Simulate the work of loading all settings at the start of every page request.

config-backend.diff

diff --git a/CRM/Core/Config.php b/CRM/Core/Config.php
index 58612b1..e922acc 100644
--- a/CRM/Core/Config.php
+++ b/CRM/Core/Config.php
@@ -262,6 +262,11 @@ class CRM_Core_Config extends CRM_Core_Config_Variables {

       // initialize authentication source
       self::$_singleton->initAuthSrc();
+
+      $dao = CRM_Core_DAO::executeQuery('SELECT config_backend FROM civicrm_domain WHERE id = 1');
+      while ($dao->fetch()) {
+        unserialize($dao->config_backend);
+      }
     }
     return self::$_singleton;
   }

config-setting.diff

diff --git a/CRM/Core/Config.php b/CRM/Core/Config.php
index 58612b1..962cf18 100644
--- a/CRM/Core/Config.php
+++ b/CRM/Core/Config.php
@@ -262,6 +262,11 @@ class CRM_Core_Config extends CRM_Core_Config_Variables {

       // initialize authentication source
       self::$_singleton->initAuthSrc();
+
+      $dao = CRM_Core_DAO::executeQuery('SELECT name, value FROM civicrm_setting WHERE domain_id = 1');
+      while ($dao->fetch()) {
+        unserialize($dao->value);
+      }
     }
     return self::$_singleton;
   }