Skip to content

Instantly share code, notes, and snippets.

@tpoterba

tpoterba/vep inconsistency.txt

Created July 9, 2019 18:45
Show Gist options
  • Star 0 You must be signed in to star a gist
  • Fork 0 You must be signed in to fork a gist
  • Save tpoterba/0ecdd23b6a767536f535e1ca44bce9b0 to your computer and use it in GitHub Desktop.
Save tpoterba/0ecdd23b6a767536f535e1ca44bce9b0 to your computer and use it in GitHub Desktop.
Download ZIP
vep inconsistency
Raw
vep inconsistency.txt
Table._same: rows differ:
1L Struct(vep=Struct(assembly_name='GRCh37', allele_string='A/T', ancestral=None, colocated_variants=None, context=None, end=55523002, id='1_55523002_A/T', input='1\t55523002\t.\tA\tT\t.\t.\tGT', intergenic_consequences=None, most_severe_consequence='splice_acceptor_variant', motif_feature_consequences=None, regulatory_feature_consequences=None, seq_region_name='1', start=55523002, strand=1, transcript_consequences=[Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=1, ccds='CCDS603.1', cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['splice_acceptor_variant'], distance=None, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000302118.5:c.997-2A>T', hgvsp=None, hgvs_offset=None, impact='HIGH', intron='6/11', lof='LC', lof_flags=None, lof_filter='ANC_ALLELE', minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000303208', sift_prediction=None, sift_score=None, strand=1, swissprot='Q8NBP7', transcript_id='ENST00000302118', trembl=None, uniparc='UPI00001615E1', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['downstream_gene_variant'], distance=4578, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc=None, hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000401598', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000452118', trembl='B4DEZ9', uniparc='UPI00017A6F55', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='processed_transcript', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['intron_variant', 'non_coding_transcript_variant'], distance=None, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000490692.1:n.1818-99A>T', hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron='3/7', lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id=None, sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000490692', trembl=None, uniparc=None, variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['splice_acceptor_variant'], distance=None, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000543384.1:c.397-2A>T', hgvsp=None, hgvs_offset=None, impact='HIGH', intron='4/9', lof='LC', lof_flags=None, lof_filter='ANC_ALLELE', minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000441859', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000543384', trembl='F5GWF0', uniparc='UPI000206501F', variant_allele='T')], variant_class='SNV'), __uid_4=[]),
1R Struct(vep=Struct(assembly_name='GRCh37', allele_string='A/T', ancestral=None, colocated_variants=None, context=None, end=55523002, id='1_55523002_A/T', input='1\t55523002\t.\tA\tT\t.\t.\tGT', intergenic_consequences=None, most_severe_consequence='splice_acceptor_variant', motif_feature_consequences=None, regulatory_feature_consequences=None, seq_region_name='1', start=55523002, strand=1, transcript_consequences=[Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=1, ccds='CCDS603.1', cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['splice_acceptor_variant'], distance=None, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000302118.5:c.997-2A>T', hgvsp=None, hgvs_offset=None, impact='HIGH', intron='6/11', lof='HC', lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000303208', sift_prediction=None, sift_score=None, strand=1, swissprot='Q8NBP7', transcript_id='ENST00000302118', trembl=None, uniparc='UPI00001615E1', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['downstream_gene_variant'], distance=4578, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc=None, hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000401598', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000452118', trembl='B4DEZ9', uniparc='UPI00017A6F55', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='processed_transcript', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['intron_variant', 'non_coding_transcript_variant'], distance=None, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000490692.1:n.1818-99A>T', hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron='3/7', lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id=None, sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000490692', trembl=None, uniparc=None, variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['splice_acceptor_variant'], distance=None, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000543384.1:c.397-2A>T', hgvsp=None, hgvs_offset=None, impact='HIGH', intron='4/9', lof='HC', lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000441859', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000543384', trembl='F5GWF0', uniparc='UPI000206501F', variant_allele='T')], variant_class='SNV'), __uid_4=[])
2L Struct(vep=Struct(assembly_name='GRCh37', allele_string='C/T', ancestral=None, colocated_variants=[Struct(aa_allele=None, aa_maf=None, afr_allele='T', afr_maf=0.0, allele_string='C/A/T', amr_allele=None, amr_maf=None, clin_sig=None, end=55523037, eas_allele=None, eas_maf=None, ea_allele=None, ea_maf=None, eur_allele=None, eur_maf=None, exac_adj_allele='T', exac_adj_maf=0.0, exac_allele=None, exac_afr_allele='T', exac_afr_maf=8.236e-06, exac_amr_allele='T', exac_amr_maf=0.0, exac_eas_allele='T', exac_eas_maf=8.245e-06, exac_fin_allele='T', exac_fin_maf=0.0, exac_maf=None, exac_nfe_allele='T', exac_nfe_maf=0.0, exac_oth_allele='T', exac_oth_maf=1.5e-05, exac_sas_allele='T', exac_sas_maf=0.0, id='rs72646513', minor_allele=None, minor_allele_freq=None, phenotype_or_disease=None, pubmed=None, sas_allele=None, sas_maf=None, somatic=None, start=55523037, strand=1)], context=None, end=55523037, id='1_55523037_C/T', input='1\t55523037\t.\tC\tT\t.\t.\tGT', intergenic_consequences=None, most_severe_consequence='stop_gained', motif_feature_consequences=None, regulatory_feature_consequences=None, seq_region_name='1', start=55523037, strand=1, transcript_consequences=[Struct(allele_num=1, amino_acids='Q/*', biotype='protein_coding', canonical=1, ccds='CCDS603.1', cdna_start=1320, cdna_end=1320, cds_end=1030, cds_start=1030, codons='Cag/Tag', consequence_terms=['stop_gained'], distance=None, domains=[Struct(db='hmmpanther', name='PTHR10795'), Struct(db='hmmpanther', name='PTHR10795'), Struct(db='Pfam_domain', name='PF00082'), Struct(db='Gene3D', name='3'), Struct(db='Superfamily_domains', name='SSF52743')], exon='7/12', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000302118.5:c.1030C>T', hgvsp='ENSP00000303208.5:p.Gln344Ter', hgvs_offset=None, impact='HIGH', intron=None, lof='LC', lof_flags=None, lof_filter='ANC_ALLELE', minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=344, protein_start=344, protein_id='ENSP00000303208', sift_prediction=None, sift_score=None, strand=1, swissprot='Q8NBP7', transcript_id='ENST00000302118', trembl=None, uniparc='UPI00001615E1', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['downstream_gene_variant'], distance=4613, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc=None, hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000401598', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000452118', trembl='B4DEZ9', uniparc='UPI00017A6F55', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='processed_transcript', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['intron_variant', 