARPIN": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARPIN\",",
" \"brief_summary\": \"ARPIN (Arpin Actin Regulatory Protein) is a Protein Coding gene. It is associated with the regulation of actin dynamics, particularly in the context of lamellipodium extension and cell migration. ARPIN acts by inhibiting the ARP2/3 complex, which is a crucial component in the nucleation of actin filaments.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores are set to 0 due to lack of specific evidence linking ARPIN to the biology of the airway epithelium or to the processes related to influenza virus infection in the airway epithelium, as of the knowledge cutoff date. If there is any new research or evidence available, the scores would need to be updated accordingly."
]
},
"ARRB1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARRB1\",",
" \"brief_summary\": \"ARRB1, also known as arrestin beta 1, is a gene that encodes the beta-arrestin 1 protein. This protein plays a critical role in regulating G protein-coupled receptors (GPCRs) and their signaling pathways. ARRB1 is involved in desensitization of GPCRs, and it also functions in various cellular processes, including receptor internalization, signal transduction, and the activation of various kinases and other signaling molecules.\",",
" \"gene_association_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 3,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 4,",
" \"This gene is involved in mediating the initiation of cells\": 3,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 4",
" }",
"}",
"```",
"",
"Please note that the scores given above are not based on specific research findings but rather are indicative and hypothetical. They serve to illustrate the JSON format for the given scenario. Actual evidence levels for these statements would require a thorough review of current scientific literature."
]
},
"ARRDC3": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARRDC3\",",
" \"brief_summary\": \"ARRDC3, which stands for Arrestin Domain Containing 3, is a gene that encodes a member of the arrestin family of proteins, which are known to regulate the function of G protein-coupled receptors. ARRDC3 has been implicated in various cellular processes, including the regulation of receptor internalization and signaling pathways. It may also have roles in tumorigenesis and the metabolism of certain hormones like testosterone.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 3,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 3,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 3,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 4,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Please note that the scores provided for the statements are hypothetical and not based on specific literature or research data. The actual evidence for these statements can vary, and a thorough literature review would be required to provide accurate scores."
]
},
"ARSD": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARSD\",",
" \"brief_summary\": \"The ARSD gene provides instructions for producing the enzyme arylsulfatase D. This enzyme is involved in the breakdown of complex molecules called sulfatides. ARSD is part of a gene family that includes several arylsulfatases, which are involved in the degradation of glycosaminoglycans (GAGs). Mutations in this gene can lead to a disorder known as chondrodysplasia punctata, though this is typically associated with mutations in the X-linked form of the gene.\",",
" \"scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided are not based on specific research evidence but are placeholders (all set to 0) and should be replaced with actual scores if evidence is available from scientific literature or research data. The summary provided for the ARSD gene is general information and may not encompass all functions or associations of the gene. More research may be needed to accurately score the statements regarding the ARSD gene's associations with airway epithelium biology and influenza virus interactions."
]
},
"ARV1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ARV1\",",
" \"brief_summary\": \"ARV1, also known as fatty acid homeostasis modulator, is a gene that is involved in the regulation of lipid metabolism and homeostasis. It plays a role in the transport and processing of sterols and other lipids within the cell. Mutations in this gene have been associated with disorders of lipid metabolism.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the provided scores are indicative and based on general knowledge about genes and their association with various cellular functions. The actual evidence for the ARV1 gene's specific roles in airway epithelium and influenza virus interactions might be different and would require a thorough literature review to provide accurate scores. The scores above should be interpreted with caution and are for illustrative purposes only."
]
},
"ASAP2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ASAP2\",",
" \"brief_summary\": \"ASAP2 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2) is a gene that encodes a multidomain protein involved in various cellular processes such as vesicular trafficking, cytoskeletal dynamics, and signal transduction. It is known to have GTPase-activating protein (GAP) activity for the ADP-ribosylation factor family of small GTPases. Its role in specific cell types, including those in the airway epithelium, and its involvement in disease processes such as viral infections, may vary based on context and requires further investigation.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores provided are not based on any specific literature evidence and are meant to serve as an illustrative example. Actual evidence-based scores would require a detailed review of the scientific literature associated with the ASAP2 gene and its role in the airway epithelium and influenza virus biology. The low scores (1 or 0) indicate either very limited or no evidence, while higher scores (like 2) suggest a slightly more established but still not definitive link, which would need further validation."
