Very basic example to set a display device's default colorsync profile.

set_default_color_profile.py

#!/usr/bin/python
 
import objc
import Foundation
import Quartz

# replace with url-encoded path to an icc profile
URL_ENCODED_ICC_PATH = 'file:///Library/Application%20Support/Adobe/Color/Profiles/SMPTE-C.icc'

# stripped bridge metadata of all we need for this sample:
objc.parseBridgeSupport("""<?xml version='1.0'?>
<!DOCTYPE signatures SYSTEM "file://localhost/System/Library/DTDs/BridgeSupport.dtd">
<signatures version='1.0'>
<constant name='kColorSyncDeviceDefaultProfileID' type='^{__CFString=}'/>
<constant name='kColorSyncDisplayDeviceClass' type='^{__CFString=}'/>
<function name='CGDisplayCreateUUIDFromDisplayID'>
<arg type='I'/>
<retval already_retained='true' type='^{__CFUUID=}'/>
</function>
<function name='ColorSyncDeviceCopyDeviceInfo'>
<arg type='^{__CFString=}'/>
<arg type='^{__CFUUID=}'/>
<retval already_retained='true' type='^{__CFDictionary=}'/>
</function>
<function name='ColorSyncDeviceSetCustomProfiles'>
<arg type='^{__CFString=}'/>
<arg type='^{__CFUUID=}'/>
<arg type='^{__CFDictionary=}'/>
<retval type='B'/>
</function>
</signatures>
""", globals(), '/System/Library/Frameworks/ApplicationServices.framework/Versions/A/Frameworks/ColorSync.framework')


main_display_id = Quartz.CGMainDisplayID()
display_uuid = CGDisplayCreateUUIDFromDisplayID(main_display_id)

print "Current device info:"
deviceInfo = ColorSyncDeviceCopyDeviceInfo(kColorSyncDisplayDeviceClass, display_uuid)
print deviceInfo

profile_url = Foundation.CFURLCreateWithString(None, URL_ENCODED_ICC_PATH, None)

# info on config dict required:
# /System/Library/Frameworks/ApplicationServices.framework/Versions/A/Frameworks/ColorSync.framework/Versions/A/Headers/ColorSyncProfile.h
# http://web.archiveorange.com/archive/print/YwdQZYJTswvvG79VTuyD
new_profile_dict = { kColorSyncDeviceDefaultProfileID: profile_url }

print "Setting profile..."
done = ColorSyncDeviceSetCustomProfiles(kColorSyncDisplayDeviceClass, display_uuid, new_profile_dict)
print "Succeeded: %s" % done
print

print "Current device info:"
deviceInfo = ColorSyncDeviceCopyDeviceInfo(kColorSyncDisplayDeviceClass, display_uuid)
print deviceInfo