'non_coding_transcript_variant'], distance=None, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000490692.1:n.1818-64C>T', hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron='3/7', lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id=None, sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000490692', trembl=None, uniparc=None, variant_allele='T'), Struct(allele_num=1, amino_acids='Q/*', biotype='protein_coding', canonical=None, ccds=None, cdna_start=689, cdna_end=689, cds_end=430, cds_start=430, codons='Cag/Tag', consequence_terms=['stop_gained'], distance=None, domains=[Struct(db='Gene3D', name='3'), Struct(db='Pfam_domain', name='PF00082'), Struct(db='hmmpanther', name='PTHR10795'), Struct(db='Superfamily_domains', name='SSF52743')], exon='5/10', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000543384.1:c.430C>T', hgvsp='ENSP00000441859.1:p.Gln144Ter', hgvs_offset=None, impact='HIGH', intron=None, lof='LC', lof_flags=None, lof_filter='ANC_ALLELE', minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=144, protein_start=144, protein_id='ENSP00000441859', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000543384', trembl='F5GWF0', uniparc='UPI000206501F', variant_allele='T')], variant_class='SNV'), __uid_4=[]),
2R Struct(vep=Struct(assembly_name='GRCh37', allele_string='C/T', ancestral=None, colocated_variants=[Struct(aa_allele=None, aa_maf=None, afr_allele='T', afr_maf=0.0, allele_string='C/A/T', amr_allele=None, amr_maf=None, clin_sig=None, end=55523037, eas_allele=None, eas_maf=None, ea_allele=None, ea_maf=None, eur_allele=None, eur_maf=None, exac_adj_allele='T', exac_adj_maf=0.0, exac_allele=None, exac_afr_allele='T', exac_afr_maf=8.236e-06, exac_amr_allele='T', exac_amr_maf=0.0, exac_eas_allele='T', exac_eas_maf=8.245e-06, exac_fin_allele='T', exac_fin_maf=0.0, exac_maf=None, exac_nfe_allele='T', exac_nfe_maf=0.0, exac_oth_allele='T', exac_oth_maf=1.5e-05, exac_sas_allele='T', exac_sas_maf=0.0, id='rs72646513', minor_allele=None, minor_allele_freq=None, phenotype_or_disease=None, pubmed=None, sas_allele=None, sas_maf=None, somatic=None, start=55523037, strand=1)], context=None, end=55523037, id='1_55523037_C/T', input='1\t55523037\t.\tC\tT\t.\t.\tGT', intergenic_consequences=None, most_severe_consequence='stop_gained', motif_feature_consequences=None, regulatory_feature_consequences=None, seq_region_name='1', start=55523037, strand=1, transcript_consequences=[Struct(allele_num=1, amino_acids='Q/*', biotype='protein_coding', canonical=1, ccds='CCDS603.1', cdna_start=1320, cdna_end=1320, cds_end=1030, cds_start=1030, codons='Cag/Tag', consequence_terms=['stop_gained'], distance=None, domains=[Struct(db='hmmpanther', name='PTHR10795'), Struct(db='hmmpanther', name='PTHR10795'), Struct(db='Pfam_domain', name='PF00082'), Struct(db='Gene3D', name='3'), Struct(db='Superfamily_domains', name='SSF52743')], exon='7/12', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000302118.5:c.1030C>T', hgvsp='ENSP00000303208.5:p.Gln344Ter', hgvs_offset=None, impact='HIGH', intron=None, lof='HC', lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=344, protein_start=344, protein_id='ENSP00000303208', sift_prediction=None, sift_score=None, strand=1, swissprot='Q8NBP7', transcript_id='ENST00000302118', trembl=None, uniparc='UPI00001615E1', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['downstream_gene_variant'], distance=4613, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc=None, hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000401598', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000452118', trembl='B4DEZ9', uniparc='UPI00017A6F55', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='processed_transcript', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['intron_variant', 'non_coding_transcript_variant'], distance=None, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000490692.1:n.1818-64C>T', hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron='3/7', lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id=None, sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000490692', trembl=None, uniparc=None, variant_allele='T'), Struct(allele_num=1, amino_acids='Q/*', biotype='protein_coding', canonical=None, ccds=None, cdna_start=689, cdna_end=689, cds_end=430, cds_start=430, codons='Cag/Tag', consequence_terms=['stop_gained'], distance=None, domains=[Struct(db='Gene3D', name='3'), Struct(db='Pfam_domain', name='PF00082'), Struct(db='hmmpanther', name='PTHR10795'), Struct(db='Superfamily_domains', name='SSF52743')], exon='5/10', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000543384.1:c.430C>T', hgvsp='ENSP00000441859.1:p.Gln144Ter', hgvs_offset=None, impact='HIGH', intron=None, lof='HC', lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=144, protein_start=144, protein_id='ENSP00000441859', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000543384', trembl='F5GWF0', uniparc='UPI000206501F', variant_allele='T')], variant_class='SNV'), __uid_4=[])
3L Struct(vep=Struct(assembly_name='GRCh37', allele_string='C/T', ancestral=None, colocated_variants=[Struct(aa_allele=None, aa_maf=None, afr_allele='T', afr_maf=0.0, allele_string='C/T', amr_allele=None, amr_maf=None, clin_sig=None, end=55523151, eas_allele=None, eas_maf=None, ea_allele=None, ea_maf=None, eur_allele=None, eur_maf=None, exac_adj_allele='T', exac_adj_maf=0.0, exac_allele=None, exac_afr_allele='T', exac_afr_maf=8.237e-06, exac_amr_allele='T', exac_amr_maf=0.0, exac_eas_allele='T', exac_eas_maf=8.937e-06, exac_fin_allele='T', exac_fin_maf=0.0, exac_maf=None, exac_nfe_allele='T', exac_nfe_maf=0.0, exac_oth_allele='T', exac_oth_maf=1.619e-05, exac_sas_allele='T', exac_sas_maf=0.0, id='rs773363923', minor_allele=None, minor_allele_freq=None, phenotype_or_disease=None, pubmed=None, sas_allele=None, sas_maf=None, somatic=None, start=55523151, strand=1)], context=None, end=55523151, id='1_55523151_C/T', input='1\t55523151\t.\tC\tT\t.\t.\tGT', intergenic_consequences=None, most_severe_consequence='stop_gained', motif_feature_consequences=None, regulatory_feature_consequences=None, seq_region_name='1', start=55523151, strand=1, transcript_consequences=[Struct(allele_num=1, amino_acids='Q/*', biotype='protein_coding', canonical=1, ccds='CCDS603.1', cdna_start=1434, cdna_end=1434, cds_end=1144, cds_start=1144, codons='Cag/Tag', consequence_terms=['stop_gained'], distance=None, domains=[Struct(db='hmmpanther', name='PTHR10795'), Struct(db='hmmpanther', name='PTHR10795'), Struct(db='Pfam_domain', name='PF00082'), Struct(db='Gene3D', name='3'), Struct(db='Superfamily_domains', name='SSF52743')], exon='7/12', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000302118.5:c.1144C>T', hgvsp='ENSP00000303208.5:p.Gln382Ter', hgvs_offset=None, impact='HIGH', intron=None, lof='LC', lof_flags=None, lof_filter='ANC_ALLELE', minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=382, protein_start=382, protein_id='ENSP00000303208', sift_prediction=None, sift_score=None, strand=1, swissprot='Q8NBP7', transcript_id='ENST00000302118', trembl=None, uniparc='UPI00001615E1', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['downstream_gene_variant'], distance=4727, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc=None, hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000401598', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000452118', trembl='B4DEZ9', uniparc='UPI00017A6F55', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='processed_transcript', canonical=None, ccds=None, cdna_start=1868, cdna_end=1868, cds_end=None, cds_start=None, codons=None, consequence_terms=['non_coding_transcript_exon_variant', 