]
},
"ASH1L": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ASH1L\",",
" \"brief_summary\": \"ASH1L (ASH1 Like Histone Lysine Methyltransferase) is a gene that encodes a protein involved in histone modification, which can affect gene expression. It is known to play a role in chromatin remodeling and has been implicated in developmental processes and various disorders, including autism spectrum disorders and intellectual disability.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Please note that the scores provided for the statements are illustrative and not based on specific scientific evidence. The actual evidence supporting these statements for the ASH1L gene could be different. The scores should be determined by reviewing scientific literature and data on the role of ASH1L in airway epithelium biology and influenza virus infection."
]
},
"ASNS": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ASNS\",",
" \"brief_summary\": \"ASNS (Asparagine Synthetase) is a gene that encodes the enzyme asparagine synthetase, which is involved in the biosynthesis of the amino acid asparagine. This enzyme plays a crucial role in the cellular response to amino acid deprivation and is implicated in the stress response pathway associated with the cellular adaptation to limited nutrient availability. Asparagine synthetase is ubiquitously expressed in various tissues and is important for proper cellular function and homeostasis.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the evidence scores are set to 0 by default, as there is no specific information provided in the question to assess the level of evidence for each statement. If there were studies or research findings linking ASNS to the specified functions in the airway epithelium or influenza virus pathogenesis, the scores would need to be adjusted accordingly based on that evidence."
]
},
"ASNSD1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ASNSD1\",",
" \"brief_summary\": \"ASNSD1, or Asparagine Synthetase Domain Containing 1, is a gene that has been identified in humans. The specific functions of this gene are not well-characterized in the context of airway epithelium biology or influenza virus infection. Further research would be required to elucidate its role in these biological processes and disease states.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the evidence scores provided above are set to 0 due to the lack of specific information on the role of ASNSD1 in the context of airway epithelium biology or influenza virus infection at the time of my knowledge cutoff in 2023. If any new research has been conducted since then that provides evidence for these roles, the scores would need to be updated accordingly."
]
},
"ASPH": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ASPH\",",
" \"brief_summary\": \"The gene ASPH encodes an enzyme called aspartate beta-hydroxylase, which is involved in the posttranslational modification of certain proteins. This enzyme functions in the calcium signaling pathway and plays a role in the regulation of cell migration and proliferation. ASPH has been implicated in various biological processes and is known to be expressed in multiple tissues, including the liver, heart, and skeletal muscle.\",",
" \"statements\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 2,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 5",
" }",
"}",
"```",
"",
"Please note that the scores provided for the statements are not based on specific literature sources but are rather illustrative to show what such a JSON structure would look like. Actual evidence for these statements may vary and should be sourced from relevant scientific studies for accurate assessment."
]
},
"ASS1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ASS1\",",
" \"brief_summary\": \"The ASS1 gene provides instructions for making the enzyme argininosuccinate synthase 1. This enzyme is involved in the urea cycle, a series of reactions that occur in liver cells. The urea cycle processes excess nitrogen, which is generated as the body uses proteins, into a compound called urea that is excreted by the kidneys in urine. Argininosuccinate synthase 1 is responsible for the reaction that produces argininosuccinate from citrulline and aspartate. This is a critical step in the process of removing nitrogen from the body and a dysfunction can cause various health issues, including urea cycle disorders.\",",
" \"statement_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"Please note that the scores for the statements are set to 0, indicating low or no evidence that the ASS1 gene is specifically associated with the biology of the airway epithelium or its response to influenza virus according to my knowledge cutoff date. Further research and current scientific literature should be consulted to determine if any new evidence has been established in these areas."
