dnspython_dynamicdns.py

from dns import query, update, tsigkeyring
from dns.tsig import HMAC_SHA256

key='EQSVvuA/KMAa/0ugdBBLqjxgP+o5rI7y8JoJbOICpJM='
bindhost='192.168.56.10'
ip='192.168.56.10'

keyring = tsigkeyring.from_text({
    'test.local' : key
    })

update = update.Update('test.local.', keyring=keyring, keyalgorithm=HMAC_SHA256)
update.replace('abc', 300, 'A', ip)

response = query.tcp(update, bindhost, timeout=10)