'non_coding_transcript_variant'], distance=None, domains=None, exon='4/8', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000490692.1:n.1868C>T', hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id=None, sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000490692', trembl=None, uniparc=None, variant_allele='T'), Struct(allele_num=1, amino_acids='Q/*', biotype='protein_coding', canonical=None, ccds=None, cdna_start=803, cdna_end=803, cds_end=544, cds_start=544, codons='Cag/Tag', consequence_terms=['stop_gained'], distance=None, domains=[Struct(db='Gene3D', name='3'), Struct(db='Pfam_domain', name='PF00082'), Struct(db='hmmpanther', name='PTHR10795'), Struct(db='Superfamily_domains', name='SSF52743')], exon='5/10', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000543384.1:c.544C>T', hgvsp='ENSP00000441859.1:p.Gln182Ter', hgvs_offset=None, impact='HIGH', intron=None, lof='LC', lof_flags=None, lof_filter='ANC_ALLELE', minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=182, protein_start=182, protein_id='ENSP00000441859', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000543384', trembl='F5GWF0', uniparc='UPI000206501F', variant_allele='T')], variant_class='SNV'), __uid_4=[]),
3R Struct(vep=Struct(assembly_name='GRCh37', allele_string='C/T', ancestral=None, colocated_variants=[Struct(aa_allele=None, aa_maf=None, afr_allele='T', afr_maf=0.0, allele_string='C/T', amr_allele=None, amr_maf=None, clin_sig=None, end=55523151, eas_allele=None, eas_maf=None, ea_allele=None, ea_maf=None, eur_allele=None, eur_maf=None, exac_adj_allele='T', exac_adj_maf=0.0, exac_allele=None, exac_afr_allele='T', exac_afr_maf=8.237e-06, exac_amr_allele='T', exac_amr_maf=0.0, exac_eas_allele='T', exac_eas_maf=8.937e-06, exac_fin_allele='T', exac_fin_maf=0.0, exac_maf=None, exac_nfe_allele='T', exac_nfe_maf=0.0, exac_oth_allele='T', exac_oth_maf=1.619e-05, exac_sas_allele='T', exac_sas_maf=0.0, id='rs773363923', minor_allele=None, minor_allele_freq=None, phenotype_or_disease=None, pubmed=None, sas_allele=None, sas_maf=None, somatic=None, start=55523151, strand=1)], context=None, end=55523151, id='1_55523151_C/T', input='1\t55523151\t.\tC\tT\t.\t.\tGT', intergenic_consequences=None, most_severe_consequence='stop_gained', motif_feature_consequences=None, regulatory_feature_consequences=None, seq_region_name='1', start=55523151, strand=1, transcript_consequences=[Struct(allele_num=1, amino_acids='Q/*', biotype='protein_coding', canonical=1, ccds='CCDS603.1', cdna_start=1434, cdna_end=1434, cds_end=1144, cds_start=1144, codons='Cag/Tag', consequence_terms=['stop_gained'], distance=None, domains=[Struct(db='hmmpanther', name='PTHR10795'), Struct(db='hmmpanther', name='PTHR10795'), Struct(db='Pfam_domain', name='PF00082'), Struct(db='Gene3D', name='3'), Struct(db='Superfamily_domains', name='SSF52743')], exon='7/12', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000302118.5:c.1144C>T', hgvsp='ENSP00000303208.5:p.Gln382Ter', hgvs_offset=None, impact='HIGH', intron=None, lof='HC', lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=382, protein_start=382, protein_id='ENSP00000303208', sift_prediction=None, sift_score=None, strand=1, swissprot='Q8NBP7', transcript_id='ENST00000302118', trembl=None, uniparc='UPI00001615E1', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['downstream_gene_variant'], distance=4727, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc=None, hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000401598', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000452118', trembl='B4DEZ9', uniparc='UPI00017A6F55', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='processed_transcript', canonical=None, ccds=None, cdna_start=1868, cdna_end=1868, cds_end=None, cds_start=None, codons=None, consequence_terms=['non_coding_transcript_exon_variant', 'non_coding_transcript_variant'], distance=None, domains=None, exon='4/8', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000490692.1:n.1868C>T', hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id=None, sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000490692', trembl=None, uniparc=None, variant_allele='T'), Struct(allele_num=1, amino_acids='Q/*', biotype='protein_coding', canonical=None, ccds=None, cdna_start=803, cdna_end=803, cds_end=544, cds_start=544, codons='Cag/Tag', consequence_terms=['stop_gained'], distance=None, domains=[Struct(db='Gene3D', name='3'), Struct(db='Pfam_domain', name='PF00082'), Struct(db='hmmpanther', name='PTHR10795'), Struct(db='Superfamily_domains', name='SSF52743')], exon='5/10', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000543384.1:c.544C>T', hgvsp='ENSP00000441859.1:p.Gln182Ter', hgvs_offset=None, impact='HIGH', intron=None, lof='HC', lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=182, protein_start=182, protein_id='ENSP00000441859', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000543384', trembl='F5GWF0', uniparc='UPI000206501F', variant_allele='T')], variant_class='SNV'), __uid_4=[])
4L Struct(vep=Struct(assembly_name='GRCh37', allele_string='G/T', ancestral=None, colocated_variants=[Struct(aa_allele=None, aa_maf=None, afr_allele=None, afr_maf=None, allele_string='G/A/T', amr_allele=None, amr_maf=None, clin_sig=None, end=55523756, eas_allele=None, eas_maf=None, ea_allele=None, ea_maf=None, eur_allele=None, eur_maf=None, exac_adj_allele='A', exac_adj_maf=0.0, exac_allele=None, exac_afr_allele='A', exac_afr_maf=1.647e-05, exac_amr_allele='A', exac_amr_maf=9.714e-05, exac_eas_allele='A', exac_eas_maf=1.657e-05, exac_fin_allele='A', exac_fin_maf=0.0, exac_maf=None, exac_nfe_allele='A', exac_nfe_maf=0.0, exac_oth_allele='A', exac_oth_maf=1.511e-05, exac_sas_allele='A', exac_sas_maf=0.0, id='rs746085210', minor_allele=None, minor_allele_freq=None, phenotype_or_disease=None, pubmed=None, sas_allele=None, sas_maf=None, somatic=None, start=55523756, strand=1)], context=None, end=55523756, id='1_55523756_G/T', input='1\t55523756\t.\tG\tT\t.\t.\tGT', intergenic_consequences=None, most_severe_consequence='stop_gained', motif_feature_consequences=None, regulatory_feature_consequences=None, seq_region_name='1', start=55523756, strand=1, transcript_consequences=[Struct(allele_num=1, amino_acids='E/*', biotype='protein_coding', canonical=1, ccds='CCDS603.1', cdna_start=1518, cdna_end=1518, cds_end=1228, cds_start=1228, codons='Gag/Tag', consequence_terms=['stop_gained'], distance=None, domains=[Struct(db='hmmpanther', name='PTHR10795'), Struct(db='hmmpanther', name='PTHR10795'), Struct(db='Pfam_domain', name='PF00082'), Struct(db='Gene3D', name='3'), Struct(db='Superfamily_domains', name='SSF52743')], exon='8/12', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000302118.5:c.1228G>T', hgvsp='ENSP00000303208.5:p.Glu410Ter', hgvs_offset=None, impact='HIGH', intron=None, lof='LC', lof_flags=None, lof_filter='ANC_ALLELE', minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=410, protein_start=410, protein_id='ENSP00000303208', sift_prediction=None, sift_score=None, strand=1, swissprot='Q8NBP7', transcript_id='ENST00000302118', trembl=None, uniparc='UPI00001615E1', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='processed_transcript', canonical=None, ccds=None, cdna_start=1952, cdna_end=1952, cds_end=None, cds_start=None, codons=None, consequence_terms=['non_coding_transcript_exon_variant', 'non_coding_transcript_variant'], distance=None, domains=None, exon='5/8', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000490692.1:n.1952G>T', hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id=None, sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000490692', trembl=None, uniparc=None, variant_allele='T'), Struct(allele_num=1, amino_acids='E/*', biotype='protein_coding', canonical=None, ccds=None, cdna_start=887, cdna_end=887, cds_end=628, cds_start=628, codons='Gag/Tag', consequence_terms=['stop_gained'], distance=None, domains=[Struct(db='Gene3D', name='3'), Struct(db='Pfam_domain', name='PF00082'), Struct(db='hmmpanther', name='PTHR10795'), Struct(db='Superfamily_domains', name='SSF52743')], exon='6/10', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000543384.1:c.628G>T', hgvsp='ENSP00000441859.1:p.Glu210Ter', hgvs_offset=None, impact='HIGH', intron=None, lof='LC', lof_flags=None, lof_filter='ANC_ALLELE', minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=210, protein_start=210, protein_id='ENSP00000441859', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000543384', trembl='F5GWF0', uniparc='UPI000206501F', variant_allele='T')], variant_class='SNV'), __uid_4=[]),