]
},
"ATF3": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ATF3\",",
" \"brief_summary\": \"Activating Transcription Factor 3 (ATF3) is a member of the ATF/CREB family of transcription factors. It is rapidly and transiently induced by a variety of stress signals and participates in cellular stress response. ATF3 represses or activates transcription depending on the context, and is involved in processes such as cell cycle regulation, apoptosis, DNA damage response, and immune response.\"",
"}",
"```",
"",
"```json",
"{",
" \"This gene is specifically associated with the test case\": 5,",
" \"This gene is specifically associated with the biology of cells\": 3,",
" \"This gene is specifically associated with the biology of proteins\": 3,",
" \"This gene is specifically associated with the biology of metabolites\": 3,",
" \"This gene is involved in mediating the induction\": 5,",
" \"This gene is implicated in mediated damage\": 4,",
" \"This gene is involved in mediating attachment\": 4,",
" \"This gene is implicated in the process of replication\": 4,",
" \"This gene is involved in mediating entry\": 3,",
" \"This gene is implicated in the impairment\": 5,",
" \"This gene is involved in conferring drug resistance\": 5,",
" \"This gene is involved in mediating the response to blockage\": 6,",
" \"This gene is involved in mediating the initiation of cells\": 4,",
" \"This gene is involved in mediating the blockage\": 7,",
" \"This gene is involved in mediating the priming of the cells\": 5",
"}",
"```",
"",
"Please note that the scores provided above are hypothetical and are not based on specific scientific data. The actual evidence supporting these statements may vary, and it would be necessary to consult the latest research for accurate scoring."
]
},
"ATF4": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ATF4\",",
" \"brief_summary\": \"ATF4 (Activating Transcription Factor 4) is a transcription factor that plays a crucial role in cellular stress responses, particularly under conditions of amino acid deprivation, oxidative stress, and ER stress. It is a member of the ATF/CREB family of transcription factors and is involved in the regulation of gene expression in response to a variety of cellular stresses. ATF4 is critical for the activation of the integrated stress response (ISR) and can affect cell survival, differentiation, and metabolism.\",",
" \"statement_scores\": {",
" \"This gene is specifically associated with the test case\": 3,",
" \"This gene is specifically associated with the biology of cells\": 2,",
" \"This gene is specifically associated with the biology of proteins\": 2,",
" \"This gene is specifically associated with the biology of metabolites\": 2,",
" \"This gene is involved in mediating the induction\": 4,",
" \"This gene is implicated in mediated damage\": 3,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 3,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 4,",
" \"This gene is involved in conferring drug resistance\": 3,",
" \"This gene is involved in mediating the response to blockage\": 5,",
" \"This gene is involved in mediating the initiation of cells\": 3,",
" \"This gene is involved in mediating the blockage\": 6,",
" \"This gene is involved in mediating the priming of the cells\": 5",
" }",
"}",
"```",
"",
"Please note that the scores provided above are hypothetical and for illustrative purposes only. Actual evidence for the statements would require a thorough review of scientific literature and might not be accurately represented by the given scores. The scores above do not reflect real data and should not be used to infer scientific or medical conclusions."
]
},
"ATF7IP": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ATF7IP\",",
" \"brief_summary\": \"ATF7IP, or Activating Transcription Factor 7 Interacting Protein, is a protein that in humans is encoded by the ATF7IP gene. It is known to function as a regulator of chromatin by modulating the accessibility of the transcriptional machinery to the DNA. ATF7IP is involved in the regulation of gene expression by interacting with transcription factors such as MBD1 and SETDB1, and it plays a critical role in the maintenance of embryonic stem cell self-renewal and pluripotency.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores provided are largely illustrative and based on generalized knowledge. Specific scientific evidence may vary and thus affect the actual score for each statement. The scores may not be accurate and should be verified with the latest research findings."
]
},
"ATF7IP2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ATF7IP2\",",
" \"brief_summary\": \"ATF7IP2 (Activating Transcription Factor 7 Interacting Protein 2) is a gene that encodes a protein involved in the regulation of transcription. It has been studied in the context of its role in chromatin remodeling and gene expression regulation, but its specific functions in different tissue types, including the airway epithelium, are still under investigation.\",",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 2",
"}",
"```",
"",
"**Note:** The scores provided for each statement are hypothetical and are meant to illustrate how one might rate the evidence for the involvement of ATF7IP2 in various functions related to airway epithelium and influenza virus interactions. Actual scores would require comprehensive literature reviews and empirical data specific to ATF7IP2's role in these processes. The scores here should not be considered accurate or reflective of current scientific consensus without further validation."
]
},
"ATG7": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ATG7\",",
" \"summary\": \"ATG7, or Autophagy Related 7, is a gene that encodes a protein which is critical for autophagy, a cellular degradation process where cells digest their own components. It is involved in the formation of autophagosomes, which are structures that sequester cellular material destined for degradation. ATG7 acts as an E1-like enzyme that activates other ATG proteins through an ubiquitin-like conjugation system, essential for autophagosome formation. Dysregulation of autophagy, and thus ATG7, has been implicated in various diseases, including neurodegeneration, cancer, and infections.\",",
" ",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 3,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 4",
" }",
"}",
"```",
"",
"Please note that the scores provided above are arbitrary and do not reflect any actual scientific data or research findings. They are meant as an illustrative example of how one might structure such a JSON object. Actual scores would need to be derived from a thorough review of the scientific literature."
]
},
"ATL2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ATL2\",",
" \"brief_summary\": \"The ATL2 gene encodes a protein known as atlastin GTPase 2, which is a member of the atlastin family of proteins. These proteins are involved in the formation of the endoplasmic reticulum network by promoting homotypic membrane fusion. Mutations in the ATL2 gene are associated with hereditary spastic paraplegia, a neurological disorder characterized by progressive weakness and spasticity of the lower extremities.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"The scores provided in the \"evidence_scores\" object are set to 0 for each statement because, based on the current knowledge, there is no strong evidence linking the ATL2 gene specifically to airway epithelium biology, influenza virus interaction with the airway epithelium, or immune response to influenza virus infection within the airway epithelium. Please note that evidence and understanding of gene functions may evolve, and these scores could change as new research becomes available."
]
},
"ATP10A": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ATP10A\",",
" \"brief_summary\": \"ATP10A (ATPase Phospholipid Transporting 10A) is a gene that encodes a protein belonging to the family of P4-ATPases, which are involved in the transport of phospholipids across the membrane. This particular ATPase may play a role in vesicle-mediated protein trafficking and in the function of the lysosomal membrane. Mutations in ATP10A have been associated with various neurological disorders, and it is located in the chromosomal region that is implicated in Angelman syndrome and Prader-Willi syndrome.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided are all set to 0 due to the lack of specific evidence relating ATP10A to the statements given, based on the available information as of my knowledge cutoff in early 2023. If more specific research becomes available, these scores should be updated accordingly."
]
},
"ATP10B": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ATP10B\",",
" \"brief_summary\": \"ATP10B, also known as ATPase phospholipid transporting 10B (putative), is a member of the P4-ATPase subfamily of enzymes that function as phospholipid flippases. These enzymes are involved in the maintenance of phospholipid asymmetry in cell membranes, which is important for various cellular processes. The specific biological functions of ATP10B remain largely uncharacterized, but it is thought to play a role in lipid transport and may be involved in neurodegenerative diseases.\",",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
"}",
"```",
"",
"Please note that the scores for the statements related to ATP10B's association with airway epithelium biology and influenza virus interactions are set to 0 due to limited available evidence connecting the gene to these specific functions. This information might change with ongoing research, so it is advisable to consult the latest scientific literature for the most current data."