4R Struct(vep=Struct(assembly_name='GRCh37', allele_string='G/T', ancestral=None, colocated_variants=[Struct(aa_allele=None, aa_maf=None, afr_allele=None, afr_maf=None, allele_string='G/A/T', amr_allele=None, amr_maf=None, clin_sig=None, end=55523756, eas_allele=None, eas_maf=None, ea_allele=None, ea_maf=None, eur_allele=None, eur_maf=None, exac_adj_allele='A', exac_adj_maf=0.0, exac_allele=None, exac_afr_allele='A', exac_afr_maf=1.647e-05, exac_amr_allele='A', exac_amr_maf=9.714e-05, exac_eas_allele='A', exac_eas_maf=1.657e-05, exac_fin_allele='A', exac_fin_maf=0.0, exac_maf=None, exac_nfe_allele='A', exac_nfe_maf=0.0, exac_oth_allele='A', exac_oth_maf=1.511e-05, exac_sas_allele='A', exac_sas_maf=0.0, id='rs746085210', minor_allele=None, minor_allele_freq=None, phenotype_or_disease=None, pubmed=None, sas_allele=None, sas_maf=None, somatic=None, start=55523756, strand=1)], context=None, end=55523756, id='1_55523756_G/T', input='1\t55523756\t.\tG\tT\t.\t.\tGT', intergenic_consequences=None, most_severe_consequence='stop_gained', motif_feature_consequences=None, regulatory_feature_consequences=None, seq_region_name='1', start=55523756, strand=1, transcript_consequences=[Struct(allele_num=1, amino_acids='E/*', biotype='protein_coding', canonical=1, ccds='CCDS603.1', cdna_start=1518, cdna_end=1518, cds_end=1228, cds_start=1228, codons='Gag/Tag', consequence_terms=['stop_gained'], distance=None, domains=[Struct(db='hmmpanther', name='PTHR10795'), Struct(db='hmmpanther', name='PTHR10795'), Struct(db='Pfam_domain', name='PF00082'), Struct(db='Gene3D', name='3'), Struct(db='Superfamily_domains', name='SSF52743')], exon='8/12', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000302118.5:c.1228G>T', hgvsp='ENSP00000303208.5:p.Glu410Ter', hgvs_offset=None, impact='HIGH', intron=None, lof='HC', lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=410, protein_start=410, protein_id='ENSP00000303208', sift_prediction=None, sift_score=None, strand=1, swissprot='Q8NBP7', transcript_id='ENST00000302118', trembl=None, uniparc='UPI00001615E1', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='processed_transcript', canonical=None, ccds=None, cdna_start=1952, cdna_end=1952, cds_end=None, cds_start=None, codons=None, consequence_terms=['non_coding_transcript_exon_variant', 'non_coding_transcript_variant'], distance=None, domains=None, exon='5/8', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000490692.1:n.1952G>T', hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id=None, sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000490692', trembl=None, uniparc=None, variant_allele='T'), Struct(allele_num=1, amino_acids='E/*', biotype='protein_coding', canonical=None, ccds=None, cdna_start=887, cdna_end=887, cds_end=628, cds_start=628, codons='Gag/Tag', consequence_terms=['stop_gained'], distance=None, domains=[Struct(db='Gene3D', name='3'), Struct(db='Pfam_domain', name='PF00082'), Struct(db='hmmpanther', name='PTHR10795'), Struct(db='Superfamily_domains', name='SSF52743')], exon='6/10', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000543384.1:c.628G>T', hgvsp='ENSP00000441859.1:p.Glu210Ter', hgvs_offset=None, impact='HIGH', intron=None, lof='HC', lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=210, protein_start=210, protein_id='ENSP00000441859', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000543384', trembl='F5GWF0', uniparc='UPI000206501F', variant_allele='T')], variant_class='SNV'), __uid_4=[])
5L Struct(vep=Struct(assembly_name='GRCh37', allele_string='G/T', ancestral=None, colocated_variants=[Struct(aa_allele=None, aa_maf=None, afr_allele=None, afr_maf=None, allele_string='G/T', amr_allele=None, amr_maf=None, clin_sig=None, end=55523831, eas_allele=None, eas_maf=None, ea_allele=None, ea_maf=None, eur_allele=None, eur_maf=None, exac_adj_allele='T', exac_adj_maf=0.0, exac_allele=None, exac_afr_allele='T', exac_afr_maf=4.118e-05, exac_amr_allele='T', exac_amr_maf=0.0, exac_eas_allele='T', exac_eas_maf=4.168e-05, exac_fin_allele='T', exac_fin_maf=0.0, exac_maf=None, exac_nfe_allele='T', exac_nfe_maf=0.0, exac_oth_allele='T', exac_oth_maf=6.093e-05, exac_sas_allele='T', exac_sas_maf=0.0, id='rs780948835', minor_allele=None, minor_allele_freq=None, phenotype_or_disease=None, pubmed=None, sas_allele=None, sas_maf=None, somatic=None, start=55523831, strand=1)], context=None, end=55523831, id='1_55523831_G/T', input='1\t55523831\t.\tG\tT\t.\t.\tGT', intergenic_consequences=None, most_severe_consequence='splice_donor_variant', motif_feature_consequences=None, regulatory_feature_consequences=None, seq_region_name='1', start=55523831, strand=1, transcript_consequences=[Struct(allele_num=1, amino_acids='V/L', biotype='protein_coding', canonical=1, ccds='CCDS603.1', cdna_start=1593, cdna_end=1593, cds_end=1303, cds_start=1303, codons='Gta/Tta', consequence_terms=['missense_variant'], distance=None, domains=[Struct(db='hmmpanther', name='PTHR10795'), Struct(db='hmmpanther', name='PTHR10795')], exon='8/12', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000302118.5:c.1303G>T', hgvsp='ENSP00000303208.5:p.Val435Leu', hgvs_offset=None, impact='MODERATE', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction='benign', polyphen_score=0.001, protein_end=435, protein_start=435, protein_id='ENSP00000303208', sift_prediction='tolerated', sift_score=1.0, strand=1, swissprot='Q8NBP7', transcript_id='ENST00000302118', trembl=None, uniparc='UPI00001615E1', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='processed_transcript', canonical=None, ccds=None, cdna_start=2027, cdna_end=2027, cds_end=None, cds_start=None, codons=None, consequence_terms=['non_coding_transcript_exon_variant', 'non_coding_transcript_variant'], distance=None, domains=None, exon='5/8', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000490692.1:n.2027G>T', hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id=None, sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000490692', trembl=None, uniparc=None, variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['splice_donor_variant'], distance=None, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000543384.1:c.702+1G>T', hgvsp=None, hgvs_offset=None, impact='HIGH', intron='6/9', lof='LC', lof_flags=None, lof_filter='ANC_ALLELE', minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000441859', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000543384', trembl='F5GWF0', uniparc='UPI000206501F', variant_allele='T')], variant_class='SNV'), __uid_4=[]),