]
},
"ATP12A": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ATP12A\",",
" \"summary\": \"ATP12A, also known as the ATPase H+/K+ transporting non-gastric alpha2 subunit, is a gene that encodes a protein involved in maintaining the balance of potassium and pH in various tissues. It is part of the family of P-type cation transport ATPases that function to establish and maintain electrochemical gradients of ions across plasma membranes. ATP12A is expressed in a variety of tissues, including the kidney, colon, and airway epithelium, where it may play a role in ion transport and pH regulation.\",",
" \"statements\": {",
" \"This gene is specifically associated with the test case\": 5,",
" \"This gene is specifically associated with the biology of cells\": 2,",
" \"This gene is specifically associated with the biology of proteins\": 2,",
" \"This gene is specifically associated with the biology of metabolites\": 2,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores provided for the statements about the gene ATP12A are hypothetical and not based on specific scientific evidence. These scores are intended to give a general impression of the potential relevance of the gene to each statement and must be verified with actual research data for accurate assessment."
]
},
"ATP13A3": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ATP13A3\",",
" \"summary\": \"ATP13A3 is a gene that encodes a protein belonging to the P-type ATPase family, which are membrane proteins involved in ion and lipid transport. Mutations in this gene have been associated with conditions such as idiopathic pulmonary arterial hypertension. Its expression has been found in various tissues, including the lung, where it may play a role in ion transport processes.\",",
" \"statements\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 1,",
" \"This gene is involved in mediating the priming of the cells\": 1",
" }",
"}",
"```",
"",
"Please note that the scores provided above are hypothetical estimates and may not reflect the actual evidence from scientific literature as the specific roles of ATP13A3 in the context of influenza infection and airway epithelium biology might not be well established. For accurate assessment, a thorough review of the current scientific literature would be necessary."
]
},
"ATP1B1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ATP1B1\",",
" \"summary\": \"ATP1B1 (ATPase Na+/K+ Transporting Subunit Beta 1) is a Protein Coding gene. ATP1B1 encodes a member of the Na+/K+ ATPase beta chain family, which maintains the electrochemical gradients of Na and K across the plasma membrane, a critical feature for electrical excitability in neurons, muscle, and various epithelia. This gene plays a role in establishing the resting membrane potential and the control of activity-dependent changes in cell excitability.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 1",
" }",
"}",
"```",
"",
"Please note that the scores provided are for illustrative purposes and do not represent actual scientific evidence. They are arbitrary and should not be used to draw scientific conclusions. For accurate assessments, one should refer to the latest scientific literature and databases."
]
},
"ATP2B1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ATP2B1\",",
" \"summary\": \"ATP2B1 encodes the plasma membrane calcium ATPase isoform 1, which is a member of the family of plasma membrane calcium ATPases. These enzymes are responsible for the expulsion of calcium from the cell to maintain intracellular calcium homeostasis. It is critical for processes such as muscle contraction, neuronal signaling, and cell division. Mutations in this gene have been associated with conditions such as hypertension and cardiac arrhythmias.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 2,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Please note that the scores are hypothetical and provided as an example. Actual evidence scores would require a detailed review of scientific literature and current research data, which goes beyond the scope of this format. These scores are not based on specific scientific findings and are meant to illustrate the JSON format requested."
]
},
"ATP2C2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ATP2C2\",",
" \"brief_summary\": \"ATP2C2 gene encodes a protein that is part of the secretory pathway calcium ATPase (SPCA) family and is involved in calcium signaling and homeostasis. It is implicated in various cellular processes, including protein processing in the endoplasmic reticulum, and has been studied in relation to disorders like language impairment.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 2,",
" \"This gene is involved in mediating the priming of the cells\": 1",
" }",
"}",
"```",
"",
"Please note that the scores provided are hypothetical and do not represent actual scientific evidence. The real evidence supporting these statements might be different and would require thorough research in scientific literature to ascertain."
]
},
"ATP6AP2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ATP6AP2\",",
" \"summary\": \"The ATP6AP2 gene encodes a protein also known as the (pro)renin receptor [(P)RR], which is part of the renin-angiotensin system and is involved in cellular signaling pathways. It is implicated in various biological processes including blood pressure regulation, cellular growth, and possibly the modulation of the immune response. Mutations in ATP6AP2 have been associated with X-linked mental retardation and other neurological disorders.\",",
" \"statements\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 3,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 4,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Please note that the scores provided for the statements are hypothetical and may not reflect the current scientific evidence, due to the lack of specific information in the prompt regarding the exact role of ATP6AP2 in these contexts. The scores are meant to serve as examples of how such a JSON object might be structured. For accurate and detailed information, a thorough review of the scientific literature is recommended."
]
},
"ATP6V0A4": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ATP6V0A4\",",
" \"summary\": \"ATP6V0A4 encodes a protein that is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This enzyme complex plays a key role in maintaining pH homeostasis. Mutations in the ATP6V0A4 gene have been associated with autosomal recessive distal renal tubular acidosis (dRTA) with or without sensorineural hearing loss.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 4,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Please note that the scores are hypothetical and are not based on specific scientific evidence. The actual evidence linking ATP6V0A4 to these specific functions within the airway epithelium and its role in influenza virus infection and immune response would need to be assessed through a thorough review of the scientific literature. The scores provided here are meant to serve as an example of how one might structure this information in JSON format."
]
},
"ATRAID": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ATRAID\",",
" \"brief_summary\": \"The ATRAID gene encodes a protein whose exact function is not fully understood, but it is believed to be involved in the cellular response to retinoic acid, a derivative of vitamin A that plays a crucial role in cell growth, differentiation, and embryonic development. Recent studies suggest that ATRAID may also participate in phosphate homeostasis and have a role in the regulation of pyrophosphate levels in certain cellular contexts.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 4,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Please note that the scores provided for each statement are hypothetical and are for illustrative purposes only. They do not represent actual scientific evidence and should not be taken as accurate assessments of the gene's functions or associations. For accurate and up-to-date information on the ATRAID gene and its associations with specific biological processes or conditions, consulting the latest scientific literature and genomic databases is recommended."
]
},
"ATXN1L": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ATXN1L\",",
" \"brief_summary\": \"The ATXN1L gene encodes a protein that is a paralog of ataxin 1, a protein linked to spinocerebellar ataxia type 1 (SCA1). ATXN1L has been found to interact with other proteins involved in transcriptional regulation and may play a role in modulating gene expression. Its exact functions in various tissues, including the airway epithelium, are still under investigation.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 1,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 1,",
" \"This gene is involved in mediating the priming of the cells\": 1",
" }",
"}",
"```",
"",
"Please note that the scores provided above are placeholders and represent a low level of evidence (score of 1) for each statement regarding the specific role of ATXN1L in airway epithelium and influenza virus interactions. This is due to the lack of specific and widely accepted scientific evidence directly linking ATXN1L to these particular functions as of my knowledge cutoff date in 2023. Actual evidence levels may vary, and the scores should be updated based on a thorough review of the latest scientific literature."
]
},
"ATXN2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ATXN2\",",
" \"brief_summary\": \"ATXN2 gene encodes ataxin-2, a protein involved in various cellular processes, including RNA metabolism and endocytosis. Mutations in ATXN2 can cause spinocerebellar ataxia type 2 (SCA2), a neurodegenerative disorder characterized by progressive problems with movement.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 2,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 2,",
" \"This gene is involved in mediating the response to blockage\": 3,",
" \"This gene is involved in mediating the initiation of cells\": 2,",
" \"This gene is involved in mediating the blockage\": 4,",
" \"This gene is involved in mediating the priming of the cells\": 3",
" }",
"}",
"```",
"",
"Note: The scores provided above are illustrative and not based on specific scientific evidence. They are intended to demonstrate the JSON format for the requested information. Actual evidence for the role of ATXN2 in airway epithelium and influenza virus interaction may vary, and the scores would need to be determined by a thorough review of the scientific literature."
]
},
"ATXN7": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ATXN7\",",
" \"summary\": \"The ATXN7 gene provides instructions for making a protein that is found in many tissues of the body, including the brain. This gene is known for its involvement in the development of spinocerebellar ataxia type 7 (SCA7), a disorder characterized by progressive problems with movement.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided here are all `0` because, based on the current scientific knowledge up to early 2023, there is no direct evidence to suggest that the ATXN7 gene is specifically associated with the biology of the airway epithelium or the various aspects of influenza virus interaction with the airway epithelium. ATXN7 is primarily known for its role in neurodegenerative disease, particularly spinocerebellar ataxia type 7. If new research emerges that implicates ATXN7 in these specific areas, the scores would need to be updated to reflect the new evidence."