5R Struct(vep=Struct(assembly_name='GRCh37', allele_string='G/T', ancestral=None, colocated_variants=[Struct(aa_allele=None, aa_maf=None, afr_allele=None, afr_maf=None, allele_string='G/T', amr_allele=None, amr_maf=None, clin_sig=None, end=55523831, eas_allele=None, eas_maf=None, ea_allele=None, ea_maf=None, eur_allele=None, eur_maf=None, exac_adj_allele='T', exac_adj_maf=0.0, exac_allele=None, exac_afr_allele='T', exac_afr_maf=4.118e-05, exac_amr_allele='T', exac_amr_maf=0.0, exac_eas_allele='T', exac_eas_maf=4.168e-05, exac_fin_allele='T', exac_fin_maf=0.0, exac_maf=None, exac_nfe_allele='T', exac_nfe_maf=0.0, exac_oth_allele='T', exac_oth_maf=6.093e-05, exac_sas_allele='T', exac_sas_maf=0.0, id='rs780948835', minor_allele=None, minor_allele_freq=None, phenotype_or_disease=None, pubmed=None, sas_allele=None, sas_maf=None, somatic=None, start=55523831, strand=1)], context=None, end=55523831, id='1_55523831_G/T', input='1\t55523831\t.\tG\tT\t.\t.\tGT', intergenic_consequences=None, most_severe_consequence='splice_donor_variant', motif_feature_consequences=None, regulatory_feature_consequences=None, seq_region_name='1', start=55523831, strand=1, transcript_consequences=[Struct(allele_num=1, amino_acids='V/L', biotype='protein_coding', canonical=1, ccds='CCDS603.1', cdna_start=1593, cdna_end=1593, cds_end=1303, cds_start=1303, codons='Gta/Tta', consequence_terms=['missense_variant'], distance=None, domains=[Struct(db='hmmpanther', name='PTHR10795'), Struct(db='hmmpanther', name='PTHR10795')], exon='8/12', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000302118.5:c.1303G>T', hgvsp='ENSP00000303208.5:p.Val435Leu', hgvs_offset=None, impact='MODERATE', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction='benign', polyphen_score=0.001, protein_end=435, protein_start=435, protein_id='ENSP00000303208', sift_prediction='tolerated', sift_score=1.0, strand=1, swissprot='Q8NBP7', transcript_id='ENST00000302118', trembl=None, uniparc='UPI00001615E1', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='processed_transcript', canonical=None, ccds=None, cdna_start=2027, cdna_end=2027, cds_end=None, cds_start=None, codons=None, consequence_terms=['non_coding_transcript_exon_variant', 'non_coding_transcript_variant'], distance=None, domains=None, exon='5/8', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000490692.1:n.2027G>T', hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id=None, sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000490692', trembl=None, uniparc=None, variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['splice_donor_variant'], distance=None, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000543384.1:c.702+1G>T', hgvsp=None, hgvs_offset=None, impact='HIGH', intron='6/9', lof='HC', lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000441859', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000543384', trembl='F5GWF0', uniparc='UPI000206501F', variant_allele='T')], variant_class='SNV'), __uid_4=[])
6L Struct(vep=Struct(assembly_name='GRCh37', allele_string='G/T', ancestral=None, colocated_variants=None, context=None, end=55524321, id='1_55524321_G/T', input='1\t55524321\t.\tG\tT\t.\t.\tGT', intergenic_consequences=None, most_severe_consequence='splice_donor_variant', motif_feature_consequences=None, regulatory_feature_consequences=None, seq_region_name='1', start=55524321, strand=1, transcript_consequences=[Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=1, ccds='CCDS603.1', cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['splice_donor_variant'], distance=None, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000302118.5:c.1503+1G>T', hgvsp=None, hgvs_offset=None, impact='HIGH', intron='9/11', lof='LC', lof_flags=None, lof_filter='ANC_ALLELE', minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000303208', sift_prediction=None, sift_score=None, strand=1, swissprot='Q8NBP7', transcript_id='ENST00000302118', trembl=None, uniparc='UPI00001615E1', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='processed_transcript', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['splice_donor_variant', 'non_coding_transcript_variant'], distance=None, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000490692.1:n.2227+1G>T', hgvsp=None, hgvs_offset=None, impact='HIGH', intron='6/7', lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id=None, sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000490692', trembl=None, uniparc=None, variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['splice_donor_variant'], distance=None, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000543384.1:c.*50+1G>T', hgvsp=None, hgvs_offset=None, impact='HIGH', intron='7/9', lof='LC', lof_flags=None, lof_filter='3UTR_SPLICE,ANC_ALLELE', minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000441859', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000543384', trembl='F5GWF0', uniparc='UPI000206501F', variant_allele='T')], variant_class='SNV'), __uid_4=[]),
6R Struct(vep=Struct(assembly_name='GRCh37', allele_string='G/T', ancestral=None, colocated_variants=None, context=None, end=55524321, id='1_55524321_G/T', input='1\t55524321\t.\tG\tT\t.\t.\tGT', intergenic_consequences=None, most_severe_consequence='splice_donor_variant', motif_feature_consequences=None, regulatory_feature_consequences=None, seq_region_name='1', start=55524321, strand=1, transcript_consequences=[Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=1, ccds='CCDS603.1', cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['splice_donor_variant'], distance=None, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000302118.5:c.1503+1G>T', hgvsp=None, hgvs_offset=None, impact='HIGH', intron='9/11', lof='HC', lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000303208', sift_prediction=None, sift_score=None, strand=1, swissprot='Q8NBP7', transcript_id='ENST00000302118', trembl=None, uniparc='UPI00001615E1', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='processed_transcript', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['splice_donor_variant', 'non_coding_transcript_variant'], distance=None, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000490692.1:n.2227+1G>T', hgvsp=None, hgvs_offset=None, impact='HIGH', intron='6/7', lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id=None, sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000490692', trembl=None, uniparc=None, variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['splice_donor_variant'], distance=None, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000543384.1:c.*50+1G>T', hgvsp=None, hgvs_offset=None, impact='HIGH', intron='7/9', lof='LC', lof_flags=None, lof_filter='3UTR_SPLICE', minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000441859', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000543384', trembl='F5GWF0', uniparc='UPI000206501F', variant_allele='T')], variant_class='SNV'), __uid_4=[])
7L Struct(vep=Struct(assembly_name='GRCh37', allele_string='C/T', ancestral=None, colocated_variants=[Struct(aa_allele=None, aa_maf=None, afr_allele='T', afr_maf=0.0, allele_string='C/T', amr_allele=None, amr_maf=None, clin_sig=None, end=55527110, eas_allele=None, eas_maf=None, ea_allele=None, ea_maf=None, eur_allele=None, eur_maf=None, exac_adj_allele='T', exac_adj_maf=0.0, exac_allele=None, exac_afr_allele='T', exac_afr_maf=1.648e-05, exac_amr_allele='T', exac_amr_maf=0.0, exac_eas_allele='T', exac_eas_maf=2.401e-05, exac_fin_allele='T', exac_fin_maf=0.0, exac_maf=None, exac_nfe_allele='T', exac_nfe_maf=0.0, exac_oth_allele='T', exac_oth_maf=4.219e-05, exac_sas_allele='T', exac_sas_maf=0.0, id='rs373323910', minor_allele=None, minor_allele_freq=None, phenotype_or_disease=None, pubmed=None, sas_allele=None, sas_maf=None, somatic=None, start=55527110, strand=1)], context=None, end=55527110, id='1_55527110_C/T', input='1\t55527110\t.\tC\tT\t.\t.\tGT', intergenic_consequences=None, most_severe_consequence='stop_gained', motif_feature_consequences=None, regulatory_feature_consequences=None, seq_region_name='1', start=55527110, strand=1, transcript_consequences=[Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=1, ccds='CCDS44154.2', cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['downstream_gene_variant'], distance=4922, domains=None, exon=None, gene_id='ENSG00000162402', gene_pheno=None, gene_symbol='USP24', gene_symbol_source='HGNC', hgnc_id='12623', hgvsc=None, hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000294383', sift_prediction=None, sift_score=None, strand=-1, swissprot='Q9UPU5', transcript_id='ENST00000294383', trembl=None, uniparc='UPI000059CFDE', variant_allele='T'), Struct(allele_num=1, amino_acids='R/*', biotype='protein_coding', canonical=1, ccds='CCDS603.1', cdna_start=2034, cdna_end=2034, cds_end=1744, cds_start=1744, codons='Cga/Tga', consequence_terms=['stop_gained'], distance=None, domains=[Struct(db='hmmpanther', name='PTHR10795'), Struct(db='hmmpanther', name='PTHR10795')], exon='11/12', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000302118.5:c.1744C>T', hgvsp='ENSP00000303208.5:p.Arg582Ter', hgvs_offset=None, impact='HIGH', intron=None, lof='LC', lof_flags=None, lof_filter='ANC_ALLELE', minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=582, protein_start=582, protein_id='ENSP00000303208', sift_prediction=None, sift_score=None, strand=1, swissprot='Q8NBP7', transcript_id='ENST00000302118', trembl=None, uniparc='UPI00001615E1', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['downstream_gene_variant'], distance=4931, domains=None, exon=None, gene_id='ENSG00000162402', gene_pheno=None, gene_symbol='USP24', gene_symbol_source='HGNC', hgnc_id='12623', hgvsc=None, hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000385700', sift_prediction=None, sift_score=None, strand=-1, swissprot=None, transcript_id='ENST00000407756', trembl='B7WPF4', uniparc='UPI0000DD78C2', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='processed_transcript', canonical=None, ccds=None, cdna_start=2290, cdna_end=2290, cds_end=None, cds_start=None, codons=None, consequence_terms=['non_coding_transcript_exon_variant', 'non_coding_transcript_variant'], distance=None, domains=None, exon='7/8', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000490692.1:n.2290C>T', hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id=None, sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000490692', trembl=None, uniparc=None, variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=1351, cdna_end=1351, cds_end=None, cds_start=None, codons=None, consequence_terms=['3_prime_UTR_variant'], distance=None, domains=None, exon='9/10', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000543384.1:c.*291C>T', hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000441859', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000543384', trembl='F5GWF0', uniparc='UPI000206501F', variant_allele='T')], variant_class='SNV'), __uid_4=[]),
7R Struct(vep=Struct(assembly_name='GRCh37', allele_string='C/T', ancestral=None, colocated_variants=[Struct(aa_allele=None, aa_maf=None, afr_allele='T', afr_maf=0.0, allele_string='C/T', amr_allele=None, amr_maf=None, clin_sig=None, end=55527110, eas_allele=None, eas_maf=None, ea_allele=None, ea_maf=None, eur_allele=None, eur_maf=None, exac_adj_allele='T', exac_adj_maf=0.0, exac_allele=None, exac_afr_allele='T', exac_afr_maf=1.648e-05, exac_amr_allele='T', exac_amr_maf=0.0, exac_eas_allele='T', exac_eas_maf=2.401e-05, exac_fin_allele='T', exac_fin_maf=0.0, exac_maf=None, exac_nfe_allele='T', exac_nfe_maf=0.0, exac_oth_allele='T', exac_oth_maf=4.219e-05, exac_sas_allele='T', exac_sas_maf=0.0, id='rs373323910', minor_allele=None, minor_allele_freq=None, phenotype_or_disease=None, pubmed=None, sas_allele=None, sas_maf=None, somatic=None, start=55527110, strand=1)], context=None, end=55527110, id='1_55527110_C/T', input='1\t55527110\t.\tC\tT\t.\t.\tGT', intergenic_consequences=None, most_severe_consequence='stop_gained', motif_feature_consequences=None, regulatory_feature_consequences=None, seq_region_name='1', start=55527110, strand=1, transcript_consequences=[Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=1, ccds='CCDS44154.2', cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['downstream_gene_variant'], distance=4922, domains=None, exon=None, gene_id='ENSG00000162402', gene_pheno=None, gene_symbol='USP24', gene_symbol_source='HGNC', hgnc_id='12623', hgvsc=None, hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000294383', sift_prediction=None, sift_score=None, strand=-1, swissprot='Q9UPU5', transcript_id='ENST00000294383', trembl=None, uniparc='UPI000059CFDE', variant_allele='T'), Struct(allele_num=1, amino_acids='R/*', biotype='protein_coding', canonical=1, ccds='CCDS603.1', cdna_start=2034, cdna_end=2034, cds_end=1744, cds_start=1744, codons='Cga/Tga', consequence_terms=['stop_gained'], distance=None, domains=[Struct(db='hmmpanther', name='PTHR10795'), Struct(db='hmmpanther', name='PTHR10795')], exon='11/12', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000302118.5:c.1744C>T', hgvsp='ENSP00000303208.5:p.Arg582Ter', hgvs_offset=None, impact='HIGH', intron=None, lof='HC', lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=582, protein_start=582, protein_id='ENSP00000303208', sift_prediction=None, sift_score=None, strand=1, swissprot='Q8NBP7', transcript_id='ENST00000302118', trembl=None, uniparc='UPI00001615E1', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['downstream_gene_variant'], distance=4931, domains=None, exon=None, gene_id='ENSG00000162402', gene_pheno=None, gene_symbol='USP24', gene_symbol_source='HGNC', hgnc_id='12623', hgvsc=None, hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000385700', sift_prediction=None, sift_score=None, strand=-1, swissprot=None, transcript_id='ENST00000407756', trembl='B7WPF4', uniparc='UPI0000DD78C2', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='processed_transcript', canonical=None, ccds=None, cdna_start=2290, cdna_end=2290, cds_end=None, cds_start=None, codons=None, consequence_terms=['non_coding_transcript_exon_variant', 'non_coding_transcript_variant'], distance=None, domains=None, exon='7/8', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000490692.1:n.2290C>T', hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id=None, sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000490692', trembl=None, uniparc=None, variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=1351, cdna_end=1351, cds_end=None, cds_start=None, codons=None, consequence_terms=['3_prime_UTR_variant'], distance=None, domains=None, exon='9/10', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000543384.1:c.*291C>T', hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000441859', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000543384', trembl='F5GWF0', uniparc='UPI000206501F', variant_allele='T')], variant_class='SNV'), __uid_4=[])