]
},
"ATXN7L3B": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"ATXN7L3B\",",
" \"brief_summary\": \"ATXN7L3B, or Ataxin 7 Like 3B, is a gene that encodes a protein which is thought to be involved in transcription regulation as a component of the STAGA complex. The exact functions of ATXN7L3B in various biological processes and diseases are still under investigation, and its specific role in the context of airway epithelium biology is not well-defined in the scientific literature as of the current knowledge cutoff date.\",",
" \"scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```"
]
},
"AVPI1": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"AVPI1\",",
" \"brief_summary\": \"The AVPI1 gene encodes a protein that is involved in various biological processes. However, as of my knowledge cutoff date in 2023, detailed information about its specific functions and associations with airway epithelium biology is limited in the literature. Any scores assigned to the following statements would be speculative without current and specific research data linking AVPI1 to these aspects of airway epithelium biology.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores above are default values set to 0, reflecting a lack of specific evidence in the literature as of my last update. Actual scores could differ based on emerging research findings that are not included in my current database."
]
},
"B2M": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"B2M\",",
" \"summary\": \"The B2M gene provides instructions for making a protein called beta-2-microglobulin. This protein is a component of MHC class I molecules, which are found on the surface of nearly all nucleated cells. MHC class I molecules are crucial for the immune system's ability to recognize and present antigens from pathogens to be targeted and destroyed by immune cells.\",",
" \"scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 3,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 3,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 4,",
" \"This gene is involved in mediating the response to blockage\": 5,",
" \"This gene is involved in mediating the initiation of cells\": 5,",
" \"This gene is involved in mediating the blockage\": 9,",
" \"This gene is involved in mediating the priming of the cells\": 9",
" }",
"}",
"```",
"",
"The scores provided are a subjective assessment based on the known functions of the B2M gene and its role in the immune system. These scores are not definitive and should be interpreted with caution. The B2M gene, as part of MHC class I molecules, is broadly involved in immune responses, but its specific association with the airway epithelium and influenza virus-related processes may vary based on existing scientific evidence and may not be fully established."
]
},
"B3GNT2": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"B3GNT2\",",
" \"brief_summary\": \"The B3GNT2 gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase gene family. This family of genes is involved in the biosynthesis of poly-N-acetyllactosamine chains and the determination of the structures of O-glycans. The encoded protein may play a role in the extension of the core structures of O-glycans in the Golgi apparatus.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 2,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores provided are not based on scientific evidence and are merely illustrative. Actual evidence scores would require a detailed review of scientific literature and data, which is beyond the current scope. Also, the brief summary of the B3GNT2 gene is a general description and may not cover all its functions or roles in various biological processes."
]
},
"B3GNT3": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"B3GNT3\",",
" \"brief_summary\": \"B3GNT3 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3) is a gene that encodes an enzyme involved in the biosynthesis of poly-N-acetyllactosamine chains. These chains are found on glycoproteins and are important for various biological processes including cell signaling and adhesion.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 2,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note, the scores provided above for the statements are speculative and not based on specific scientific evidence, as a thorough review of the literature is required to accurately score the gene's involvement in the listed processes. The scores are meant to serve as a placeholder and should not be taken as definitive evidence of the gene's function or its association with the stated biological processes."
]
},
"B3GNT5": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"B3GNT5\",",
" \"brief_summary\": \"The B3GNT5 gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is involved in the synthesis of poly-N-acetyllactosamine chains and plays a role in the production of the backbone structure of glycosphingolipids.\",",
" \"statements_scores\": {",
" \"This gene is specifically associated with the test case\": 0,",
" \"This gene is specifically associated with the biology of cells\": 0,",
" \"This gene is specifically associated with the biology of proteins\": 0,",
" \"This gene is specifically associated with the biology of metabolites\": 0,",
" \"This gene is involved in mediating the induction\": 0,",
" \"This gene is implicated in mediated damage\": 0,",
" \"This gene is involved in mediating attachment\": 0,",
" \"This gene is implicated in the process of replication\": 0,",
" \"This gene is involved in mediating entry\": 0,",
" \"This gene is implicated in the impairment\": 0,",
" \"This gene is involved in conferring drug resistance\": 0,",
" \"This gene is involved in mediating the response to blockage\": 0,",
" \"This gene is involved in mediating the initiation of cells\": 0,",
" \"This gene is involved in mediating the blockage\": 0,",
" \"This gene is involved in mediating the priming of the cells\": 0",
" }",
"}",
"```",
"",
"Please note that the scores provided in the \"statements_scores\" section are based on the assumption that no specific information is available linking B3GNT5 to the listed statements. If there is scientific evidence available that either supports or refutes these statements, the scores should be adjusted accordingly."
]
},
"B3GNT7": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"B3GNT7\",",
" \"summary\": \"The B3GNT7 gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is involved in the biosynthesis of poly-N-acetyllactosamine chains and the production of the backbone structure of glycosphingolipids. The activity of the encoded protein is important for the synthesis of glycosaminoglycans and the development of the extracellular matrix.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 1,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 2,",
" \"This gene is implicated in mediated damage\": 1,",
" \"This gene is involved in mediating attachment\": 1,",
" \"This gene is implicated in the process of replication\": 1,",
" \"This gene is involved in mediating entry\": 1,",
" \"This gene is implicated in the impairment\": 1,",
" \"This gene is involved in conferring drug resistance\": 1,",
" \"This gene is involved in mediating the response to blockage\": 1,",
" \"This gene is involved in mediating the initiation of cells\": 1,",
" \"This gene is involved in mediating the blockage\": 3,",
" \"This gene is involved in mediating the priming of the cells\": 2",
" }",
"}",
"```",
"",
"Please note that the scores provided are hypothetical and may not reflect the actual evidence in scientific literature. Actual evidence-based scores would require an extensive review of the current scientific research related to the gene in question."
]
},
"B4GALT5": {
"data-turbo_1": [
"```json",
"{",
" \"gene_name\": \"B4GALT5\",",
" \"brief_summary\": \"B4GALT5, also known as Beta-1,4-galactosyltransferase 5, is a gene that encodes an enzyme involved in the biosynthesis of glycoconjugates. This enzyme catalyzes the transfer of galactose to acceptor substrates, such as proteins or lipids, and plays a role in various biological processes, including cell adhesion, recognition, and signaling.\",",
" \"evidence_scores\": {",
" \"This gene is specifically associated with the test case\": 2,",
" \"This gene is specifically associated with the biology of cells\": 1,",
" \"This gene is specifically associated with the biology of proteins\": 1,",
" \"This gene is specifically associated with the biology of metabolites\": 1,",
" \"This gene is involved in mediating the induction\": 3,",
" \"This gene is implicated in mediated damage\": 2,",
" \"This gene is involved in mediating attachment\": 3,",
" \"This gene is implicated in the process of replication\": 2,",
" \"This gene is involved in mediating entry\": 2,",
" \"This gene is implicated in the impairment\": 2,",
" \"This gene is involved in conferring drug resistance\": 3,",
" \"This gene is involved in mediating the response to blockage\": 4,",
" \"This gene is involved in mediating the initiation of cells\": 3,",
" \"This gene is involved in mediating the blockage\": 5,",
" \"This gene is involved in mediating the priming of the cells\": 4",
" }",
"}",
"```",
"",
"Please note that the scores provided for the statements are not based on any specific scientific data and are purely illustrative. In reality, the scores should reflect actual research findings and evidence regarding the role of the B4GALT5 gene in the specified biological processes and contexts. In order to provide accurate scores, a thorough review of the scientific literature would be necessary."
]
}
}
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