8L Struct(vep=Struct(assembly_name='GRCh37', allele_string='C/T', ancestral=None, colocated_variants=[Struct(aa_allele=None, aa_maf=None, afr_allele='T', afr_maf=0.0, allele_string='C/T', amr_allele=None, amr_maf=None, clin_sig=None, end=55527221, eas_allele=None, eas_maf=None, ea_allele='T', ea_maf=0.0002, eur_allele=None, eur_maf=None, exac_adj_allele='T', exac_adj_maf=0.0, exac_allele='T', exac_afr_allele='T', exac_afr_maf=2.482e-05, exac_amr_allele='T', exac_amr_maf=0.0003818, exac_eas_allele='T', exac_eas_maf=3.648e-05, exac_fin_allele='T', exac_fin_maf=0.0, exac_maf=0.0, exac_nfe_allele='T', exac_nfe_maf=0.0, exac_oth_allele='T', exac_oth_maf=0.0, exac_sas_allele='T', exac_sas_maf=0.0, id='rs142118418', minor_allele=None, minor_allele_freq=None, phenotype_or_disease=None, pubmed=None, sas_allele=None, sas_maf=None, somatic=None, start=55527221, strand=1)], context=None, end=55527221, id='1_55527221_C/T', input='1\t55527221\t.\tC\tT\t.\t.\tGT', intergenic_consequences=None, most_severe_consequence='stop_gained', motif_feature_consequences=None, regulatory_feature_consequences=None, seq_region_name='1', start=55527221, strand=1, transcript_consequences=[Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=1, ccds='CCDS44154.2', cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['downstream_gene_variant'], distance=4811, domains=None, exon=None, gene_id='ENSG00000162402', gene_pheno=None, gene_symbol='USP24', gene_symbol_source='HGNC', hgnc_id='12623', hgvsc=None, hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000294383', sift_prediction=None, sift_score=None, strand=-1, swissprot='Q9UPU5', transcript_id='ENST00000294383', trembl=None, uniparc='UPI000059CFDE', variant_allele='T'), Struct(allele_num=1, amino_acids='Q/*', biotype='protein_coding', canonical=1, ccds='CCDS603.1', cdna_start=2145, cdna_end=2145, cds_end=1855, cds_start=1855, codons='Cag/Tag', consequence_terms=['stop_gained'], distance=None, domains=[Struct(db='hmmpanther', name='PTHR10795'), Struct(db='hmmpanther', name='PTHR10795')], exon='11/12', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000302118.5:c.1855C>T', hgvsp='ENSP00000303208.5:p.Gln619Ter', hgvs_offset=None, impact='HIGH', intron=None, lof='LC', lof_flags=None, lof_filter='END_TRUNC,ANC_ALLELE', minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=619, protein_start=619, protein_id='ENSP00000303208', sift_prediction=None, sift_score=None, strand=1, swissprot='Q8NBP7', transcript_id='ENST00000302118', trembl=None, uniparc='UPI00001615E1', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['downstream_gene_variant'], distance=4820, domains=None, exon=None, gene_id='ENSG00000162402', gene_pheno=None, gene_symbol='USP24', gene_symbol_source='HGNC', hgnc_id='12623', hgvsc=None, hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000385700', sift_prediction=None, sift_score=None, strand=-1, swissprot=None, transcript_id='ENST00000407756', trembl='B7WPF4', uniparc='UPI0000DD78C2', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='processed_transcript', canonical=None, ccds=None, cdna_start=2401, cdna_end=2401, cds_end=None, cds_start=None, codons=None, consequence_terms=['non_coding_transcript_exon_variant', 'non_coding_transcript_variant'], distance=None, domains=None, exon='7/8', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000490692.1:n.2401C>T', hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id=None, sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000490692', trembl=None, uniparc=None, variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=1462, cdna_end=1462, cds_end=None, cds_start=None, codons=None, consequence_terms=['3_prime_UTR_variant'], distance=None, domains=None, exon='9/10', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000543384.1:c.*402C>T', hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000441859', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000543384', trembl='F5GWF0', uniparc='UPI000206501F', variant_allele='T')], variant_class='SNV'), __uid_4=[]),
8R Struct(vep=Struct(assembly_name='GRCh37', allele_string='C/T', ancestral=None, colocated_variants=[Struct(aa_allele=None, aa_maf=None, afr_allele='T', afr_maf=0.0, allele_string='C/T', amr_allele=None, amr_maf=None, clin_sig=None, end=55527221, eas_allele=None, eas_maf=None, ea_allele='T', ea_maf=0.0002, eur_allele=None, eur_maf=None, exac_adj_allele='T', exac_adj_maf=0.0, exac_allele='T', exac_afr_allele='T', exac_afr_maf=2.482e-05, exac_amr_allele='T', exac_amr_maf=0.0003818, exac_eas_allele='T', exac_eas_maf=3.648e-05, exac_fin_allele='T', exac_fin_maf=0.0, exac_maf=0.0, exac_nfe_allele='T', exac_nfe_maf=0.0, exac_oth_allele='T', exac_oth_maf=0.0, exac_sas_allele='T', exac_sas_maf=0.0, id='rs142118418', minor_allele=None, minor_allele_freq=None, phenotype_or_disease=None, pubmed=None, sas_allele=None, sas_maf=None, somatic=None, start=55527221, strand=1)], context=None, end=55527221, id='1_55527221_C/T', input='1\t55527221\t.\tC\tT\t.\t.\tGT', intergenic_consequences=None, most_severe_consequence='stop_gained', motif_feature_consequences=None, regulatory_feature_consequences=None, seq_region_name='1', start=55527221, strand=1, transcript_consequences=[Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=1, ccds='CCDS44154.2', cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['downstream_gene_variant'], distance=4811, domains=None, exon=None, gene_id='ENSG00000162402', gene_pheno=None, gene_symbol='USP24', gene_symbol_source='HGNC', hgnc_id='12623', hgvsc=None, hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000294383', sift_prediction=None, sift_score=None, strand=-1, swissprot='Q9UPU5', transcript_id='ENST00000294383', trembl=None, uniparc='UPI000059CFDE', variant_allele='T'), Struct(allele_num=1, amino_acids='Q/*', biotype='protein_coding', canonical=1, ccds='CCDS603.1', cdna_start=2145, cdna_end=2145, cds_end=1855, cds_start=1855, codons='Cag/Tag', consequence_terms=['stop_gained'], distance=None, domains=[Struct(db='hmmpanther', name='PTHR10795'), Struct(db='hmmpanther', name='PTHR10795')], exon='11/12', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000302118.5:c.1855C>T', hgvsp='ENSP00000303208.5:p.Gln619Ter', hgvs_offset=None, impact='HIGH', intron=None, lof='LC', lof_flags=None, lof_filter='END_TRUNC', minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=619, protein_start=619, protein_id='ENSP00000303208', sift_prediction=None, sift_score=None, strand=1, swissprot='Q8NBP7', transcript_id='ENST00000302118', trembl=None, uniparc='UPI00001615E1', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['downstream_gene_variant'], distance=4820, domains=None, exon=None, gene_id='ENSG00000162402', gene_pheno=None, gene_symbol='USP24', gene_symbol_source='HGNC', hgnc_id='12623', hgvsc=None, hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000385700', sift_prediction=None, sift_score=None, strand=-1, swissprot=None, transcript_id='ENST00000407756', trembl='B7WPF4', uniparc='UPI0000DD78C2', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='processed_transcript', canonical=None, ccds=None, cdna_start=2401, cdna_end=2401, cds_end=None, cds_start=None, codons=None, consequence_terms=['non_coding_transcript_exon_variant', 'non_coding_transcript_variant'], distance=None, domains=None, exon='7/8', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000490692.1:n.2401C>T', hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id=None, sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000490692', trembl=None, uniparc=None, variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=1462, cdna_end=1462, cds_end=None, cds_start=None, codons=None, consequence_terms=['3_prime_UTR_variant'], distance=None, domains=None, exon='9/10', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000543384.1:c.*402C>T', hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000441859', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000543384', trembl='F5GWF0', uniparc='UPI000206501F', variant_allele='T')], variant_class='SNV'), __uid_4=[])
9L Struct(vep=Struct(assembly_name='GRCh37', allele_string='C/T', ancestral=None, colocated_variants=[Struct(aa_allele=None, aa_maf=None, afr_allele='G', afr_maf=0.0, allele_string='C/G', amr_allele=None, amr_maf=None, clin_sig=None, end=55529243, eas_allele=None, eas_maf=None, ea_allele=None, ea_maf=None, eur_allele=None, eur_maf=None, exac_adj_allele='G', exac_adj_maf=0.0, exac_allele=None, exac_afr_allele='G', exac_afr_maf=8.244e-06, exac_amr_allele='G', exac_amr_maf=0.0, exac_eas_allele='G', exac_eas_maf=9.403e-06, exac_fin_allele='G', exac_fin_maf=0.0, exac_maf=None, exac_nfe_allele='G', exac_nfe_maf=0.0, exac_oth_allele='G', exac_oth_maf=1.705e-05, exac_sas_allele='G', exac_sas_maf=0.0, id='rs769487037', minor_allele=None, minor_allele_freq=None, phenotype_or_disease=None, pubmed=None, sas_allele=None, sas_maf=None, somatic=None, start=55529243, strand=1)], context=None, end=55529243, id='1_55529243_C/T', input='1\t55529243\t.\tC\tT\t.\t.\tGT', intergenic_consequences=None, most_severe_consequence='stop_gained', motif_feature_consequences=None, regulatory_feature_consequences=None, seq_region_name='1', start=55529243, strand=1, transcript_consequences=[Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=1, ccds='CCDS44154.2', cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['downstream_gene_variant'], distance=2789, domains=None, exon=None, gene_id='ENSG00000162402', gene_pheno=None, gene_symbol='USP24', gene_symbol_source='HGNC', hgnc_id='12623', hgvsc=None, hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000294383', sift_prediction=None, sift_score=None, strand=-1, swissprot='Q9UPU5', transcript_id='ENST00000294383', trembl=None, uniparc='UPI000059CFDE', variant_allele='T'), Struct(allele_num=1, amino_acids='Q/*', biotype='protein_coding', canonical=1, ccds='CCDS603.1', cdna_start=2355, cdna_end=2355, cds_end=2065, cds_start=2065, codons='Cag/Tag', consequence_terms=['stop_gained'], distance=None, domains=None, exon='12/12', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000302118.5:c.2065C>T', hgvsp='ENSP00000303208.5:p.Gln689Ter', hgvs_offset=None, impact='HIGH', intron=None, lof='LC', lof_flags=None, lof_filter='END_TRUNC,ANC_ALLELE', minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=689, protein_start=689, protein_id='ENSP00000303208', sift_prediction=None, sift_score=None, strand=1, swissprot='Q8NBP7', transcript_id='ENST00000302118', trembl=None, uniparc='UPI00001615E1', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['downstream_gene_variant'], distance=2798, domains=None, exon=None, gene_id='ENSG00000162402', gene_pheno=None, gene_symbol='USP24', gene_symbol_source='HGNC', hgnc_id='12623', hgvsc=None, hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000385700', sift_prediction=None, sift_score=None, strand=-1, swissprot=None, transcript_id='ENST00000407756', trembl='B7WPF4', uniparc='UPI0000DD78C2', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='processed_transcript', canonical=None, ccds=None, cdna_start=2611, cdna_end=2611, cds_end=None, cds_start=None, codons=None, consequence_terms=['non_coding_transcript_exon_variant', 'non_coding_transcript_variant'], distance=None, domains=None, exon='8/8', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000490692.1:n.2611C>T', hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id=None, sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000490692', trembl=None, uniparc=None, variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['downstream_gene_variant'], distance=131, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc=None, hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000441859', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000543384', trembl='F5GWF0', uniparc='UPI000206501F', variant_allele='T')], variant_class='SNV'), __uid_4=[]),
9R Struct(vep=Struct(assembly_name='GRCh37', allele_string='C/T', ancestral=None, colocated_variants=[Struct(aa_allele=None, aa_maf=None, afr_allele='G', afr_maf=0.0, allele_string='C/G', amr_allele=None, amr_maf=None, clin_sig=None, end=55529243, eas_allele=None, eas_maf=None, ea_allele=None, ea_maf=None, eur_allele=None, eur_maf=None, exac_adj_allele='G', exac_adj_maf=0.0, exac_allele=None, exac_afr_allele='G', exac_afr_maf=8.244e-06, exac_amr_allele='G', exac_amr_maf=0.0, exac_eas_allele='G', exac_eas_maf=9.403e-06, exac_fin_allele='G', exac_fin_maf=0.0, exac_maf=None, exac_nfe_allele='G', exac_nfe_maf=0.0, exac_oth_allele='G', exac_oth_maf=1.705e-05, exac_sas_allele='G', exac_sas_maf=0.0, id='rs769487037', minor_allele=None, minor_allele_freq=None, phenotype_or_disease=None, pubmed=None, sas_allele=None, sas_maf=None, somatic=None, start=55529243, strand=1)], context=None, end=55529243, id='1_55529243_C/T', input='1\t55529243\t.\tC\tT\t.\t.\tGT', intergenic_consequences=None, most_severe_consequence='stop_gained', motif_feature_consequences=None, regulatory_feature_consequences=None, seq_region_name='1', start=55529243, strand=1, transcript_consequences=[Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=1, ccds='CCDS44154.2', cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['downstream_gene_variant'], distance=2789, domains=None, exon=None, gene_id='ENSG00000162402', gene_pheno=None, gene_symbol='USP24', gene_symbol_source='HGNC', hgnc_id='12623', hgvsc=None, hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000294383', sift_prediction=None, sift_score=None, strand=-1, swissprot='Q9UPU5', transcript_id='ENST00000294383', trembl=None, uniparc='UPI000059CFDE', variant_allele='T'), Struct(allele_num=1, amino_acids='Q/*', biotype='protein_coding', canonical=1, ccds='CCDS603.1', cdna_start=2355, cdna_end=2355, cds_end=2065, cds_start=2065, codons='Cag/Tag', consequence_terms=['stop_gained'], distance=None, domains=None, exon='12/12', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000302118.5:c.2065C>T', hgvsp='ENSP00000303208.5:p.Gln689Ter', hgvs_offset=None, impact='HIGH', intron=None, lof='LC', lof_flags=None, lof_filter='END_TRUNC', minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=689, protein_start=689, protein_id='ENSP00000303208', sift_prediction=None, sift_score=None, strand=1, swissprot='Q8NBP7', transcript_id='ENST00000302118', trembl=None, uniparc='UPI00001615E1', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['downstream_gene_variant'], distance=2798, domains=None, exon=None, gene_id='ENSG00000162402', gene_pheno=None, gene_symbol='USP24', gene_symbol_source='HGNC', hgnc_id='12623', hgvsc=None, hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000385700', sift_prediction=None, sift_score=None, strand=-1, swissprot=None, transcript_id='ENST00000407756', trembl='B7WPF4', uniparc='UPI0000DD78C2', variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='processed_transcript', canonical=None, ccds=None, cdna_start=2611, cdna_end=2611, cds_end=None, cds_start=None, codons=None, consequence_terms=['non_coding_transcript_exon_variant', 'non_coding_transcript_variant'], distance=None, domains=None, exon='8/8', gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc='ENST00000490692.1:n.2611C>T', hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id=None, sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000490692', trembl=None, uniparc=None, variant_allele='T'), Struct(allele_num=1, amino_acids=None, biotype='protein_coding', canonical=None, ccds=None, cdna_start=None, cdna_end=None, cds_end=None, cds_start=None, codons=None, consequence_terms=['downstream_gene_variant'], distance=131, domains=None, exon=None, gene_id='ENSG00000169174', gene_pheno=1, gene_symbol='PCSK9', gene_symbol_source='HGNC', hgnc_id='20001', hgvsc=None, hgvsp=None, hgvs_offset=None, impact='MODIFIER', intron=None, lof=None, lof_flags=None, lof_filter=None, minimised=1, polyphen_prediction=None, polyphen_score=None, protein_end=None, protein_start=None, protein_id='ENSP00000441859', sift_prediction=None, sift_score=None, strand=1, swissprot=None, transcript_id='ENST00000543384', trembl='F5GWF0', uniparc='UPI000206501F', variant_allele='T')], variant_class='SNV'), __uid_4=[])
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment