Created
November 8, 2017 10:17
-
-
Save vanangamudi/d96de99b81749456a6a278df6b91c846 to your computer and use it in GitHub Desktop.
samples with ade masks
We can't make this file beautiful and searchable because it's too large.
This file contains bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
| ade,neurologic deterioration | |
| drug,nitrous oxide | |
| sequence,Patients,with,vitamin,B12,deficiency,are,exceedingly,sensitive,to,neurologic,deterioration,following,nitrous,oxide,anesthesia,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,1,3,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,prolonged jaundice,sicca complex | |
| drug,thiabendazole | |
| sequence,A,55-yr-old,man,developed,prolonged,jaundice,and,sicca,complex,after,a,course,of,thiabendazole,therapy,. | |
| labels,0,0,0,0,5,7,0,5,7,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,1,1,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fatal case of acute interstitial pneumonitis | |
| drug,BCNU | |
| sequence,We,report,a,fatal,case,of,acute,interstitial,pneumonitis,in,a,patient,treated,with,carmustine,(,BCNU,),for,a,brain,tumor,. | |
| labels,0,0,0,5,6,6,6,6,7,0,0,0,0,0,4,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fatal case of acute interstitial pneumonitis | |
| drug,carmustine | |
| sequence,We,report,a,fatal,case,of,acute,interstitial,pneumonitis,in,a,patient,treated,with,carmustine,(,BCNU,),for,a,brain,tumor,. | |
| labels,0,0,0,5,6,6,6,6,7,0,0,0,0,0,4,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Fatal digoxin poisoning | |
| drug,digoxin | |
| sequence,Fatal,digoxin,poisoning,:,an,unsuccessful,resuscitation,with,use,of,digoxin-immune,Fab,. | |
| labels,5,9,7,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypokalemia,cardiac toxicity | |
| drug,Albuterol | |
| sequence,Albuterol-induced,hypokalemia,and,its,potential,cardiac,toxicity,are,discussed,briefly,. | |
| labels,4,8,0,0,0,5,7,0,0,0,0 | |
| ade_mask,0,1,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Ovarian endometrioid adenocarcinoma | |
| drug,tamoxifen | |
| sequence,Ovarian,endometrioid,adenocarcinoma,arising,from,an,endometriotic,cyst,in,a,postmenopausal,woman,under,tamoxifen,therapy,for,breast,cancer,:,a,case,report,. | |
| labels,5,6,7,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neurotoxicity | |
| drug,lithium | |
| sequence,Prior,neurologic,illness,and,the,syndrome,of,irreversible,lithium-effectuated,neurotoxicity,(,SILENT,),. | |
| labels,0,0,0,0,0,0,0,0,4,8,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,glaucoma | |
| drug,Ritalin | |
| sequence,However,,,an,association,of,Ritalin,with,glaucoma,has,been,reported,. | |
| labels,0,0,0,0,0,4,0,8,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,SLE | |
| drug,rIFN-gamma | |
| sequence,We,assume,that,rIFN-gamma,induced,the,de,novo,development,of,SLE,in,our,patient,. | |
| labels,0,0,0,4,0,0,0,0,0,0,8,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Nail-changes | |
| drug,penicillamine | |
| sequence,Nail-changes,induced,by,penicillamine,. | |
| labels,8,0,0,4,0 | |
| ade_mask,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,growth retardation,adrenal suppression | |
| drug,fluticasone propionate | |
| sequence,FINDINGS,:,Six,children,with,growth,retardation,noted,after,treatment,with,high-dose,fluticasone,propionate,were,found,to,have,adrenal,suppression,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,1,3,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,CDI,NDI | |
| drug,lithium | |
| sequence,To,the,best,of,our,knowledge,,,this,is,the,first,case,of,lithium-associated,CDI,and,NDI,presenting,concurrently,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0,8,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,jaundice,severe dyspnea,tachypnea | |
| drug,adalimumab | |
| sequence,A,65-year-old,female,patient,presented,with,jaundice,followed,2,days,later,by,severe,dyspnea,and,tachypnea,which,worsened,when,patient,was,lying,flat,,,1,week,after,the,fourth,dose,of,adalimumab,. | |
| labels,0,0,0,0,0,0,8,0,0,0,0,0,5,7,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,IDDM | |
| drug,interferon | |
| sequence,We,report,a,case,of,IDDM,which,occurred,during,interferon,therapy,for,chronic,hepatitis,. | |
| labels,0,0,0,0,0,8,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,CNS abnormalities | |
| drug,methotrexate | |
| sequence,MR,findings,in,methotrexate-induced,CNS,abnormalities,. | |
| labels,0,0,0,4,5,7,0 | |
| ade_mask,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Second cancers,hematological malignancy | |
| drug,interferon alfa | |
| sequence,Second,cancers,including,various,types,of,hematological,malignancy,have,been,reported,in,patients,with,hairy,cell,leukemia,treated,with,chemotherapy,or,interferon,alfa,. | |
| labels,5,7,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,1,3,0 | |
| ade_mask,1,1,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anaphylactoid reaction | |
| drug,Gelofusine | |
| sequence,A,case,of,anaphylactoid,reaction,due,solely,to,the,use,of,Gelofusine,in,a,patient,with,non-haemorrhagic,hypovolaemia,is,presented,,,with,a,discussion,on,the,management,and,the,use,of,allergy,identification,jewellery,. | |
| labels,0,0,0,5,7,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,deaths | |
| drug,quetiapine | |
| sequence,These,cases,were,chosen,for,study,because,they,were,all,deaths,as,a,result,of,suicidal,ingestion,of,drugs,in,which,quetiapine,was,considered,a,significant,factor,. | |
| labels,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Anaphylaxis | |
| drug,cisplatin | |
| sequence,Anaphylaxis,to,cisplatin,following,nine,previous,uncomplicated,cycles,. | |
| labels,8,0,4,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,abnormal posture of extreme forward flexion,camptocormia | |
| drug,valproate | |
| sequence,A,mentally,retarded,23-year-old,woman,with,myoclonic,astatic,epilepsy,developed,an,abnormal,posture,of,extreme,forward,flexion,,,called,camptocormia,,,during,valproate,monotherapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,7,0,0,8,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,1,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bilateral sensorineural hearing loss | |
| drug,ketoralac | |
| sequence,We,report,the,case,of,a,20-year-old,female,with,polyarteritis,nodosa,(,PAN,),who,developed,bilateral,sensorineural,hearing,loss,25,minutes,after,receiving,30,mg,of,intravenous,ketoralac,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,colon perforation | |
| drug,chromic phosphate | |
| sequence,This,report,presents,a,case,of,colon,perforation,which,occurred,4,months,after,treatment,with,intraperitoneal,chromic,phosphate,for,stage,IB,ovarian,papillary,serous,cystadenocarcinoma,. | |
| labels,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,1,3,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thoracic aortic dissection | |
| drug,Warfarin | |
| sequence,Warfarin-associated,thoracic,aortic,dissection,in,an,elderly,woman,. | |
| labels,4,5,6,7,0,0,0,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nephrogenic diabetes insipidus | |
| drug,foscarnet | |
| sequence,No,cases,of,renal,acidosis,,,and,only,one,case,of,nephrogenic,diabetes,insipidus,,,has,been,previously,reported,as,a,complication,of,foscarnet,treatment,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,birth defects | |
| drug,Zidovudine | |
| sequence,Zidovudine,use,in,pregnancy,:,a,report,on,104,cases,and,the,occurrence,of,birth,defects,. | |
| labels,4,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,fatal hepatotoxic effects | |
| drug,valproic acid | |
| sequence,L-Carnitine,supplementation,has,been,recommended,to,prevent,the,fatal,hepatotoxic,effects,associated,with,valproic,acid,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,1,3,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Rhabdomyolysis | |
| drug,ritodrine hydrochloride | |
| sequence,Rhabdomyolysis,caused,by,tocolysis,with,oral,ritodrine,hydrochloride,in,a,pregnant,patient,with,myotonic,dystrophy,. | |
| labels,8,0,0,0,0,0,1,3,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Fatal interstitial pneumonitis | |
| drug,chlorambucil | |
| sequence,Fatal,interstitial,pneumonitis,following,high-dose,intermittent,chlorambucil,therapy,for,chronic,lymphocyte,leukemia,. | |
| labels,5,6,7,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Changes in the plasma cortisol level | |
| drug,alprazolam | |
| sequence,1,.,Changes,in,the,plasma,cortisol,level,were,reported,in,a,male,patient,with,panic,disorder,during,the,period,of,low-dose,alprazolam,treatment,(,mean,0.62,+,-,0.15,mg,day,),compared,with,during,the,period,of,high-dose,period,(,mean,1.08,+,-,0.28,mg,day,),. | |
| labels,0,0,5,6,6,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperammonemia | |
| drug,carbamazepine | |
| sequence,PURPOSE,:,A,case,of,carbamazepine-induced,hyperammonemia,is,presented,. | |
| labels,0,0,0,0,0,4,8,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,neuroleptic malignant syndrome | |
| drug,metoclopramide | |
| sequence,We,report,a,case,of,fulminant,neuroleptic,malignant,syndrome,in,a,man,aged,70,developing,within,12,hours,of,starting,six-hourly,intravenous,metoclopramide,. | |
| labels,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anhedonic ejaculation,ejaculation without orgasm | |
| drug,desipramine | |
| sequence,We,report,two,patients,with,anhedonic,ejaculation,(,ejaculation,without,orgasm,),associated,with,initiation,of,treatment,with,desipramine,. | |
| labels,0,0,0,0,0,5,7,0,5,6,7,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,accumulation of the parent drug,CNS depressive effects | |
| drug,meperidine | |
| sequence,In,patients,with,cirrhosis,,,the,metabolism,of,meperidine,is,decreased,,,leading,to,accumulation,of,the,parent,drug,and,possible,CNS,depressive,effects,similar,to,hepatic,encephalopathy,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,0,0,5,6,6,6,7,0,0,5,6,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,1,0,0,0,0,0,0,1,0,0,1,1,0,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Syncope | |
| drug,propranolol | |
| sequence,Syncope,induced,by,propranolol,in,hypertrophic,cardiomyopathy,. | |
| labels,8,0,0,4,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ST elevation in right precordial leads,type 1 Brugada syndrome | |
| drug,propafenone | |
| sequence,We,report,a,case,of,ST,elevation,in,right,precordial,leads,compatible,with,type,1,Brugada,syndrome,following,administration,of,propafenone,in,a,patient,with,Wolff-Parkinson-White,syndrome,who,was,receiving,lithium,at,concentrations,within,therapeutic,levels,. | |
| labels,0,0,0,0,0,5,6,6,6,6,7,0,0,5,6,6,7,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,1,1,1,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,AILD,generalized pruritic maculopapular eruption,fever | |
| drug,doxycycline | |
| sequence,We,report,a,case,of,AILD,in,an,80-year-old,male,who,presented,with,a,generalized,pruritic,maculopapular,eruption,and,fever,following,doxycycline,administration,. | |
| labels,0,0,0,0,0,8,0,0,0,0,0,0,0,0,5,6,6,7,0,8,0,4,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,1,1,1,1,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,allergic contact dermatitis | |
| drug,benzoin | |
| sequence,Nineteen,cases,of,allergic,contact,dermatitis,to,compound,tincture,of,benzoin,are,described,. | |
| labels,0,0,0,5,6,7,0,0,0,0,4,0,0,0 | |
| ade_mask,0,0,0,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hives | |
| drug,insulin | |
| sequence,She,continued,to,receive,regular,insulin,4,times,per,day,over,the,following,3,years,with,only,occasional,hives,. | |
| labels,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Creutzfeldt-Jakob syndrome | |
| drug,Lithium | |
| sequence,Lithium-induced,Creutzfeldt-Jakob,syndrome,. | |
| labels,4,5,7,0 | |
| ade_mask,0,1,1,0 | |
| ==============================, ============================= | |
| ade,reversible granulocytopenia | |
| drug,procainamide | |
| sequence,Sustained-release,procainamide-induced,reversible,granulocytopenia,after,myocardial,infarction,. | |
| labels,0,4,5,7,0,0,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypophosphatemia,hypocalcemic tetany | |
| drug,alendronate | |
| sequence,This,case,report,describes,a,patient,who,was,previously,prescribed,alendronate,(,Fosamax,),and,presented,with,postoperative,hypophosphatemia,and,hypocalcemic,tetany,after,bowel,preparation,with,Fleet,Phospho-Soda,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,8,0,5,7,0,0,0,0,1,3,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypophosphatemia,hypocalcemic tetany | |
| drug,Fleet Phospho-Soda | |
| sequence,This,case,report,describes,a,patient,who,was,previously,prescribed,alendronate,(,Fosamax,),and,presented,with,postoperative,hypophosphatemia,and,hypocalcemic,tetany,after,bowel,preparation,with,Fleet,Phospho-Soda,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,8,0,5,7,0,0,0,0,1,3,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypophosphatemia,hypocalcemic tetany | |
| drug,Fosamax | |
| sequence,This,case,report,describes,a,patient,who,was,previously,prescribed,alendronate,(,Fosamax,),and,presented,with,postoperative,hypophosphatemia,and,hypocalcemic,tetany,after,bowel,preparation,with,Fleet,Phospho-Soda,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,8,0,5,7,0,0,0,0,1,3,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Gynecomastia | |
| drug,fluoresone | |
| sequence,Gynecomastia,in,epileptics,treated,with,phenobarbital,,,phenytoin,and,fluoresone,:,two,case,reports,. | |
| labels,8,0,0,0,0,4,0,4,0,4,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Gynecomastia | |
| drug,phenobarbital | |
| sequence,Gynecomastia,in,epileptics,treated,with,phenobarbital,,,phenytoin,and,fluoresone,:,two,case,reports,. | |
| labels,8,0,0,0,0,4,0,4,0,4,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Gynecomastia | |
| drug,phenytoin | |
| sequence,Gynecomastia,in,epileptics,treated,with,phenobarbital,,,phenytoin,and,fluoresone,:,two,case,reports,. | |
| labels,8,0,0,0,0,4,0,4,0,4,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bilateral gynaecomastia | |
| drug,RH | |
| sequence,After,four,months,,,while,receiving,RH,,,he,developed,painful,bilateral,gynaecomastia,. | |
| labels,0,0,0,0,0,0,4,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,cholestasis,sicca complex | |
| drug,thiabendazole | |
| sequence,The,literature,on,thiabendazole-induced,cholestasis,and,its,association,with,sicca,complex,is,reviewed,. | |
| labels,0,0,0,4,8,0,0,0,0,5,7,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,increasing Hb F | |
| drug,HU | |
| sequence,Sodium,phenylbutyrate,was,added,to,treatment,with,HU,in,two,patients,,,but,failed,to,produce,an,increase,in,total,Hb,despite,increasing,Hb,F,levels,. | |
| labels,1,3,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,0,0 | |
| ==============================, ============================= | |
| ade,increasing Hb F | |
| drug,Sodium phenylbutyrate | |
| sequence,Sodium,phenylbutyrate,was,added,to,treatment,with,HU,in,two,patients,,,but,failed,to,produce,an,increase,in,total,Hb,despite,increasing,Hb,F,levels,. | |
| labels,1,3,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,0,0 | |
| ==============================, ============================= | |
| ade,hemolytic uremic syndrome,hemolytic anemia,thrombocytopenia,progressive renal failure | |
| drug,mitomycin C | |
| sequence,In,rare,cases,mitomycin,C,(,MMC,),may,induce,cancer-associated,hemolytic,uremic,syndrome,,,which,is,characterized,by,hemolytic,anemia,,,thrombocytopenia,and,progressive,renal,failure,. | |
| labels,0,0,0,1,3,0,4,0,0,0,0,5,6,7,0,0,0,0,0,5,7,0,8,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,1,0,1,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,hemolytic uremic syndrome,hemolytic anemia,thrombocytopenia,progressive renal failure | |
| drug,MMC | |
| sequence,In,rare,cases,mitomycin,C,(,MMC,),may,induce,cancer-associated,hemolytic,uremic,syndrome,,,which,is,characterized,by,hemolytic,anemia,,,thrombocytopenia,and,progressive,renal,failure,. | |
| labels,0,0,0,1,3,0,4,0,0,0,0,5,6,7,0,0,0,0,0,5,7,0,8,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,1,0,1,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,Portal vein thrombosis | |
| drug,F VIII | |
| sequence,Portal,vein,thrombosis,in,a,patient,with,severe,haemophilia,A,and,F,V,G1691A,mutation,during,continuous,infusion,of,F,VIII,after,intramural,jejunal,bleeding,--,successful,thrombolysis,under,heparin,therapy,. | |
| labels,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,3,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,skin rash,fever,hypereosinophilia,acute renal failure | |
| drug,chlorambucil | |
| sequence,He,developed,recurrent,skin,rash,,,fever,,,hypereosinophilia,,,and,acute,renal,failure,after,rechallenge,with,chlorambucil,. | |
| labels,0,0,0,5,7,0,8,0,8,0,0,5,6,7,0,0,0,4,0 | |
| ade_mask,0,0,0,1,1,0,1,0,1,0,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,tumor lysis syndrome | |
| drug,Sorafenib | |
| sequence,Sorafenib,induced,tumor,lysis,syndrome,in,an,advanced,hepatocellular,carcinoma,patient,. | |
| labels,4,0,5,6,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rash | |
| drug,cephalexin | |
| sequence,The,rash,seen,in,this,patient,,,who,was,treated,with,cephalexin,,,may,be,similar,to,the,rash,seen,with,ampicillin,treatment,of,patients,with,infectious,mononucleosis,. | |
| labels,0,8,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rash | |
| drug,ampicillin | |
| sequence,The,rash,seen,in,this,patient,,,who,was,treated,with,cephalexin,,,may,be,similar,to,the,rash,seen,with,ampicillin,treatment,of,patients,with,infectious,mononucleosis,. | |
| labels,0,8,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,IDDM | |
| drug,interferon | |
| sequence,Occurrence,of,IDDM,during,interferon,therapy,for,chronic,viral,hepatitis,. | |
| labels,0,0,8,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,right leg weakness,foot drop | |
| drug,CAP-XRT | |
| sequence,Patient,A,reported,right,leg,weakness,(,foot,drop,),during,week,4,of,CAP-XRT,(,1600,mg,m2,),. | |
| labels,0,0,0,5,6,7,0,5,7,0,0,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,inflammatory bowel disease,IBD | |
| drug,rofecoxib | |
| sequence,RESULTS,:,Three,patients,who,developed,symptoms,of,inflammatory,bowel,disease,(,IBD,),during,rofecoxib,exposure,are,described,along,with,pathology,findings,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,8,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,erythema,cross-reaction to promethazine,decreased MED to both UVA and UVB,persistence of the photosensitivity | |
| drug,mequitazine | |
| sequence,In,case,no,.,2,,,the,pathogenic,mechanism,seemed,to,be,persistent,light,reaction,preceded,by,systemic,photoallergy,,,as,he,had,taken,mequitazine,for,6,months,,,and,there,were,strong,positive,photopatch,test,results,with,immediate,erythema,reaction,,,cross-reaction,to,promethazine,,,decreased,MED,to,both,UVA,and,UVB,,,and,persistence,of,the,photosensitivity,over,a,3-year,follow-up,period,after,discontinuation,of,the,mequitazine,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,5,6,9,0,5,6,6,6,6,6,7,0,0,5,6,6,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,1,0,1,0,1,1,0,1,1,0,1,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,erythema,cross-reaction to promethazine,decreased MED to both UVA and UVB,persistence of the photosensitivity | |
| drug,promethazine | |
| sequence,In,case,no,.,2,,,the,pathogenic,mechanism,seemed,to,be,persistent,light,reaction,preceded,by,systemic,photoallergy,,,as,he,had,taken,mequitazine,for,6,months,,,and,there,were,strong,positive,photopatch,test,results,with,immediate,erythema,reaction,,,cross-reaction,to,promethazine,,,decreased,MED,to,both,UVA,and,UVB,,,and,persistence,of,the,photosensitivity,over,a,3-year,follow-up,period,after,discontinuation,of,the,mequitazine,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,5,6,9,0,5,6,6,6,6,6,7,0,0,5,6,6,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,1,0,1,0,1,1,0,1,1,0,1,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,agranulocytosis | |
| drug,quetiapine | |
| sequence,CONCLUSION,:,Although,a,definite,association,has,not,been,proven,,,clinicians,should,be,aware,of,the,possibility,of,agranulocytosis,while,using,quetiapine,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cranial polyneuropathy | |
| drug,vincristine | |
| sequence,We,describe,a,5-year-old,girl,showed,recovery,of,vincristine,induced,cranial,polyneuropathy,with,pyridoxine,and,pyridostigmine,treatment,. | |
| labels,0,0,0,0,0,0,0,0,4,0,5,7,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperkalemia | |
| drug,ACTH | |
| sequence,We,wish,to,call,for,cautious,approach,at,time,of,cessation,of,prolonged,ACTH,therapy,because,of,possible,unexpected,and,only,partially,understood,hazardous,side,effects,such,as,hyperkalemia,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,thrombocytopenia | |
| drug,heparin | |
| sequence,Severe,heparin,associated,thrombocytopenia,is,a,rare,complication,of,heparin,therapy,. | |
| labels,0,4,0,8,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypertension | |
| drug,Propranolol | |
| sequence,Propranolol-induced,hypertension,in,treatment,of,cocaine,intoxication,. | |
| labels,4,8,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,immunemediated hypersensitivity reaction | |
| drug,TMP-SMX | |
| sequence,Due,to,the,increasing,use,of,TMP-SMX,in,children,,,clinicians,should,be,aware,of,this,potentially,life-threatening,,,immunemediated,hypersensitivity,reaction,. | |
| labels,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,cardiac arrests,deaths | |
| drug,Halfan | |
| sequence,The,pharmaceutical,company,producing,Halfan,has,reported,8,cardiac,arrests,,,leading,to,6,deaths,,,when,a,higher,dose,than,recommended,was,used,,,there,was,recent,or,concomitant,treatment,with,mefloquine,,,there,was,pre-existing,prolongation,of,the,QT,interval,or,the,patient,had,a,thiamine,deficiency,. | |
| labels,0,0,0,0,4,0,0,0,5,7,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cardiac arrests,deaths | |
| drug,mefloquine | |
| sequence,The,pharmaceutical,company,producing,Halfan,has,reported,8,cardiac,arrests,,,leading,to,6,deaths,,,when,a,higher,dose,than,recommended,was,used,,,there,was,recent,or,concomitant,treatment,with,mefloquine,,,there,was,pre-existing,prolongation,of,the,QT,interval,or,the,patient,had,a,thiamine,deficiency,. | |
| labels,0,0,0,0,4,0,0,0,5,7,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity pneumonitis | |
| drug,Mesalamine | |
| sequence,Mesalamine,may,cause,hypersensitivity,pneumonitis,in,patients,with,Crohn,'s,disease,. | |
| labels,4,0,0,5,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,gastric LPD | |
| drug,MTX | |
| sequence,To,our,knowledge,,,this,is,the,first,case,of,spontaneous,remission,of,MTX-associated,gastric,LPD,after,discontinuation,of,MTX,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,AML,lung cancer | |
| drug,fludarabine | |
| sequence,We,describe,the,exceptional,development,of,AML,and,lung,cancer,in,a,patient,with,previously,diagnosed,CLL,in,minimal,residual,disease,status,after,fludarabine,treatment,followed,by,autologous,peripheral,blood,stem-cell,transplantation,. | |
| labels,0,0,0,0,0,0,8,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute leukemia | |
| drug,Treosulfan | |
| sequence,Seven,of,the,eight,cases,of,acute,leukemia,occurred,in,a,series,of,553,patients,treated,with,Treosulfan,for,ovarian,cancer,in,the,period,from,1970,to,1977,and,followed,closely,for,a,total,of,1159,patient-years,up,to,February,1978,. | |
| labels,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hemorrhage | |
| drug,metformin | |
| sequence,Although,no,coagulation,study,was,done,and,the,Meckel,'s,diverticulum,is,normally,associated,with,bleeding,,,the,particular,intensity,of,the,following,hemorrhage,may,have,been,favored,by,metformin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anaphylaxis | |
| drug,Isoniazid | |
| sequence,Isoniazid-induced,anaphylaxis,. | |
| labels,4,8,0 | |
| ade_mask,0,1,0 | |
| ==============================, ============================= | |
| ade,inflammation | |
| drug,cyanamide | |
| sequence,When,cyanamide-treated,alcoholics,relapse,into,drinking,,,more,severe,inflammation,develops,in,the,liver,. | |
| labels,0,4,0,0,0,0,0,0,0,8,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute renal impairment,transient anuria | |
| drug,captopril | |
| sequence,We,report,on,a,patient,with,renal,artery,stenosis,who,had,only,1,kidney,and,in,whom,acute,renal,impairment,developed,with,transient,anuria,after,the,administration,of,captopril,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,5,7,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,SIADH | |
| drug,mizoribin | |
| sequence,A,case,of,SIADH,induced,by,mizoribin,administration,. | |
| labels,0,0,0,8,0,0,4,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Delusional parasitosis | |
| drug,phenelzine | |
| sequence,Delusional,parasitosis,associated,with,phenelzine,. | |
| labels,5,7,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,destroyed the gastric mucosal barrier,thrombocytopenia due to bone marrow disorder,hemorrhagic gastritis | |
| drug,AZ | |
| sequence,We,thus,concluded,that,an,excessive,dose,of,AZ,had,probably,destroyed,the,gastric,mucosal,barrier,or,thrombocytopenia,due,to,bone,marrow,disorder,and,thus,eventually,led,to,the,development,of,hemorrhagic,gastritis,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,5,6,6,6,7,0,5,6,6,6,6,7,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,0,1,1,1,1,1,1,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,potentially toxic | |
| drug,Methotrexate | |
| sequence,Methotrexate,is,an,effective,but,potentially,toxic,treatment,for,psoriasis,. | |
| labels,4,0,0,0,0,5,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,CDIC,diarrhea,C. difficile toxin | |
| drug,clindamycin | |
| sequence,CONCLUSIONS,:,This,report,indicates,clindamycin,phosphate,vaginal,cream,as,the,most,probable,cause,of,CDIC,due,to,the,temporal,relationship,between,the,occurrence,of,diarrhea,and,clindamycin,administration,,,lack,of,concomitant,medications,,,and,documentation,of,C.,difficile,toxin,. | |
| labels,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,CDIC,diarrhea,C. difficile toxin | |
| drug,clindamycin phosphate | |
| sequence,CONCLUSIONS,:,This,report,indicates,clindamycin,phosphate,vaginal,cream,as,the,most,probable,cause,of,CDIC,due,to,the,temporal,relationship,between,the,occurrence,of,diarrhea,and,clindamycin,administration,,,lack,of,concomitant,medications,,,and,documentation,of,C.,difficile,toxin,. | |
| labels,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,Corneal endothelial deposits | |
| drug,rifabutin | |
| sequence,Corneal,endothelial,deposits,associated,with,rifabutin,use,. | |
| labels,5,6,7,0,0,4,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,dyspnea,acute asthma | |
| drug,verapamil | |
| sequence,Although,dyspnea,associated,with,verapamil,administration,has,been,reported,,,this,is,the,first,report,of,an,elderly,asymptomatic,asthmatic,patient,with,hypertension,who,developed,an,acute,asthma,attack,following,sustained-release,verapamil,administration,. | |
| labels,0,8,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,colitis | |
| drug,rofecoxib | |
| sequence,CONCLUSIONS,:,Symptoms,and,pathologic,changes,of,colitis,are,associated,with,exposure,to,rofecoxib,. | |
| labels,0,0,0,0,0,0,0,8,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypothyroidism | |
| drug,alpha interferon | |
| sequence,Diagnosis,of,hypothyroidism,during,treatment,can,be,difficult,because,of,the,common,side,effects,of,alpha,interferon,. | |
| labels,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,1,3,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,supraventricular tachycardia | |
| drug,Partusisten | |
| sequence,After,treatment,with,a,beta-sympathomimetic,drug,(,Partusisten,),one,fetus,developed,supraventricular,tachycardia,. | |
| labels,0,0,0,0,0,0,0,4,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,DIC,acute hemoglobinemia,hemoglobinuria | |
| drug,anti-D IGIV | |
| sequence,This,review,presents,the,first,case,series,of,DIC,associated,with,acute,hemoglobinemia,or,hemoglobinuria,following,anti-D,IGIV,administration,for,ITP,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,5,7,0,8,0,1,3,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,1,1,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,skin toxicity | |
| drug,bleomycin | |
| sequence,The,hyperpigmentation,was,diffuse,scattered,,,flagellate,like,and,linear,streaking,which,was,thought,to,be,mainly,related,to,the,skin,toxicity,of,bleomycin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,ulcer | |
| drug,theophylline | |
| sequence,A,study,following,large,patient,groups,on,theophylline,and,a,combination,of,theophylline,and,steroids,might,clarify,the,risk,of,ulcer,formation,in,patients,being,treated,with,these,medications,for,asthma,. | |
| labels,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myopathy | |
| drug,colchicine | |
| sequence,Both,colchicine,and,statin,therapy,may,be,associated,with,myopathy,,,which,usually,occurs,after,several,months,of,therapy,. | |
| labels,0,4,0,4,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myopathy | |
| drug,statin | |
| sequence,Both,colchicine,and,statin,therapy,may,be,associated,with,myopathy,,,which,usually,occurs,after,several,months,of,therapy,. | |
| labels,0,4,0,4,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Theophylline intoxication | |
| drug,Theophylline | |
| sequence,Theophylline,intoxication,mimicking,diabetic,ketoacidosis,in,a,child,. | |
| labels,9,7,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,embryopathy | |
| drug,cyclophosphamide | |
| sequence,Apparent,cyclophosphamide,(,cytoxan,),embryopathy,:,a,distinct,phenotype,? | |
| labels,0,4,0,0,0,8,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,life-threatening arrhythmias | |
| drug,pilsicainide | |
| sequence,When,pilsicainide,is,prescribed,in,patients,with,coronary,artery,disease,or,renal,dysfunction,,,close,attention,must,be,paid,to,avoid,life-threatening,arrhythmias,due,to,high,plasma,concentrations,of,the,drug,. | |
| labels,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Thrombotic microangiopathy,renal failure | |
| drug,gemcitabine | |
| sequence,Thrombotic,microangiopathy,with,renal,failure,in,two,patients,undergoing,gemcitabine,chemotherapy,. | |
| labels,5,7,0,5,7,0,0,0,0,4,0,0 | |
| ade_mask,1,1,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,portal hypertension,ascites,oesophageal varices,jaundice | |
| drug,busulphan | |
| sequence,A,patient,with,chronic,myeloid,leukaemia,treated,with,busulphan,for,4-5,years,,,developed,signs,of,busulphan,toxicity,and,portal,hypertension,with,ascites,,,oesophageal,varices,and,jaundice,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,5,7,0,8,0,5,7,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0,1,1,0,1,0 | |
| ==============================, ============================= | |
| ade,hepatic angiosarcoma | |
| drug,cyclophosphamide | |
| sequence,A,review,of,the,literature,revealed,two,other,cases,of,hepatic,angiosarcoma,in,patients,after,long-term,cyclophosphamide,treatment,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Tardive dyskinesia | |
| drug,sulpiride | |
| sequence,Tardive,dyskinesia,induced,by,sulpiride,. | |
| labels,5,7,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,teratogenicity,agenesis of the cerebellar vermis,multiple leptomeningeal neuroglial heterotopias,hydrocephalus,abnormalities of the corticospinal tracts | |
| drug,isotretinoin | |
| sequence,We,report,an,additional,case,of,isotretinoin,teratogenicity,in,which,the,patient,had,agenesis,of,the,cerebellar,vermis,,,multiple,leptomeningeal,neuroglial,heterotopias,,,hydrocephalus,,,and,abnormalities,of,the,corticospinal,tracts,. | |
| labels,0,0,0,0,0,0,4,8,0,0,0,0,0,5,6,6,6,7,0,5,6,6,7,0,8,0,0,5,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,1,0,1,0,0,1,0,0,1,0,0,1,1,0,1,1,1,1,0,1,0,0,1,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,cardiac failure | |
| drug,insulin | |
| sequence,This,report,describes,the,first,case,of,insulin-induced,cardiac,failure,in,a,patient,without,underlying,heart,disease,. | |
| labels,0,0,0,0,0,0,0,4,5,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,B-cell non-Hodgkin's lymphoma | |
| drug,infliximab | |
| sequence,The,first,patient,was,a,61-year-old,man,with,a,30-year,history,of,fistulizing,CD,in,whom,B-cell,non-Hodgkin,'s,lymphoma,was,diagnosed,9,months,after,treatment,with,infliximab,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,abdominal pain,collapse | |
| drug,vasopressin | |
| sequence,The,condition,should,be,suspected,in,patients,who,develop,unexplained,abdominal,pain,or,collapse,following,vasopressin,treatment,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,8,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Tuberculous uveitis | |
| drug,etanercept | |
| sequence,Tuberculous,uveitis,after,treatment,with,etanercept,. | |
| labels,5,7,0,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Musculoskeletal complaints | |
| drug,cyclophosphamide | |
| sequence,Musculoskeletal,complaints,were,the,presenting,symptoms,in,four,of,44,children,(,9,%,),treated,for,relapsed,Wilms,tumors,with,ifosfamide,,,a,derivative,of,cyclophosphamide,. | |
| labels,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Musculoskeletal complaints | |
| drug,ifosfamide | |
| sequence,Musculoskeletal,complaints,were,the,presenting,symptoms,in,four,of,44,children,(,9,%,),treated,for,relapsed,Wilms,tumors,with,ifosfamide,,,a,derivative,of,cyclophosphamide,. | |
| labels,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperpigmentation | |
| drug,bleomycin | |
| sequence,Although,this,type,of,hyperpigmentation,has,been,previously,seen,in,patients,with,cancer,who,are,receiving,bleomycin,,,this,is,,,to,our,knowledge,,,the,first,reported,case,of,bleomycin-induced,hyperpigmentation,in,an,AIDS,patient,and,should,be,added,to,the,growing,list,of,cutaneous,eruptions,seen,in,these,patients,. | |
| labels,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,type I anaphylaxis | |
| drug,protamine | |
| sequence,Although,adverse,reactions,to,protamine,are,reported,infrequently,and,are,usually,mild,,,we,recently,observed,the,first,fatal,case,of,type,I,anaphylaxis,resulting,from,protamine,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,papular eruption,cutaneous vasculitis | |
| drug,methotrexate | |
| sequence,Pathogenesis,of,methotrexate-induced,papular,eruption,in,psoriasis,may,involve,immune,mechanisms,other,than,those,of,methotrexate-induced,cutaneous,vasculitis,in,collagen,vascular,disease,. | |
| labels,0,0,4,5,7,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Adrenal suppression in a fetus | |
| drug,methylprednisolone | |
| sequence,Adrenal,suppression,in,a,fetus,due,to,administration,of,methylprednisolone,has,hitherto,been,rarely,published,. | |
| labels,5,6,6,6,7,0,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,transient hemiparesis | |
| drug,phenytoin | |
| sequence,A,52-year-old,Black,woman,on,phenytoin,therapy,for,post-traumatic,epilepsy,developed,transient,hemiparesis,contralateral,to,the,injury,. | |
| labels,0,0,0,0,0,4,0,0,0,0,0,5,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,leucopenia,thrombocytopenia | |
| drug,Quetiapine | |
| sequence,Quetiapine-induced,leucopenia,and,thrombocytopenia,. | |
| labels,4,8,0,8,0 | |
| ade_mask,0,1,0,1,0 | |
| ==============================, ============================= | |
| ade,elevation of serum transaminases | |
| drug,6-TG | |
| sequence,We,describe,a,case,of,significant,elevation,of,serum,transaminases,in,a,patient,treated,with,6-TG,for,a,flare,of,Crohn,'s,disease,. | |
| labels,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,discrepancies between hematologic, marrow morphologic, and cytogenetic responses | |
| drug,imatinib mesylate | |
| sequence,CONTEXT,:,Previous,investigators,have,reported,discrepancies,between,hematologic,,,marrow,morphologic,,,and,cytogenetic,responses,to,imatinib,mesylate,among,patients,with,chronic,myeloid,leukemia,(,CML,),. | |
| labels,0,0,0,0,0,0,5,6,6,6,6,6,0,6,6,7,0,1,3,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,1,1,1,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,syncope | |
| drug,isosorbide dinitrate | |
| sequence,A,65-year-old,woman,with,angina,pectoris,presented,with,syncope,after,sublingual,ingestion,of,isosorbide,dinitrate,(,5,mg,),. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,0,0,1,3,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sensorineural hearing loss | |
| drug,naproxen | |
| sequence,This,article,reports,the,case,of,an,otherwise,healthy,patient,who,experienced,permanent,sensorineural,hearing,loss,after,a,brief,course,of,naproxen,and,reviews,the,literature,on,NSAID-related,permanent,sensorineural,hearing,loss,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neuralgic amyotrophy | |
| drug,piperacillin | |
| sequence,DISCUSSION,:,To,our,knowledge,,,this,is,the,first,case,report,illustrating,neuralgic,amyotrophy,triggered,by,exposure,to,the,antibiotics,vancomycin,,,tobramycin,,,and,piperacillin,tazobactam,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,4,0,4,0,0,4,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neuralgic amyotrophy | |
| drug,tazobactam | |
| sequence,DISCUSSION,:,To,our,knowledge,,,this,is,the,first,case,report,illustrating,neuralgic,amyotrophy,triggered,by,exposure,to,the,antibiotics,vancomycin,,,tobramycin,,,and,piperacillin,tazobactam,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,4,0,4,0,0,4,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neuralgic amyotrophy | |
| drug,tobramycin | |
| sequence,DISCUSSION,:,To,our,knowledge,,,this,is,the,first,case,report,illustrating,neuralgic,amyotrophy,triggered,by,exposure,to,the,antibiotics,vancomycin,,,tobramycin,,,and,piperacillin,tazobactam,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,4,0,4,0,0,4,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neuralgic amyotrophy | |
| drug,vancomycin | |
| sequence,DISCUSSION,:,To,our,knowledge,,,this,is,the,first,case,report,illustrating,neuralgic,amyotrophy,triggered,by,exposure,to,the,antibiotics,vancomycin,,,tobramycin,,,and,piperacillin,tazobactam,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,4,0,4,0,0,4,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe acidosis | |
| drug,acetazolamide | |
| sequence,An,insulin-dependent,diabetic,patient,with,nephropathy,developed,severe,acidosis,after,treatment,with,acetazolamide,for,glaucoma,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,oculogyric crisis | |
| drug,metoclopramide | |
| sequence,A,case,of,oculogyric,crisis,induced,by,metoclopramide,is,described,in,this,paper,. | |
| labels,0,0,0,5,7,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,stroke-like leukoencephalopathy | |
| drug,methotrexate | |
| sequence,OBJECTIVES,:,A,delayed,stroke-like,leukoencephalopathy,has,been,observed,in,patients,receiving,methotrexate,(,MTX,),for,childhood,leukemia,. | |
| labels,0,0,0,0,5,7,0,0,0,0,0,0,4,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,stroke-like leukoencephalopathy | |
| drug,MTX | |
| sequence,OBJECTIVES,:,A,delayed,stroke-like,leukoencephalopathy,has,been,observed,in,patients,receiving,methotrexate,(,MTX,),for,childhood,leukemia,. | |
| labels,0,0,0,0,5,7,0,0,0,0,0,0,4,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,large cerebral infarction | |
| drug,praziquantel | |
| sequence,CASE,DESCRIPTION,:,A,59-year-old,man,with,known,neurocysticercosis,developed,a,large,cerebral,infarction,during,praziquantel,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,reversible corneal edema | |
| drug,Amantadine | |
| sequence,CONCLUSIONS,:,Amantadine,can,cause,reversible,corneal,edema,but,can,irreversibly,reduce,the,density,of,endothelial,cells,. | |
| labels,0,0,4,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatitis B virus reactivation | |
| drug,rituximab | |
| sequence,Late,lethal,hepatitis,B,virus,reactivation,after,rituximab,treatment,of,low-grade,cutaneous,B-cell,lymphoma,. | |
| labels,0,0,5,6,6,7,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,panic anxiety | |
| drug,mianserin | |
| sequence,This,panic,anxiety,was,not,relieved,by,taking,etizolam,and,flunitrazepam,again,,,but,subsided,rapidly,by,the,re-administration,of,mianserin,30,mg,day,,,and,because,of,that,the,depressive,symptom,also,disappeared,. | |
| labels,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Carbamazepine toxicity | |
| drug,Carbamazepine | |
| sequence,Carbamazepine,toxicity,induced,by,clarithromycin,coadministration,in,psychiatric,patients,. | |
| labels,9,7,0,0,4,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Carbamazepine toxicity | |
| drug,clarithromycin | |
| sequence,Carbamazepine,toxicity,induced,by,clarithromycin,coadministration,in,psychiatric,patients,. | |
| labels,9,7,0,0,4,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,carcinoma,endometrial lesions | |
| drug,tamoxifen | |
| sequence,CONCLUSIONS,:,The,value,of,multihormonal,therapy,in,breast,carcinoma,is,not,established,,,and,the,addition,of,progestogens,to,tamoxifen,may,not,reduce,of,developing,endometrial,lesions,,,including,carcinoma,. | |
| labels,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,5,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,elevated serum triglyceride levels | |
| drug,clozapine | |
| sequence,This,increase,when,clozapine,was,switched,to,risperidone,and,vice,versa,is,consistent,with,our,previous,report,of,elevated,serum,triglyceride,levels,in,clozapine-treated,patients,. | |
| labels,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pure red cell aplasia | |
| drug,fenoprofen | |
| sequence,A,69-year-old,man,developed,pure,red,cell,aplasia,after,taking,fenoprofen,for,ten,months,. | |
| labels,0,0,0,0,5,6,6,7,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,eosinophilic pneumonia reaction | |
| drug,beclomethasone diproprionate | |
| sequence,The,use,of,beclomethasone,diproprionate,inhaler,complicated,by,the,development,of,an,eosinophilic,pneumonia,reaction,. | |
| labels,0,0,0,1,3,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,peripheral vasculopathy | |
| drug,dextroamphetamine | |
| sequence,Methylphenidate,and,dextroamphetamine-induced,peripheral,vasculopathy,. | |
| labels,4,0,4,5,7,0 | |
| ade_mask,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,peripheral vasculopathy | |
| drug,Methylphenidate | |
| sequence,Methylphenidate,and,dextroamphetamine-induced,peripheral,vasculopathy,. | |
| labels,4,0,4,5,7,0 | |
| ade_mask,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,serotonin syndrome | |
| drug,clomipramine | |
| sequence,He,was,diagnosed,with,possible,serotonin,syndrome,;,his,symptoms,resolved,after,clomipramine,was,stopped,but,before,clozapine,was,restarted,eight,days,later,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,encephalopathy | |
| drug,LTG | |
| sequence,CONCLUSIONS,:,LTG,overdose,may,result,in,a,severe,but,reversible,encephalopathy,,,a,previously,undescribed,phenomenon,. | |
| labels,0,0,4,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,autoimmune hemolytic anemia | |
| drug,rituximab | |
| sequence,We,report,the,first,case,,,to,our,knowledge,,,of,rituximab-related,autoimmune,hemolytic,anemia,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,4,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,anemia | |
| drug,MMF | |
| sequence,The,dermatology,literature,heretofore,has,not,noted,that,anemia,is,a,side,effect,of,patients,taking,MMF,to,treat,pemphigus,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,contact dermatitis | |
| drug,sodium bisulfite | |
| sequence,We,report,a,case,of,contact,dermatitis,due,to,sodium,bisulfite,in,Tathion,eye,drops,. | |
| labels,0,0,0,0,0,5,7,0,0,1,3,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,subfulminant hepatitis B | |
| drug,infliximab | |
| sequence,In,this,case,report,,,we,have,described,a,patient,with,Crohn,'s,disease,who,developed,subfulminant,hepatitis,B,after,the,fourth,infusion,of,infliximab,due,to,an,unrecognized,HBs-antigen,carrier,state,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,elevated hepato-biliary enzymes,transient biliary stasis | |
| drug,ceftriaxone | |
| sequence,Ceftriaxone,was,approved,in,1997,for,the,treatment,of,otitis,media,despite,previous,studies,that,documented,an,association,of,ceftriaxone,with,elevated,hepato-biliary,enzymes,and,transient,biliary,stasis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,5,6,7,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,Severe osteomalacia | |
| drug,acetazolamide | |
| sequence,Severe,osteomalacia,was,present,in,two,epileptic,patients,who,were,under,long-term,treatment,with,congeners,of,phenytoin,,,phenobarbital,,,and,acetazolamide,. | |
| labels,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Severe osteomalacia | |
| drug,phenobarbital | |
| sequence,Severe,osteomalacia,was,present,in,two,epileptic,patients,who,were,under,long-term,treatment,with,congeners,of,phenytoin,,,phenobarbital,,,and,acetazolamide,. | |
| labels,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Severe osteomalacia | |
| drug,phenytoin | |
| sequence,Severe,osteomalacia,was,present,in,two,epileptic,patients,who,were,under,long-term,treatment,with,congeners,of,phenytoin,,,phenobarbital,,,and,acetazolamide,. | |
| labels,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fever,sepsis,fevers of neutropenia | |
| drug,amifostine | |
| sequence,Patients,receiving,amifostine,who,develop,only,fever,should,be,evaluated,for,an,adverse,drug,reaction,,,as,well,as,for,sepsis,and,fevers,of,neutropenia,,,and,it,may,be,necessary,to,discontinue,the,drug,. | |
| labels,0,0,4,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypothyroidism | |
| drug,amiodarone | |
| sequence,Such,a,case,induced,by,hypothyroidism,complicating,long-term,therapy,with,amiodarone,in,a,45,year,old,woman,with,pre-excitation,is,presented,. | |
| labels,0,0,0,0,0,8,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,asthma | |
| drug,captopril | |
| sequence,This,confirmed,the,history,of,captopril-related,asthma,. | |
| labels,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Severe hepatotoxicity | |
| drug,phenobarbital | |
| sequence,Severe,hepatotoxicity,from,phenobarbital,occurred,in,an,infant,boy,who,had,a,complicated,illness,with,chronic,bilateral,subdural,hematomas,and,sepsis,. | |
| labels,5,7,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Crohn's disease | |
| drug,copaxone | |
| sequence,Development,of,Crohn,'s,disease,in,a,patient,with,multiple,sclerosis,treated,with,copaxone,. | |
| labels,0,0,5,6,7,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,autoimmune hepatitis | |
| drug,Minocycline | |
| sequence,Minocycline-induced,autoimmune,hepatitis,is,usually,identical,to,sporadic,autoimmune,hepatitis,. | |
| labels,4,5,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Generalized argyria | |
| drug,AgNO3 | |
| sequence,Generalized,argyria,after,habitual,use,of,AgNO3,. | |
| labels,5,7,0,0,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,seizures | |
| drug,amphotericin B | |
| sequence,The,time,course,of,events,suggested,that,amphotericin,B,was,the,cause,of,the,seizures,in,this,AIDS,patient,. | |
| labels,0,0,0,0,0,0,0,1,3,0,0,0,0,0,8,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,mammary hyperplasias | |
| drug,D-penicillamine | |
| sequence,Drug-induced,mammary,hyperplasias,have,been,reported,as,rare,complications,of,D-penicillamine,and,Neothetazone,. | |
| labels,0,5,7,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,mammary hyperplasias | |
| drug,Neothetazone | |
| sequence,Drug-induced,mammary,hyperplasias,have,been,reported,as,rare,complications,of,D-penicillamine,and,Neothetazone,. | |
| labels,0,5,7,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,encephalopathy,cardiomyopathy | |
| drug,aluminum | |
| sequence,An,encephalopathy,and,cardiomyopathy,developed,in,a,seventeen-year-old,girl,with,chemotherapy-induced,renal,failure,while,receiving,an,intravesical,aluminum,infusion,for,hemorrhagic,cystitis,. | |
| labels,0,8,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombocytopenia | |
| drug,heparin | |
| sequence,Type,II,heparin-induced,thrombocytopenia,(,HIT,),is,an,immunological,disorder,characterized,by,antibodies,to,heparin-platelet,factor,4,complexes,and,a,high,risk,of,thrombotic,complications,. | |
| labels,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,akathisia | |
| drug,fluvoxamine | |
| sequence,In,the,presented,case,fluvoxamine-induced,akathisia,in,an,OCD,patient,was,partially,resistant,to,the,anticholinergic,agent,biperiden,,,and,was,successfully,treated,with,the,5-HT2A,5-HT2C,antagonist,mianserin,. | |
| labels,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,interstitial pneumopathy | |
| drug,amiodarone | |
| sequence,In,a,61-year-old,man,receiving,chronic,low-dosage,amiodarone,an,interstitial,pneumopathy,was,observed,. | |
| labels,0,0,0,0,0,0,0,4,0,5,7,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombotic microangiopathy | |
| drug,gemcitabine | |
| sequence,Described,here,are,2,patients,who,developed,thrombotic,microangiopathy,of,the,kidneys,after,receiving,high,cumulative,doses,of,the,new,anticancer,drug,gemcitabine,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,photo-onycholysis | |
| drug,olanzapine | |
| sequence,We,report,the,case,of,a,woman,who,developed,photo-onycholysis,on,multiple,nails,after,uptake,of,olanzapine,. | |
| labels,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neuroleptic malignant syndrome | |
| drug,metoclopramide | |
| sequence,Fulminant,metoclopramide,induced,neuroleptic,malignant,syndrome,rapidly,responsive,to,intravenous,dantrolene,. | |
| labels,0,4,0,5,6,7,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myotonia | |
| drug,pravastatin | |
| sequence,This,case,suggests,that,sarcoidosis,and,pravastatin,,,two,entities,not,frequently,associated,with,myotonia,,,may,interact,in,a,synergistic,manner,to,produce,severe,clinical,myotonia,in,humans,. | |
| labels,0,0,0,0,0,0,4,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,diminishing carbamazepine metabolism,increase in serum levels,clinical toxicity | |
| drug,Ritonavir | |
| sequence,Ritonavir,acted,as,a,CYP3A4,inhibitor,,,diminishing,carbamazepine,metabolism,and,provoking,an,increase,in,serum,levels,and,clinical,toxicity,. | |
| labels,4,0,0,0,0,0,0,5,6,7,0,0,0,5,6,6,7,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,0,1,1,1,1,0,1,1,0 | |
| ==============================, ============================= | |
| ade,sulphasalazine syndrome,fatal,immunoallergic reaction | |
| drug,sulphasalazine | |
| sequence,It,is,thought,that,the,clinico-pathological,features,and,chronology,of,this,case,bore,the,hallmarks,of,the,so-called,``,3-week,sulphasalazine,syndrome,'',,,a,rare,,,but,often,fatal,,,immunoallergic,reaction,to,sulphasalazine,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,7,0,0,0,0,0,0,0,8,0,5,7,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,1,0,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,piloerection | |
| drug,fluvoxamine | |
| sequence,CONCLUSIONS,:,The,piloerection,observed,after,the,replacement,of,fluvoxamine,with,milnacipran,in,this,patient,appears,to,have,been,due,to,an,increase,in,the,alpha,(,1,),-adrenoceptor,occupancy,by,endogenous,norepinephrine,induced,by,milnacipran,. | |
| labels,0,0,0,8,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,piloerection | |
| drug,milnacipran | |
| sequence,CONCLUSIONS,:,The,piloerection,observed,after,the,replacement,of,fluvoxamine,with,milnacipran,in,this,patient,appears,to,have,been,due,to,an,increase,in,the,alpha,(,1,),-adrenoceptor,occupancy,by,endogenous,norepinephrine,induced,by,milnacipran,. | |
| labels,0,0,0,8,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,involuntary movements | |
| drug,trazodone | |
| sequence,When,the,trazodone,was,reduced,,,the,involuntary,movements,promptly,ceased,. | |
| labels,0,0,4,0,0,0,0,5,7,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,interstitial pneumonitis | |
| drug,hydroxyurea | |
| sequence,The,clinical,course,suggests,that,the,interstitial,pneumonitis,was,induced,by,hydroxyurea,. | |
| labels,0,0,0,0,0,0,5,7,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombosis | |
| drug,GnRH-a | |
| sequence,CONCLUSION,:,While,thrombosis,has,been,reported,with,GnRH-a,therapy,in,men,with,prostate,cancer,,,its,association,with,treatment,in,this,benign,case,may,have,been,a,consequence,of,the,massive,tumor,size,. | |
| labels,0,0,0,8,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myelosuppression | |
| drug,Azathioprine | |
| sequence,Azathioprine-induced,myelosuppression,due,to,thiopurine,methyltransferase,deficiency,in,a,patient,with,autoimmune,hepatitis,. | |
| labels,4,8,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Magnesium toxicosis | |
| drug,Magnesium | |
| sequence,Magnesium,toxicosis,in,two,horses,. | |
| labels,9,7,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyponatremia | |
| drug,desmopressin | |
| sequence,Intranasal,desmopressin-induced,hyponatremia,. | |
| labels,0,4,8,0 | |
| ade_mask,0,0,1,0 | |
| ==============================, ============================= | |
| ade,isolated idential sensory neuropathy | |
| drug,sulindac | |
| sequence,A,healthy,,,30-year-old,man,,,exposed,to,sulindac,on,two,separate,occasions,,,had,an,incapacitating,isolated,idential,sensory,neuropathy,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,5,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,respiratory failure | |
| drug,gold | |
| sequence,We,report,a,case,of,severe,respiratory,failure,due,to,gold,salt,toxicity,in,a,patient,suffering,from,rheumatoid,arthritis,requiring,mechanical,ventilation,. | |
| labels,0,0,0,0,0,0,5,7,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Ovarian endometrioid carcinoma,endometriosis | |
| drug,tamoxifen | |
| sequence,Ovarian,endometrioid,carcinoma,and,endometriosis,developing,in,a,postmenopausal,breast,cancer,patient,during,tamoxifen,therapy,:,a,case,report,and,review,of,the,literature,. | |
| labels,5,6,7,0,8,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,leukopenia | |
| drug,Ibopamine | |
| sequence,Ibopamine-induced,reversible,leukopenia,during,treatment,for,congestive,heart,failure,. | |
| labels,4,0,8,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe hypersensitivity reactions,cardiac arrest,apnea,eruptions,hypotension,tachycardia | |
| drug,CBDCA | |
| sequence,However,,,one,patient,exhibited,severe,hypersensitivity,reactions,including,cardiac,arrest,and,apnea,,,and,another,four,patients,developed,eruptions,,,hypotension,,,and,tachycardia,soon,after,administration,of,CBDCA,. | |
| labels,0,0,0,0,0,5,6,7,0,5,7,0,8,0,0,0,0,0,0,8,0,8,0,0,8,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,1,1,0,1,0,0,0,0,0,0,1,0,1,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,inhibits metabolism of tacrolimus | |
| drug,nefazodone | |
| sequence,We,suspect,that,nefazodone,inhibits,metabolism,of,tacrolimus,. | |
| labels,0,0,0,4,5,6,6,9,0 | |
| ade_mask,0,0,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,inhibits metabolism of tacrolimus | |
| drug,tacrolimus | |
| sequence,We,suspect,that,nefazodone,inhibits,metabolism,of,tacrolimus,. | |
| labels,0,0,0,4,5,6,6,9,0 | |
| ade_mask,0,0,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,systemic iron toxicity | |
| drug,iron sucrose | |
| sequence,The,case,reported,here,is,of,a,child,given,a,large,dose,of,intravenous,iron,sucrose,(,16,mg,kg,),over,3,hours,,,who,subsequently,developed,features,of,systemic,iron,toxicity,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0 | |
| ==============================, ============================= | |
| ade,mania | |
| drug,fluoxetine | |
| sequence,A,case,of,mania,associated,with,fluoxetine,. | |
| labels,0,0,0,8,0,0,4,0 | |
| ade_mask,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,coronary vasoconstriction | |
| drug,dopamine | |
| sequence,Although,the,existence,of,an,acute,pericarditis,or,an,acute,myocarditis,as,possible,causes,of,the,ST,elevation,can,not,be,fully,ruled,out,,,the,sudden,onset,,,prominent,magnitude,,,and,brief,duration,of,the,ST,elevation,are,perhaps,more,indicative,of,an,acute,ischemic,event,,,possibly,related,to,a,transient,coronary,vasoconstriction,induced,by,the,dopamine,infusion,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sarcoidosis | |
| drug,interferon alfa | |
| sequence,We,report,two,new,cases,of,sarcoidosis,in,two,patients,with,hepatitis,C,virus,infection,treated,with,interferon,alfa,and,ribavirin,. | |
| labels,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,1,3,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sarcoidosis | |
| drug,ribavirin | |
| sequence,We,report,two,new,cases,of,sarcoidosis,in,two,patients,with,hepatitis,C,virus,infection,treated,with,interferon,alfa,and,ribavirin,. | |
| labels,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,1,3,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Colonic necrosis | |
| drug,Kayexalate | |
| sequence,Colonic,necrosis,is,known,as,a,rare,complication,following,the,administration,of,Kayexalate,(,sodium,polystryrene,sulfonate,),in,sorbitol,. | |
| labels,5,7,0,0,0,0,0,0,0,0,0,0,4,0,1,2,3,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Colonic necrosis | |
| drug,sodium polystryrene sulfonate | |
| sequence,Colonic,necrosis,is,known,as,a,rare,complication,following,the,administration,of,Kayexalate,(,sodium,polystryrene,sulfonate,),in,sorbitol,. | |
| labels,5,7,0,0,0,0,0,0,0,0,0,0,4,0,1,2,3,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Fulminant hepatitis,severe lactate acidosis | |
| drug,didanosine | |
| sequence,Fulminant,hepatitis,with,severe,lactate,acidosis,in,HIV-infected,patients,on,didanosine,therapy,. | |
| labels,5,7,0,5,6,7,0,0,0,0,4,0,0 | |
| ade_mask,1,1,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sudden bilateral, sequential visual loss | |
| drug,interferon alfa | |
| sequence,PATIENTS,:,Two,patients,,,ages,40,and,51,years,,,undergoing,treatment,with,interferon,alfa,for,malignant,neoplasms,experienced,sudden,bilateral,,,sequential,visual,loss,with,disc-related,field,defects,and,segmental,optic,disc,edema,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,3,0,0,0,0,5,6,6,6,6,7,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Gold nephropathy | |
| drug,auranofin | |
| sequence,Gold,nephropathy,due,to,auranofin,obscured,by,tolmetin,pseudoproteinuria,. | |
| labels,9,7,0,0,4,0,0,4,8,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Gold nephropathy | |
| drug,Gold | |
| sequence,Gold,nephropathy,due,to,auranofin,obscured,by,tolmetin,pseudoproteinuria,. | |
| labels,9,7,0,0,4,0,0,4,8,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Gold nephropathy,pseudoproteinuria | |
| drug,tolmetin | |
| sequence,Gold,nephropathy,due,to,auranofin,obscured,by,tolmetin,pseudoproteinuria,. | |
| labels,9,7,0,0,4,0,0,4,8,0 | |
| ade_mask,1,1,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,vasculitis,lupus-like syndrome | |
| drug,vancomycin | |
| sequence,The,possible,development,of,a,drug-induced,vasculitis,or,lupus-like,syndrome,should,be,added,to,the,list,of,rare,toxic,effects,of,vancomycin,. | |
| labels,0,0,0,0,0,0,8,0,5,7,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypernatraemia | |
| drug,Kayexalate | |
| sequence,We,describe,two,ELBW,infants,affected,by,hyperkalaemia,,,treated,with,Kayexalate,,,who,developed,serious,hypernatraemia,,,that,has,never,been,reported,before,in,preterm,infants,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cutaneous leucocytoclastic vasculitis | |
| drug,amphotericin B | |
| sequence,We,present,a,case,of,cutaneous,leucocytoclastic,vasculitis,in,which,amphotericin,B,might,presumably,be,the,aetiological,factor,. | |
| labels,0,0,0,0,0,5,6,7,0,0,1,3,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,maculopathy | |
| drug,Niacin | |
| sequence,Niacin,maculopathy,. | |
| labels,4,8,0 | |
| ade_mask,0,1,0 | |
| ==============================, ============================= | |
| ade,field defects | |
| drug,vigabatrin | |
| sequence,The,field,defects,and,some,electrophysiological,abnormalities,persist,when,vigabatrin,therapy,is,withdrawn,. | |
| labels,0,5,7,0,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Pulmonary eosinophilia,granulomas,pneumonitis | |
| drug,methotrexate | |
| sequence,Pulmonary,eosinophilia,or,granulomas,,,classically,seen,in,previously,reported,cases,of,methotrexate,pneumonitis,,,were,not,observed,. | |
| labels,5,7,0,8,0,0,0,0,0,0,0,0,4,8,0,0,0,0,0 | |
| ade_mask,1,1,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute neutrophilic dermatosis | |
| drug,all-trans-retinoic acid | |
| sequence,Acute,neutrophilic,dermatosis,induced,by,all-trans-retinoic,acid,treatment,for,acute,promyelocytic,leukemia,. | |
| labels,5,6,7,0,0,1,3,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bradycardia | |
| drug,clonidine | |
| sequence,Possible,mechanisms,by,which,clonidine,decreases,spasticity,are,described,,,probable,mechanisms,of,induced,bradycardia,are,reviewed,,,and,specific,treatment,recommendations,for,the,use,of,clonidine,in,spinal,cord,injured,patients,are,presented,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity pneumonitis | |
| drug,Mesalamine | |
| sequence,Mesalamine-induced,hypersensitivity,pneumonitis,. | |
| labels,4,5,7,0 | |
| ade_mask,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Alveolar-interstitial pneumopathy | |
| drug,gold | |
| sequence,Alveolar-interstitial,pneumopathy,after,gold-salts,compounds,administration,,,requiring,mechanical,ventilation,. | |
| labels,5,7,0,4,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,angioedema | |
| drug,losartan | |
| sequence,OBJECTIVE,:,To,report,a,case,of,angioedema,associated,with,losartan,administration,. | |
| labels,0,0,0,0,0,0,0,8,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Anaphylactic reaction | |
| drug,prednisone | |
| sequence,Anaphylactic,reaction,to,oral,prednisone,:,a,case,report,and,review,of,the,literature,. | |
| labels,5,7,0,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,circulatory collapse,deep coma | |
| drug,perospirone hydrochloride | |
| sequence,A,32-year-old,man,with,a,family,history,of,type,2,diabetes,mellitus,presented,with,circulatory,collapse,and,deep,coma,after,9,days,of,treatment,with,perospirone,hydrochloride,,,a,recently,developed,atypical,antipsychotic,agent,available,only,in,Japan,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,5,7,0,0,0,0,0,0,1,3,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,first trimester abortions,fetal abnormality | |
| drug,zidovudine | |
| sequence,In,a,series,of,104,cases,of,intentional,or,inadvertent,use,of,zidovudine,at,differing,gestations,in,pregnancy,,,there,were,eight,spontaneous,first,trimester,abortions,,,eight,therapeutic,terminations,,,and,eight,cases,of,fetal,abnormality,occurring,among,a,total,of,88,cases,where,the,pregnancy,progressed,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neurotoxicity | |
| drug,MTX | |
| sequence,We,believe,that,this,represents,an,unusual,case,of,moderate-dose,MTX-induced,neurotoxicity,in,a,patient,with,gastric,cancer,,,which,has,not,previously,been,reported,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Radiation recall | |
| drug,gemcitabine | |
| sequence,Radiation,recall,from,gemcitabine,is,rare,,,but,can,potentially,arise,in,any,site,that,has,been,previously,irradiated,. | |
| labels,5,7,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute renal failure,pancytopenia,vomiting,diarrhea,elevated liver transaminases,jaundice,mucosal ulcerations,pyrexia | |
| drug,MTX | |
| sequence,Previous,studies,have,demonstrated,the,interaction,of,MTX,and,a,variety,of,non-steroidal,,,anti-inflammatory,drugs,(,NSAIDs,),with,various,clinical,manifestations,including,acute,renal,failure,,,pancytopenia,,,vomiting,,,diarrhea,,,elevated,liver,transaminases,,,jaundice,,,mucosal,ulcerations,,,and,pyrexia,. | |
| labels,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,8,0,8,0,8,0,5,6,7,0,8,0,5,7,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0,1,0,1,0,1,1,1,0,1,0,1,1,0,0,1,0 | |
| ==============================, ============================= | |
| ade,serotonin syndrome,extrapyramidal reactions | |
| drug,metoclopramide | |
| sequence,CONCLUSIONS,:,Clinicians,should,be,aware,of,a,risk,of,serotonin,syndrome,with,serious,extrapyramidal,reactions,in,patients,receiving,sertraline,or,venlafaxine,when,metoclopramide,is,coadministered,even,in,a,single,,,conventional,dose,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,0,5,7,0,0,0,4,0,4,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,serotonin syndrome,extrapyramidal reactions | |
| drug,sertraline | |
| sequence,CONCLUSIONS,:,Clinicians,should,be,aware,of,a,risk,of,serotonin,syndrome,with,serious,extrapyramidal,reactions,in,patients,receiving,sertraline,or,venlafaxine,when,metoclopramide,is,coadministered,even,in,a,single,,,conventional,dose,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,0,5,7,0,0,0,4,0,4,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,serotonin syndrome,extrapyramidal reactions | |
| drug,venlafaxine | |
| sequence,CONCLUSIONS,:,Clinicians,should,be,aware,of,a,risk,of,serotonin,syndrome,with,serious,extrapyramidal,reactions,in,patients,receiving,sertraline,or,venlafaxine,when,metoclopramide,is,coadministered,even,in,a,single,,,conventional,dose,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,0,5,7,0,0,0,4,0,4,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,retroperitoneal fibrosis | |
| drug,Methysergide | |
| sequence,Methysergide-induced,retroperitoneal,fibrosis,:,successful,outcome,and,two,new,laboratory,features,. | |
| labels,4,5,7,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fulminant hepatic failure | |
| drug,Nicotinic acid | |
| sequence,Nicotinic,acid-induced,fulminant,hepatic,failure,. | |
| labels,1,3,5,6,7,0 | |
| ade_mask,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,acute encephalopathy,high-pressure hydrocephalus | |
| drug,doxorubicin | |
| sequence,In,a,female,with,acute,lymphoblastic,leukemia,,,inadvertent,doxorubicin,administration,intrathecally,caused,severe,,,life-threatening,,,acute,encephalopathy,with,high-pressure,hydrocephalus,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,5,7,0,5,7,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,0 | |
| ==============================, ============================= | |
| ade,catatonia | |
| drug,disulfiram | |
| sequence,Neurophysiological,mechanisms,which,aid,in,elucidating,the,role,of,disulfiram,in,the,etiology,of,catatonia,are,discussed,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,0,0,8,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,fever,autonomic instability | |
| drug,baclofen | |
| sequence,The,patient,continued,to,have,fever,and,autonomic,instability,without,evidence,of,infection,which,entirely,resolved,within,24,hours,of,reinstitution,of,full,preadmission,dosing,of,oral,baclofen,. | |
| labels,0,0,0,0,0,8,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,encephalopathy syndrome | |
| drug,BH-AC | |
| sequence,This,case,suggests,that,BH-AC,,,a,derivative,of,cytosine,arabinoside,(,1-beta-D-arabinofuranosylcytosine,),could,be,a,cause,of,reversible,encephalopathy,syndrome,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Recurrent hyponatremia | |
| drug,citalopram | |
| sequence,Recurrent,hyponatremia,associated,with,citalopram,and,mirtazapine,. | |
| labels,5,7,0,0,4,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Recurrent hyponatremia | |
| drug,mirtazapine | |
| sequence,Recurrent,hyponatremia,associated,with,citalopram,and,mirtazapine,. | |
| labels,5,7,0,0,4,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,renal deterioration | |
| drug,cefuroxime | |
| sequence,The,diagnosis,was,supported,by,the,temporal,course,of,renal,deterioration,during,exposure,to,cefuroxime,and,improvement,on,its,discontinuation,;,the,pattern,repeated,with,rechallenge,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,granulomatosis | |
| drug,interferon alfa | |
| sequence,There,have,been,more,than,20,observations,of,the,appearance,or,aggravation,of,this,granulomatosis,with,interferon,alfa,and,more,recently,with,the,combination,of,interferon,alfa,plus,ribavirin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,1,3,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,granulomatosis | |
| drug,ribavirin | |
| sequence,There,have,been,more,than,20,observations,of,the,appearance,or,aggravation,of,this,granulomatosis,with,interferon,alfa,and,more,recently,with,the,combination,of,interferon,alfa,plus,ribavirin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,1,3,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fibrosing alveolitis | |
| drug,amiodarone | |
| sequence,We,describe,a,case,of,fibrosing,alveolitis,,,diagnosed,by,lung,biopsy,,,in,a,patient,receiving,amiodarone,which,responded,to,corticosteroid,therapy,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nail changes | |
| drug,Clofazimine | |
| sequence,Clofazimine,induced,nail,changes,. | |
| labels,4,0,5,7,0 | |
| ade_mask,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Painful erosion of psoriatic plaques,methotrexate toxicity,bone marrow suppression | |
| drug,methotrexate | |
| sequence,Painful,erosion,of,psoriatic,plaques,is,a,less,common,sign,of,methotrexate,toxicity,that,may,precede,evidence,of,bone,marrow,suppression,. | |
| labels,5,6,6,6,7,0,0,0,0,0,0,9,7,0,0,0,0,0,5,6,7,0 | |
| ade_mask,1,1,1,1,1,0,0,0,0,0,0,1,1,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,renal insufficiency,seizures | |
| drug,ofloxacin | |
| sequence,The,renal,insufficiency,of,three,patients,and,the,timing,of,the,seizures,implicate,accumulation,of,ofloxacin,as,a,contributing,factor,. | |
| labels,0,5,7,0,0,0,0,0,0,0,0,8,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lung disease,bronchiolitis obliterans organising pneumonia,BOOP | |
| drug,nitrofurantoin | |
| sequence,The,case,histories,are,presented,of,two,patients,who,developed,lung,disease,associated,with,the,use,of,nitrofurantoin,with,histological,features,of,bronchiolitis,obliterans,organising,pneumonia,(,BOOP,),,,a,rare,but,recognised,form,of,drug,induced,injury,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,4,0,0,0,0,5,6,6,7,0,8,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute generalized exanthematous pustulosis | |
| drug,morphine | |
| sequence,Acute,generalized,exanthematous,pustulosis,caused,by,morphine,,,confirmed,by,positive,patch,test,and,lymphocyte,transformation,test,. | |
| labels,5,6,6,7,0,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thyrotoxicosis | |
| drug,Triiodothyronine | |
| sequence,Triiodothyronine-induced,thyrotoxicosis,in,ophthalmic,Graves,disease,. | |
| labels,4,8,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Alternating sinus rhythm,intermittent sinoatrial (S-A) block | |
| drug,propranolol | |
| sequence,Alternating,sinus,rhythm,and,intermittent,sinoatrial,(,S-A,),block,was,observed,in,a,57-year-old,woman,,,under,treatment,for,angina,with,80,mg,propranolol,daily,. | |
| labels,5,6,7,0,5,6,6,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,1,1,1,0,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,priapism | |
| drug,heparin | |
| sequence,One,case,of,priapism,occurred,during,heparin,therapy,for,a,previous,surgical,operation,to,the,knee,is,reported,. | |
| labels,0,0,0,8,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ADH hypersecretion,SIADH | |
| drug,mizoribin | |
| sequence,ADH,hypersecretion,in,relation,to,plasma,osmolality,was,reversed,by,mizoribin,withdrawal,,,suggesting,that,bredinin,might,adversely,induce,SIADH,. | |
| labels,5,7,0,0,0,0,0,0,0,0,4,0,0,0,0,4,0,0,0,8,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,SIADH | |
| drug,bredinin | |
| sequence,ADH,hypersecretion,in,relation,to,plasma,osmolality,was,reversed,by,mizoribin,withdrawal,,,suggesting,that,bredinin,might,adversely,induce,SIADH,. | |
| labels,5,7,0,0,0,0,0,0,0,0,4,0,0,0,0,4,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,septal hypertrophy,left ventricular outflow tract obstruction | |
| drug,dexamethasone | |
| sequence,STUDY,DESIGN,:,Case,reports,are,presented,of,three,premature,infants,(,mean,gestational,age,27,weeks,),cared,for,in,the,intensive,care,nursery,in,whom,clinically,significant,septal,hypertrophy,and,left,ventricular,outflow,tract,obstruction,developed,during,dexamethasone,treatment,for,bronchopulmonary,dysplasia,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,5,6,6,6,7,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,1,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,development of visually related side effects | |
| drug,Ethambutol | |
| sequence,RESULTS,:,Ethambutol,,,and,to,a,lesser,extent,isoniazid,,,are,both,implicated,in,the,development,of,visually,related,side,effects,. | |
| labels,0,0,4,0,0,0,0,0,0,4,0,0,0,0,0,0,5,6,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,development of visually related side effects | |
| drug,isoniazid | |
| sequence,RESULTS,:,Ethambutol,,,and,to,a,lesser,extent,isoniazid,,,are,both,implicated,in,the,development,of,visually,related,side,effects,. | |
| labels,0,0,4,0,0,0,0,0,0,4,0,0,0,0,0,0,5,6,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,mortality,cardiac arrhythmias | |
| drug,amphotericin B | |
| sequence,Hydrocortisone,may,decrease,the,incidence,of,mortality,associated,with,cardiac,arrhythmias,in,children,receiving,amphotericin,B,overdoses,. | |
| labels,0,0,0,0,0,0,8,0,0,5,7,0,0,0,1,3,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lithium toxicity,polyuria,nephrogenic diabetes insipidus | |
| drug,lithium | |
| sequence,Clinicians,have,been,aware,of,lithium,toxicity,for,many,years,and,traditionally,have,administered,thiazide,diuretics,for,lithium-induced,polyuria,and,nephrogenic,diabetes,insipidus,. | |
| labels,0,0,0,0,0,9,7,0,0,0,0,0,0,0,0,0,0,0,8,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity | |
| drug,sulfadiazine | |
| sequence,This,case,underscores,problems,in,clinical,management,with,sulfadiazine,hypersensitivity,,,potential,immunosuppression,from,corticosteroids,and,selection,of,medications,for,recurrences,of,toxoplasmic,chorioretinitis,. | |
| labels,0,0,0,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nonoliguric renal failure | |
| drug,suramin | |
| sequence,We,describe,a,patient,with,metastatic,prostate,cancer,who,developed,nonoliguric,renal,failure,during,treatment,with,suramin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,respiratory distress | |
| drug,chlorambucil | |
| sequence,Following,several,of,these,courses,of,therapy,,,respiratory,distress,occurred,9,to,12,days,after,the,chlorambucil,was,given,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,proliferative lesions of the endometrium | |
| drug,tamoxifen | |
| sequence,Although,its,side,effects,are,few,,,tamoxifen,increases,the,incidence,of,proliferative,lesions,of,the,endometrium,,,which,theoretically,should,be,preventable,with,progestational,agents,. | |
| labels,0,0,0,0,0,0,0,4,0,0,0,0,5,6,6,6,7,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,1,1,1,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bullous lesions on the hands and soles that disseminated, evolving to necrosis,sepsis,death | |
| drug,ARA-C | |
| sequence,On,the,fifth,day,after,administration,of,a,high,dose,of,ARA-C,(,2,g,m2,intravenously,every,12,hours,),,,she,developed,bullous,lesions,on,the,hands,and,soles,that,disseminated,,,evolving,to,necrosis,,,sepsis,,,and,death,on,the,22nd,day,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,6,6,6,6,6,6,6,7,0,8,0,0,8,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,1,0,1,1,1,1,1,0,1,1,1,0,1,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Scleroderma | |
| drug,bleomycin | |
| sequence,Scleroderma,in,association,with,the,use,of,bleomycin,:,a,report,of,3,cases,. | |
| labels,8,0,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe hemodynamic deterioration,systemic hypotension,pulmonary hypertension,bronchoconstriction | |
| drug,protamine | |
| sequence,The,reversal,of,heparin,by,protamine,may,cause,severe,hemodynamic,deterioration,,,characterized,by,systemic,hypotension,,,pulmonary,hypertension,,,and,bronchoconstriction,. | |
| labels,0,0,0,0,0,4,0,0,5,6,7,0,0,0,5,7,0,5,7,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,1,1,0,1,1,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Central pontine myelinolysis,temporary blindness | |
| drug,lithium | |
| sequence,Central,pontine,myelinolysis,manifested,by,temporary,blindness,:,a,possible,complication,of,lithium,toxicity,. | |
| labels,5,6,7,0,0,5,7,0,0,0,0,0,4,0,0 | |
| ade_mask,1,1,1,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Radiation recall | |
| drug,gemcitabine | |
| sequence,Radiation,recall,related,to,gemcitabine,has,been,reported,in,lung,and,breast,cancer,. | |
| labels,5,7,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lost vision | |
| drug,Bromocryptine | |
| sequence,An,infertile,patient,with,amenorrhea-galactorrhea,syndrome,lost,vision,during,a,pregnancy,occurring,after,Bromocryptine,treatment,. | |
| labels,0,0,0,0,0,0,5,7,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Severe aphthous stomatitis | |
| drug,calcineurin | |
| sequence,Severe,aphthous,stomatitis,associated,with,oral,calcineurin,and,mTOR,inhibitors,. | |
| labels,5,6,7,0,0,0,4,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Prolonged prostate-specific antigen response,flutamide withdrawal syndrome | |
| drug,flutamide | |
| sequence,Prolonged,prostate-specific,antigen,response,in,flutamide,withdrawal,syndrome,despite,disease,progression,. | |
| labels,5,6,6,7,0,9,6,7,0,0,0,0 | |
| ade_mask,1,1,1,1,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperpigmented skin,tongue lesions | |
| drug,IFN | |
| sequence,We,describe,two,dark-skinned,patients,who,developed,hyperpigmented,skin,and,tongue,lesions,during,combination,therapy,with,IFN,and,ribavirin,. | |
| labels,0,0,0,0,0,0,0,5,7,0,5,7,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperpigmented skin,tongue lesions | |
| drug,ribavirin | |
| sequence,We,describe,two,dark-skinned,patients,who,developed,hyperpigmented,skin,and,tongue,lesions,during,combination,therapy,with,IFN,and,ribavirin,. | |
| labels,0,0,0,0,0,0,0,5,7,0,5,7,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pancreatitis | |
| drug,ezetimibe | |
| sequence,Since,its,FDA,approval,in,2002,,,there,are,no,known,citations,of,ezetimibe-induced,pancreatitis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,cardiac rhythms,hypokalemia | |
| drug,garenoxacin | |
| sequence,Therefore,,,although,garenoxacin,reportedly,causes,fewer,adverse,reactions,for,cardiac,rhythms,than,third-generation,quinolone,antibiotics,,,one,must,be,cautious,of,the,interference,of,other,drugs,during,hypokalemia,in,order,to,prevent,TdP,. | |
| labels,0,0,0,4,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,leg pain | |
| drug,cyclosporine | |
| sequence,With,the,first,cyclosporine,dose,,,the,patient,complained,of,leg,pain,that,was,most,severe,during,the,cyclosporine,infusion,. | |
| labels,0,0,0,4,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,agranulocytosis | |
| drug,clozapine | |
| sequence,The,female,patient,received,clozapine,in,a,daily,dose,of,400,mg,,,which,induced,agranulocytosis,after,2,months,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Meibomian duct inflammation and blockage,chalazion | |
| drug,Docetaxel | |
| sequence,Docetaxel-induced,Meibomian,duct,inflammation,and,blockage,leading,to,chalazion,formation,. | |
| labels,4,5,6,6,6,7,0,0,8,0,0 | |
| ade_mask,0,1,1,1,1,1,0,0,1,0,0 | |
| ==============================, ============================= | |
| ade,AL | |
| drug,hydroxyurea | |
| sequence,In,this,report,,,two,cases,of,ET,which,evolved,into,AL,without,prior,exposure,to,radiation,or,alkylating,agents,,,and,which,were,treated,with,long-term,hydroxyurea,therapy,,,are,described,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis | |
| drug,propylthiouracil | |
| sequence,Antineutrophil,cytoplasmic,antibody-positive,crescentic,glomerulonephritis,associated,with,propylthiouracil,therapy,. | |
| labels,5,6,6,6,7,0,0,4,0,0 | |
| ade_mask,1,1,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nonconvulsive generalized status epilepticus | |
| drug,lorazepam | |
| sequence,The,aim,of,this,report,is,to,describe,the,clinical,and,electroencephalographic,findings,seen,in,an,elderly,woman,without,previous,history,of,seizures,who,developed,a,nonconvulsive,generalized,status,epilepticus,following,acute,withdrawal,of,lorazepam,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Ulcerating enteritis | |
| drug,flucytosine | |
| sequence,Ulcerating,enteritis,associated,with,flucytosine,therapy,. | |
| labels,5,7,0,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,diabetes | |
| drug,indapamide | |
| sequence,CONCLUSION,:,Therapy,with,indapamide,may,induce,diabetes,in,essential,hypertension,patients,. | |
| labels,0,0,0,0,4,0,0,8,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Toxic epidermal necrolysis | |
| drug,interleukin-2 | |
| sequence,Toxic,epidermal,necrolysis,associated,with,interleukin-2,. | |
| labels,5,6,7,0,0,4,0 | |
| ade_mask,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,skin necrosis | |
| drug,warfarin | |
| sequence,Herein,is,reported,an,unusual,case,of,coexistent,warfarin-induced,skin,necrosis,and,heparin-induced,thrombocytopenia,following,mitral,valve,replacement,for,thromboembolic,phenomena,associated,with,marantic,endocarditis,and,bronchial,adenocarcinoma,. | |
| labels,0,0,0,0,0,0,0,0,4,5,7,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,skin necrosis,thrombocytopenia | |
| drug,heparin | |
| sequence,Herein,is,reported,an,unusual,case,of,coexistent,warfarin-induced,skin,necrosis,and,heparin-induced,thrombocytopenia,following,mitral,valve,replacement,for,thromboembolic,phenomena,associated,with,marantic,endocarditis,and,bronchial,adenocarcinoma,. | |
| labels,0,0,0,0,0,0,0,0,4,5,7,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,headache | |
| drug,fluoxetine | |
| sequence,Although,fluoxetine-induced,headache,occurred,in,one,patient,,,the,other,five,reported,no,side,effects,at,the,doses,used,. | |
| labels,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,increase total Hb | |
| drug,HU | |
| sequence,We,conclude,that,low-dose,HU,therapy,in,patients,with,thalassemia,intermedia,may,increase,total,Hb,levels,sufficiently,to,eliminate,the,need,for,transfusions,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thyrotoxicosis,severe exophthalmos | |
| drug,lithium | |
| sequence,The,case,of,a,bipolar,patient,who,developed,thyrotoxicosis,with,severe,exophthalmos,while,on,lithium,therapy,is,described,. | |
| labels,0,0,0,0,0,0,0,0,8,0,5,7,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,overanticoagulation | |
| drug,acenocoumarol | |
| sequence,Early,overanticoagulation,with,acenocoumarol,due,to,a,genetic,polymorphism,of,cytochrome,P450,CYP2C9,. | |
| labels,0,8,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,visual loss | |
| drug,ethambutol | |
| sequence,During,the,anti-tuberculous,therapy,,,visual,loss,can,be,related,to,ethambutol,toxicity,or,the,tuberculosis,infection,itself,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute asthma | |
| drug,verapamil | |
| sequence,OBJECTIVE,:,To,describe,a,patient,with,asymptomatic,bronchial,asthma,and,hypertension,who,developed,an,acute,asthma,attack,after,receiving,sustained-release,verapamil,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,serum lithium level had increased | |
| drug,acyclovir | |
| sequence,When,measured,,,the,serum,lithium,level,had,increased,4-fold,during,acyclovir,therapy,. | |
| labels,0,0,0,0,5,9,6,6,7,0,0,4,0,0 | |
| ade_mask,0,0,0,0,1,1,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,serum lithium level had increased | |
| drug,lithium | |
| sequence,When,measured,,,the,serum,lithium,level,had,increased,4-fold,during,acyclovir,therapy,. | |
| labels,0,0,0,0,5,9,6,6,7,0,0,4,0,0 | |
| ade_mask,0,0,0,0,1,1,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,central nervous system (CNS) excitatory toxicities,accumulation of the active metabolite normeperidine | |
| drug,Meperidine | |
| sequence,Meperidine-associated,central,nervous,system,(,CNS,),excitatory,toxicities,are,believed,to,be,caused,by,accumulation,of,the,active,metabolite,normeperidine,. | |
| labels,4,5,6,6,6,6,6,6,7,0,0,0,0,0,0,5,6,6,6,6,7,0 | |
| ade_mask,0,1,1,1,1,1,1,1,1,0,0,0,0,0,0,1,1,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,acute interstitial pneumonitis | |
| drug,hydroxyurea | |
| sequence,This,is,the,first,case,of,hydroxyurea-induced,acute,interstitial,pneumonitis,reported,in,the,literature,. | |
| labels,0,0,0,0,0,0,4,5,6,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Thrombotic Thrombocytopenic Purpura | |
| drug,sulfamethoxazole | |
| sequence,We,report,a,case,of,Thrombotic,Thrombocytopenic,Purpura,occurring,as,an,allergic,response,to,trimethoprim-sulfamethoxazole,therapy,(,Bactrim,,,Septra,),in,a,Jehovah,'s,Witness,patient,. | |
| labels,0,0,0,0,0,5,6,7,0,0,0,0,0,0,4,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Thrombotic Thrombocytopenic Purpura | |
| drug,trimethoprim | |
| sequence,We,report,a,case,of,Thrombotic,Thrombocytopenic,Purpura,occurring,as,an,allergic,response,to,trimethoprim-sulfamethoxazole,therapy,(,Bactrim,,,Septra,),in,a,Jehovah,'s,Witness,patient,. | |
| labels,0,0,0,0,0,5,6,7,0,0,0,0,0,0,4,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hashimoto's disease | |
| drug,IFN-alpha | |
| sequence,CONCLUSIONS,:,This,case,report,showed,that,the,clinical,appearance,of,Hashimoto,'s,disease,after,IFN-alpha,therapy,for,chronic,C,hepatitis,in,our,patient,was,associated,with,a,specific,genetic,predisposition,(,DR5,),for,this,pathology,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypoglycemia | |
| drug,Disopyramide | |
| sequence,Disopyramide,(,Norpace,),-induced,hypoglycemia,. | |
| labels,4,0,4,0,0,8,0 | |
| ade_mask,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,hypoglycemia | |
| drug,Norpace | |
| sequence,Disopyramide,(,Norpace,),-induced,hypoglycemia,. | |
| labels,4,0,4,0,0,8,0 | |
| ade_mask,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,constellation of dermatitis,fever,lymphadenopathy,hepatitis | |
| drug,sulphasalazine | |
| sequence,A,34-year-old,lady,developed,a,constellation,of,dermatitis,,,fever,,,lymphadenopathy,and,hepatitis,,,beginning,on,the,17th,day,of,a,course,of,oral,sulphasalazine,for,sero-negative,rheumatoid,arthritis,. | |
| labels,0,0,0,0,0,5,6,7,0,8,0,8,0,8,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,1,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,toxic hepatitis | |
| drug,etretinate | |
| sequence,A,case,of,toxic,hepatitis,caused,by,combination,therapy,with,methotrexate,and,etretinate,in,the,treatment,of,severe,psoriasis,is,presented,in,a,47-year-old,woman,. | |
| labels,0,0,0,5,7,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,toxic hepatitis | |
| drug,methotrexate | |
| sequence,A,case,of,toxic,hepatitis,caused,by,combination,therapy,with,methotrexate,and,etretinate,in,the,treatment,of,severe,psoriasis,is,presented,in,a,47-year-old,woman,. | |
| labels,0,0,0,5,7,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Pleuropulmonary fibrosis | |
| drug,pergolide | |
| sequence,Pleuropulmonary,fibrosis,after,long-term,treatment,with,the,dopamine,agonist,pergolide,for,Parkinson,Disease,. | |
| labels,5,7,0,0,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,diabetic ketoacidosis | |
| drug,quetiapine | |
| sequence,METHOD,:,We,describe,two,patients,who,presented,with,diabetic,ketoacidosis,after,treatment,with,quetiapine,and,risperidone,,,respectively,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,0,0,4,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,diabetic ketoacidosis | |
| drug,risperidone | |
| sequence,METHOD,:,We,describe,two,patients,who,presented,with,diabetic,ketoacidosis,after,treatment,with,quetiapine,and,risperidone,,,respectively,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,0,0,4,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,leukopenia,agranulocytosis | |
| drug,olanzapine | |
| sequence,These,cases,suggest,the,possibility,that,,,in,some,patients,,,leukopenia,or,agranulocytosis,during,olanzapine,treatment,might,be,dose-related,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,8,0,8,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Goiter,hypothyroidism,thyrotoxicosis | |
| drug,amiodarone | |
| sequence,Goiter,and,hypothyroidism,during,re-treatment,with,amiodarone,in,a,patient,who,previously,experienced,amiodarone-induced,thyrotoxicosis,. | |
| labels,8,0,8,0,0,0,4,0,0,0,0,0,0,0,8,0 | |
| ade_mask,1,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,meningitis | |
| drug,SMX | |
| sequence,We,present,a,46-year-old,African-American,man,with,AIDS,who,was,admitted,on,two,different,occasions,within,three,weeks,for,signs,and,symptoms,of,meningitis,after,using,trimethoprim,sulfamethoxazole,(,TMP,SMX,),. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,4,4,0,4,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,meningitis | |
| drug,sulfamethoxazole | |
| sequence,We,present,a,46-year-old,African-American,man,with,AIDS,who,was,admitted,on,two,different,occasions,within,three,weeks,for,signs,and,symptoms,of,meningitis,after,using,trimethoprim,sulfamethoxazole,(,TMP,SMX,),. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,4,4,0,4,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,meningitis | |
| drug,TMP | |
| sequence,We,present,a,46-year-old,African-American,man,with,AIDS,who,was,admitted,on,two,different,occasions,within,three,weeks,for,signs,and,symptoms,of,meningitis,after,using,trimethoprim,sulfamethoxazole,(,TMP,SMX,),. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,4,4,0,4,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,meningitis | |
| drug,trimethoprim | |
| sequence,We,present,a,46-year-old,African-American,man,with,AIDS,who,was,admitted,on,two,different,occasions,within,three,weeks,for,signs,and,symptoms,of,meningitis,after,using,trimethoprim,sulfamethoxazole,(,TMP,SMX,),. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,4,4,0,4,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fever | |
| drug,acyclovir | |
| sequence,The,fever,abated,promptly,following,discontinuation,of,acyclovir,,,and,radiographic,abnormalities,resolved,over,ten,days,. | |
| labels,0,8,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,polyuria | |
| drug,Lithium | |
| sequence,Lithium,therapy,was,discontinued,because,of,poor,compliance,to,the,medication,and,intolerable,polyuria,. | |
| labels,4,0,0,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,visual field constriction | |
| drug,vigabatrin | |
| sequence,Electro-oculography,,,electroretinography,,,visual,evoked,potentials,,,and,multifocal,electroretinography,in,patients,with,vigabatrin-attributed,visual,field,constriction,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,5,6,7,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Severe rash,Stevens-Johnson syndrome,SJS | |
| drug,nevirapine | |
| sequence,Severe,rash,,,including,the,Stevens-Johnson,syndrome,(,SJS,),,,is,the,major,toxicity,of,nevirapine,and,is,described,in,the,package,labeling,with,a,prominent,,,boxed,warning,. | |
| labels,5,7,0,0,0,5,7,0,8,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Interstitial pneumopathy | |
| drug,amiodarone | |
| sequence,Interstitial,pneumopathy,and,low-dosage,amiodarone,. | |
| labels,5,7,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,dermatologic, hematologic, and pulmonary adverse effects | |
| drug,Captopril | |
| sequence,Captopril,is,known,to,be,associated,with,dermatologic,,,hematologic,,,and,pulmonary,adverse,effects,. | |
| labels,4,0,0,0,0,0,0,5,6,6,0,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,bleeding | |
| drug,warfarin | |
| sequence,The,most,common,complication,of,warfarin,use,is,adverse,bleeding,. | |
| labels,0,0,0,0,0,4,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Pellagra encephalopathy | |
| drug,isoniazid | |
| sequence,Pellagra,encephalopathy,among,tuberculous,patients,:,its,relation,to,isoniazid,therapy,. | |
| labels,5,7,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,generalized pustular psoriasis,GPP | |
| drug,Molipaxin | |
| sequence,We,report,a,patient,in,whom,the,anti-depressant,trazodone,hydrochloride,(,Molipaxin,,,Roussel,),,,a,serotonin,antagonist,,,provoked,generalized,pustular,psoriasis,(,GPP,),. | |
| labels,0,0,0,0,0,0,0,0,1,3,0,4,0,0,0,0,0,0,0,0,0,5,6,7,0,8,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0,0 | |
| ==============================, ============================= | |
| ade,generalized pustular psoriasis,GPP | |
| drug,trazodone hydrochloride | |
| sequence,We,report,a,patient,in,whom,the,anti-depressant,trazodone,hydrochloride,(,Molipaxin,,,Roussel,),,,a,serotonin,antagonist,,,provoked,generalized,pustular,psoriasis,(,GPP,),. | |
| labels,0,0,0,0,0,0,0,0,1,3,0,4,0,0,0,0,0,0,0,0,0,5,6,7,0,8,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0,0 | |
| ==============================, ============================= | |
| ade,Acute coronary events | |
| drug,cisplatin | |
| sequence,Acute,coronary,events,following,cisplatin-based,chemotherapy,. | |
| labels,5,6,7,0,4,0,0 | |
| ade_mask,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe angioedematous reaction | |
| drug,BP | |
| sequence,Factors,that,suggested,an,association,between,the,severe,angioedematous,reaction,and,BP,topical,application,include,the,strong,reaction,to,BP,in,the,patch-test,,,the,temporal,relationship,,,the,complete,resolution,of,symptoms,after,the,drug,was,withdrawn,and,the,absence,of,other,identified,explanations,. | |
| labels,0,0,0,0,0,0,0,5,6,7,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,IgA deficiency,IgE increase | |
| drug,phenytoin | |
| sequence,Transient,phenytoin,induced,IgA,deficiency,and,permanent,IgE,increase,. | |
| labels,0,4,0,5,7,0,0,5,7,0 | |
| ade_mask,0,0,0,1,1,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,pulmonary fibrosis | |
| drug,CCNU | |
| sequence,The,responsibility,of,CCNU,in,the,pathogenesis,of,pulmonary,fibrosis,seems,very,likely,. | |
| labels,0,0,0,4,0,0,0,0,5,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,agitation,dysarthria,diaphoresis,movement disorder | |
| drug,metoclopramide | |
| sequence,She,was,administered,metoclopramide,because,of,nausea,and,,,within,2,hours,,,developed,agitation,,,dysarthria,,,diaphoresis,,,and,a,movement,disorder,. | |
| labels,0,0,0,4,0,0,0,0,0,0,0,0,0,0,8,0,8,0,8,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Anterior ischemic optic neuropathy | |
| drug,interferon alfa | |
| sequence,CONCLUSION,:,Anterior,ischemic,optic,neuropathy,may,complicate,treatment,with,interferon,alfa,. | |
| labels,0,0,5,6,6,7,0,0,0,0,1,3,0 | |
| ade_mask,0,0,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ototoxicity,antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis | |
| drug,propylthiouracil | |
| sequence,OBJECTIVE,:,To,report,the,case,of,a,young,woman,with,Graves,disease,in,whom,ototoxicity,developed,because,of,propylthiouracil,(,PTU,),-induced,antineutrophil,cytoplasmic,antibody,(,ANCA,),-associated,vasculitis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,4,0,4,0,0,5,6,6,6,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,1,0,1,0,1,1,1,0,1,0,1,1,0 | |
| ==============================, ============================= | |
| ade,ototoxicity,antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis | |
| drug,PTU | |
| sequence,OBJECTIVE,:,To,report,the,case,of,a,young,woman,with,Graves,disease,in,whom,ototoxicity,developed,because,of,propylthiouracil,(,PTU,),-induced,antineutrophil,cytoplasmic,antibody,(,ANCA,),-associated,vasculitis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,4,0,4,0,0,5,6,6,6,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,1,0,1,0,1,1,1,0,1,0,1,1,0 | |
| ==============================, ============================= | |
| ade,hepatotoxicity | |
| drug,Sirolimus | |
| sequence,Sirolimus-associated,hepatotoxicity,in,the,kidney,graft,recipient,. | |
| labels,4,8,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Sunburn,skin extremely sensitive | |
| drug,psoralen | |
| sequence,Sunburn,may,sometimes,be,a,major,injury,in,psoralen,users,because,high,doses,or,inappropriate,use,of,the,drug,may,render,the,skin,extremely,sensitive,. | |
| labels,8,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,Acute unilateral total visual loss | |
| drug,phenol | |
| sequence,Acute,unilateral,total,visual,loss,after,retrogasserian,phenol,injection,for,the,treatment,of,trigeminal,neuralgia,:,a,case,report,. | |
| labels,5,6,6,6,7,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,radiation recall | |
| drug,Gemcitabine | |
| sequence,Gemcitabine-related,radiation,recall,in,a,patient,with,pancreatic,cancer,. | |
| labels,4,5,7,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rash | |
| drug,cephalexin | |
| sequence,The,case,of,a,patient,with,infectious,mononucleosis,treated,with,cephalexin,who,later,showed,a,rash,is,presented,and,the,previous,literature,is,reviewed,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,8,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,RBD | |
| drug,fluoxetine | |
| sequence,In,addition,,,a,31-year-old,man,with,obsessive-compulsive,disorder,developed,RBD,soon,after,starting,fluoxetine,therapy,,,which,persisted,at,PSG,study,19,months,after,fluoxetine,discontinuation,. | |
| labels,0,0,0,0,0,0,0,0,0,0,8,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,respiratory depression | |
| drug,morphine-6-glucuronide | |
| sequence,Long,lasting,respiratory,depression,induced,by,morphine-6-glucuronide,? | |
| labels,0,0,5,7,0,0,4,0 | |
| ade_mask,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute reversible ataxo-myoclonic encephalopathy | |
| drug,flecainide | |
| sequence,Acute,reversible,ataxo-myoclonic,encephalopathy,with,flecainide,therapy,. | |
| labels,5,6,6,7,0,4,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Spindle coma | |
| drug,benzodiazepine | |
| sequence,Spindle,coma,in,benzodiazepine,toxicity,:,case,report,. | |
| labels,5,7,0,4,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lipoatrophy | |
| drug,Insulin | |
| sequence,Insulin-induced,lipoatrophy,in,type,I,diabetes,. | |
| labels,4,8,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,asystole | |
| drug,esmolol hydrochloride | |
| sequence,After,induction,of,general,anesthesia,and,administration,of,a,standard,dose,of,intravenous,esmolol,hydrochloride,,,her,cardiac,rhythm,progressed,to,asystole,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,1,3,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,irritant type of reaction | |
| drug,calcipotriol | |
| sequence,The,present,observation,suggests,,,that,a,batch,of,different,testing,doses,,,including,lower,testing,doses,may,help,to,differentiate,between,an,allergic,type,of,contact,dermatitis,and,an,irritant,type,of,reaction,after,treatment,with,calcipotriol,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,multiple seizures | |
| drug,bupropion | |
| sequence,We,report,a,case,of,pediatric,bupropion,ingestion,resulting,in,multiple,seizures,. | |
| labels,0,0,0,0,0,0,4,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,SIADH | |
| drug,Tegretol | |
| sequence,This,case,report,describes,a,38-year-old,male,in,whom,SIADH,was,strongly,suspected,secondary,to,Tegretol,therapy,to,control,a,seizure,disorder,. | |
| labels,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute pneumonitis | |
| drug,bleomycin | |
| sequence,A,case,of,a,53-year-old,man,who,developed,acute,pneumonitis,after,bleomycin,and,moderate,oxygen,administration,is,presented,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,4,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute pneumonitis | |
| drug,oxygen | |
| sequence,A,case,of,a,53-year-old,man,who,developed,acute,pneumonitis,after,bleomycin,and,moderate,oxygen,administration,is,presented,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,4,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,agranulocytosis | |
| drug,infliximab | |
| sequence,Drug-induced,agranulocytosis,during,treatment,with,infliximab,in,enteropathic,spondyloarthropathy,. | |
| labels,0,8,0,0,0,4,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,blood levels in the toxic range | |
| drug,phenytoin | |
| sequence,Seventy-four,per,cent,of,patients,with,epileptogenic,disorders,seen,at,the,Emergency,Unit,at,Groote,Schuur,Hospital,were,on,phenytoin,and,11.6,%,of,these,had,blood,levels,in,the,toxic,range,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,5,6,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,1,0 | |
| ==============================, ============================= | |
| ade,diffuse interstitial pulmonary fibrosis | |
| drug,Methotrexate | |
| sequence,Methotrexate-induced,diffuse,interstitial,pulmonary,fibrosis,. | |
| labels,4,5,6,6,7,0 | |
| ade_mask,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,histamine reaction | |
| drug,isoniazid | |
| sequence,When,tuberculosis,patients,on,isoniazid,eat,certain,varieties,of,fish,they,may,develop,a,histamine,reaction,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,type 5 Bartter-like syndrome,severe hypocalcemia | |
| drug,Amikacin | |
| sequence,Amikacin-induced,type,5,Bartter-like,syndrome,with,severe,hypocalcemia,. | |
| labels,4,5,6,6,7,0,5,7,0 | |
| ade_mask,0,1,1,1,1,0,1,1,0 | |
| ==============================, ============================= | |
| ade,severe hypertension | |
| drug,epinephrine | |
| sequence,We,report,the,specifics,of,12,cases,of,severe,hypertension,after,the,intraoperative,use,of,topical,phenylephrine,,,submucosal,epinephrine,,,or,both,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,4,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe hypertension | |
| drug,phenylephrine | |
| sequence,We,report,the,specifics,of,12,cases,of,severe,hypertension,after,the,intraoperative,use,of,topical,phenylephrine,,,submucosal,epinephrine,,,or,both,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,4,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hypersensitivity reactions | |
| drug,Cremophor EL | |
| sequence,CONCLUSIONS,:,Hypersensitivity,reactions,to,cyclosporine,are,due,to,Cremophor,EL,. | |
| labels,0,0,5,7,0,4,0,0,0,1,3,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hypersensitivity reactions | |
| drug,cyclosporine | |
| sequence,CONCLUSIONS,:,Hypersensitivity,reactions,to,cyclosporine,are,due,to,Cremophor,EL,. | |
| labels,0,0,5,7,0,4,0,0,0,1,3,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,skin necrosis | |
| drug,vasopressin | |
| sequence,OBJECTIVE,:,To,describe,a,case,of,severe,skin,necrosis,resulting,from,peripheral,intravenous,administration,of,low-dose,vasopressin,in,a,patient,with,catecholamine-resistant,septic,shock,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Pleuropulmonary changes | |
| drug,cabergoline | |
| sequence,Pleuropulmonary,changes,during,treatment,of,Parkinson,'s,disease,with,a,long-acting,ergot,derivative,,,cabergoline,. | |
| labels,5,7,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Skin rash,hepatocellular failure | |
| drug,phenobarbital | |
| sequence,Skin,rash,began,after,2,weeks,of,treatment,,,and,signs,of,hepatocellular,failure,developed,3,weeks,after,phenobarbital,had,been,started,. | |
| labels,5,7,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,injury to the urinary tract | |
| drug,sulfonamide | |
| sequence,Physicians,using,this,``,new,'',drug,must,be,aware,of,the,potential,danger,of,sulfonamide-induced,injury,to,the,urinary,tract,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,5,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,1,1,0,1,1,0 | |
| ==============================, ============================= | |
| ade,paresthesias | |
| drug,Ara-C | |
| sequence,Administration,of,intrathecal,Ara-C,in,the,same,dose,over,longer,intervals,within,3-5,days,between,consecutive,doses,resulted,in,mild,,,transient,neurological,symptoms,(,paresthesias,),in,only,one,of,30,patients,so,treated,. | |
| labels,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,exacerbation in myasthenic weakness | |
| drug,verapamil | |
| sequence,In,a,postoperative,patient,with,pre-existent,myasthenia,gravis,,,oral,verapamil,caused,a,marked,exacerbation,in,myasthenic,weakness,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,0,0,0,5,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,liver injury,cholestatic pattern of injury,damage to the interlobular bile ducts,ductopenia | |
| drug,Itraconazole | |
| sequence,CONCLUSIONS,:,Itraconazole-induced,liver,injury,presents,with,a,cholestatic,pattern,of,injury,with,damage,to,the,interlobular,bile,ducts,,,possibly,leading,to,ductopenia,. | |
| labels,0,0,4,5,7,0,0,0,5,6,6,7,0,5,6,6,6,6,7,0,0,0,0,8,0 | |
| ade_mask,0,0,0,1,1,0,0,0,1,1,1,0,0,1,1,1,1,1,1,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Reye-like syndrome | |
| drug,calcium hopantenate | |
| sequence,Reye-like,syndrome,following,treatment,with,the,pantothenic,acid,antagonist,,,calcium,hopantenate,. | |
| labels,5,7,0,0,0,0,0,0,0,0,1,3,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,recurrent eosinophilia,severe persistent bronchospasm | |
| drug,tobramycin | |
| sequence,CASE,PRESENTATION,:,We,report,a,patient,with,CF,who,developed,recurrent,eosinophilia,and,severe,persistent,bronchospasm,following,repeated,administration,of,preservative-free,tobramycin,by,inhalation,,,beginning,at,16,months,of,age,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,7,0,5,6,7,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombotic microangiopathy,TMA | |
| drug,quinine | |
| sequence,A,retrospective,review,of,TTP,patients,with,quinine-associated,thrombotic,microangiopathy,(,TMA,),for,whom,ADAMTS13,was,measured,before,plasma,exchange,was,performed,. | |
| labels,0,0,0,0,0,0,0,4,5,7,0,8,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cognitive impairments | |
| drug,amoxapine | |
| sequence,Two,patients,are,described,in,whom,subtle,cognitive,impairments,are,associated,with,therapeutic,doses,of,amoxapine,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Gelofusine allergy | |
| drug,Gelofusine | |
| sequence,Gelofusine,allergy,--,the,need,for,identification,jewellery,. | |
| labels,9,7,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperlactatemia | |
| drug,stavudine | |
| sequence,INTRODUCTION,:,In,resource,limited,settings,patients,on,antiretroviral,treatment,who,develop,stavudine,induced,hyperlactatemia,are,often,switched,to,zidovudine,on,the,basis,of,published,studies,that,demonstrate,that,this,agent,can,be,a,safe,alternative,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,leukopenia | |
| drug,L-T4 | |
| sequence,A,study,of,in,vitro,reactivity,to,L-T4,,,as,assessed,by,peripheral,blood,lymphocyte,transformation,,,was,carried,out,in,a,patient,with,Hashimoto,'s,disease,who,developed,leukopenia,during,treatment,with,L-T4,. | |
| labels,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Clostridium difficile toxin-induced colitis | |
| drug,clindamycin phosphate | |
| sequence,Clostridium,difficile,toxin-induced,colitis,after,use,of,clindamycin,phosphate,vaginal,cream,. | |
| labels,5,6,6,7,0,0,0,1,3,0,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,headache | |
| drug,Capecitabine | |
| sequence,Capecitabine-induced,headache,responding,to,diltiazem,. | |
| labels,4,8,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cataract,glaucoma | |
| drug,methylphenidate | |
| sequence,Large,dose,of,methylphenidate,may,cause,cataract,and,glaucoma,. | |
| labels,0,0,0,4,0,0,8,0,8,0 | |
| ade_mask,0,0,0,0,0,0,1,0,1,0 | |
| ==============================, ============================= | |
| ade,facial motor tics | |
| drug,CBZ | |
| sequence,We,report,3,children,with,epilepsy,who,developed,facial,motor,tics,after,initiation,of,CBZ,for,complex,partial,seizures,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,RSDS | |
| drug,tacrolimus | |
| sequence,We,now,present,four,cases,of,RSDS,in,kidney,transplant,recipients,treated,with,tacrolimus,. | |
| labels,0,0,0,0,0,0,8,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nonoliguric acute renal failure | |
| drug,captopril | |
| sequence,In,a,patient,with,severe,renovascular,hypertension,,,nonoliguric,acute,renal,failure,developed,after,she,received,captopril,treatment,. | |
| labels,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Erythema Multiforme Bullosum | |
| drug,Rifampicin | |
| sequence,A,case,of,Erythema,Multiforme,Bullosum,in,patient,of,lepromatous,leprosy,with,pulmonary,tuberculosis,due,to,Rifampicin,is,described,. | |
| labels,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,4,0,0,0 | |
| ade_mask,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute encephalopathy | |
| drug,calcium hopantenate | |
| sequence,A,case,of,the,Rett,syndrome,with,acute,encephalopathy,induced,during,calcium,hopantenate,treatment,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,1,3,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,gynaecomastia | |
| drug,sunitinib | |
| sequence,The,mechanism,by,which,sunitinib,induces,gynaecomastia,is,thought,to,be,associated,with,an,unknown,direct,action,on,breast,hormonal,receptors,. | |
| labels,0,0,0,0,4,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypercalciuria,hypercalcemia | |
| drug,tacalcitol | |
| sequence,We,experienced,a,male,patient,with,psoriasis,and,hypertension,whose,conditions,were,treated,with,tacalcitol,ointment,and,thiazide,,,respectively,,,resulting,in,hypercalciuria,and,hypercalcemia,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,0,0,0,0,0,8,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0 | |
| ==============================, ============================= | |
| ade,hypercalciuria,hypercalcemia | |
| drug,thiazide | |
| sequence,We,experienced,a,male,patient,with,psoriasis,and,hypertension,whose,conditions,were,treated,with,tacalcitol,ointment,and,thiazide,,,respectively,,,resulting,in,hypercalciuria,and,hypercalcemia,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,0,0,0,0,0,8,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0 | |
| ==============================, ============================= | |
| ade,Ulcer became worse | |
| drug,gentamycin | |
| sequence,Ulcer,became,worse,after,tobramycin,and,gentamycin,treatment,for,2,days,. | |
| labels,5,6,7,0,4,0,4,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Ulcer became worse | |
| drug,tobramycin | |
| sequence,Ulcer,became,worse,after,tobramycin,and,gentamycin,treatment,for,2,days,. | |
| labels,5,6,7,0,4,0,4,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatic VOD | |
| drug,tacrolimus | |
| sequence,One,case,of,tacrolimus-induced,hepatic,VOD,developing,after,lung,transplantation,(,LT,),has,been,recently,reported,. | |
| labels,0,0,0,4,5,7,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Visual hallucinations | |
| drug,zonisamide | |
| sequence,Visual,hallucinations,associated,with,zonisamide,. | |
| labels,5,7,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,swallowing dysfunction,pneumonia,ELP | |
| drug,mineral oil | |
| sequence,In,patients,with,swallowing,dysfunction,and,pneumonia,,,a,history,of,mineral,oil,use,should,be,obtained,and,a,diagnosis,of,ELP,should,be,considered,in,the,differential,diagnoses,if,mineral,oil,use,has,occurred,. | |
| labels,0,0,0,5,7,0,8,0,0,0,0,1,3,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,prostaglandin-mediated vasodilatation,hyperalgesia of sensory nerve receptors,potentiation of inflammation in the gingiva,pain to the teeth | |
| drug,niacin | |
| sequence,The,cause,of,these,previously,unreported,side,effects,of,niacin,therapy,is,uncertain,but,may,be,related,to,prostaglandin-mediated,vasodilatation,,,hyperalgesia,of,sensory,nerve,receptors,,,and,potentiation,of,inflammation,in,the,gingiva,with,referral,of,pain,to,the,teeth,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,5,7,0,5,6,6,6,7,0,0,5,6,6,6,6,7,0,0,0,5,6,6,7,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0,1,1,1,0,0,1,0,1,1,1,1,0,0,0,1,0,0,1,0 | |
| ==============================, ============================= | |
| ade,diarrhea | |
| drug,Flucytosine | |
| sequence,Flucytosine-associated,diarrhea,has,been,previously,described,in,6,%,-10,%,of,patients,receiving,the,drug,. | |
| labels,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nonconvulsive status epilepticus | |
| drug,ifosfamide | |
| sequence,CONCLUSIONS,:,There,was,a,temporal,relationship,between,the,onset,of,nonconvulsive,status,epilepticus,and,initiation,of,ifosfamide,infusion,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ectropion | |
| drug,5-FU | |
| sequence,Differential,diagnoses,included,ocular,rosacea,with,cicatrizing,conjunctivitis,and,5-FU-induced,ectropion,. | |
| labels,0,0,0,0,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,alterations in heart rate | |
| drug,adenosine | |
| sequence,Life-threatening,alterations,in,heart,rate,after,the,use,of,adenosine,in,atrial,flutter,. | |
| labels,0,5,6,6,7,0,0,0,0,4,0,0,0,0 | |
| ade_mask,0,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Cushing's syndrome | |
| drug,TCA | |
| sequence,The,presented,patient,was,treated,with,200,mg,TCA,and,developed,Cushing,'s,syndrome,6,weeks,later,(,cortisol,and,ACTH,concentrations,were,below,limits,of,detection,,,TCA,concentrations,were,>,3,micrograms,l,),. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Bronchiolitis obliterans with organizing pneumonia | |
| drug,rituximab | |
| sequence,Bronchiolitis,obliterans,with,organizing,pneumonia,after,rituximab,therapy,for,non-Hodgkin,'s,lymphoma,. | |
| labels,5,6,6,6,7,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,erythroderma | |
| drug,Dapsone | |
| sequence,Dapsone-induced,erythroderma,with,Beau,'s,lines,. | |
| labels,4,8,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Glaucoma | |
| drug,5-fluorouracil | |
| sequence,Glaucoma,secondary,to,epithelial,downgrowth,and,5-fluorouracil,. | |
| labels,8,0,0,0,0,0,4,0 | |
| ade_mask,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,interstitial nephritis | |
| drug,Ciprofloxacin | |
| sequence,Ciprofloxacin,is,one,drug,that,has,been,reported,to,cause,interstitial,nephritis,. | |
| labels,4,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,seizures | |
| drug,CBZ | |
| sequence,Continuous,EEG,monitoring,is,helpful,in,managing,seizures,that,occur,as,a,complication,of,CBZ,OD,,,after,the,course,of,recovery,or,worsening,,,and,in,providing,assistance,with,prognosis,. | |
| labels,0,0,0,0,0,0,0,8,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypokalemia | |
| drug,phosphate | |
| sequence,High-dose,phosphate,treatment,leads,to,hypokalemia,in,hypophosphatemic,osteomalacia,. | |
| labels,0,4,0,0,0,8,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Disulfiram-like reactions | |
| drug,cefmenoxime | |
| sequence,Disulfiram-like,reactions,with,newer,cephalosporins,:,cefmenoxime,. | |
| labels,5,7,0,0,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hallucinations,agitation,vomiting,tachycardia,seizures | |
| drug,bupropion | |
| sequence,The,patient,experienced,hallucinations,,,agitation,,,vomiting,,,tachycardia,and,seizures,after,ingestion,of,1050,(,48,mg,kg,),of,extended-release,bupropion,. | |
| labels,0,0,0,8,0,8,0,8,0,8,0,8,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,1,0,1,0,1,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Cutaneous ulceration | |
| drug,pentamidine | |
| sequence,Cutaneous,ulceration,:,an,unusual,complication,of,intravenous,pentamidine,therapy,. | |
| labels,5,7,0,0,0,0,0,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Palpable purpuric skin lesions | |
| drug,amphotericin B | |
| sequence,Palpable,purpuric,skin,lesions,on,the,anterior,surface,of,both,legs,appeared,on,the,55th,day,of,amphotericin,B,treatment,. | |
| labels,5,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,1,3,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,akathisia,neurotoxicity | |
| drug,interferon-alpha | |
| sequence,The,present,report,illustrates,a,rare,case,of,refractory,akathisia,after,interferon-alpha,treatment,and,also,that,levodopa,treatment,would,be,theoretically,and,practically,useful,in,reducing,the,neurotoxicity,associated,with,interferon-alpha,. | |
| labels,0,0,0,0,0,0,0,0,0,8,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cutaneous seeding | |
| drug,ethanol injection | |
| sequence,We,describe,a,case,of,needle-track,cutaneous,seeding,of,hepatocellular,carcinoma,(,HCC,),after,sonographically,guided,percutaneous,ethanol,injection,(,PEI,),. | |
| labels,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,1,3,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Neurotoxicity | |
| drug,methotrexate | |
| sequence,Neurotoxicity,of,intrathecal,methotrexate,:,MR,imaging,findings,. | |
| labels,8,0,0,4,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,vasculitis | |
| drug,cladribine | |
| sequence,Although,vasculitis,has,been,reported,in,the,course,of,hairy,cell,leukaemia,,,it,has,only,rarely,been,reported,as,the,consequence,of,cladribine,treatment,. | |
| labels,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute tubular necrosis | |
| drug,cefoxitin | |
| sequence,The,other,woman,had,rheumatoid,arthritis,and,developed,acute,tubular,necrosis,after,treatment,with,gentamicin,and,cefoxitin,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute tubular necrosis | |
| drug,gentamicin | |
| sequence,The,other,woman,had,rheumatoid,arthritis,and,developed,acute,tubular,necrosis,after,treatment,with,gentamicin,and,cefoxitin,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Syndrome of inappropriate secretion of ADH,SIADH | |
| drug,cisplatin | |
| sequence,Syndrome,of,inappropriate,secretion,of,ADH,(,SIADH,),following,cisplatin,administration,in,a,pulmonary,adenocarcinoma,patient,with,a,malignant,pleural,effusion,. | |
| labels,5,6,6,6,0,7,0,8,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatitis | |
| drug,Diclofenac | |
| sequence,Diclofenac-associated,hepatitis,. | |
| labels,4,8,0 | |
| ade_mask,0,1,0 | |
| ==============================, ============================= | |
| ade,Insulin-dependent diabetes mellitus | |
| drug,danazol | |
| sequence,Insulin-dependent,diabetes,mellitus,developed,in,a,young,woman,8,weeks,after,the,initiation,of,danazol,for,treatment,of,pelvic,endometriosis,. | |
| labels,5,6,7,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Fatal pulmonary fibrosis | |
| drug,1,3-bis(2-chloroethyl)-1-nitrosourea | |
| sequence,Fatal,pulmonary,fibrosis,following,1,3-bis,(,2-chloroethyl,),-1-nitrosourea,(,BCNU,),therapy,. | |
| labels,5,6,7,0,1,2,2,2,3,0,4,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Fatal pulmonary fibrosis | |
| drug,BCNU | |
| sequence,Fatal,pulmonary,fibrosis,following,1,3-bis,(,2-chloroethyl,),-1-nitrosourea,(,BCNU,),therapy,. | |
| labels,5,6,7,0,1,2,2,2,3,0,4,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pleuropulmonary abnormalities | |
| drug,bromocriptine | |
| sequence,A,patient,with,Parkinson,'s,disease,,,initially,treated,with,bromocriptine,and,subsequently,with,cabergoline,,,developed,progressive,pleuropulmonary,abnormalities,during,the,latter,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,0,0,0,4,0,0,0,5,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pleuropulmonary abnormalities | |
| drug,cabergoline | |
| sequence,A,patient,with,Parkinson,'s,disease,,,initially,treated,with,bromocriptine,and,subsequently,with,cabergoline,,,developed,progressive,pleuropulmonary,abnormalities,during,the,latter,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,0,0,0,4,0,0,0,5,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Intra-neural ceroid-like pigment | |
| drug,B663 | |
| sequence,Intra-neural,ceroid-like,pigment,following,the,treatment,of,lepromatous,leprosy,with,clofazimine,(,B663,;,Lamprene,),. | |
| labels,5,6,7,0,0,0,0,0,0,0,4,0,4,0,4,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Intra-neural ceroid-like pigment | |
| drug,clofazimine | |
| sequence,Intra-neural,ceroid-like,pigment,following,the,treatment,of,lepromatous,leprosy,with,clofazimine,(,B663,;,Lamprene,),. | |
| labels,5,6,7,0,0,0,0,0,0,0,4,0,4,0,4,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Intra-neural ceroid-like pigment | |
| drug,Lamprene | |
| sequence,Intra-neural,ceroid-like,pigment,following,the,treatment,of,lepromatous,leprosy,with,clofazimine,(,B663,;,Lamprene,),. | |
| labels,5,6,7,0,0,0,0,0,0,0,4,0,4,0,4,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Herpes simplex esophagitis | |
| drug,cyclosporine A | |
| sequence,Herpes,simplex,esophagitis,in,a,renal,transplant,patient,treated,with,cyclosporine,A,:,a,case,report,. | |
| labels,5,6,7,0,0,0,0,0,0,0,1,3,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hemiparesis,dysarthria,altered consciousness | |
| drug,HD-MTX | |
| sequence,This,patient,developed,sequential,symptoms,including,alternative,hemiparesis,,,dysarthria,and,altered,consciousness,5,days,after,the,second,course,of,HD-MTX,(,8,gm,m2,by,6,h,continuous,infusion,),with,leucovorin,rescue,. | |
| labels,0,0,0,0,0,0,0,8,0,8,0,5,7,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ANCA | |
| drug,PTU | |
| sequence,It,was,concluded,that,ANCA,is,closely,related,to,the,pathogenesis,of,crescentic,glomerulonephritis,and,that,treatment,with,PTU,appeared,to,induce,ANCA,. | |
| labels,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypoglycemia | |
| drug,doxycycline | |
| sequence,We,report,the,first,case,of,doxycycline-induced,hypoglycemia,in,a,young,nondiabetic,man,. | |
| labels,0,0,0,0,0,0,4,8,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,transient structured visual hallucinations | |
| drug,Avastin | |
| sequence,PURPOSE,:,To,describe,transient,structured,visual,hallucinations,in,a,patient,with,vascular,age-related,macular,degeneration,(,AMD,),,,following,an,intravitreal,Avastin-injection,. | |
| labels,0,0,0,0,5,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cataract,glaucoma | |
| drug,Ritalin | |
| sequence,We,report,a,case,of,Ritalin-associated,cataract,and,glaucoma,. | |
| labels,0,0,0,0,0,4,8,0,8,0 | |
| ade_mask,0,0,0,0,0,0,1,0,1,0 | |
| ==============================, ============================= | |
| ade,visual field loss | |
| drug,vigabatrin | |
| sequence,The,current,study,investigated,the,visual,fields,and,visual,electrophysiology,of,eight,patients,with,known,vigabatrin-attributed,visual,field,loss,,,three,of,whom,were,reported,previously,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,5,6,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypokalemic | |
| drug,albuterol | |
| sequence,The,cases,of,two,asthmatic,patients,who,became,hypokalemic,after,inhalation,of,normal,doses,of,albuterol,are,presented,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,large amounts of type I interferon production | |
| drug,imiquimod | |
| sequence,Since,imiquimod,induces,large,amounts,of,type,I,interferon,production,from,TLR7-expressing,plasmacytoid,dendritic,cell,precursors,(,PDCs,),,,the,natural,interferon-producing,cells,of,the,peripheral,blood,,,we,asked,whether,PDCs,are,present,in,psoriatic,skin,. | |
| labels,0,4,0,5,6,6,6,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fever | |
| drug,amifostine | |
| sequence,A,56-year-old,Caucasian,man,who,received,concomitant,chemotherapy,and,radiation,for,head,and,neck,cancer,developed,fever,concurrent,with,the,administration,of,amifostine,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombocytopenia | |
| drug,Danazol | |
| sequence,Danazol,induced,thrombocytopenia,. | |
| labels,4,0,8,0 | |
| ade_mask,0,0,1,0 | |
| ==============================, ============================= | |
| ade,life-threatening hypoglycaemia | |
| drug,sulfadoxine-pyrimethamine | |
| sequence,Case,report,:,life-threatening,hypoglycaemia,associated,with,sulfadoxine-pyrimethamine,,,a,commonly,used,antimalarial,drug,. | |
| labels,0,0,0,5,7,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe liver disease | |
| drug,ivermectin | |
| sequence,To,our,knowledge,,,this,is,the,first,case,of,ivermectin-induced,severe,liver,disease,published,in,the,literature,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,5,6,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,prolapse of the urethral mucosa | |
| drug,calcium hydroxylapatite | |
| sequence,Massive,prolapse,of,the,urethral,mucosa,following,periurethral,injection,of,calcium,hydroxylapatite,for,stress,urinary,incontinence,. | |
| labels,0,5,6,6,6,7,0,0,0,0,1,3,0,0,0,0,0 | |
| ade_mask,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatic adenomas | |
| drug,danazol | |
| sequence,We,report,the,case,of,a,female,acromegalic,patient,in,whom,multiple,hepatic,adenomas,appeared,soon,after,danazol,treatment,for,uterine,fibromatosis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,eruptive mollusca contagiosa | |
| drug,efalizumab | |
| sequence,We,report,a,45-year-old,psoriasis,patient,who,developed,eruptive,mollusca,contagiosa,during,an,antipsoriatic,treatment,with,efalizumab,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neuroleptic malignant extrapyramidal syndrome,lithium toxicity | |
| drug,lithium | |
| sequence,The,authors,postulate,that,two,types,of,combined,lithium-neuroleptic,toxicity,occur,:,a,neuroleptic,malignant,extrapyramidal,syndrome,and,a,lithium,toxicity,that,occurs,in,combination,with,phenothiazines,,,primarily,thioridazine,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,9,7,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,1,1,1,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neuroleptic malignant extrapyramidal syndrome,lithium toxicity | |
| drug,thioridazine | |
| sequence,The,authors,postulate,that,two,types,of,combined,lithium-neuroleptic,toxicity,occur,:,a,neuroleptic,malignant,extrapyramidal,syndrome,and,a,lithium,toxicity,that,occurs,in,combination,with,phenothiazines,,,primarily,thioridazine,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,9,7,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,1,1,1,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Fever,lymphadenopathy,eosinophilia,lymphocytosis,hepatitis,dermatitis | |
| drug,minocycline | |
| sequence,Fever,,,lymphadenopathy,,,eosinophilia,,,lymphocytosis,,,hepatitis,,,and,dermatitis,:,a,severe,adverse,reaction,to,minocycline,. | |
| labels,8,0,8,0,8,0,8,0,8,0,0,8,0,0,0,0,0,0,4,0 | |
| ade_mask,1,0,1,0,1,0,1,0,1,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Reversible cardiomyopathy | |
| drug,interferon alpha | |
| sequence,Reversible,cardiomyopathy,caused,by,administration,of,interferon,alpha,. | |
| labels,5,7,0,0,0,0,1,3,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,potential hazards | |
| drug,mineral oil | |
| sequence,Our,case,points,to,the,need,for,increased,awareness,by,the,general,pediatricians,of,the,potential,hazards,of,mineral,oil,use,for,chronic,constipation,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,1,3,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fatal outcome,nitrofurantoin induced BOOP | |
| drug,nitrofurantoin | |
| sequence,The,favourable,outcome,in,these,two,patients,contrasts,with,the,fatal,outcome,of,the,two,other,reported,cases,of,nitrofurantoin,induced,BOOP,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,9,6,7,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,generalized exanthem | |
| drug,Enoxaparin | |
| sequence,Enoxaparin-induced,generalized,exanthem,. | |
| labels,4,5,7,0 | |
| ade_mask,0,1,1,0 | |
| ==============================, ============================= | |
| ade,nephrotic syndrome | |
| drug,interferon-alpha | |
| sequence,We,herein,report,this,rare,case,of,acute,onset,of,nephrotic,syndrome,during,interferon-alpha,retreatment,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nodular sclerosing Hodgkin's lymphoma | |
| drug,infliximab | |
| sequence,The,second,is,a,29-year-old,man,with,CD,in,whom,nodular,sclerosing,Hodgkin,'s,lymphoma,was,diagnosed,3,weeks,after,infusion,with,infliximab,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,6,6,6,7,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rapidly progressive erythema,scaling,nausea,vomiting,fever | |
| drug,epoprostenol | |
| sequence,We,report,a,case,of,a,patient,with,pulmonary,hypertension,and,undifferentiated,connective,tissue,disease,who,,,after,2,months,of,treatment,with,epoprostenol,,,presented,with,rapidly,progressive,erythema,,,scaling,,,nausea,and,vomiting,,,and,fever,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,5,6,7,0,8,0,8,0,8,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0,1,0,1,0,0,1,0 | |
| ==============================, ============================= | |
| ade,hearing loss | |
| drug,Quinine | |
| sequence,Quinine-induced,hearing,loss,. | |
| labels,4,5,7,0 | |
| ade_mask,0,1,1,0 | |
| ==============================, ============================= | |
| ade,vitreous hemorrhage | |
| drug,tPA | |
| sequence,However,,,1,eye,had,vitreous,hemorrhage,after,repeated,injections,of,tPA,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Squamous-cell carcinoma | |
| drug,5-fluorouracil | |
| sequence,Squamous-cell,carcinoma,arising,in,a,basal-cell,epithelioma,treated,with,5-fluorouracil,. | |
| labels,5,7,0,0,0,0,0,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lithium toxicity | |
| drug,acyclovir | |
| sequence,Six,days,after,starting,acyclovir,she,exhibited,signs,of,lithium,toxicity,. | |
| labels,0,0,0,0,4,0,0,0,0,9,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,lithium toxicity | |
| drug,lithium | |
| sequence,Six,days,after,starting,acyclovir,she,exhibited,signs,of,lithium,toxicity,. | |
| labels,0,0,0,0,4,0,0,0,0,9,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Anaphylactic reaction | |
| drug,bacitracin | |
| sequence,Anaphylactic,reaction,to,bacitracin,ointment,. | |
| labels,5,7,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,agranulocytosis | |
| drug,Dipyrone | |
| sequence,Dipyrone,,,also,known,as,metamizole,,,is,an,analgesic,and,antipyretic,drug,that,was,banned,by,the,United,States,Food,and,Drug,Administration,because,of,its,association,with,agranulocytosis,. | |
| labels,4,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,agranulocytosis | |
| drug,metamizole | |
| sequence,Dipyrone,,,also,known,as,metamizole,,,is,an,analgesic,and,antipyretic,drug,that,was,banned,by,the,United,States,Food,and,Drug,Administration,because,of,its,association,with,agranulocytosis,. | |
| labels,4,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,severe akathisia | |
| drug,olanzapine | |
| sequence,We,report,on,three,patients,with,acute,schizophrenia,,,who,developed,severe,akathisia,during,treatment,with,olanzapine,(,20-25,mg,d,),. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,aseptic meningitis | |
| drug,SMX | |
| sequence,We,reviewed,the,literature,in,an,attempt,to,characterize,the,pattern,and,predictors,of,TMP,SMX-induced,aseptic,meningitis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,4,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,aseptic meningitis | |
| drug,TMP | |
| sequence,We,reviewed,the,literature,in,an,attempt,to,characterize,the,pattern,and,predictors,of,TMP,SMX-induced,aseptic,meningitis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,4,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Diabetes mellitus | |
| drug,Carbamazepine | |
| sequence,Carbamazepine-induced,Diabetes,mellitus,. | |
| labels,4,5,7,0 | |
| ade_mask,0,1,1,0 | |
| ==============================, ============================= | |
| ade,hyperphosphatemia | |
| drug,sodium biphosphate | |
| sequence,We,report,a,case,of,acute,hyperphosphatemia,secondary,to,rectal,administration,of,sodium,phosphate,and,sodium,biphosphate,(,Fleet,enema,),. | |
| labels,0,0,0,0,0,0,8,0,0,0,0,0,1,3,0,1,3,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperphosphatemia | |
| drug,sodium phosphate | |
| sequence,We,report,a,case,of,acute,hyperphosphatemia,secondary,to,rectal,administration,of,sodium,phosphate,and,sodium,biphosphate,(,Fleet,enema,),. | |
| labels,0,0,0,0,0,0,8,0,0,0,0,0,1,3,0,1,3,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thyrotoxicosis | |
| drug,amiodarone | |
| sequence,A,potential,role,for,renal,and,hepatic,impairment,in,the,observed,protracted,course,of,amiodarone-induced,thyrotoxicosis,is,suggested,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,drug eruption | |
| drug,AZA | |
| sequence,We,report,AZA-induced,drug,eruption,that,developed,in,two,cases,of,systemic,scleroderma,with,polymyositis,. | |
| labels,0,0,4,5,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,TEN | |
| drug,lamotrigine | |
| sequence,Administration,of,lamotrigine,,,especially,in,combination,with,valproic,acid,,,may,lead,to,the,development,of,TEN,. | |
| labels,0,0,4,0,0,0,0,0,1,3,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,TEN | |
| drug,valproic acid | |
| sequence,Administration,of,lamotrigine,,,especially,in,combination,with,valproic,acid,,,may,lead,to,the,development,of,TEN,. | |
| labels,0,0,4,0,0,0,0,0,1,3,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,nephrotoxicity | |
| drug,ciprofloxacin | |
| sequence,Multiple,mechanisms,for,ciprofloxacin-induced,nephrotoxicity,have,been,proposed,. | |
| labels,0,0,0,4,8,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Anterior ischemic optic neuropathy | |
| drug,interferon alfa | |
| sequence,Anterior,ischemic,optic,neuropathy,secondary,to,interferon,alfa,. | |
| labels,5,6,6,7,0,0,1,3,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,SJS,VBDS | |
| drug,ciprofloxacin | |
| sequence,We,report,a,case,of,a,patient,with,ciprofloxacin-induced,SJS,and,acute,onset,of,VBDS,,,and,reviewed,the,related,literature,. | |
| labels,0,0,0,0,0,0,0,0,4,8,0,0,0,0,8,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,penile fibrosis | |
| drug,papaverine | |
| sequence,We,report,a,case,of,penile,fibrosis,after,intracavernous,self-injection,of,a,combination,of,phentolamine,and,papaverine,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,penile fibrosis | |
| drug,phentolamine | |
| sequence,We,report,a,case,of,penile,fibrosis,after,intracavernous,self-injection,of,a,combination,of,phentolamine,and,papaverine,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Leiomyosarcoma | |
| drug,cyclophosphamide | |
| sequence,Leiomyosarcoma,in,urinary,bladder,after,cyclophosphamide,therapy,for,retinoblastoma,and,review,of,bladder,sarcomas,. | |
| labels,8,0,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ibuprofen intoxication | |
| drug,ibuprofen | |
| sequence,Presently,,,treatment,of,acute,ibuprofen,intoxication,with,complications,requires,supportive,therapy,until,the,symptoms,resolve,over,24,to,48,hours,. | |
| labels,0,0,0,0,0,9,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Pemphigus vulgaris | |
| drug,glibenclamide | |
| sequence,Pemphigus,vulgaris,precipitated,by,glibenclamide,therapy,. | |
| labels,5,7,0,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Photo-onycholysis | |
| drug,aripiprazole | |
| sequence,Photo-onycholysis,caused,by,olanzapine,and,aripiprazole,. | |
| labels,8,0,0,4,0,4,0 | |
| ade_mask,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Photo-onycholysis | |
| drug,olanzapine | |
| sequence,Photo-onycholysis,caused,by,olanzapine,and,aripiprazole,. | |
| labels,8,0,0,4,0,4,0 | |
| ade_mask,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Focal glomerulonephritis,interstitial nephritis | |
| drug,methicillin | |
| sequence,Focal,glomerulonephritis,and,interstitial,nephritis,in,methicillin-treated,,,heroin-related,infective,endocarditis,. | |
| labels,5,7,0,5,7,0,4,0,0,0,0,0 | |
| ade_mask,1,1,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,toxic epidermal necrolysis | |
| drug,ofloxacin | |
| sequence,OBJECTIVE,:,To,report,a,fatal,case,of,toxic,epidermal,necrolysis,in,a,man,who,was,treated,with,oral,ofloxacin,for,epididymitis,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,High-grade endometrial stromal sarcoma | |
| drug,tamoxifen | |
| sequence,High-grade,endometrial,stromal,sarcoma,after,tamoxifen,therapy,for,breast,cancer,. | |
| labels,5,6,6,7,0,4,0,0,0,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,visual changes,ocular effects | |
| drug,amiodarone | |
| sequence,While,both,amiodarone,and,digoxin,can,cause,permanent,visual,changes,,,the,ocular,effects,are,often,reversible,. | |
| labels,0,0,4,0,4,0,0,0,5,7,0,0,5,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,visual changes,ocular effects | |
| drug,digoxin | |
| sequence,While,both,amiodarone,and,digoxin,can,cause,permanent,visual,changes,,,the,ocular,effects,are,often,reversible,. | |
| labels,0,0,4,0,4,0,0,0,5,7,0,0,5,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Erythema multiforme | |
| drug,phenytoin | |
| sequence,Erythema,multiforme,associated,with,phenytoin,and,cranial,radiation,therapy,:,a,report,of,three,patients,and,review,of,the,literature,. | |
| labels,5,7,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,multiple skin cancers,nail changes | |
| drug,hydroxyurea | |
| sequence,CONCLUSIONS,:,We,report,this,case,of,the,concomitant,appearance,of,multiple,skin,cancers,and,nail,changes,associated,with,hydroxyurea,use,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,5,7,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Localized panniculitis,lipoatrophy | |
| drug,Copaxone | |
| sequence,Localized,panniculitis,and,subsequent,lipoatrophy,with,subcutaneous,glatiramer,acetate,(,Copaxone,),injection,for,the,treatment,of,multiple,sclerosis,. | |
| labels,5,7,0,0,8,0,0,1,3,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Localized panniculitis,lipoatrophy | |
| drug,glatiramer acetate | |
| sequence,Localized,panniculitis,and,subsequent,lipoatrophy,with,subcutaneous,glatiramer,acetate,(,Copaxone,),injection,for,the,treatment,of,multiple,sclerosis,. | |
| labels,5,7,0,0,8,0,0,1,3,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hemolytic uremic syndrome,HUS | |
| drug,Gemcitabine | |
| sequence,Gemcitabine,is,a,known,risk,factor,for,hemolytic,uremic,syndrome,(,HUS,),,,which,can,often,have,a,rapidly,fatal,clinical,course,despite,intervention,with,steroids,,,plasmapheresis,and,hemodialysis,. | |
| labels,4,0,0,0,0,0,0,5,6,7,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,akathisia | |
| drug,fluvoxamine | |
| sequence,However,,,the,occurrence,and,management,of,akathisia,induced,by,fluvoxamine,have,not,been,described,. | |
| labels,0,0,0,0,0,0,0,8,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,non-sustained polymorphic ventricular tachycardia | |
| drug,verapamil | |
| sequence,We,describe,two,cases,of,PSVT,that,changed,to,non-sustained,polymorphic,ventricular,tachycardia,after,administration,of,verapamil,. | |
| labels,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Severe hemolytic uremic syndrome | |
| drug,carboplatin | |
| sequence,Severe,hemolytic,uremic,syndrome,in,an,advanced,ovarian,cancer,patient,treated,with,carboplatin,and,gemcitabine,. | |
| labels,5,6,6,7,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Severe hemolytic uremic syndrome | |
| drug,gemcitabine | |
| sequence,Severe,hemolytic,uremic,syndrome,in,an,advanced,ovarian,cancer,patient,treated,with,carboplatin,and,gemcitabine,. | |
| labels,5,6,6,7,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Incomplete posterior hyaloid detachment | |
| drug,pegaptanib | |
| sequence,Incomplete,posterior,hyaloid,detachment,after,intravitreal,pegaptanib,injection,in,diabetic,macular,edema,. | |
| labels,5,6,6,7,0,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fever,skin eruptions,leukocytopenia,thrombocytopenia | |
| drug,sulfasalazine | |
| sequence,A,58-year-old,woman,with,rheumatoid,arthritis,(,RA,),developed,fever,,,skin,eruptions,,,leukocytopenia,,,and,thrombocytopenia,,,3,weeks,after,treatment,with,sulfasalazine,. | |
| labels,0,0,0,0,0,0,0,0,0,0,8,0,5,7,0,8,0,0,8,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,1,1,0,1,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bilateral pulmonary infiltrates | |
| drug,methotrexate | |
| sequence,Three,patients,received,respectively,190,mg,,,175,mg,,,and,196,mg,of,methotrexate,and,developed,bilateral,pulmonary,infiltrates,without,evidence,of,peripheral,blood,eosinophilia,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,5,6,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,choanal atresia,athelia,mental retardation | |
| drug,methimazole | |
| sequence,An,infant,girl,with,choanal,atresia,,,athelia,,,minor,anomalies,,,and,mild,to,moderate,mental,retardation,was,born,to,a,woman,treated,for,hyperthyroidism,throughout,pregnancy,with,methimazole,and,propranolol,. | |
| labels,0,0,0,0,5,7,0,8,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,choanal atresia,athelia,mental retardation | |
| drug,propranolol | |
| sequence,An,infant,girl,with,choanal,atresia,,,athelia,,,minor,anomalies,,,and,mild,to,moderate,mental,retardation,was,born,to,a,woman,treated,for,hyperthyroidism,throughout,pregnancy,with,methimazole,and,propranolol,. | |
| labels,0,0,0,0,5,7,0,8,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis,delirium,hyponatremia | |
| drug,caffeine | |
| sequence,The,clinical,course,suggests,that,caffeine,,,which,is,present,in,oolong,tea,,,was,mainly,responsible,for,the,rhabdomyolysis,as,well,as,the,delirium,,,although,severe,hyponatremia,has,been,reported,to,cause,rhabdomyolysis,on,rare,occasions,. | |
| labels,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,8,0,0,0,8,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pigmentation | |
| drug,tacrolimus | |
| sequence,The,relation,between,tacrolimus,treatment,and,staining,was,suggested,by,the,appearance,of,pigmentation,during,topical,tacrolimus,treatment,and,its,clinical,disappearance,when,treatment,was,stopped,. | |
| labels,0,0,0,4,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,chronic, watery diarrhea | |
| drug,lansoprazole | |
| sequence,A,57-year-old,man,developed,chronic,,,watery,diarrhea,four,weeks,after,Helicobacter,pylori,eradication,therapy,including,lansoprazole,followed,by,lansoprazole,monotherapy,for,gastroesophageal,reflux,disease,. | |
| labels,0,0,0,0,5,6,6,7,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myasthenic syndrome | |
| drug,statin | |
| sequence,A,few,recent,individual,case,reports,have,suggested,that,a,myasthenic,syndrome,may,be,associated,with,statin,treatment,,,but,this,association,is,not,well,described,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hemolytic reaction | |
| drug,oxaliplatin | |
| sequence,An,immediate,hemolytic,reaction,induced,by,repeated,administration,of,oxaliplatin,. | |
| labels,0,0,5,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute pancreatitis | |
| drug,betamethasone | |
| sequence,Can,roxithromycin,and,betamethasone,induce,acute,pancreatitis,?,A,case,report,. | |
| labels,0,4,0,4,0,5,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute pancreatitis | |
| drug,roxithromycin | |
| sequence,Can,roxithromycin,and,betamethasone,induce,acute,pancreatitis,?,A,case,report,. | |
| labels,0,4,0,4,0,5,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,eosinophilia | |
| drug,clozapine | |
| sequence,Drug-induced,eosinophilia,is,a,non-dose-dependent,side,effect,of,clozapine,. | |
| labels,0,8,0,0,0,0,0,0,4,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Linear IgA bullous dermatosis | |
| drug,carbamazepine | |
| sequence,Linear,IgA,bullous,dermatosis,occurring,after,carbamazepine,. | |
| labels,5,6,6,7,0,0,4,0 | |
| ade_mask,1,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neurotoxicity | |
| drug,HDARAC | |
| sequence,The,neurotoxicity,seen,with,HDARAC,is,dose-related,and,has,occurred,in,up,to,60,percent,of,treated,patients,. | |
| labels,0,8,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,oral lesions of PV | |
| drug,glibenclamide | |
| sequence,The,patient,described,in,this,paper,was,a,78-year-old,diabetic,man,who,developed,oral,lesions,of,PV,following,institution,of,glibenclamide,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Epstein-Barr virus-associated lymphoproliferative disorder | |
| drug,methotrexate | |
| sequence,Epstein-Barr,virus-associated,lymphoproliferative,disorder,in,a,patient,with,rheumatoid,arthritis,on,methotrexate,and,rofecoxib,:,idiosyncratic,reaction,or,pharmacogenetics,? | |
| labels,5,6,6,7,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Epstein-Barr virus-associated lymphoproliferative disorder | |
| drug,rofecoxib | |
| sequence,Epstein-Barr,virus-associated,lymphoproliferative,disorder,in,a,patient,with,rheumatoid,arthritis,on,methotrexate,and,rofecoxib,:,idiosyncratic,reaction,or,pharmacogenetics,? | |
| labels,5,6,6,7,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,corneal ulcers | |
| drug,moxifloxacin | |
| sequence,RESULTS,:,Both,cases,presented,here,describe,corneal,ulcers,that,persisted,and,showed,signs,of,worsening,during,weeks,of,frequent,topical,dosing,with,moxifloxacin,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,mild parkinsonian signs,camptocormia | |
| drug,olanzapine | |
| sequence,We,present,a,depressive,patient,who,developed,mild,parkinsonian,signs,and,camptocormia,after,the,introduction,of,olanzapine,. | |
| labels,0,0,0,0,0,0,0,5,6,7,0,8,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cardiomyopathy | |
| drug,doxorubicin | |
| sequence,Aggressive,management,of,doxorubicin-induced,cardiomyopathy,associated,with,low,doses,of,doxorubicin,. | |
| labels,0,0,0,0,8,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,tuberculous uveitis | |
| drug,etanercept | |
| sequence,DISCUSSION,:,To,our,knowledge,this,is,the,first,reported,case,of,tuberculous,uveitis,following,treatment,with,etanercept,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Choroidal hemorrhage | |
| drug,tissue plasminogen activator | |
| sequence,Choroidal,hemorrhage,associated,with,systemic,tissue,plasminogen,activator,. | |
| labels,5,7,0,0,0,1,2,3,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,type 1 diabetes mellitus | |
| drug,alpha-2b peginterferon | |
| sequence,A,51-year-old,man,developed,type,1,diabetes,mellitus,following,24,weeks,of,treatment,with,recombinant,alpha-2b,peginterferon,plus,ribavirin,for,chronic,hepatitis,C,. | |
| labels,0,0,0,0,5,6,6,7,0,0,0,0,0,0,0,1,3,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,type 1 diabetes mellitus | |
| drug,ribavirin | |
| sequence,A,51-year-old,man,developed,type,1,diabetes,mellitus,following,24,weeks,of,treatment,with,recombinant,alpha-2b,peginterferon,plus,ribavirin,for,chronic,hepatitis,C,. | |
| labels,0,0,0,0,5,6,6,7,0,0,0,0,0,0,0,1,3,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,muscle twitches,tremulousness,anxiety | |
| drug,foscarnet | |
| sequence,The,patient,experienced,muscle,twitches,,,tremulousness,,,and,anxiety,on,day,17,of,foscarnet,therapy,. | |
| labels,0,0,0,5,7,0,8,0,0,8,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,1,1,0,1,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Fatal pulmonary fibrosis | |
| drug,paclitaxel | |
| sequence,Fatal,pulmonary,fibrosis,induced,by,paclitaxel,:,a,case,report,and,review,of,the,literature,. | |
| labels,5,6,7,0,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,transient renal failure | |
| drug,MP | |
| sequence,Three,nephrotic,patients,who,had,reduced,renal,function,and,active,renal,disease,with,progressive,deterioration,of,renal,function,prior,to,the,use,of,MP,developed,transient,renal,failure,following,an,MP,pulse,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,5,6,7,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,squamous metaplasia | |
| drug,progestin | |
| sequence,RESULTS,:,Extensive,squamous,metaplasia,was,found,in,endometrial,glands,following,progestin,therapy,. | |
| labels,0,0,0,5,7,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,corneal deposits | |
| drug,amiodarone | |
| sequence,Biomicroscopy,revealed,amiodarone,corneal,deposits,. | |
| labels,0,0,4,5,7,0 | |
| ade_mask,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity pneumonitis | |
| drug,Flecainide | |
| sequence,Flecainide,is,a,rare,cause,of,hypersensitivity,pneumonitis,,,and,few,cases,have,been,reported,. | |
| labels,4,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe dermatologic toxicity,acute hypersensitivity reaction | |
| drug,MTX | |
| sequence,In,the,absence,of,mucositis,or,diarrhea,,,severe,dermatologic,toxicity,following,a,single,low,dose,of,the,drug,suggests,an,allergic,or,acute,hypersensitivity,reaction,to,MTX,in,this,patient,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Severe respiratory syncytial virus pulmonary infection | |
| drug,fludarabine | |
| sequence,Severe,respiratory,syncytial,virus,pulmonary,infection,in,a,patient,treated,with,fludarabine,for,chronic,lymphocytic,leukemia,. | |
| labels,5,6,6,6,6,7,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,corneal endothelial deposits | |
| drug,rifabutin | |
| sequence,PURPOSE,:,The,aim,of,this,study,was,to,report,on,the,possible,development,of,corneal,endothelial,deposits,resulting,from,the,use,of,rifabutin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,retinopathy | |
| drug,Tamoxifen | |
| sequence,Tamoxifen,retinopathy,. | |
| labels,4,8,0 | |
| ade_mask,0,1,0 | |
| ==============================, ============================= | |
| ade,Cardiac toxicity | |
| drug,BCNU | |
| sequence,Cardiac,toxicity,related,to,BCNU,has,not,been,described,well,. | |
| labels,5,7,0,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rapidly progressive glomerulonephritis | |
| drug,D-penicillamine | |
| sequence,The,9,other,reported,cases,of,D-penicillamine,induced,rapidly,progressive,glomerulonephritis,have,been,reviewed,. | |
| labels,0,0,0,0,0,0,4,0,5,6,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypercalcemia | |
| drug,thiazide | |
| sequence,The,present,case,is,the,first,report,of,hypercalcemia,induced,by,vitamin,D3,ointment,and,thiazide,simultaneously,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,1,3,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypercalcemia | |
| drug,vitamin D3 | |
| sequence,The,present,case,is,the,first,report,of,hypercalcemia,induced,by,vitamin,D3,ointment,and,thiazide,simultaneously,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,1,3,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Staphylococcus aureus knee arthritis | |
| drug,corticosteroids | |
| sequence,One,patient,was,an,80-year-old,woman,who,was,admitted,for,Staphylococcus,aureus,knee,arthritis,after,several,intraarticular,injections,of,sodium,hyaluronate,and,corticosteroids,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,1,3,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Staphylococcus aureus knee arthritis | |
| drug,sodium hyaluronate | |
| sequence,One,patient,was,an,80-year-old,woman,who,was,admitted,for,Staphylococcus,aureus,knee,arthritis,after,several,intraarticular,injections,of,sodium,hyaluronate,and,corticosteroids,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,1,3,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anaphylactoid reaction | |
| drug,methylprednisolone | |
| sequence,A,further,case,of,anaphylactoid,reaction,to,methylprednisolone,is,reported,. | |
| labels,0,0,0,0,5,7,0,4,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hypogammaglobulinemia | |
| drug,gold | |
| sequence,Hypogammaglobulinemia,associated,with,gold,therapy,:,evidence,for,a,partial,maturation,blockade,of,B,cells,. | |
| labels,8,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,RLS symptoms | |
| drug,olanzapine | |
| sequence,The,fourth,patient,showed,RLS,symptoms,that,were,initially,caused,by,a,20-mg,daily,olanzapine,dosage,and,were,later,mitigated,when,olanzapine,was,reduced,and,ropinirole,was,administered,. | |
| labels,0,0,0,0,5,7,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,dystonia | |
| drug,risperidone | |
| sequence,The,cases,are,important,in,documenting,that,drug-induced,dystonias,do,occur,in,patients,with,dementia,,,that,risperidone,appears,to,have,contributed,to,dystonia,among,elderly,patients,,,and,that,the,categorization,of,dystonic,reactions,needs,further,clarification,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatotoxicity,(sub)fulminant hepatitis,cirrhosis | |
| drug,benzarone | |
| sequence,Our,cases,constitute,the,most,severe,cases,of,benzarone,hepatotoxicity,reported,so,far,,,and,comprise,the,first,cases,of,(,sub,),fulminant,hepatitis,and,cirrhosis,related,to,benzarone,. | |
| labels,0,0,0,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0,5,6,6,6,7,0,8,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,generalized rash,itching,sore throat,dizziness | |
| drug,capecitabine | |
| sequence,She,developed,a,generalized,rash,and,itching,,,sore,throat,,,and,dizziness,approximately,4,hours,after,the,first,dose,of,capecitabine,. | |
| labels,0,0,0,5,7,0,8,0,5,7,0,0,8,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,1,1,0,1,0,1,1,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,carbamazepine toxicity | |
| drug,carbamazepine | |
| sequence,Protease,inhibitor-induced,carbamazepine,toxicity,. | |
| labels,0,0,9,7,0 | |
| ade_mask,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,TD | |
| drug,clozapine | |
| sequence,However,,,several,case,reports,have,suggested,that,clozapine,could,also,cause,TD,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Vogt-Koyanagi-Harada disease | |
| drug,interferon alpha | |
| sequence,Vogt-Koyanagi-Harada,disease,occurring,during,interferon,alpha,therapy,for,chronic,hepatitis,C,. | |
| labels,5,7,0,0,1,3,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pulmonary fibrosis | |
| drug,nitrofurantoin | |
| sequence,A,chronic,reaction,associated,with,long-term,treatment,with,nitrofurantoin,has,also,been,reported,and,causes,irreversible,pulmonary,fibrosis,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,positive U waves | |
| drug,phenylephrine | |
| sequence,While,on,a,maximal,dose,of,phenylephrine,she,developed,prominent,positive,U,waves,,,which,disappeared,with,the,cessation,of,the,drug,. | |
| labels,0,0,0,0,0,0,4,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,skin necrosis | |
| drug,low-molecular weight heparin | |
| sequence,We,describe,a,patient,with,the,antiphospholipid,syndrome,who,had,skin,necrosis,develop,from,low-molecular,weight,heparin,therapy,at,sites,distant,from,injection,sites,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,0,1,2,3,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Pulmonary fibrosis | |
| drug,BCNU | |
| sequence,Pulmonary,fibrosis,is,a,severe,complication,associated,with,bis-chloronitrosourea,(,BCNU,),therapy,. | |
| labels,5,7,0,0,0,0,0,0,4,0,4,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Pulmonary fibrosis | |
| drug,bis-chloronitrosourea | |
| sequence,Pulmonary,fibrosis,is,a,severe,complication,associated,with,bis-chloronitrosourea,(,BCNU,),therapy,. | |
| labels,5,7,0,0,0,0,0,0,4,0,4,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cutaneous and hematologic toxicity | |
| drug,IL-2 | |
| sequence,OBJECTIVE,:,To,report,a,case,of,cutaneous,and,hematologic,toxicity,in,a,patient,treated,with,IL-2,. | |
| labels,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,interstitial pneumonia | |
| drug,sorafenib | |
| sequence,However,,,a,recent,post-marketing,survey,in,Japan,revealed,that,interstitial,pneumonia,occurred,in,4,among,approximately,2,000,Japanese,patients,treated,with,sorafenib,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Severe hypo-alpha-lipoproteinemia | |
| drug,rosiglitazone | |
| sequence,Severe,hypo-alpha-lipoproteinemia,during,treatment,with,rosiglitazone,. | |
| labels,5,7,0,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,extensive skin rash | |
| drug,MTX | |
| sequence,Development,of,an,extensive,skin,rash,following,a,single,dose,of,MTX,may,be,an,early,warning,sign,for,life-threatening,bone,marrow,aplasia,. | |
| labels,0,0,0,5,6,7,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,weight loss | |
| drug,leflunomide | |
| sequence,CONCLUSION,:,Significant,weight,loss,is,a,potential,adverse,event,in,patients,with,rheumatoid,arthritis,treated,with,leflunomide,. | |
| labels,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,leukopenia,agranulocytosis,cutaneous eruptions,peripheral neuropathy,psychosis,toxic hepatitis,cholestatic jaundice,nephrotic syndrome,renal papillary necrosis,severe hypoalbuminemia without proteinuria,an infectious mononucleosis-like syndrome,minor neurological and gastrointestinal complaints | |
| drug,dapsone | |
| sequence,Less,common,adverse,events,to,dapsone,include,the,idiosyncratic,reactions,of,leukopenia,and,agranulocytosis,,,cutaneous,eruptions,,,peripheral,neuropathy,,,psychosis,,,toxic,hepatitis,,,cholestatic,jaundice,,,nephrotic,syndrome,,,renal,papillary,necrosis,,,severe,hypoalbuminemia,without,proteinuria,,,an,infectious,mononucleosis-like,syndrome,,,and,minor,neurological,and,gastrointestinal,complaints,. | |
| labels,0,0,0,0,0,4,0,0,0,0,0,8,0,8,0,5,7,0,5,7,0,8,0,5,7,0,5,7,0,5,7,0,5,6,7,0,5,6,6,7,0,5,6,6,7,0,0,5,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,1,0,1,1,0,1,0,1,1,0,1,1,0,1,1,0,1,1,1,0,1,1,1,1,0,1,1,1,0,0,0,1,1,0,1,1,0 | |
| ==============================, ============================= | |
| ade,hypoglycaemic coma | |
| drug,para-aminosalicylic acid | |
| sequence,The,introduction,of,para-aminosalicylic,acid,(,PAS,),led,to,hypoglycaemic,coma,. | |
| labels,0,0,0,1,3,0,4,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,hypoglycaemic coma | |
| drug,PAS | |
| sequence,The,introduction,of,para-aminosalicylic,acid,(,PAS,),led,to,hypoglycaemic,coma,. | |
| labels,0,0,0,1,3,0,4,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,gynecomastia | |
| drug,theophylline | |
| sequence,No,other,endogenous,or,exogenous,cause,for,the,gynecomastia,could,be,found,except,for,the,theophylline,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,damage to the urinary tract | |
| drug,ketamine | |
| sequence,Can,ketamine,prescribed,for,pain,cause,damage,to,the,urinary,tract,? | |
| labels,0,4,0,0,0,0,5,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,thrombosis | |
| drug,heparin | |
| sequence,When,thrombosis,develops,during,heparin,treatment,,,it,is,important,to,suspect,HITTs,and,to,assay,for,the,associated,antibodies,,,regardless,of,the,actual,platelet,count,. | |
| labels,0,8,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,toxic myelopathy | |
| drug,doxorubicin | |
| sequence,STUDY,DESIGN,:,Case,report,of,a,31-year-old,woman,who,presented,with,toxic,myelopathy,due,to,intrathecal,administration,of,doxorubicin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,steroid diabetes | |
| drug,methylprednisolone | |
| sequence,After,five,and,six,weeks,of,continuous,oral,administration,of,methylprednisolone,,,the,boys,developed,steroid,diabetes,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,acute cytolytic hepatitis,hepatitis | |
| drug,itraconazole | |
| sequence,OBJECTIVE,:,To,report,the,occurrence,of,acute,cytolytic,hepatitis,in,a,patient,exposed,to,pulse,itraconazole,therapy,for,24,weeks,and,provide,a,concise,review,of,the,literature,on,cases,of,itraconazole-induced,hepatitis,. | |
| labels,0,0,0,0,0,0,0,5,6,8,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Neutrophilic eccrine hidradenitis | |
| drug,cyclophosphamide | |
| sequence,Neutrophilic,eccrine,hidradenitis,mimicking,cutaneous,vasculitis,in,a,lupus,patient,:,a,complication,of,cyclophosphamide,. | |
| labels,5,6,7,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hallucinations | |
| drug,interferon | |
| sequence,METHOD,:,The,authors,followed,a,patient,with,chronic,HCV,who,received,interferon,and,ribavirin,and,who,developed,hallucinations,ultimately,requiring,psychiatric,hospitalization,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,8,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hallucinations | |
| drug,ribavirin | |
| sequence,METHOD,:,The,authors,followed,a,patient,with,chronic,HCV,who,received,interferon,and,ribavirin,and,who,developed,hallucinations,ultimately,requiring,psychiatric,hospitalization,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,8,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,transient intraoperative hypertension | |
| drug,epinephrine | |
| sequence,The,other,patient,developed,transient,intraoperative,hypertension,immediately,after,inadvertent,submucosal,injection,of,concentrated,epinephrine,. | |
| labels,0,0,0,0,5,6,7,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Atrial fibrillation | |
| drug,vardenafil | |
| sequence,Atrial,fibrillation,after,vardenafil,therapy,. | |
| labels,5,7,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nonthrombocytopenic palpable purpura | |
| drug,metoclopramide | |
| sequence,Reversible,nonthrombocytopenic,palpable,purpura,associated,with,metoclopramide,. | |
| labels,0,5,6,7,0,0,4,0 | |
| ade_mask,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,BOOP | |
| drug,rituximab | |
| sequence,Moreover,,,these,findings,suggest,that,the,incidence,of,BOOP,following,rituximab,therapy,may,be,higher,than,has,been,previously,appreciated,. | |
| labels,0,0,0,0,0,0,0,0,0,8,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute amnestic episode | |
| drug,clioquinol | |
| sequence,Five,personal,observations,of,an,acute,amnestic,episode,in,younger,individuals,after,intake,of,clioquinol,are,described,together,with,three,observations,from,the,medical,literature,. | |
| labels,0,0,0,0,0,5,6,7,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cardiac toxicity,ventricular arrhythmias,bradycardia | |
| drug,Amphotericin B deoxycholate | |
| sequence,DISCUSSION,:,Amphotericin,B,deoxycholate,has,been,reported,to,produce,significant,cardiac,toxicity,,,with,ventricular,arrhythmias,and,bradycardia,reported,in,overdoses,in,children,and,in,adults,with,preexisting,cardiac,disease,,,even,when,administered,in,conventional,dosages,and,infusion,rates,. | |
| labels,0,0,1,2,3,0,0,0,0,0,0,5,7,0,0,5,7,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,carcinoma of the corpus uteri | |
| drug,tamoxifen | |
| sequence,Data,have,been,published,regarding,the,possibility,that,tamoxifen,may,be,responsible,for,the,subsequent,development,of,carcinoma,of,the,corpus,uteri,in,these,patients,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,5,6,6,6,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Anterior spinal artery syndrome | |
| drug,phenol | |
| sequence,Anterior,spinal,artery,syndrome,--,a,complication,of,cervical,intrathecal,phenol,injection,. | |
| labels,5,6,6,7,0,0,0,0,0,0,4,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypothyroidism | |
| drug,radioiodine | |
| sequence,Except,hypothyroidism,after,radioiodine,treatment,(,euthyroid,under,substitutional,therapy,),,,she,suffered,from,no,other,diseases,. | |
| labels,0,8,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,monocytosis | |
| drug,G-CSF | |
| sequence,We,describe,a,patient,with,M4,AML,treated,with,standard,chemotherapy,followed,by,G-CSF,who,developed,marked,monocytosis,on,day,8,of,G-CSF,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,8,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hepatitis | |
| drug,cimetidine | |
| sequence,Hepatitis,following,cimetidine,administration,. | |
| labels,8,0,4,0,0 | |
| ade_mask,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatitis | |
| drug,octreotide | |
| sequence,We,report,on,a,patient,with,acromegaly,who,developed,severe,drug-induced,hepatitis,during,combined,treatment,with,the,long-acting,somatostatin-analog,octreotide,and,the,GH,receptor,antagonist,pegvisomant,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,4,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatitis | |
| drug,pegvisomant | |
| sequence,We,report,on,a,patient,with,acromegaly,who,developed,severe,drug-induced,hepatitis,during,combined,treatment,with,the,long-acting,somatostatin-analog,octreotide,and,the,GH,receptor,antagonist,pegvisomant,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,4,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Dermatitis | |
| drug,captopril | |
| sequence,Dermatitis,to,captopril,. | |
| labels,8,0,4,0 | |
| ade_mask,1,0,0,0 | |
| ==============================, ============================= | |
| ade,PSA continued to decrease | |
| drug,flutamide | |
| sequence,We,describe,a,patient,with,androgen-independent,prostate,cancer,in,whom,PSA,continued,to,decrease,for,a,period,of,15,months,after,flutamide,withdrawal,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperammonemia,mental status changes | |
| drug,valproate | |
| sequence,The,authors,describe,valproate-induced,hyperammonemia,and,mental,status,changes,in,an,88-year-old,man,,,the,first,known,reported,case,in,an,elderly,patient,. | |
| labels,0,0,0,4,8,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Reversible corneal keratinization | |
| drug,5-fluorouracil | |
| sequence,Reversible,corneal,keratinization,following,trabeculectomy,and,treatment,with,5-fluorouracil,. | |
| labels,5,6,7,0,0,0,0,0,4,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,congestive heart failure,liver failure,haemosiderosis | |
| drug,desferrioxamine | |
| sequence,She,died,within,six,weeks,of,developing,congestive,heart,failure,coupled,with,liver,failure,due,to,haemosiderosis,despite,regular,use,of,desferrioxamine,. | |
| labels,0,0,0,0,0,0,0,5,6,7,0,0,5,7,0,0,8,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,1,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nonconvulsive status epilepticus | |
| drug,ifosfamide | |
| sequence,This,represents,the,first,report,of,nonconvulsive,status,epilepticus,induced,by,ifosfamide,. | |
| labels,0,0,0,0,0,0,5,6,7,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Extensive forearm deep venous thrombosis | |
| drug,infliximab | |
| sequence,Extensive,forearm,deep,venous,thrombosis,following,a,severe,infliximab,infusion,reaction,. | |
| labels,5,6,6,6,7,0,0,0,4,0,0,0 | |
| ade_mask,1,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neuromuscular block | |
| drug,magnesium | |
| sequence,We,also,describe,a,new,,,noninvasive,method,to,assess,magnesium-induced,neuromuscular,block,when,curariform,muscle,relaxant,was,given,simultaneously,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,5,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity | |
| drug,carboplatin | |
| sequence,This,regimen,could,prove,useful,for,other,patients,who,develop,hypersensitivity,reactions,to,carboplatin,and,allow,therapy,to,continue,. | |
| labels,0,0,0,0,0,0,0,0,0,0,8,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cough | |
| drug,quinapril | |
| sequence,OBJECTIVE,:,To,report,a,case,of,chronic,,,nonproductive,cough,secondary,to,the,angiotensin-converting,enzyme,(,ACE,),inhibitor,quinapril,,,with,complete,resolution,after,switching,to,another,ACE,inhibitor,,,fosinopril,. | |
| labels,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe cholestasis | |
| drug,oxacillin | |
| sequence,Prolonged,severe,cholestasis,induced,by,oxacillin,derivatives,. | |
| labels,0,5,7,0,0,4,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Localized purpura | |
| drug,lamotrigine | |
| sequence,Localized,purpura,associated,with,lamotrigine,. | |
| labels,5,7,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,angioedema | |
| drug,losartan | |
| sequence,CONCLUSIONS,:,This,case,suggests,that,losartan,can,induce,late-onset,angioedema,in,patients,with,normal,renal,function,and,that,the,reaction,can,recur,after,initial,resolution,of,the,symptoms,. | |
| labels,0,0,0,0,0,0,4,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,CIPS | |
| drug,cyclosporine | |
| sequence,In,this,case,,,CIPS,was,considered,to,be,probably,associated,with,cyclosporine,according,to,the,Naranjo,probability,scale,. | |
| labels,0,0,0,0,8,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute oliguric renal failure | |
| drug,PI | |
| sequence,We,describe,a,63,year,old,woman,with,a,suppurative,mediastinitis,,,treated,with,continuous,PI,irrigation,who,developed,an,acute,oliguric,renal,failure,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,5,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,liver injury | |
| drug,itraconazole | |
| sequence,METHODS,:,Three,patients,with,apparent,itraconazole-induced,liver,injury,were,studied,. | |
| labels,0,0,0,0,0,0,4,5,7,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,membranous nephropathy | |
| drug,infliximab | |
| sequence,This,report,describes,a,probable,case,of,infliximab-induced,membranous,nephropathy,. | |
| labels,0,0,0,0,0,0,0,4,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,impair mucociliary transport | |
| drug,Mineral oil | |
| sequence,Mineral,oil,,,a,hydrocarbon,,,may,not,elicit,a,normal,protective,cough,reflex,and,may,impair,mucociliary,transport,. | |
| labels,1,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,Pure red cell aplasia | |
| drug,fenoprofen | |
| sequence,Pure,red,cell,aplasia,associated,with,fenoprofen,. | |
| labels,5,6,6,7,0,0,4,0 | |
| ade_mask,1,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thyrotoxicosis | |
| drug,lithium | |
| sequence,Four,Chinese,female,patients,who,suffered,from,manic-depressive,disorder,and,underlying,autoimmune,thyroiditis,developed,transient,episodes,of,thyrotoxicosis,during,maintenance,lithium,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Aluminum intoxication,TC | |
| drug,Aluminum | |
| sequence,Aluminum,intoxication,,,along,with,other,factors,,,was,considered,to,be,the,cause,of,TC,development,. | |
| labels,9,7,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0 | |
| ==============================, ============================= | |
| ade,spontaneous splenic infarction | |
| drug,sumatriptan | |
| sequence,We,report,a,patient,who,developed,spontaneous,splenic,infarction,after,the,use,of,sumatriptan,for,the,treatment,of,migraine,headache,. | |
| labels,0,0,0,0,0,0,5,6,7,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lupus erythematosus | |
| drug,Sulfasalazine | |
| sequence,Sulfasalazine-induced,lupus,erythematosus,. | |
| labels,4,5,7,0 | |
| ade_mask,0,1,1,0 | |
| ==============================, ============================= | |
| ade,acute generalized exanthematous pustulosis,AGEP | |
| drug,nimesulide | |
| sequence,We,report,a,case,of,acute,generalized,exanthematous,pustulosis,(,AGEP,),in,a,50-year-old,woman,that,was,attributed,to,the,ingestion,of,nimesulide,. | |
| labels,0,0,0,0,0,5,6,6,7,0,8,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,NEH | |
| drug,cytarabine | |
| sequence,We,describe,a,patient,who,developed,NEH,on,three,separate,occasions,provoked,by,two,different,chemotherapeutic,agents,--,cytarabine,and,mitoxantrone,. | |
| labels,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,NEH | |
| drug,mitoxantrone | |
| sequence,We,describe,a,patient,who,developed,NEH,on,three,separate,occasions,provoked,by,two,different,chemotherapeutic,agents,--,cytarabine,and,mitoxantrone,. | |
| labels,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Cardiac arrest | |
| drug,esmolol | |
| sequence,Cardiac,arrest,after,esmolol,administration,:,a,review,of,acute,beta-blocker,toxicity,. | |
| labels,5,7,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,tardive OGC | |
| drug,clozapine | |
| sequence,Surprisingly,,,we,found,that,three,patients,appeared,to,develop,tardive,OGC,while,taking,clozapine,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,painful, oedematous, cyanosed hand | |
| drug,diamorphine | |
| sequence,A,patient,presented,with,a,painful,,,oedematous,,,cyanosed,hand,having,injected,a,solution,of,diamorphine,and,methylphenidate,into,his,radial,artery,. | |
| labels,0,0,0,0,0,5,6,6,0,6,7,0,0,0,0,0,4,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,painful, oedematous, cyanosed hand | |
| drug,methylphenidate | |
| sequence,A,patient,presented,with,a,painful,,,oedematous,,,cyanosed,hand,having,injected,a,solution,of,diamorphine,and,methylphenidate,into,his,radial,artery,. | |
| labels,0,0,0,0,0,5,6,6,0,6,7,0,0,0,0,0,4,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute interstitial nephritis | |
| drug,pantoprazole | |
| sequence,OBJECTIVE,:,To,describe,what,is,believed,,,as,of,November,4,,,2003,,,to,be,the,first,case,published,in,the,literature,of,acute,interstitial,nephritis,(,AIN,),due,to,pantoprazole,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,jaundice,marked increase in serum transaminase levels,fall in prothrombin time,severe centrilobular necrosis | |
| drug,amiodarone | |
| sequence,After,therapy,with,parenteral,amiodarone,(,2300,mg,in,3,days,),and,other,measures,,,signs,of,congestive,heart,failure,disappeared,;,subsequently,the,patient,developed,jaundice,,,marked,increase,in,serum,transaminase,levels,and,fall,in,prothrombin,time,,,and,histologic,changes,of,severe,centrilobular,necrosis,were,observed,in,hepatic,biopsy,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,5,6,6,6,6,7,0,5,6,6,7,0,0,0,0,0,5,6,7,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,0,1,1,1,0,1,0,1,1,0,0,0,0,0,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Brugada type electrocardiographic changes | |
| drug,lithium | |
| sequence,Brugada,type,electrocardiographic,changes,induced,by,concomitant,use,of,lithium,and,propafenone,in,patient,with,Wolff-Parkinson-White,syndrome,. | |
| labels,5,6,6,7,0,0,0,0,0,4,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Brugada type electrocardiographic changes | |
| drug,propafenone | |
| sequence,Brugada,type,electrocardiographic,changes,induced,by,concomitant,use,of,lithium,and,propafenone,in,patient,with,Wolff-Parkinson-White,syndrome,. | |
| labels,5,6,6,7,0,0,0,0,0,4,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Balint syndrome,posterior leukoencephalopathy | |
| drug,cytarabine | |
| sequence,The,authors,report,a,case,of,Balint,syndrome,with,irreversible,posterior,leukoencephalopathy,on,MRI,following,intrathecal,methotrexate,and,cytarabine,. | |
| labels,0,0,0,0,0,0,5,7,0,0,5,7,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Balint syndrome,posterior leukoencephalopathy | |
| drug,methotrexate | |
| sequence,The,authors,report,a,case,of,Balint,syndrome,with,irreversible,posterior,leukoencephalopathy,on,MRI,following,intrathecal,methotrexate,and,cytarabine,. | |
| labels,0,0,0,0,0,0,5,7,0,0,5,7,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,vincristine neurotoxicity | |
| drug,Itraconazole | |
| sequence,Itraconazole-related,increased,vincristine,neurotoxicity,:,case,report,and,review,of,literature,. | |
| labels,4,0,9,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,vincristine neurotoxicity | |
| drug,vincristine | |
| sequence,Itraconazole-related,increased,vincristine,neurotoxicity,:,case,report,and,review,of,literature,. | |
| labels,4,0,9,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,negative myoclonus | |
| drug,pregabalin | |
| sequence,We,describe,a,patient,who,,,after,receiving,his,first,dose,of,pregabalin,to,relieve,neuropathic,pain,,,presented,with,a,negative,myoclonus,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,ocular hypertension | |
| drug,ranibizumab | |
| sequence,BACKGROUND,:,To,describe,the,occurrence,of,ocular,hypertension,in,four,patients,following,injection,of,ranibizumab,intravitreally,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperkalemia | |
| drug,Heparin | |
| sequence,Heparin-induced,hyperkalemia,. | |
| labels,4,8,0 | |
| ade_mask,0,1,0 | |
| ==============================, ============================= | |
| ade,psychotic symptoms,intense anxiety,neurotoxicity | |
| drug,lithium | |
| sequence,When,the,acute,manic,state,is,characterized,by,marked,psychotic,symptoms,and,intense,anxiety,,,it,may,be,associated,with,increased,vulnerability,to,the,development,of,severe,lithium,neurotoxicity,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Pemphigus foliaceus | |
| drug,rifampicin | |
| sequence,Pemphigus,foliaceus,induced,by,rifampicin,. | |
| labels,5,7,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Skin necrosis | |
| drug,vasopressin | |
| sequence,Skin,necrosis,after,extravasation,of,low-dose,vasopressin,administered,for,septic,shock,. | |
| labels,5,7,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fatal pulmonary fibrosis | |
| drug,CCNU | |
| sequence,Two,patients,treated,for,chronic,myeloid,leukemia,with,high,doses,of,CCNU,(,1100,mg,m2,and,1240,mg,m2,,,respectively,),developed,a,fatal,pulmonary,fibrosis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,acute renal insufficiency | |
| drug,ciprofloxacin | |
| sequence,We,report,two,young,patients,with,cystic,fibrosis,who,presented,with,acute,renal,insufficiency,after,2-3,weeks,of,oral,ciprofloxacin,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cardiac arrhythmia | |
| drug,amphotericin B | |
| sequence,Correction,of,serum,electrolyte,imbalance,prevents,cardiac,arrhythmia,during,amphotericin,B,administration,. | |
| labels,0,0,0,0,0,0,5,7,0,1,3,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,mortality rate <3 | |
| drug,IL-2 | |
| sequence,Subcutaneous,IL-2,is,safe,and,well,tolerated,,,with,a,mortality,rate,<,3,%,. | |
| labels,0,4,0,0,0,0,0,0,0,0,5,6,6,7,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0 | |
| ==============================, ============================= | |
| ade,increased serum lithium | |
| drug,acyclovir | |
| sequence,This,case,suggests,that,acyclovir,when,given,intravenously,in,doses,of,10,mg,kg,may,result,in,increased,serum,lithium,concentrations,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,5,6,9,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0 | |
| ==============================, ============================= | |
| ade,increased serum lithium | |
| drug,lithium | |
| sequence,This,case,suggests,that,acyclovir,when,given,intravenously,in,doses,of,10,mg,kg,may,result,in,increased,serum,lithium,concentrations,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,5,6,9,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0 | |
| ==============================, ============================= | |
| ade,confusion,agitation,tachycardia,tremors,myoclonic jerks,unsteady gait,serotonin syndrome | |
| drug,citalopram | |
| sequence,CASE,SUMMARY,:,A,65-year-old,patient,chronically,treated,with,the,selective,serotonin,reuptake,inhibitor,(,SSRI,),citalopram,developed,confusion,,,agitation,,,tachycardia,,,tremors,,,myoclonic,jerks,and,unsteady,gait,,,consistent,with,serotonin,syndrome,,,following,initiation,of,fentanyl,,,and,all,symptoms,and,signs,resolved,following,discontinuation,of,fentanyl,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,8,0,8,0,8,0,8,0,5,7,0,5,7,0,0,0,5,7,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,1,0,1,0,1,0,1,1,0,1,1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,confusion,agitation,tachycardia,tremors,myoclonic jerks,unsteady gait,serotonin syndrome | |
| drug,fentanyl | |
| sequence,CASE,SUMMARY,:,A,65-year-old,patient,chronically,treated,with,the,selective,serotonin,reuptake,inhibitor,(,SSRI,),citalopram,developed,confusion,,,agitation,,,tachycardia,,,tremors,,,myoclonic,jerks,and,unsteady,gait,,,consistent,with,serotonin,syndrome,,,following,initiation,of,fentanyl,,,and,all,symptoms,and,signs,resolved,following,discontinuation,of,fentanyl,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,8,0,8,0,8,0,8,0,5,7,0,5,7,0,0,0,5,7,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,1,0,1,0,1,0,1,1,0,1,1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Pulmonary fibrosis | |
| drug,nabumetone | |
| sequence,Pulmonary,fibrosis,associated,with,nabumetone,. | |
| labels,5,7,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,tardive dyskinesia,TD | |
| drug,Risperidone | |
| sequence,Risperidone,is,a,frequently,used,member,of,a,new,class,of,atypical,antipsychotics-the,serotonin-dopamine,antagonists,(,SDAs,),-due,to,its,comparatively,high,efficacy,and,low,D2,5HT2,binding,ratio,,,which,results,in,a,low,incidence,of,extrapyramidal,side,effects,including,tardive,dyskinesia,(,TD,),. | |
| labels,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,8,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0,0 | |
| ==============================, ============================= | |
| ade,Malignant mixed mullerian tumor of the uterus | |
| drug,raloxifene | |
| sequence,Malignant,mixed,mullerian,tumor,of,the,uterus,in,a,patient,taking,raloxifene,. | |
| labels,5,6,6,6,6,6,7,0,0,0,0,4,0 | |
| ade_mask,1,1,1,1,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,non-convulsive status epilepticus | |
| drug,tiagabine | |
| sequence,This,is,the,first,report,of,non-convulsive,status,epilepticus,provoked,by,tiagabine,in,adolescent,patients,. | |
| labels,0,0,0,0,0,0,5,6,7,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,diarrhoea | |
| drug,spironolactone | |
| sequence,In,some,cases,this,seems,to,happen,because,spironolactone,causes,diarrhoea,. | |
| labels,0,0,0,0,0,0,0,0,4,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Depressive symptoms | |
| drug,interferon | |
| sequence,Depressive,symptoms,disappeared,after,interferon,therapy,was,stopped,. | |
| labels,5,7,0,0,4,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pericardial effusion | |
| drug,gemcitabine | |
| sequence,We,report,four,cases,of,hemodynamically,significant,pericardial,effusion,in,patients,with,refractory,lymphoma,who,were,receiving,gemcitabine,,,all,of,whom,had,a,history,of,mediastinal,radiation,without,subcarinal,blocking,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,GI upset,dizziness,mild sedation | |
| drug,Ibuprofen | |
| sequence,Ibuprofen,overdose,is,usually,characterized,by,GI,upset,,,dizziness,,,and,mild,sedation,. | |
| labels,4,0,0,0,0,0,5,7,0,8,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,1,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity reactions | |
| drug,cyclosporine | |
| sequence,A,MEDLINE,search,identified,all,the,reported,cases,of,hypersensitivity,reactions,to,cyclosporine,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,skeletal fluorosis | |
| drug,Niflumic acid | |
| sequence,Niflumic,acid-induced,skeletal,fluorosis,:,iatrogenic,disease,or,therapeutic,perspective,for,osteoporosis,? | |
| labels,1,3,5,7,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,primary and secondary perforation of the bladder | |
| drug,epirubicin | |
| sequence,MATERIALS,AND,METHODS,:,We,present,two,cases,of,significant,morbidity,related,to,primary,and,secondary,perforation,of,the,bladder,following,two,instillations,of,epirubicin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,6,7,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,1,1,1,1,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,aplastic anemia | |
| drug,Methimazole | |
| sequence,Methimazole-induced,aplastic,anemia,in,third,exposure,:,successful,treatment,with,recombinant,human,granulocyte,colony-stimulating,factor,. | |
| labels,4,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Pemphigus foliaceus | |
| drug,rifampicin | |
| sequence,Pemphigus,foliaceus,was,seen,in,a,patient,with,pulmonary,tuberculosis,during,rifampicin,therapy,. | |
| labels,5,7,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatitis | |
| drug,octreotide | |
| sequence,Drug-induced,hepatitis,in,an,acromegalic,patient,during,combined,treatment,with,pegvisomant,and,octreotide,long-acting,repeatable,attributed,to,the,use,of,pegvisomant,. | |
| labels,0,8,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatitis | |
| drug,pegvisomant | |
| sequence,Drug-induced,hepatitis,in,an,acromegalic,patient,during,combined,treatment,with,pegvisomant,and,octreotide,long-acting,repeatable,attributed,to,the,use,of,pegvisomant,. | |
| labels,0,8,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Atrial fibrillation | |
| drug,etanercept | |
| sequence,Atrial,fibrillation,occurring,in,a,patient,taking,etanercept,plus,methotrexate,for,rheumatoid,arthritis,. | |
| labels,5,7,0,0,0,0,0,4,0,4,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Atrial fibrillation | |
| drug,methotrexate | |
| sequence,Atrial,fibrillation,occurring,in,a,patient,taking,etanercept,plus,methotrexate,for,rheumatoid,arthritis,. | |
| labels,5,7,0,0,0,0,0,4,0,4,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,methotrexate toxicity,bone marrow suppression,oral and gastrointestinal ulceration | |
| drug,methotrexate | |
| sequence,Well-known,signs,of,methotrexate,toxicity,include,bone,marrow,suppression,and,oral,and,gastrointestinal,ulceration,. | |
| labels,0,0,0,9,7,0,5,6,7,0,5,6,6,7,0 | |
| ade_mask,0,0,0,1,1,0,1,1,1,1,1,0,1,1,0 | |
| ==============================, ============================= | |
| ade,osteonecrosis | |
| drug,dexamethasone | |
| sequence,Patients,should,be,informed,about,the,risk,of,osteonecrosis,when,taking,dexamethasone,as,an,antiemetic,drug,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Carbamazepine toxicity | |
| drug,Carbamazepine | |
| sequence,OBJECTIVE,:,To,report,a,case,of,Carbamazepine,toxicity,following,the,administration,of,Oxybutynin,and,Dantrolene,. | |
| labels,0,0,0,0,0,0,0,9,7,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Carbamazepine toxicity | |
| drug,Dantrolene | |
| sequence,OBJECTIVE,:,To,report,a,case,of,Carbamazepine,toxicity,following,the,administration,of,Oxybutynin,and,Dantrolene,. | |
| labels,0,0,0,0,0,0,0,9,7,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Carbamazepine toxicity | |
| drug,Oxybutynin | |
| sequence,OBJECTIVE,:,To,report,a,case,of,Carbamazepine,toxicity,following,the,administration,of,Oxybutynin,and,Dantrolene,. | |
| labels,0,0,0,0,0,0,0,9,7,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,CNS lymphoma | |
| drug,MM | |
| sequence,Primary,CNS,lymphoma,regressed,on,withdrawal,of,MM,. | |
| labels,0,5,7,0,0,0,0,4,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cranial dystonia | |
| drug,trihexyphenidyl | |
| sequence,Life-threatening,cranial,dystonia,following,trihexyphenidyl,withdrawal,. | |
| labels,0,5,7,0,4,0,0 | |
| ade_mask,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nephrotic syndrome | |
| drug,macrophage-colony-stimulating factor | |
| sequence,We,describe,a,patient,with,acute,myeloblastic,leukemia,(,AML,),who,developed,nephrotic,syndrome,after,receiving,several,courses,of,chemotherapy,,,including,macrophage-colony-stimulating,factor,(,M-CSF,),. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,1,3,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nephrotic syndrome | |
| drug,M-CSF | |
| sequence,We,describe,a,patient,with,acute,myeloblastic,leukemia,(,AML,),who,developed,nephrotic,syndrome,after,receiving,several,courses,of,chemotherapy,,,including,macrophage-colony-stimulating,factor,(,M-CSF,),. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,1,3,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperpyrexia,severe rigidity,mutism,irreversible tardive dyskinesia | |
| drug,haloperidol | |
| sequence,The,authors,describe,a,case,of,combined,lithium,and,haloperidol,toxicity,characterized,by,hyperpyrexia,,,severe,rigidity,,,mutism,,,and,development,of,irreversible,tardive,dyskinesia,. | |
| labels,0,0,0,0,0,0,0,4,0,4,0,0,0,8,0,5,7,0,8,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,0,1,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,hyperpyrexia,severe rigidity,mutism,irreversible tardive dyskinesia | |
| drug,lithium | |
| sequence,The,authors,describe,a,case,of,combined,lithium,and,haloperidol,toxicity,characterized,by,hyperpyrexia,,,severe,rigidity,,,mutism,,,and,development,of,irreversible,tardive,dyskinesia,. | |
| labels,0,0,0,0,0,0,0,4,0,4,0,0,0,8,0,5,7,0,8,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,0,1,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,subcutaneous metastasis | |
| drug,ethanol | |
| sequence,We,describe,a,case,of,subcutaneous,metastasis,along,the,needle,track,after,percutaneous,ethanol,injection,(,PEI,),for,treatment,of,hepatocellular,carcinoma,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatocellular damage | |
| drug,danazol | |
| sequence,Additionally,,,danazol,produces,hepatocellular,damage,in,approximately,10,%,of,women,. | |
| labels,0,0,4,0,5,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,leukopenia | |
| drug,cefazolin | |
| sequence,OBJECTIVE,:,To,describe,a,case,of,cefazolin-induced,leukopenia,in,a,critically,ill,patient,who,developed,this,adverse,reaction,upon,rechallenge,with,cefoxitin,. | |
| labels,0,0,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Worsening of neurologic syndrome | |
| drug,penicillamine | |
| sequence,Worsening,of,neurologic,syndrome,in,patients,with,Wilson,'s,disease,with,initial,penicillamine,therapy,. | |
| labels,5,6,6,7,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,renal disease | |
| drug,gold | |
| sequence,These,findings,are,consistent,with,an,immune-complex,form,of,glomerulopathy,in,which,gold,is,neither,the,antigen,nor,a,hapten,in,the,glomerular,deposits,,,and,they,suggest,the,hypothesis,that,antibodies,to,tubular,epithelial,antigens,induced,by,gold,therapy,may,be,a,causative,factor,in,the,renal,disease,associated,with,gold,therapy,in,rheumatoid,arthritis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Disseminated intravascular coagulation,acute hemoglobinemia,hemoglobinuria | |
| drug,Rh(0)(D) immune globulin | |
| sequence,Disseminated,intravascular,coagulation,associated,with,acute,hemoglobinemia,or,hemoglobinuria,following,Rh,(,0,),(,D,),immune,globulin,intravenous,administration,for,immune,thrombocytopenic,purpura,. | |
| labels,5,6,7,0,0,5,7,0,8,0,1,2,2,2,0,2,0,2,3,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,painful ulcers,reticulate erythema | |
| drug,interferon beta-1b | |
| sequence,46-year-old,woman,developed,painful,ulcers,over,her,lower,abdomen,in,the,form,of,reticulate,erythema,after,injecting,interferon,beta-1b,subcutaneously,for,multiple,sclerosis,. | |
| labels,0,0,0,5,7,0,0,0,0,0,0,0,0,5,7,0,0,1,3,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity reaction | |
| drug,chloramphenicol sodium succinate | |
| sequence,We,present,a,case,report,of,a,patient,with,typhoid,fever,who,experienced,a,hypersensitivity,reaction,subsequent,to,the,infusion,of,chloramphenicol,sodium,succinate,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,1,2,3,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,optic neuropathy | |
| drug,amiodarone | |
| sequence,An,amiodarone,optic,neuropathy,has,been,described,. | |
| labels,0,4,5,7,0,0,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,optic neuropathies | |
| drug,Ethambutol | |
| sequence,Ethambutol,is,frequently,used,in,the,treatment,of,tuberculosis,,,and,,,although,optic,neuropathies,have,been,reported,with,the,use,of,ethambutol,,,this,adverse,side,effect,has,been,considered,to,be,rare,and,generally,reversible,with,discontinuation,of,the,medication,. | |
| labels,4,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute interstitial nephritis | |
| drug,pantoprazole | |
| sequence,Acute,interstitial,nephritis,due,to,pantoprazole,. | |
| labels,5,6,7,0,0,4,0 | |
| ade_mask,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,loss of glomerular filtration rate,effective renal plasma flow | |
| drug,cyclosporine A | |
| sequence,After,a,six-week,course,of,low-dose,cyclosporine,A,,,she,developed,a,severe,but,reversible,loss,of,glomerular,filtration,rate,and,effective,renal,plasma,flow,despite,of,low,cyclosporine,A,plasma,levels,. | |
| labels,0,0,0,0,0,0,1,3,0,0,0,0,0,0,0,5,6,6,6,7,0,5,6,6,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,1,0,1,1,1,0,1,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pulmonary fibrosis,pulmonary toxicity | |
| drug,erlotinib | |
| sequence,Similar,to,reports,in,patients,receiving,gefitinib,,,those,with,pathologic,findings,of,UIP,on,resected,lung,specimens,or,known,pulmonary,fibrosis,may,be,at,particular,risk,for,erlotinib,pulmonary,toxicity,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,4,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,eye irritation and dryness | |
| drug,docetaxel | |
| sequence,We,report,a,71-year,male,with,castration-resistant,metastatic,prostate,cancer,who,was,treated,with,weekly,docetaxel,for,12,weeks,and,developed,significant,eye,irritation,and,dryness,during,treatment,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,5,6,6,7,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperglycemia | |
| drug,insulin | |
| sequence,Rebound,hyperglycemia,following,overdosing,of,insulin,in,cats,with,diabetes,mellitus,. | |
| labels,0,8,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,adverse effect on wound healing,collagenase activation | |
| drug,Colchicine | |
| sequence,BACKGROUND,:,Colchicine,has,a,known,adverse,effect,on,wound,healing,through,its,inhibitory,effect,on,tubulin-dependent,cell,functions,and,through,collagenase,activation,. | |
| labels,0,0,4,0,0,0,5,6,6,6,7,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,recall pneumonitis | |
| drug,gemcitabine | |
| sequence,A,case,of,recall,pneumonitis,induced,by,gemcitabine,is,reported,. | |
| labels,0,0,0,5,7,0,0,4,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,EEG abnormalities | |
| drug,chlorambucil | |
| sequence,EEG,abnormalities,were,observed,in,two,of,the,nine,children,during,chlorambucil,therapy,. | |
| labels,5,7,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Lymphoma | |
| drug,methotrexate | |
| sequence,Lymphoma,developing,in,a,patient,with,rheumatoid,arthritis,taking,methotrexate,. | |
| labels,8,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,headache | |
| drug,capecitabine | |
| sequence,The,patient,developed,grade,3,capecitabine-induced,headache,. | |
| labels,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,delirious | |
| drug,oolong tea | |
| sequence,A,36-y-o,patient,with,schizophrenia,,,who,had,consumed,gradually,increasing,quantities,of,oolong,tea,that,eventually,reached,15,L,each,day,,,became,delirious,and,was,admitted,to,a,psychiatric,hospital,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,1,3,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombocytopenia,schistocytosis,TTP HUS | |
| drug,quinine | |
| sequence,We,conclude,that,while,thrombocytopenia,and,schistocytosis,can,be,seen,in,quinine-associated,TTP,HUS,,,the,pathophysiology,seems,to,be,distinct,from,that,seen,in,most,cases,of,idiopathic,TTP,(,i.e.,,,severely,decreased,ADAMTS13,with,an,inhibitor,),. | |
| labels,0,0,0,0,8,0,8,0,0,0,0,4,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,1,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,toxic epidermal necrolysis | |
| drug,Phenolphthalein | |
| sequence,Phenolphthalein-induced,toxic,epidermal,necrolysis,. | |
| labels,4,5,6,7,0 | |
| ade_mask,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,Epstein-Barr virus-associated polymorphic lymphoproliferative disorder,LPD,immunodeficiency | |
| drug,MTX | |
| sequence,She,was,diagnosed,with,Epstein-Barr,virus-associated,polymorphic,lymphoproliferative,disorder,(,LPD,),due,to,immunodeficiency,caused,by,MTX,administration,. | |
| labels,0,0,0,0,5,6,6,6,7,0,8,0,0,0,8,0,0,4,0,0 | |
| ade_mask,0,0,0,0,1,1,1,1,1,0,1,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,psychosis | |
| drug,Interferon | |
| sequence,Interferon-induced,psychosis,as,a,``,psychiatric,contraindication,'',to,hepatitis,C,treatment,:,a,review,and,case-based,discussion,. | |
| labels,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,osteomyelitis in the left calcaneus | |
| drug,BCG | |
| sequence,An,8-year-old,girl,,,who,had,been,vaccinated,with,BCG,without,subsequent,regional,reactions,,,developed,osteomyelitis,in,the,left,calcaneus,7,months,later,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,5,6,6,6,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,glaucoma | |
| drug,steroid | |
| sequence,Severe,steroid-induced,glaucoma,following,intravitreal,injection,of,triamcinolone,acetonide,. | |
| labels,0,4,8,0,0,0,0,1,3,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,glaucoma | |
| drug,triamcinolone acetonide | |
| sequence,Severe,steroid-induced,glaucoma,following,intravitreal,injection,of,triamcinolone,acetonide,. | |
| labels,0,4,8,0,0,0,0,1,3,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,dyskinesia | |
| drug,amoxapine | |
| sequence,Occurrence,of,withdrawal,dyskinesia,indicates,that,the,neuroleptic,effects,of,amoxapine,may,be,clinically,significant,. | |
| labels,0,0,0,8,0,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Increased ocular pressure | |
| drug,venlafaxine | |
| sequence,Increased,ocular,pressure,in,two,patients,with,narrow,angle,glaucoma,treated,with,venlafaxine,. | |
| labels,5,6,7,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Masculinization of a female fetus,clitoral hypertrophy | |
| drug,norethisterone | |
| sequence,Masculinization,of,a,female,fetus,occurred,in,5,of,39,(,12.8,%,),exposed,to,norethisterone,;,all,were,cases,of,clitoral,hypertrophy,not,requiring,surgical,treatment,. | |
| labels,5,6,6,6,7,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,5,7,0,0,0,0,0 | |
| ade_mask,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,RLS | |
| drug,olanzapine | |
| sequence,Increasing,the,olanzapine,dosage,severely,aggravated,the,symptoms,of,RLS,. | |
| labels,0,0,4,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,subacute cholestatic hepatitis,liver injury | |
| drug,senna | |
| sequence,In,this,case,senna,was,likely,the,cause,of,a,subacute,cholestatic,hepatitis,exemplifying,again,the,potential,role,of,herbal,related,liver,injury,. | |
| labels,0,0,0,4,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,fatal perhexiline maleate liver injury | |
| drug,perhexiline maleate | |
| sequence,This,paper,reports,a,case,of,fatal,perhexiline,maleate,liver,injury,. | |
| labels,0,0,0,0,0,0,5,9,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,polyserositis,pericardial effusion,pleural effusion,pericarditis | |
| drug,clozapine | |
| sequence,We,report,the,case,of,a,patient,who,developed,polyserositis,(,pericardial,effusion,,,pleural,effusion,,,and,pericarditis,),after,being,started,on,clozapine,,,and,whose,symptoms,remitted,upon,discontinuation,of,clozapine,. | |
| labels,0,0,0,0,0,0,0,0,0,8,0,5,7,0,5,7,0,0,8,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,1,1,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Gigantomastia | |
| drug,bucillamine | |
| sequence,Gigantomastia,induced,by,bucillamine,. | |
| labels,8,0,0,4,0 | |
| ade_mask,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,paralytic ileus,neurogenic bladder,mild left ptosis,absence of deep reflexes,severe paralysis of the lower extremities,mild weakness of the upper extremities | |
| drug,itraconazole | |
| sequence,Ten,days,after,itraconazole,was,started,,,he,developed,paralytic,ileus,,,neurogenic,bladder,,,mild,left,ptosis,,,and,absence,of,deep,reflexes,,,with,severe,paralysis,of,the,lower,extremities,and,mild,weakness,of,the,upper,extremities,. | |
| labels,0,0,0,4,0,0,0,0,0,5,7,0,5,7,0,5,6,7,0,0,5,6,6,7,0,0,5,6,6,6,6,7,0,5,6,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,1,1,0,1,1,1,0,0,1,1,1,1,0,0,1,1,0,1,1,1,0,0,1,0,0,1,0,0 | |
| ==============================, ============================= | |
| ade,ankle, hand, and facial swelling | |
| drug,rosiglitazone | |
| sequence,A,77-year-old,man,developed,ankle,,,hand,,,and,facial,swelling,2,weeks,after,starting,rosiglitazone,. | |
| labels,0,0,0,0,5,6,6,0,6,6,7,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,1,1,1,0,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,angio-oedema | |
| drug,VRC | |
| sequence,To,our,knowledge,,,this,is,the,first,report,of,an,angio-oedema,associated,with,VRC,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,8,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,keratitis,toxic effects | |
| drug,lidocaine | |
| sequence,Potential,causes,of,methamphetamine-related,keratitis,can,be,divided,into,four,categories,resulting,from,(,a,),direct,pharmacologic,and,physical,effects,of,methamphetamine,;,(,b,),the,toxic,effects,of,diluting,or,``,cutting,'',agents,such,as,lidocaine,and,quinine,;,(,c,),effects,related,to,the,route,of,drug,administration,(,intravenous,,,inhalation,,,smoking,),;,and,(,d,),manufacture-related,effects,of,exposure,to,unintentional,caustic,contaminants,in,the,final,product,. | |
| labels,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,keratitis,toxic effects | |
| drug,methamphetamine | |
| sequence,Potential,causes,of,methamphetamine-related,keratitis,can,be,divided,into,four,categories,resulting,from,(,a,),direct,pharmacologic,and,physical,effects,of,methamphetamine,;,(,b,),the,toxic,effects,of,diluting,or,``,cutting,'',agents,such,as,lidocaine,and,quinine,;,(,c,),effects,related,to,the,route,of,drug,administration,(,intravenous,,,inhalation,,,smoking,),;,and,(,d,),manufacture-related,effects,of,exposure,to,unintentional,caustic,contaminants,in,the,final,product,. | |
| labels,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,keratitis,toxic effects | |
| drug,quinine | |
| sequence,Potential,causes,of,methamphetamine-related,keratitis,can,be,divided,into,four,categories,resulting,from,(,a,),direct,pharmacologic,and,physical,effects,of,methamphetamine,;,(,b,),the,toxic,effects,of,diluting,or,``,cutting,'',agents,such,as,lidocaine,and,quinine,;,(,c,),effects,related,to,the,route,of,drug,administration,(,intravenous,,,inhalation,,,smoking,),;,and,(,d,),manufacture-related,effects,of,exposure,to,unintentional,caustic,contaminants,in,the,final,product,. | |
| labels,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe chloroquine toxicity | |
| drug,chloroquine | |
| sequence,OBJECTIVE,:,To,report,a,case,of,severe,chloroquine,toxicity,in,the,presence,of,high-grade,chloroquine-resistant,Plasmodium,vivax,. | |
| labels,0,0,0,0,0,0,0,5,9,7,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Agranulocytosis | |
| drug,vancomycin | |
| sequence,Agranulocytosis,induced,by,vancomycin,in,an,ESRD,patient,on,CAPD,. | |
| labels,8,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,syncope,atrioventricular block | |
| drug,propranolol | |
| sequence,After,the,first,oral,dose,of,propranolol,,,syncope,developed,together,with,atrioventricular,block,. | |
| labels,0,0,0,0,0,0,4,0,8,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,interstitial pneumonitis | |
| drug,bleomycin | |
| sequence,A,42,year,old,man,,,treated,for,testicular,carcinoma,with,combination,chemotherapy,that,included,bleomycin,,,developed,life,threatening,interstitial,pneumonitis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,aplastic anemia | |
| drug,Gold | |
| sequence,Gold-induced,aplastic,anemia,. | |
| labels,4,5,7,0 | |
| ade_mask,0,1,1,0 | |
| ==============================, ============================= | |
| ade,aplastic anemia | |
| drug,lenalidomide | |
| sequence,Although,moderate,myelosuppression,is,not,uncommonly,seen,in,patients,treated,with,lenalidomide,,,aplastic,anemia,has,not,previously,been,reported,to,be,associated,with,this,agent,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,4,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cytotoxic edema | |
| drug,methotrexate | |
| sequence,We,attribute,the,clinical,and,radiographic,findings,to,cytotoxic,edema,secondary,to,intrathecal,methotrexate,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,colitis | |
| drug,cisplatin | |
| sequence,Although,both,patients,recovered,from,the,colitis,after,the,administration,of,vancomycin,,,the,first,case,demonstrated,a,relapse,of,the,colitis,after,receiving,a,subsequent,course,of,the,same,chemotherapy,with,cisplatin,. | |
| labels,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypercalcemia | |
| drug,1,24(OH)2D3 | |
| sequence,Iatrogenic,hypercalcemia,due,to,vitamin,D3,ointment,(,1,24,(,OH,),2D3,),combined,with,thiazide,diuretics,in,a,case,of,psoriasis,. | |
| labels,0,8,0,0,1,3,0,0,1,2,2,2,3,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypercalcemia | |
| drug,thiazide | |
| sequence,Iatrogenic,hypercalcemia,due,to,vitamin,D3,ointment,(,1,24,(,OH,),2D3,),combined,with,thiazide,diuretics,in,a,case,of,psoriasis,. | |
| labels,0,8,0,0,1,3,0,0,1,2,2,2,3,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypercalcemia | |
| drug,vitamin D3 | |
| sequence,Iatrogenic,hypercalcemia,due,to,vitamin,D3,ointment,(,1,24,(,OH,),2D3,),combined,with,thiazide,diuretics,in,a,case,of,psoriasis,. | |
| labels,0,8,0,0,1,3,0,0,1,2,2,2,3,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bleeding | |
| drug,Warfarin | |
| sequence,Warfarin-associated,bleeding,generally,is,considered,deleterious,;,however,,,in,our,patient,it,unmasked,an,early,stage,of,colon,cancer,and,thus,may,have,saved,the,patient,'s,life,. | |
| labels,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,eosinophilic pleural effusion | |
| drug,Divalproex sodium | |
| sequence,Divalproex,sodium-induced,eosinophilic,pleural,effusion,. | |
| labels,1,3,5,6,7,0 | |
| ade_mask,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,liver failure,fulminant hepatic failure | |
| drug,clarithromycin | |
| sequence,The,most,likely,cause,of,liver,failure,in,this,patient,was,,,therefore,,,clarithromycin,,,which,undergoes,hepatic,metabolism,and,has,been,reported,to,cause,fulminant,hepatic,failure,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,Hepato-biliary abnormalities | |
| drug,ceftriaxone | |
| sequence,Hepato-biliary,abnormalities,secondary,to,ceftriaxone,use,:,a,case,report,. | |
| labels,5,7,0,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Retinal dysfunction,anterior segment deposits | |
| drug,rifabutin | |
| sequence,Retinal,dysfunction,and,anterior,segment,deposits,in,a,patient,treated,with,rifabutin,. | |
| labels,5,7,0,5,6,7,0,0,0,0,0,4,0 | |
| ade_mask,1,1,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,intrahepatic cholestasis | |
| drug,chlorpropamide | |
| sequence,These,features,have,not,previously,been,reported,as,side,effects,of,glibenclamide,therapy,,,but,intrahepatic,cholestasis,may,occur,with,chlorpropamide,,,a,similar,sulphonylurea,agent,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,psoriasiform eruption | |
| drug,carbamazepine | |
| sequence,We,present,findings,from,three,patients,who,experienced,a,psoriasiform,eruption,apparently,due,to,the,antiepileptic,agents,sodium,valproate,and,carbamazepine,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,1,3,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,psoriasiform eruption | |
| drug,sodium valproate | |
| sequence,We,present,findings,from,three,patients,who,experienced,a,psoriasiform,eruption,apparently,due,to,the,antiepileptic,agents,sodium,valproate,and,carbamazepine,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,1,3,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cerebral atrophy | |
| drug,ACTH | |
| sequence,It,is,concluded,that,cerebral,atrophy,on,CT,scans,may,represent,an,accumulative,effect,of,ACTH,and,that,ACTH,should,be,given,with,the,utmost,discretion,,,and,in,as,low,a,dose,as,possible,. | |
| labels,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Nephropathy | |
| drug,methicillin | |
| sequence,Nephropathy,caused,by,methicillin,therapy,for,staphylococcal,septicemia,. | |
| labels,8,0,0,4,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,systemic lupus erythematosus-like disease | |
| drug,Carbamazepine | |
| sequence,Carbamazepine-induced,systemic,lupus,erythematosus-like,disease,. | |
| labels,4,5,6,6,7,0 | |
| ade_mask,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,choroidal detachment | |
| drug,Dorzolamide | |
| sequence,Dorzolamide-induced,choroidal,detachment,in,a,surgically,untreated,eye,. | |
| labels,4,5,7,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fulminant hepatic failure,aplastic anaemia | |
| drug,flucloxacillin | |
| sequence,We,report,the,case,of,a,40-year-old,woman,who,developed,fulminant,hepatic,failure,and,aplastic,anaemia,following,a,course,of,oral,flucloxacillin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,6,7,0,5,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,increased libido | |
| drug,fluvoxamine | |
| sequence,OBJECTIVE,:,The,aim,of,this,paper,is,to,describe,a,case,of,increased,libido,during,fluvoxamine,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,transient brain stem or neuromuscular dysfunction,eye movement abnormality | |
| drug,cyclosporin | |
| sequence,We,postulate,that,cyclosporin,,,possibly,together,with,ganciclovir,,,can,produce,transient,brain,stem,or,neuromuscular,dysfunction,with,eye,movement,abnormality,in,occasional,patients,. | |
| labels,0,0,0,4,0,0,0,0,4,0,0,0,5,6,6,6,6,7,0,5,6,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,1,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,transient brain stem or neuromuscular dysfunction,eye movement abnormality | |
| drug,ganciclovir | |
| sequence,We,postulate,that,cyclosporin,,,possibly,together,with,ganciclovir,,,can,produce,transient,brain,stem,or,neuromuscular,dysfunction,with,eye,movement,abnormality,in,occasional,patients,. | |
| labels,0,0,0,4,0,0,0,0,4,0,0,0,5,6,6,6,6,7,0,5,6,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,1,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,reproductive endocrine disorders | |
| drug,valproate | |
| sequence,CONCLUSIONS,:,The,3,cases,presented,here,illustrate,the,development,of,reproductive,endocrine,disorders,after,the,initiation,of,valproate,therapy,in,women,with,epilepsy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,renal failure | |
| drug,dextran | |
| sequence,While,the,mechanism,of,dextran-associated,renal,failure,remains,unsolved,,,plasma,exchange,seems,to,be,effective,therapy,. | |
| labels,0,0,0,0,4,5,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rash,TEN | |
| drug,phenolphthalein | |
| sequence,The,patient,'s,previous,rash,and,the,temporal,relation,of,this,event,and,the,ingestion,of,phenolphthalein,,,as,well,as,the,similarity,of,this,case,to,other,reports,,,point,to,phenolphthalein,as,the,cause,of,TEN,in,this,patient,. | |
| labels,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Purple glove syndrome,purple discoloration,swelling of the hands | |
| drug,phenytoin | |
| sequence,Purple,glove,syndrome,,,named,for,its,distinctive,purple,discoloration,and,swelling,of,the,hands,in,the,distribution,of,a,glove,,,is,an,uncommon,complication,of,intravenous,phenytoin,administration,through,small,dorsal,veins,of,the,hands,. | |
| labels,5,6,7,0,0,0,0,0,5,7,0,5,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,1,1,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,dyskinesias | |
| drug,L-dopa | |
| sequence,CONCLUSION,:,The,present,findings,suggest,that,:,(,i,),amantadine,probably,exerts,its,anti-dyskinetic,effect,by,acting,on,the,``,indirect,'',pathway,;,(,ii,),the,pathophysiological,mechanisms,of,subthalamotomy,induced,dyskinesias,may,differ,from,those,involved,in,L-dopa,induced,dyskinesias,;,(,iii,),dyskinesias,induced,by,STN,surgery,resolve,spontaneously,as,compensatory,mechanisms,develop,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Thrombo-embolic complication | |
| drug,streptokinase | |
| sequence,Thrombo-embolic,complication,after,streptokinase,therapy,of,pulmonary,emboli,. | |
| labels,5,7,0,4,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe symptomatic hepatitis | |
| drug,itraconazole | |
| sequence,Only,one,case,of,severe,symptomatic,hepatitis,occurring,after,pulse,therapy,with,itraconazole,for,onychomycosis,and,requiring,transplantation,has,been,reported,previously,. | |
| labels,0,0,0,0,5,6,7,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cholestasis | |
| drug,azathioprine | |
| sequence,It,is,believed,that,this,is,the,first,reported,case,of,reversible,azathioprine-induced,cholestasis,associated,with,histological,evidence,of,bile,duct,injury,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Neuroleptic malignant syndrome | |
| drug,risperidone | |
| sequence,Neuroleptic,malignant,syndrome,due,to,risperidone,treatment,in,a,child,with,Joubert,syndrome,. | |
| labels,5,6,7,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,polyarthritis,rash,hepatitis,anti-native DNA antibodies | |
| drug,ethambutol | |
| sequence,After,seven,months,continuous,treatment,for,suspected,tuberculosis,with,rifampicin,and,ethambutol,a,nine-year-old,boy,developed,polyarthritis,,,rash,and,hepatitis,in,association,with,anti-native,DNA,antibodies,and,positive,antinuclear,factor,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,8,0,8,0,8,0,0,0,5,6,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,0,0,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,toxic and immunomodulatory roles | |
| drug,lithium | |
| sequence,They,seemed,to,involve,multiple,aetiological,factors,,,such,as,autoimmune,thyroid,disease,,,the,toxic,and,immunomodulatory,roles,of,lithium,and,perhaps,genetic,and,dietary,factors,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute coronary syndrome | |
| drug,Capecitabine | |
| sequence,This,case,highlights,the,possible,development,of,acute,coronary,syndrome,as,a,side,effect,of,Capecitabine,therapy,. | |
| labels,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Aminophylline hypersensitivity | |
| drug,Aminophylline | |
| sequence,Aminophylline,hypersensitivity,apparently,due,to,ethylenediamine,. | |
| labels,9,7,0,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Aminophylline hypersensitivity | |
| drug,ethylenediamine | |
| sequence,Aminophylline,hypersensitivity,apparently,due,to,ethylenediamine,. | |
| labels,9,7,0,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,second-degree heart block,sinus bradycardia | |
| drug,pentamidine | |
| sequence,Early-onset,pentamidine-associated,second-degree,heart,block,and,sinus,bradycardia,:,case,report,and,review,of,the,literature,. | |
| labels,0,4,5,6,7,0,5,7,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,1,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sarcoidosis | |
| drug,interferon alpha | |
| sequence,We,report,a,case,with,chronic,hepatitis,C,(,CHC,),who,developed,sarcoidosis,after,the,treatment,by,interferon,alpha,and,ribavirin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,1,3,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sarcoidosis | |
| drug,ribavirin | |
| sequence,We,report,a,case,with,chronic,hepatitis,C,(,CHC,),who,developed,sarcoidosis,after,the,treatment,by,interferon,alpha,and,ribavirin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,1,3,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myasthenia gravis | |
| drug,Statin | |
| sequence,Statin-associated,myasthenia,gravis,:,report,of,4,cases,and,review,of,the,literature,. | |
| labels,4,5,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,TEN | |
| drug,lamotrigine | |
| sequence,A,54-year-old,man,developed,TEN,4,weeks,after,beginning,lamotrigine,for,complex,partial,seizures,related,to,a,glioblastoma,multiforme,brain,tumor,. | |
| labels,0,0,0,0,8,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,chest pain,elevated cardiac biomarkers,acute left ventricular dysfunction | |
| drug,methylphenidate | |
| sequence,We,report,the,case,of,a,17-year-old,male,who,developed,chest,pain,,,elevated,cardiac,biomarkers,,,and,acute,left,ventricular,dysfunction,following,a,single,dose,of,methylphenidate,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,5,6,7,0,0,5,6,6,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,1,1,1,0,0,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,exacerbating OCS | |
| drug,quetiapine | |
| sequence,The,first,known,report,of,quetiapine,exacerbating,OCS,in,a,43-year-old,man,with,obsessive-compulsive,disorder,(,OCD,),,,trichotillomania,,,delusional,disorder,and,bipolar,II,disorder,is,presented,. | |
| labels,0,0,0,0,0,4,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,urticaria,angioedema | |
| drug,insulin | |
| sequence,The,patient,had,recurrence,of,urticaria,and,angioedema,a,year,and,a,half,later,,,at,which,point,the,NPH,was,stopped,and,she,was,desensitized,to,regular,insulin,. | |
| labels,0,0,0,0,0,8,0,8,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,urticaria,angioedema | |
| drug,NPH | |
| sequence,The,patient,had,recurrence,of,urticaria,and,angioedema,a,year,and,a,half,later,,,at,which,point,the,NPH,was,stopped,and,she,was,desensitized,to,regular,insulin,. | |
| labels,0,0,0,0,0,8,0,8,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,tubular and interstitial lesions | |
| drug,rifampin | |
| sequence,Prior,reports,have,emphasized,the,tubular,and,interstitial,lesions,associated,with,intermittent,or,discontinuous,rifampin,therapy,for,tuberculosis,. | |
| labels,0,0,0,0,0,5,6,6,7,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fulminant liver failure | |
| drug,clarithromycin | |
| sequence,CASE,SUMMARY,:,A,58-year-old,white,woman,developed,fulminant,liver,failure,while,being,treated,with,the,macrolide,antibiotic,clarithromycin,for,pneumonia,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,respiratory dyskinesia | |
| drug,Risperidone | |
| sequence,Risperidone,withdrawal-related,respiratory,dyskinesia,:,a,case,diagnosed,by,spirography,and,fibroscopy,. | |
| labels,4,0,5,7,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cerebellar syndrome | |
| drug,Cytarabine | |
| sequence,Cytarabine-induced,cerebellar,syndrome,:,case,report,and,literature,review,. | |
| labels,4,5,7,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,generalized erythema | |
| drug,sulfamethoxazole | |
| sequence,A,61-year-old,man,with,early,diffuse,cutaneous,scleroderma,with,myositis,and,progressive,interstitial,pneumonia,developed,generalized,erythema,with,high,fever,3,weeks,after,taking,sulfamethoxazole,trimethoprim,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,4,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,generalized erythema | |
| drug,trimethoprim | |
| sequence,A,61-year-old,man,with,early,diffuse,cutaneous,scleroderma,with,myositis,and,progressive,interstitial,pneumonia,developed,generalized,erythema,with,high,fever,3,weeks,after,taking,sulfamethoxazole,trimethoprim,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,4,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,enteropathy | |
| drug,Clofazimine | |
| sequence,Clofazimine,enteropathy,in,a,pediatric,bone,marrow,transplant,recipient,. | |
| labels,4,8,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,exophthalmos | |
| drug,lithium | |
| sequence,The,exophthalmos,improved,dramatically,within,72,hours,of,the,withdrawal,of,lithium,. | |
| labels,0,8,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,seizures | |
| drug,amphotercin B | |
| sequence,Despite,administration,of,phenytoin,and,lorazepam,,,the,seizures,persisted,and,occurred,only,during,amphotercin,B,administration,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,0,0,0,1,3,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,normotensive scleroderma renal crisis | |
| drug,methylprednisolone | |
| sequence,A,case,of,normotensive,scleroderma,renal,crisis,after,high-dose,methylprednisolone,treatment,. | |
| labels,0,0,0,5,6,6,7,0,0,4,0,0 | |
| ade_mask,0,0,0,1,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Nail staining | |
| drug,hydroquinone | |
| sequence,Nail,staining,from,hydroquinone,cream,. | |
| labels,5,7,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity,fever,a pruritic desquamating erythrodermic rash,alopecia,icterus,protein-losing enteropathy,myositis,nephritis | |
| drug,phenobarbital | |
| sequence,A,child,in,whom,a,phenobarbital,hypersensitivity,drug,reaction,developed,which,consisted,of,fever,,,a,pruritic,desquamating,erythrodermic,rash,,,alopecia,,,icterus,,,protein-losing,enteropathy,,,myositis,,,and,nephritis,,,is,described,. | |
| labels,0,0,0,0,0,4,8,0,0,0,0,0,0,8,0,5,6,6,6,7,0,8,0,8,0,5,7,0,8,0,0,8,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,1,0,0,0,0,0,0,1,0,0,1,1,1,1,0,1,0,1,0,1,1,0,1,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sexual dysfunction | |
| drug,baclofen | |
| sequence,RESULTS,:,A,male,and,a,female,patient,with,spasticity,treated,with,intrathecal,baclofen,were,recognized,to,have,sexual,dysfunction,side,effects,from,treatment,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,5,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe hepatitis | |
| drug,ivermectin | |
| sequence,We,report,the,case,of,a,20-year-old,woman,originally,from,Cameroon,who,was,infected,by,the,L.,loa,parasite,and,developed,severe,hepatitis,,,identified,1,month,after,a,single,dose,of,ivermectin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Fatal toxic epidermal necrolysis | |
| drug,lamotrigine | |
| sequence,Fatal,toxic,epidermal,necrolysis,related,to,lamotrigine,administration,. | |
| labels,5,6,6,7,0,0,4,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,panhypogammaglobulinaemia | |
| drug,cyclophosphamide | |
| sequence,We,observed,transient,panhypogammaglobulinaemia,in,a,patient,with,neuropsychiatric,SLE,after,treatment,with,prednisolone,and,cyclophosphamide,. | |
| labels,0,0,0,8,0,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,panhypogammaglobulinaemia | |
| drug,prednisolone | |
| sequence,We,observed,transient,panhypogammaglobulinaemia,in,a,patient,with,neuropsychiatric,SLE,after,treatment,with,prednisolone,and,cyclophosphamide,. | |
| labels,0,0,0,8,0,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,diffuse pruritic papular eruption | |
| drug,methotrexate | |
| sequence,Ten,hours,after,the,second,methotrexate,injection,,,the,patient,experienced,a,diffuse,pruritic,papular,eruption,located,mainly,on,the,limbs,. | |
| labels,0,0,0,0,0,4,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Torsades de Pointes | |
| drug,disopyramide | |
| sequence,Torsades,de,Pointes,induced,by,a,combination,of,garenoxacin,and,disopyramide,and,other,cytochrome,P450,,,family,3,,,subfamily,A,polypeptide-4-influencing,drugs,during,hypokalemia,due,to,licorice,. | |
| labels,5,6,7,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Torsades de Pointes | |
| drug,garenoxacin | |
| sequence,Torsades,de,Pointes,induced,by,a,combination,of,garenoxacin,and,disopyramide,and,other,cytochrome,P450,,,family,3,,,subfamily,A,polypeptide-4-influencing,drugs,during,hypokalemia,due,to,licorice,. | |
| labels,5,6,7,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cerebrospinal fluid eosinophilia,CSFE | |
| drug,vancomycin | |
| sequence,We,report,two,cases,of,cerebrospinal,fluid,eosinophilia,(,CSFE,),secondary,to,the,intraventricular,administration,of,vancomycin,. | |
| labels,0,0,0,0,0,5,6,7,0,8,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute pancreatitis | |
| drug,mesalamine | |
| sequence,We,describe,two,cases,of,acute,pancreatitis,that,occurred,after,long,term,mesalamine,therapy,for,ulcerative,colitis,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,non-convulsive status epilepticus | |
| drug,tiagabine | |
| sequence,The,events,of,non-convulsive,status,epilepticus,subsided,following,reduction,in,tiagabine,dosages,. | |
| labels,0,0,0,5,6,7,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,leucopenia,cholestasis,fatty liver parenchyma degeneration,granulocytic portal infiltration,bile stasis | |
| drug,methimazole | |
| sequence,The,main,clinical,features,of,this,58-year-old,female,patient,were,laboratory,evidence,of,leucopenia,and,cholestasis,,,and,biopsy,features,of,fatty,liver,parenchyma,degeneration,with,granulocytic,portal,infiltration,and,bile,stasis,,,demonstrated,20,days,after,the,initiation,of,antithyroid,therapy,with,20,mg,methimazole,daily,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,8,0,0,0,0,0,5,6,6,7,0,5,6,7,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,1,1,1,0,1,1,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,visual disturbances | |
| drug,BTX-B | |
| sequence,To,date,,,there,have,been,few,reports,of,visual,disturbances,associated,with,BTX-B,use,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Akathisia | |
| drug,fluoxetine | |
| sequence,Akathisia,appeared,to,be,a,common,side,effect,of,fluoxetine,and,generally,responded,well,to,treatment,with,the,beta-adrenergic,antagonist,propranolol,,,dose,reduction,,,or,both,. | |
| labels,8,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,systemic allergic contact dermatitis | |
| drug,8-MOP | |
| sequence,We,describe,a,patient,who,had,a,systemic,allergic,contact,dermatitis,to,8-MOP,develop,during,her,second,course,of,PUVA,treatment,for,psoriasis,. | |
| labels,0,0,0,0,0,0,0,5,6,6,7,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,QT interval was prolonged | |
| drug,halofantrine | |
| sequence,In,the,present,paper,,,we,discuss,the,first,Japanese,vivax,malaria,patient,whose,QT,interval,was,prolonged,after,treatment,with,halofantrine,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,collagenous colitis | |
| drug,lansoprazole | |
| sequence,The,reported,case,represents,an,unusual,association,between,medication,with,the,proton,pump,inhibitor,lansoprazole,and,the,development,of,collagenous,colitis,suggesting,the,importance,of,evaluation,of,drug,use,in,patients,with,microscopic,colitis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,renal disease,nephrotic syndrome | |
| drug,M-CSF | |
| sequence,The,possibility,can,be,raised,that,M-CSF,accelerated,the,underlying,renal,disease,in,this,case,through,enhancing,macrophage,accumulation,into,the,glomerulus,,,leading,to,the,development,of,nephrotic,syndrome,. | |
| labels,0,0,0,0,0,0,4,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Atrioventricular block,hypothyroidism | |
| drug,amiodarone | |
| sequence,Atrioventricular,block,complicating,amiodarone-induced,hypothyroidism,in,a,patient,with,pre-excitation,and,rate-dependent,bilateral,bundle,branch,block,. | |
| labels,5,7,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,inhibition of hematopoiesis | |
| drug,D-penicillamine | |
| sequence,In,vitro,inhibition,of,hematopoiesis,in,a,patient,with,systemic,sclerosis,treated,with,D-penicillamine,. | |
| labels,0,0,5,6,7,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Cutaneous sarcoidosis | |
| drug,interferon alfa | |
| sequence,Cutaneous,sarcoidosis,during,interferon,alfa,and,ribavirin,treatment,of,hepatitis,C,virus,infection,:,two,cases,. | |
| labels,5,7,0,1,3,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Cutaneous sarcoidosis | |
| drug,ribavirin | |
| sequence,Cutaneous,sarcoidosis,during,interferon,alfa,and,ribavirin,treatment,of,hepatitis,C,virus,infection,:,two,cases,. | |
| labels,5,7,0,1,3,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pulmonary toxicity,hepatotoxicity,aggravation of arrhythmia,thyroid diseases | |
| drug,amiodarone | |
| sequence,Adverse,effects,of,amiodarone,including,pulmonary,toxicity,,,hepatotoxicity,,,aggravation,of,arrhythmia,,,and,thyroid,diseases,are,well,understood,. | |
| labels,0,0,0,4,0,5,7,0,8,0,5,6,7,0,0,5,7,0,0,0,0 | |
| ade_mask,0,0,1,0,0,1,1,0,1,0,1,0,1,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Polymyositis | |
| drug,interferon alpha | |
| sequence,Polymyositis,is,a,rare,complication,of,interferon,alpha,treatment,as,a,result,of,immune-modulating,role,of,the,drug,itself,. | |
| labels,8,0,0,0,0,0,1,3,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,granulomatous hepatitis | |
| drug,Cefoxitin | |
| sequence,Cefoxitin,therapy,for,Mycobacterium,fortuitum,bacteremia,with,associated,granulomatous,hepatitis,. | |
| labels,4,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,syndrome of increased affect | |
| drug,risperidone | |
| sequence,A,syndrome,of,increased,affect,in,response,to,risperidone,among,patients,with,schizophrenia,. | |
| labels,0,5,6,6,7,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute renal failure | |
| drug,captopril | |
| sequence,Acute,renal,failure,most,likely,was,secondary,to,the,nephrotoxic,effect,of,captopril,on,chronically,hypoperfused,kidneys,. | |
| labels,5,6,7,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sideroblastic anemia | |
| drug,linezolid | |
| sequence,A,case,of,sideroblastic,anemia,is,presented,in,a,patient,with,a,left,ventricular,assist,device,drive-line,infection,who,was,receiving,linezolid,,,an,antibiotic,used,for,serious,infections,with,gram-positive,organisms,. | |
| labels,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Exacerbations of the heart failure | |
| drug,actinomycin-D | |
| sequence,Exacerbations,of,the,heart,failure,were,temporally,related,to,the,administration,of,the,antitumor,antibiotics,actinomycin-D,(,NSC-3053,),and,mithramycin,(,NSC-24559,),. | |
| labels,5,6,6,6,7,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,4,0,4,0,0 | |
| ade_mask,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Exacerbations of the heart failure | |
| drug,mithramycin | |
| sequence,Exacerbations,of,the,heart,failure,were,temporally,related,to,the,administration,of,the,antitumor,antibiotics,actinomycin-D,(,NSC-3053,),and,mithramycin,(,NSC-24559,),. | |
| labels,5,6,6,6,7,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,4,0,4,0,0 | |
| ade_mask,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Exacerbations of the heart failure | |
| drug,NSC-24559 | |
| sequence,Exacerbations,of,the,heart,failure,were,temporally,related,to,the,administration,of,the,antitumor,antibiotics,actinomycin-D,(,NSC-3053,),and,mithramycin,(,NSC-24559,),. | |
| labels,5,6,6,6,7,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,4,0,4,0,0 | |
| ade_mask,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Exacerbations of the heart failure | |
| drug,NSC-3053 | |
| sequence,Exacerbations,of,the,heart,failure,were,temporally,related,to,the,administration,of,the,antitumor,antibiotics,actinomycin-D,(,NSC-3053,),and,mithramycin,(,NSC-24559,),. | |
| labels,5,6,6,6,7,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,4,0,4,0,0 | |
| ade_mask,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Contact dermatitis | |
| drug,budesonide | |
| sequence,Contact,dermatitis,due,to,budesonide,:,report,of,five,cases,and,review,of,the,Japanese,literature,. | |
| labels,5,7,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,side-effect on retinal function | |
| drug,rifabutin | |
| sequence,CONCLUSION,:,Long-term,treatment,with,rifabutin,may,have,a,reversible,and,previously,undescribed,side-effect,on,retinal,function,. | |
| labels,0,0,0,0,0,4,0,0,0,0,0,0,0,5,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,acute respiratory failure | |
| drug,adalimumab | |
| sequence,A,case,of,acute,respiratory,failure,due,to,diaphragmatic,weakness,following,adalimumab,therapy,for,psoriasis,is,described,. | |
| labels,0,0,0,5,6,7,0,0,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,endometrial carcinoma | |
| drug,tamoxifen | |
| sequence,However,,,in,the,mid-to-late,1980s,,,a,series,of,letters,to,the,editor,and,case,reports,announced,an,association,between,tamoxifen,therapy,in,women,with,breast,cancer,and,the,development,of,endometrial,carcinoma,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,progression of marrow reticulin fibrosis | |
| drug,imatinib | |
| sequence,Our,findings,suggest,that,significant,progression,of,marrow,reticulin,fibrosis,during,imatinib,therapy,can,be,an,indicator,for,a,return,or,progression,of,CML,and,,,in,some,patients,with,CML,,,imatinib,may,promote,cytogenetic,clonal,evolution,,,resulting,in,a,poor,response,to,treatment,. | |
| labels,0,0,0,0,0,5,6,6,6,7,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Visual loss | |
| drug,vincristine | |
| sequence,Visual,loss,after,a,single,small,dose,of,vincristine,has,never,been,reported,. | |
| labels,5,7,0,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,dystonia | |
| drug,carbamazepine | |
| sequence,The,currently,available,clinical,and,neuropharmacologic,data,suggest,that,carbamazepine,may,be,an,antagonist,of,dopamine,and,that,this,property,is,responsible,for,the,production,of,dystonia,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,pancreatitis,lethal complication | |
| drug,L-asparaginase | |
| sequence,L-asparaginase-induced,pancreatitis,is,an,uncommon,but,potential,lethal,complication,of,the,treatment,of,leukemia,. | |
| labels,4,8,0,0,0,0,0,5,7,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anaphylactic reaction | |
| drug,vancomycin | |
| sequence,Severe,vancomycin-induced,anaphylactic,reaction,. | |
| labels,0,4,5,7,0 | |
| ade_mask,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,lead toxicity | |
| drug,lead | |
| sequence,This,case,demonstrates,an,occupational,activity,(,construction,),that,has,now,become,the,dominant,source,of,lead,exposure,for,U.S.,adults,,,the,importance,of,a,good,occupational,history,to,suspecting,and,making,a,diagnosis,,,the,possible,outcomes,of,chronic,lead,toxicity,,,and,the,importance,of,preventing,further,exposure,and,using,proper,methods,to,treat,acute,toxicity,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatotoxicity | |
| drug,salicylate | |
| sequence,Hepatotoxicity,associated,with,choline,magnesium,trisalicylate,:,case,report,and,review,of,salicylate-induced,hepatotoxicity,. | |
| labels,8,0,0,1,2,3,4,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Hepatotoxicity,hepatotoxicity | |
| drug,choline magnesium trisalicylate | |
| sequence,Hepatotoxicity,associated,with,choline,magnesium,trisalicylate,:,case,report,and,review,of,salicylate-induced,hepatotoxicity,. | |
| labels,8,0,0,1,2,3,4,0,0,0,0,0,0,8,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,laryngeal hematoma | |
| drug,acenocoumarol | |
| sequence,CONCLUSION,:,This,report,describes,a,case,of,a,probable,interaction,between,topical,econazole,lotion,1,%,and,acenocoumarol,that,resulted,in,overanticoagulation,and,a,life-threatening,laryngeal,hematoma,in,this,elderly,patient,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,4,0,0,0,0,0,0,0,5,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,laryngeal hematoma | |
| drug,econazole | |
| sequence,CONCLUSION,:,This,report,describes,a,case,of,a,probable,interaction,between,topical,econazole,lotion,1,%,and,acenocoumarol,that,resulted,in,overanticoagulation,and,a,life-threatening,laryngeal,hematoma,in,this,elderly,patient,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,4,0,0,0,0,0,0,0,5,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,metabolic acidosis | |
| drug,cetrimide | |
| sequence,A,patient,with,a,large,hydatid,cyst,of,the,left,lobe,of,the,liver,developed,metabolic,acidosis,following,rather,liberal,use,of,cetrimide-chlorhexidine,solution,as,a,scolicidal,agent,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,4,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,metabolic acidosis | |
| drug,chlorhexidine | |
| sequence,A,patient,with,a,large,hydatid,cyst,of,the,left,lobe,of,the,liver,developed,metabolic,acidosis,following,rather,liberal,use,of,cetrimide-chlorhexidine,solution,as,a,scolicidal,agent,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,4,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,eruption | |
| drug,omeprazole | |
| sequence,The,objective,of,this,report,is,to,describe,a,case,of,fixed,drug,eruption,that,occurred,during,omeprazole,treatment,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,protamine allergy | |
| drug,insulin | |
| sequence,CONCLUSION,:,Patients,with,insulin,allergy,may,not,have,complete,resolution,of,their,symptoms,after,standard,desensitization,,,particularly,those,patients,with,concomitant,protamine,allergy,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0 | |
| ==============================, ============================= | |
| ade,lung toxicity | |
| drug,bleomycin | |
| sequence,This,report,suggests,that,bleomycin,lung,toxicity,may,be,reversible,if,treated,aggressively,. | |
| labels,0,0,0,0,4,5,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute myopia | |
| drug,topiramate | |
| sequence,METHODS,:,In,an,institutional,practice,setting,,,two,women,,,aged,25,and,45,,,developed,acute,myopia,after,starting,topiramate,for,epilepsy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cutaneous vasculitis | |
| drug,ramipril | |
| sequence,Here,we,report,ramipril-induced,cutaneous,vasculitis,in,a,patient,who,required,steroid,therapy,to,control,it,. | |
| labels,0,0,0,4,5,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Toxic epidermal necrolysis | |
| drug,cytosine arabinoside | |
| sequence,Toxic,epidermal,necrolysis,after,the,use,of,high-dose,cytosine,arabinoside,. | |
| labels,5,6,7,0,0,0,0,0,1,3,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,immunosuppression,T-cell lymphocytopenia,infections with Pneumocystis jiroveci pneumonia,brain abscess with Listeria monocytogenes,cutaneous Kaposi's sarcoma | |
| drug,temozolomide | |
| sequence,DIAGNOSIS,:,Severe,temozolomide-induced,immunosuppression,,,exacerbated,by,corticosteroids,,,with,profound,T-cell,lymphocytopenia,and,simultaneous,opportunistic,infections,with,Pneumocystis,jiroveci,pneumonia,,,brain,abscess,with,Listeria,monocytogenes,,,and,cutaneous,Kaposi,'s,sarcoma,. | |
| labels,0,0,0,4,8,0,0,0,0,0,0,0,5,7,0,0,0,5,6,6,6,7,0,5,6,6,6,7,0,0,5,6,6,7,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,1,0,1,1,0,0,0,1,0,1,1,1,0,1,1,0,1,1,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,worsening diarrhea,abdominal pain,fever | |
| drug,albendazole | |
| sequence,While,undergoing,treatment,with,albendazole,,,he,developed,worsening,diarrhea,with,abdominal,pain,and,fever,. | |
| labels,0,0,0,0,4,0,0,0,5,7,0,5,7,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,1,1,0,1,0 | |
| ==============================, ============================= | |
| ade,hypoadrenalism | |
| drug,o,p-DDD | |
| sequence,Both,patients,developed,hypoadrenalism,while,on,o,,,p-DDD,and,apparently,adequate,dexamethasone,replacement,therapy,. | |
| labels,0,0,0,8,0,0,1,2,3,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatotoxicity | |
| drug,sirolimus | |
| sequence,The,aim,of,our,paper,was,to,describe,hepatotoxicity,of,sirolimus,(,SRL,),in,a,kidney,graft,recipient,. | |
| labels,0,0,0,0,0,0,0,0,8,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,unilateral gingival hyperplasia | |
| drug,phenytoin | |
| sequence,A,15-year,follow-up,of,phenytoin-induced,unilateral,gingival,hyperplasia,:,a,case,report,. | |
| labels,0,0,0,0,4,5,6,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Pulmonary toxicity | |
| drug,procarbazine | |
| sequence,Pulmonary,toxicity,secondary,to,procarbazine,. | |
| labels,5,7,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,tracheal compression | |
| drug,aspirin | |
| sequence,This,progressed,to,tracheal,compression,with,stridor,after,he,had,taken,some,aspirin,for,relief,of,the,neck,pain,. | |
| labels,0,0,0,5,7,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thyrotoxicosis | |
| drug,amiodarone | |
| sequence,Treatment,of,amiodarone-induced,thyrotoxicosis,(,AIT,),with,thionamide,,,lithium,or,radioactive,iodine,is,ineffective,. | |
| labels,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,testicular swelling,pain | |
| drug,desipramine | |
| sequence,The,observations,suggest,that,testicular,swelling,and,pain,are,side,effects,of,desipramine,. | |
| labels,0,0,0,0,5,7,0,8,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,1,1,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute subdural haematoma | |
| drug,aspirin | |
| sequence,A,case,of,acute,subdural,haematoma,originating,spontaneously,from,an,angiomatous,meningioma,in,a,patient,receiving,prophylactic,aspirin,therapy,is,presented,. | |
| labels,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,spontaneous choroidal hemorrhage | |
| drug,tissue plasminogen activator | |
| sequence,PURPOSE,:,To,determine,the,cause,of,spontaneous,choroidal,hemorrhage,in,a,67-year-old,man,after,a,myocardial,infarction,and,administration,of,tissue,plasminogen,activator,. | |
| labels,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,1,2,3,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Electrolyte disorders | |
| drug,foscarnet | |
| sequence,DISCUSSION,:,Electrolyte,disorders,associated,with,foscarnet,are,reviewed,. | |
| labels,0,0,5,7,0,0,4,0,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,extrapyramidal side effects | |
| drug,olanzapine | |
| sequence,Like,other,atypical,neuroleptics,olanzapine,is,considered,to,show,a,reduced,prevalence,of,extrapyramidal,side,effects,when,compared,to,classical,neuroleptic,drugs,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatitis,mononucleosis,hypersensitivity reactions | |
| drug,phenytoin | |
| sequence,A,case,of,phenytoin-induced,hepatitis,with,mononucleosis,is,reported,,,and,syndromes,associated,with,phenytoin,hypersensitivity,reactions,are,discussed,. | |
| labels,0,0,0,0,8,0,8,0,0,0,0,0,0,0,4,5,7,0,0,0 | |
| ade_mask,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,behavioural side effects | |
| drug,gabapentin | |
| sequence,We,report,two,adults,who,received,gabapentin,(,GBP,),and,subsequently,developed,behavioural,side,effects,. | |
| labels,0,0,0,0,0,0,4,0,4,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,behavioural side effects | |
| drug,GBP | |
| sequence,We,report,two,adults,who,received,gabapentin,(,GBP,),and,subsequently,developed,behavioural,side,effects,. | |
| labels,0,0,0,0,0,0,4,0,4,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,increasing the hepatic toxicity | |
| drug,clarithromycin | |
| sequence,A,second,possibility,is,an,interaction,between,clarithromycin,and,isradipine,,,potentially,increasing,the,hepatic,toxicity,of,isradipine,. | |
| labels,0,0,0,0,0,0,0,4,0,4,0,0,5,6,6,7,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,increasing the hepatic toxicity | |
| drug,isradipine | |
| sequence,A,second,possibility,is,an,interaction,between,clarithromycin,and,isradipine,,,potentially,increasing,the,hepatic,toxicity,of,isradipine,. | |
| labels,0,0,0,0,0,0,0,4,0,4,0,0,5,6,6,7,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,Retinal abnormalities,retinal hemorrhage,"cotton-wool" spots | |
| drug,interferon | |
| sequence,Retinal,abnormalities,,,including,retinal,hemorrhage,and,``,cotton-wool,'',spots,,,often,occur,within,the,first,8,weeks,in,the,course,of,interferon,therapy,in,patients,with,chronic,hepatitis,C,. | |
| labels,5,7,0,0,5,7,0,5,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,1,1,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,arterial thrombosis | |
| drug,thrombin | |
| sequence,Lower,extremity,arterial,thrombosis,following,sonographically,guided,thrombin,injection,of,a,femoral,pseudoaneurysm,. | |
| labels,0,0,5,7,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sub-acute leukoencephalopathy | |
| drug,methotrexate | |
| sequence,We,describe,longitudinal,diffusion-weighted,MRI,findings,of,sub-acute,leukoencephalopathy,following,methotrexate,therapy,in,a,24-year-old,man,diagnosed,with,pre-B-cell,acute,lymphoblastic,leukemia,(,ALL,),,,presenting,with,right-sided,paralysis,and,aphasia,after,second,consolidation,with,intrathecal,triple-drug,therapy,given,intrathecally,. | |
| labels,0,0,0,0,0,0,0,5,7,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,respiratory failure | |
| drug,vecuronium | |
| sequence,This,entity,is,probably,related,to,a,combination,of,high,doses,of,corticosteroids,,,vecuronium,administration,and,metabolic,abnormalities,associated,with,respiratory,failure,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,high blood lead level | |
| drug,lead | |
| sequence,After,several,unrevealing,medical,work-ups,,,he,was,found,to,have,a,high,blood,lead,level,(,122,microg,dL,),;,he,has,a,history,of,scraping,and,sanding,lead,paint,without,adequate,protective,measures,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,5,6,9,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis | |
| drug,cyclosporine | |
| sequence,Discontinuation,of,simvastatin,and,cyclosporine,resulted,in,resolution,of,rhabdomyolysis,and,normalization,of,renal,function,. | |
| labels,0,0,4,0,4,0,0,0,0,8,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis | |
| drug,simvastatin | |
| sequence,Discontinuation,of,simvastatin,and,cyclosporine,resulted,in,resolution,of,rhabdomyolysis,and,normalization,of,renal,function,. | |
| labels,0,0,4,0,4,0,0,0,0,8,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,maculopapular eruption,fever | |
| drug,ritonavir | |
| sequence,We,report,2,cases,of,maculopapular,eruption,and,fever,in,patients,infected,with,human,immunodeficiency,virus,(,HIV,),on,the,2nd,day,of,first,administration,of,ritonavir,,,a,protease,inhibitor,. | |
| labels,0,0,0,0,0,5,7,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,optic neuropathy | |
| drug,ethambutol | |
| sequence,Isoniazid,and,ethambutol,as,a,cause,of,optic,neuropathy,. | |
| labels,4,0,4,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,optic neuropathy | |
| drug,Isoniazid | |
| sequence,Isoniazid,and,ethambutol,as,a,cause,of,optic,neuropathy,. | |
| labels,4,0,4,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,bilateral breast enlargement | |
| drug,sunitinib | |
| sequence,However,,,re-initiation,of,sunitinib,treatment,was,followed,by,bilateral,breast,enlargement,again,. | |
| labels,0,0,0,0,4,0,0,0,0,5,6,7,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,0,0 | |
| ==============================, ============================= | |
| ade,hemorrhage,hemorrhagic choroidal detachment | |
| drug,tissue plasminogen activator | |
| sequence,CONCLUSION,:,The,administration,of,tissue,plasminogen,activator,was,responsible,for,the,large,extent,of,hemorrhage,and,should,be,considered,in,the,differential,diagnosis,of,hemorrhagic,choroidal,detachment,. | |
| labels,0,0,0,0,0,1,2,3,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,pseudoporphyria | |
| drug,naproxen | |
| sequence,METHODS,:,We,report,two,cases,of,pseudoporphyria,caused,by,naproxen,and,oxaprozin,. | |
| labels,0,0,0,0,0,0,0,8,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pseudoporphyria | |
| drug,oxaprozin | |
| sequence,METHODS,:,We,report,two,cases,of,pseudoporphyria,caused,by,naproxen,and,oxaprozin,. | |
| labels,0,0,0,0,0,0,0,8,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anagen effluvium,lichenoid eruption | |
| drug,Isonicotinic acid hydrazide | |
| sequence,Isonicotinic,acid,hydrazide,induced,anagen,effluvium,and,associated,lichenoid,eruption,. | |
| labels,1,2,3,0,5,7,0,0,5,7,0 | |
| ade_mask,0,0,0,0,1,1,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,neurotoxicity | |
| drug,HDARAC | |
| sequence,This,case,report,illustrates,the,neurotoxicity,unique,to,HDARAC,. | |
| labels,0,0,0,0,0,8,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fatal hyperkalemia | |
| drug,succinylcholine | |
| sequence,We,believe,that,mucositis,was,a,contributing,factor,to,this,case,of,fatal,hyperkalemia,after,administration,of,succinylcholine,,,with,a,mechanism,similar,to,that,reported,with,thermal,injury,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,multiform ventricular tachycardia | |
| drug,haloperidol | |
| sequence,Intravenous,haloperidol,is,generally,well,tolerated,,,but,multiform,ventricular,tachycardia,has,been,reported,. | |
| labels,0,4,0,0,0,0,0,0,5,6,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,SIADH | |
| drug,CDDP | |
| sequence,Interestingly,,,the,use,of,carboplatin,(,CBDCA,),and,VDS,in,the,subsequent,treatment,course,was,well,tolerated,indicating,that,the,SIADH,was,most,likely,to,have,been,induced,by,administration,of,CDDP,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Sarcoma | |
| drug,cyclophosphamide | |
| sequence,Sarcoma,complicating,therapy,with,cyclophosphamide,. | |
| labels,8,0,0,0,4,0 | |
| ade_mask,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Coagulopathy | |
| drug,cephalosporin | |
| sequence,Coagulopathy,associated,with,the,use,of,cephalosporin,or,moxalactam,antibiotics,in,acute,and,chronic,renal,failure,. | |
| labels,8,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Coagulopathy | |
| drug,moxalactam | |
| sequence,Coagulopathy,associated,with,the,use,of,cephalosporin,or,moxalactam,antibiotics,in,acute,and,chronic,renal,failure,. | |
| labels,8,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,electrolyte disorders | |
| drug,foscarnet | |
| sequence,CONCLUSIONS,:,It,is,probable,that,foscarnet,contributed,to,the,electrolyte,disorders,and,symptomatology,in,this,patient,. | |
| labels,0,0,0,0,0,0,4,0,0,0,5,7,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,seizures | |
| drug,nafcillin | |
| sequence,We,report,a,premature,infant,who,developed,seizures,associated,with,intraventricular,administration,of,nafcillin,and,discuss,the,need,for,electroencephalographic,monitoring,of,patients,receiving,intraventricular,antibiotics,. | |
| labels,0,0,0,0,0,0,0,8,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,swelling of the face and legs,pruritus | |
| drug,phenytoin | |
| sequence,Phenytoin,was,discontinued,after,admission,;,however,,,phenytoin,1,g,i.v,.,was,given,for,a,tonic-clonic,seizure,two,days,after,admission,,,after,which,swelling,of,the,face,and,legs,and,pruritus,developed,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,7,0,8,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,1,0,1,0,0 | |
| ==============================, ============================= | |
| ade,anemia | |
| drug,enalapril | |
| sequence,Two,renal,transplant,patients,developed,anemia,during,treatment,of,hypertension,with,enalapril,medication,. | |
| labels,0,0,0,0,0,8,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rapidly progressive glomerulonephritis,epithelial crescents,hemoptysis | |
| drug,D-penicillamine | |
| sequence,A,56-year-old,woman,with,scleroderma,developed,rapidly,progressive,glomerulonephritis,with,epithelial,crescents,associated,with,hemoptysis,after,27,months,of,D-penicillamine,therapy,and,a,cumulative,dose,of,1,200,g,. | |
| labels,0,0,0,0,0,0,5,6,7,0,5,7,0,0,8,0,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,1,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,AVT | |
| drug,Amiodarone | |
| sequence,Amiodarone,was,the,third,drug,to,induce,AVT,in,this,patient,;,she,received,200,mg,day,six,days,per,week,for,six,months,. | |
| labels,4,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,irritability,angry outbursts | |
| drug,lithium | |
| sequence,We,describe,two,cases,that,illustrate,the,use,of,lithium,in,the,treatment,of,veterans,with,PTSD,who,complained,of,serious,problems,with,irritability,or,angry,outbursts,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,0 | |
| ==============================, ============================= | |
| ade,granulocytopenia | |
| drug,clozapine | |
| sequence,BACKGROUND,:,How,to,best,treat,psychotic,patients,who,have,had,past,clozapine-induced,agranulocytosis,or,granulocytopenia,remains,a,problem,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,8,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,adrenocortical insufficiency | |
| drug,fentanyl | |
| sequence,We,report,a,case,of,a,64-year-old,man,with,secondary,adrenocortical,insufficiency,who,has,been,on,a,chronic,transdermal,fentanyl,treatment,because,of,sciatic,pain,syndrome,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Crohn's disease,long-term immunosuppression | |
| drug,Copaxone | |
| sequence,RESULTS,:,Our,patient,developed,Crohn,'s,disease,while,on,Copaxone,treatment,as,a,consequence,of,long-term,immunosuppression,. | |
| labels,0,0,0,0,0,5,6,7,0,0,4,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,bilateral ballism | |
| drug,heroin | |
| sequence,Patient,1,presented,bilateral,ballism,1,week,after,intravenous,heroin,injection,. | |
| labels,0,0,0,5,7,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,SIADH | |
| drug,mizoribin | |
| sequence,In,summary,,,we,report,herein,the,first,case,of,SIADH,believed,to,be,an,adverse,effect,of,mizoribin,,,which,may,therefore,needed,to,be,added,to,the,list,of,drugs,which,can,induce,SIADH,. | |
| labels,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,allergic reactions | |
| drug,capecitabine | |
| sequence,Fluorouracil,for,allergic,reactions,to,capecitabine,. | |
| labels,0,0,5,7,0,4,0 | |
| ade_mask,0,0,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,aplastic anemia | |
| drug,acetazolamide | |
| sequence,Several,case,reports,of,aplastic,anemia,with,use,of,acetazolamide,,,and,two,cases,with,use,of,methazolamide,,,have,appeared,in,the,literature,. | |
| labels,0,0,0,0,5,7,0,0,0,4,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,aplastic anemia | |
| drug,methazolamide | |
| sequence,Several,case,reports,of,aplastic,anemia,with,use,of,acetazolamide,,,and,two,cases,with,use,of,methazolamide,,,have,appeared,in,the,literature,. | |
| labels,0,0,0,0,5,7,0,0,0,4,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,mild nitritoid symptoms | |
| drug,GSTM | |
| sequence,The,second,patient,experienced,mild,nitritoid,symptoms,following,several,GSTM,injections,prior,experiencing,a,cerebrovascular,accident,within,several,hours,of,her,next,injection,. | |
| labels,0,0,0,0,5,6,7,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,symptomatic hyperlactatemia | |
| drug,stavudine | |
| sequence,CASE,REPORT,:,We,describe,here,a,case,of,a,60,year,old,female,that,experienced,a,relapse,of,symptomatic,hyperlactatemia,after,being,switched,from,stavudine,to,zidovudine,and,how,the,case,was,managed,at,the,Infectious,Diseases,Institute,,,Kampala,,,Uganda,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,symptomatic hyperlactatemia | |
| drug,zidovudine | |
| sequence,CASE,REPORT,:,We,describe,here,a,case,of,a,60,year,old,female,that,experienced,a,relapse,of,symptomatic,hyperlactatemia,after,being,switched,from,stavudine,to,zidovudine,and,how,the,case,was,managed,at,the,Infectious,Diseases,Institute,,,Kampala,,,Uganda,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,withdrawal syndrome | |
| drug,Chlormadinone acetate | |
| sequence,Chlormadinone,acetate,withdrawal,syndrome,under,combined,androgen,blockade,for,advanced,prostate,cancer,. | |
| labels,1,3,5,7,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pulmonary infiltrates,plural effusion dyspnoea | |
| drug,trastuzumab | |
| sequence,A,female,patient,with,HER2,positive,,,metastatic,breast,cancer,presented,with,pulmonary,infiltrates,,,and,a,plural,effusion,dyspnoea,after,several,months,of,trastuzumab,treatment,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,5,6,7,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute severe hepatitis | |
| drug,erlotinib | |
| sequence,CASE,REPORT,:,We,report,a,case,of,acute,severe,hepatitis,resulting,from,erlotinib,monotherapy,in,a,patient,with,locally,advanced,pancreatic,cancer,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,priapism | |
| drug,trazodone | |
| sequence,A,case,of,priapism,associated,with,trazodone,is,described,. | |
| labels,0,0,0,8,0,0,4,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ileus | |
| drug,acarbose | |
| sequence,Oral,intake,and,acarbose,were,withheld,and,the,ileus,spontaneously,resolved,after,2,days,. | |
| labels,0,0,0,4,0,0,0,0,8,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute renal failure,tubulo-interstitial disease,proteinuria,nephrotic syndrome | |
| drug,Lithium | |
| sequence,Lithium,is,known,to,cause,acute,renal,failure,and,tubulo-interstitial,disease,,,but,the,recently,described,association,with,proteinuria,or,nephrotic,syndrome,is,little,recognized,. | |
| labels,4,0,0,0,0,5,6,7,0,5,7,0,0,0,0,0,0,0,8,0,5,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,1,1,0,0,0,0,0,0,0,1,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hypersensitivity reactions | |
| drug,cyclosporine | |
| sequence,BACKGROUND,:,Hypersensitivity,reactions,to,cyclosporine,are,rare,. | |
| labels,0,0,5,7,0,4,0,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatotoxicity | |
| drug,methylprednisolone | |
| sequence,We,observed,2,cases,of,hepatotoxicity,after,a,high-dose,methylprednisolone,treatment,of,a,demyelinating,disease,and,evaluated,the,potential,relationship,in,the,light,of,available,evidence,. | |
| labels,0,0,0,0,0,8,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,submassive hepatic necrosis | |
| drug,barbiturate | |
| sequence,A,case,of,barbiturate-induced,submassive,hepatic,necrosis,is,presented,and,the,literature,is,reviewed,. | |
| labels,0,0,0,4,5,6,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,jaundice | |
| drug,streptokinase | |
| sequence,Only,a,few,reports,of,overt,jaundice,are,associated,with,streptokinase,. | |
| labels,0,0,0,0,0,0,8,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ballistic movements | |
| drug,heroin | |
| sequence,Two,heroin,addicts,,,aged,34,and,19,years,,,developed,ballistic,movements,after,intravenous,heroin,overdose,. | |
| labels,0,4,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fever | |
| drug,diltiazem | |
| sequence,Drug-induced,fever,should,be,considered,in,patients,who,have,unexplained,high,temperatures,during,diltiazem,therapy,. | |
| labels,0,8,0,0,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Stevens-Johnson syndrome,toxic epidermal necrolysis | |
| drug,ofloxacin | |
| sequence,However,,,a,large,case-control,study,included,three,cases,of,either,Stevens-Johnson,syndrome,or,toxic,epidermal,necrolysis,associated,with,ofloxacin,use,,,but,no,details,of,the,cases,were,given,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,7,0,5,6,7,0,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,persistent hypoglycemia | |
| drug,etanercept | |
| sequence,We,report,a,patient,with,type,2,diabetes,mellitus,who,,,while,treated,with,the,antitumor,necrosis,factor-alpha,blocking,agent,etanercept,for,severe,plaque,psoriasis,,,experienced,persistent,hypoglycemia,requiring,the,lowering,and,eventual,elimination,of,his,previous,insulin,regimen,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Alternating sinus rhythm,intermittent sinoatrial block | |
| drug,propranolol | |
| sequence,Alternating,sinus,rhythm,and,intermittent,sinoatrial,block,induced,by,propranolol,. | |
| labels,5,6,7,0,5,6,7,0,0,4,0 | |
| ade_mask,1,1,1,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,feeding gastrostomy,worsening parkinsonism | |
| drug,risperidone | |
| sequence,One,patient,required,nursing,home,placement,and,a,feeding,gastrostomy,as,a,result,of,the,worsening,parkinsonism,during,risperidone,treatment,,,but,was,able,to,return,home,and,have,the,gastrostomy,removed,after,switching,from,risperidone,to,clozapine,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,5,7,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe agitation,aggressive behavior | |
| drug,carbamazepine | |
| sequence,After,three,weeks,of,carbamazepine,therapy,,,the,patient,arrived,at,the,emergency,department,(,ED,),with,severe,agitation,and,aggressive,behavior,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,1,0 | |
| ==============================, ============================= | |
| ade,symptomatic hypoglycemia | |
| drug,glipizide | |
| sequence,An,83-year-old,man,receiving,glipizide,10,mg,bid,developed,symptomatic,hypoglycemia,within,three,days,of,adding,trimethoprim,sulfamethoxazole,(,TMP,SMX,),to,his,regimen,. | |
| labels,0,0,0,0,4,0,0,0,0,5,7,0,0,0,0,0,4,4,0,4,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,symptomatic hypoglycemia | |
| drug,SMX | |
| sequence,An,83-year-old,man,receiving,glipizide,10,mg,bid,developed,symptomatic,hypoglycemia,within,three,days,of,adding,trimethoprim,sulfamethoxazole,(,TMP,SMX,),to,his,regimen,. | |
| labels,0,0,0,0,4,0,0,0,0,5,7,0,0,0,0,0,4,4,0,4,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,symptomatic hypoglycemia | |
| drug,sulfamethoxazole | |
| sequence,An,83-year-old,man,receiving,glipizide,10,mg,bid,developed,symptomatic,hypoglycemia,within,three,days,of,adding,trimethoprim,sulfamethoxazole,(,TMP,SMX,),to,his,regimen,. | |
| labels,0,0,0,0,4,0,0,0,0,5,7,0,0,0,0,0,4,4,0,4,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,symptomatic hypoglycemia | |
| drug,TMP | |
| sequence,An,83-year-old,man,receiving,glipizide,10,mg,bid,developed,symptomatic,hypoglycemia,within,three,days,of,adding,trimethoprim,sulfamethoxazole,(,TMP,SMX,),to,his,regimen,. | |
| labels,0,0,0,0,4,0,0,0,0,5,7,0,0,0,0,0,4,4,0,4,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,symptomatic hypoglycemia | |
| drug,trimethoprim | |
| sequence,An,83-year-old,man,receiving,glipizide,10,mg,bid,developed,symptomatic,hypoglycemia,within,three,days,of,adding,trimethoprim,sulfamethoxazole,(,TMP,SMX,),to,his,regimen,. | |
| labels,0,0,0,0,4,0,0,0,0,5,7,0,0,0,0,0,4,4,0,4,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Pilocarpine toxicity | |
| drug,Pilocarpine | |
| sequence,Pilocarpine,toxicity,and,the,treatment,of,xerostomia,. | |
| labels,9,7,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Syndrome of inappropriate antidiuretic hormone | |
| drug,vinorelbine | |
| sequence,Syndrome,of,inappropriate,antidiuretic,hormone,associated,with,vinorelbine,therapy,. | |
| labels,5,6,6,6,7,0,0,4,0,0 | |
| ade_mask,1,1,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,IgG lambda-type monoclonal gammopathy,multiple myeloma | |
| drug,DILANTIN | |
| sequence,The,development,of,an,IgG,lambda-type,monoclonal,gammopathy,and,subsequent,multiple,myeloma,in,an,epilepsy,patient,on,diphenylhydantoin,(,DILANTIN,),therapy,for,20,years,is,reported,. | |
| labels,0,0,0,0,5,6,6,7,0,0,5,7,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,1,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,IgG lambda-type monoclonal gammopathy,multiple myeloma | |
| drug,diphenylhydantoin | |
| sequence,The,development,of,an,IgG,lambda-type,monoclonal,gammopathy,and,subsequent,multiple,myeloma,in,an,epilepsy,patient,on,diphenylhydantoin,(,DILANTIN,),therapy,for,20,years,is,reported,. | |
| labels,0,0,0,0,5,6,6,7,0,0,5,7,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,1,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute toxic delirium,EEG abnormalities | |
| drug,amphotericin B | |
| sequence,A,patient,with,coccidioidal,meningitis,was,treated,with,intrathecally,administered,amphotericin,B,,,and,an,acute,toxic,delirium,with,EEG,abnormalities,developed,. | |
| labels,0,0,0,0,0,0,0,0,0,0,1,3,0,0,0,5,6,7,0,5,7,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,1,0,0 | |
| ==============================, ============================= | |
| ade,gastritis | |
| drug,dexamethasone | |
| sequence,We,postulate,that,gastritis,caused,by,dexamethasone,,,mucositis,caused,by,doxorubicin,,,and,the,unique,anatomic,nature,of,a,Meckel,diverticulum,may,have,contributed,to,this,extremely,unlikely,and,previously,unreported,event,. | |
| labels,0,0,0,8,0,0,4,0,8,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,mucositis | |
| drug,doxorubicin | |
| sequence,We,postulate,that,gastritis,caused,by,dexamethasone,,,mucositis,caused,by,doxorubicin,,,and,the,unique,anatomic,nature,of,a,Meckel,diverticulum,may,have,contributed,to,this,extremely,unlikely,and,previously,unreported,event,. | |
| labels,0,0,0,8,0,0,4,0,8,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperkalemia | |
| drug,heparin | |
| sequence,We,present,four,cases,in,which,the,use,of,heparin,was,associated,with,hyperkalemia,and,discuss,the,pathophysiology,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,0,8,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,optic neuropathy | |
| drug,penicillamine | |
| sequence,The,case,resembles,two,previously,reported,cases,of,optic,neuropathy,which,occurred,in,patients,with,Wilson,'s,disease,who,were,receiving,penicillamine,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Sustained ventricular tachycardia | |
| drug,thalidomide | |
| sequence,Sustained,ventricular,tachycardia,in,a,thalidomide-treated,patient,with,primary,plasma-cell,leukemia,. | |
| labels,5,6,7,0,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nephropathy | |
| drug,Gold | |
| sequence,Gold,nephropathy,. | |
| labels,4,8,0 | |
| ade_mask,0,1,0 | |
| ==============================, ============================= | |
| ade,Lethal anuria | |
| drug,ifosfamide | |
| sequence,Lethal,anuria,complicating,high,dose,ifosfamide,chemotherapy,in,a,breast,cancer,patient,with,an,impaired,renal,function,. | |
| labels,5,7,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bradypneic,hypotensive | |
| drug,morphine | |
| sequence,Approximately,15,min,after,the,first,administration,of,nebulised,morphine,the,patient,became,markedly,bradypneic,(,respiratory,rate,:,4-5,bpm,),,,hypotensive,(,BP,70,40,mmHg,),,,and,responded,only,partially,to,command,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,0,0,8,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myocardial infarction | |
| drug,Etoposide | |
| sequence,Etoposide-related,myocardial,infarction,. | |
| labels,4,5,7,0 | |
| ade_mask,0,1,1,0 | |
| ==============================, ============================= | |
| ade,contact dermatitis | |
| drug,budesonide | |
| sequence,CONCLUSIONS,:,Although,budesonide,may,be,beneficial,because,of,its,anti-inflammatory,effects,,,clinicians,should,be,alert,to,its,potential,for,causing,contact,dermatitis,. | |
| labels,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,increased libido | |
| drug,fluvoxamine | |
| sequence,RESULTS,:,The,patient,,,a,27-year-old,married,Japanese,woman,with,borderline,personality,disorder,,,developed,an,increased,libido,with,the,administration,of,fluvoxamine,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity reactions,general erythema,dyspnea,hypotension,abdominal pain,fever | |
| drug,cisplatin | |
| sequence,Two,patients,with,ovarian,cancer,who,had,received,multiple,courses,of,cisplatin,without,complications,experienced,hypersensitivity,reactions,to,cisplatin,:,one,,,involving,intrahepatic,artery,infusion,,,manifested,general,erythema,,,dyspnea,,,and,hypotension,;,the,other,,,involving,intravenous,infusion,,,manifested,abdominal,pain,,,general,erythema,,,and,fever,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,5,7,0,8,0,0,8,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0,0,1,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,acute hepatitis | |
| drug,amiodarone | |
| sequence,Therefore,,,parenteral,amiodarone,was,implicated,as,the,cause,of,acute,hepatitis,in,this,patient,. | |
| labels,0,0,0,4,0,0,0,0,0,0,5,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,coagulopathy | |
| drug,cephalosporin | |
| sequence,Nine,azotemic,patients,who,developed,a,coagulopathy,associated,with,the,use,of,either,cephalosporin,or,moxalactam,antibiotics,are,reported,. | |
| labels,0,0,0,0,0,0,8,0,0,0,0,0,0,4,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,coagulopathy | |
| drug,moxalactam | |
| sequence,Nine,azotemic,patients,who,developed,a,coagulopathy,associated,with,the,use,of,either,cephalosporin,or,moxalactam,antibiotics,are,reported,. | |
| labels,0,0,0,0,0,0,8,0,0,0,0,0,0,4,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,biochemical hyperparathyroidism | |
| drug,lithium | |
| sequence,These,results,indicate,that,lithium,may,cause,biochemical,hyperparathyroidism,. | |
| labels,0,0,0,0,4,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Kaposi's sarcoma,KS | |
| drug,rituximab | |
| sequence,Flare,of,Kaposi,'s,sarcoma,(,KS,),is,well,described,in,immunosuppressed,patients,treated,with,corticosteroids,and,rituximab,,,but,has,not,yet,been,reported,during,treatment,with,imatinib,. | |
| labels,0,0,5,6,7,0,8,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Skin rash,splinter hemorrhages | |
| drug,ganciclovir | |
| sequence,Skin,rash,and,splinter,hemorrhages,from,ganciclovir,. | |
| labels,5,7,0,5,7,0,4,0 | |
| ade_mask,1,1,0,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,died,Adriamycin toxicity | |
| drug,Adriamycin | |
| sequence,She,was,placed,on,adjuvant,Adriamycin,(,doxorubicin,),chemotherapy,,,but,6,months,later,died,of,Adriamycin,toxicity,. | |
| labels,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,8,0,5,7,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,1,0 | |
| ==============================, ============================= | |
| ade,died,Adriamycin toxicity | |
| drug,doxorubicin | |
| sequence,She,was,placed,on,adjuvant,Adriamycin,(,doxorubicin,),chemotherapy,,,but,6,months,later,died,of,Adriamycin,toxicity,. | |
| labels,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,8,0,5,7,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Progressive hypokalemia | |
| drug,phosphate | |
| sequence,Progressive,hypokalemia,developed,during,phosphate,treatment,. | |
| labels,5,7,0,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Anaphylaxis | |
| drug,calcitonin | |
| sequence,Anaphylaxis,to,calcitonin,. | |
| labels,8,0,4,0 | |
| ade_mask,1,0,0,0 | |
| ==============================, ============================= | |
| ade,leukopenia | |
| drug,Cefazolin | |
| sequence,CONCLUSIONS,:,Cefazolin,was,a,probable,cause,of,this,patient,'s,leukopenia,. | |
| labels,0,0,4,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity rash | |
| drug,HCQ | |
| sequence,Some,patients,develop,hypersensitivity,rash,in,response,to,HCQ,. | |
| labels,0,0,0,5,7,0,0,0,4,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,prolongation of the QT interval,T wave inversion | |
| drug,pirmenol | |
| sequence,We,report,on,a,56-year-old,female,who,exhibited,drug,refractory,paroxysmal,atrial,fibrillation,,,in,which,marked,prolongation,of,the,QT,interval,and,T,wave,inversion,on,electrocardiogram,was,demonstrated,reproducibly,shortly,after,the,administration,of,oral,pirmenol,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,7,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,central nervous system disturbances | |
| drug,propranolol | |
| sequence,The,potential,role,of,propranolol,in,inducing,central,nervous,system,disturbances,is,emphasized,,,and,the,literature,on,the,subject,is,reviewed,. | |
| labels,0,0,0,0,4,0,0,5,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Intracranial hemorrhage,focal seizures | |
| drug,L-asparaginase | |
| sequence,Intracranial,hemorrhage,and,focal,seizures,secondary,to,use,of,L-asparaginase,during,induction,therapy,of,acute,lymphocytic,leukemia,. | |
| labels,5,7,0,5,7,0,0,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Bone marrow aplasia,severe skin rash | |
| drug,methotrexate | |
| sequence,Bone,marrow,aplasia,and,severe,skin,rash,after,a,single,low,dose,of,methotrexate,. | |
| labels,5,6,7,0,5,6,7,0,0,0,0,0,0,4,0 | |
| ade_mask,1,1,1,0,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity | |
| drug,allopurinol | |
| sequence,A,case,of,allopurinol,hypersensitivity,,,possibly,the,first,in,a,black,African,,,is,reported,. | |
| labels,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neurotoxicity | |
| drug,INH | |
| sequence,CONCLUSIONS,:,We,have,seen,an,increased,incidence,of,acute,INH,neurotoxicity,because,of,the,resurgence,of,TB,in,New,York,City,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Myoclonus,seizures | |
| drug,levodopa | |
| sequence,Myoclonus,and,seizures,in,a,patient,with,parkinsonism,:,induction,by,levodopa,and,its,confirmation,on,SEPs,. | |
| labels,8,0,8,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myopathy | |
| drug,colchicine | |
| sequence,In,our,patient,,,an,objective,causality,scale,showed,that,therapeutic,doses,of,colchicine,for,FMF,were,the,definite,cause,of,myopathy,,,even,though,his,renal,and,hepatic,function,were,normal,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,symptomatic methemoglobinemia | |
| drug,valproate | |
| sequence,Acute,valproate,ingestion,induces,symptomatic,methemoglobinemia,. | |
| labels,0,4,0,0,5,7,0 | |
| ade_mask,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,skin eruptions,neutrophilic dermatoses | |
| drug,G-CSF | |
| sequence,We,believe,that,these,skin,eruptions,belong,to,a,spectrum,of,neutrophilic,dermatoses,that,can,be,induced,or,aggravated,by,G-CSF,therapy,. | |
| labels,0,0,0,0,5,7,0,0,0,0,0,5,7,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,complete atrioventricular block | |
| drug,digoxin | |
| sequence,A,66-year-old,mand,suffering,from,severe,coronary,heart,disease,took,digoxin,with,suicidal,intent,an,was,treated,for,the,ensuing,complete,atrioventricular,block,with,digoxin-specific,antibody,fragments,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,non-convulsive status epilepticus | |
| drug,tiagabine | |
| sequence,Provocation,of,non-convulsive,status,epilepticus,by,tiagabine,in,three,adolescent,patients,. | |
| labels,0,0,5,6,7,0,4,0,0,0,0,0 | |
| ade_mask,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Myoglobinuria,acute renal failure | |
| drug,vasopressin | |
| sequence,Myoglobinuria,and,acute,renal,failure,were,observed,in,two,patients,with,vasopressin-treated,gastrointestinal,hemorrhage,. | |
| labels,8,0,5,6,7,0,0,0,0,0,0,4,0,0,0 | |
| ade_mask,1,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Nephrogenic diabetes insipidus,renal tubular acidosis | |
| drug,foscarnet | |
| sequence,Nephrogenic,diabetes,insipidus,and,renal,tubular,acidosis,secondary,to,foscarnet,therapy,. | |
| labels,5,6,7,0,5,6,7,0,0,4,0,0 | |
| ade_mask,1,1,1,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute lymphoblastic leukemia | |
| drug,methotrexate | |
| sequence,We,describe,a,15-year-old,female,patient,diagnosed,with,acute,lymphoblastic,leukemia,presenting,with,status,epilepticus,after,receiving,intrathecal,methotrexate,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myocardial ischemia | |
| drug,BCNU | |
| sequence,Three,patients,are,reported,without,a,history,of,angina,pectoris,who,had,clinical,and,electrocardiographic,evidence,of,myocardial,ischemia,during,and,immediately,after,BCNU,infusion,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis | |
| drug,cyclosporine | |
| sequence,Simvastatin-induced,rhabdomyolysis,following,cyclosporine,treatment,for,uveitis,. | |
| labels,4,8,0,4,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis | |
| drug,Simvastatin | |
| sequence,Simvastatin-induced,rhabdomyolysis,following,cyclosporine,treatment,for,uveitis,. | |
| labels,4,8,0,4,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ocular toxicity | |
| drug,ethambutol | |
| sequence,There,is,documentation,of,ocular,toxicity,with,ethambutol,when,administered,at,dosages,generally,pronounced,as,being,safe,. | |
| labels,0,0,0,0,5,7,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Cholesterol crystal embolization,renal failure | |
| drug,tissue-type plasminogen activator | |
| sequence,Cholesterol,crystal,embolization-associated,renal,failure,after,therapy,with,recombinant,tissue-type,plasminogen,activator,. | |
| labels,5,6,7,5,7,0,0,0,0,1,2,3,0 | |
| ade_mask,1,1,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,type 1 diabetes mellitus | |
| drug,recombinant alpha-2b peginterferon | |
| sequence,The,clinical,course,suggested,that,recombinant,alpha-2b,peginterferon,plus,ribavirin,provoked,type,1,diabetes,mellitus,,,therefore,,,in,patients,who,are,candidates,for,interferon,therapy,the,presence,of,pancreatic,autoantibodies,and,the,fasting,plasma,glucose,level,should,be,investigated,before,and,during,treatment,. | |
| labels,0,0,0,0,0,1,2,3,0,4,0,5,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,type 1 diabetes mellitus | |
| drug,ribavirin | |
| sequence,The,clinical,course,suggested,that,recombinant,alpha-2b,peginterferon,plus,ribavirin,provoked,type,1,diabetes,mellitus,,,therefore,,,in,patients,who,are,candidates,for,interferon,therapy,the,presence,of,pancreatic,autoantibodies,and,the,fasting,plasma,glucose,level,should,be,investigated,before,and,during,treatment,. | |
| labels,0,0,0,0,0,1,2,3,0,4,0,5,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,leukoencephalopathy | |
| drug,methotrexate | |
| sequence,An,episode,of,leukoencephalopathy,is,reported,in,a,13-year-old,girl,who,,,after,standard,radiotherapy,for,a,posterior,fossa,medulloblastoma,,,received,8,treatments,with,a,protocol,containing,a,4-hour,infusion,of,500,mg,m2,methotrexate,and,12,mg,intrathecal,methotrexate,. | |
| labels,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,renal toxicity | |
| drug,MTX | |
| sequence,Although,his,renal,function,recovered,completely,with,high-dose,leucovorin,,,hemodialysis,,,charcoal,hemoperfusion,,,and,carboxypeptidase,G2,,,we,present,this,case,to,emphasize,that,signs,of,renal,toxicity,may,be,present,as,early,as,2,hours,after,the,completion,of,a,4-hour,MTX,infusion,,,and,to,suggest,that,monitoring,for,MTX,toxicity,should,perhaps,begin,within,a,few,hours,after,the,completion,of,4-hour,MTX,infusion,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,collagenous colitis | |
| drug,Lansoprazole | |
| sequence,Lansoprazole-associated,collagenous,colitis,:,a,case,report,. | |
| labels,4,5,7,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperglycemia | |
| drug,olanzapine | |
| sequence,Rapidly,developing,hyperglycemia,during,treatment,with,olanzapine,. | |
| labels,0,0,8,0,0,0,4,0 | |
| ade_mask,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,AZ intoxication | |
| drug,AZ | |
| sequence,She,was,thus,diagnosed,as,having,AZ,intoxication,. | |
| labels,0,0,0,0,0,0,9,7,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,cardiac arrhythmias | |
| drug,chloral hydrate | |
| sequence,The,pharmacology,and,toxicology,of,chloral,hydrate,are,discussed,with,particular,reference,to,the,cardiac,arrhythmias,that,are,seen,with,overdosage,. | |
| labels,0,0,0,0,0,1,3,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hemoglobinemia,disseminated intravascular coagulation,DIC | |
| drug,anti-D IGIV | |
| sequence,That,review,suggested,that,patients,receiving,anti-D,IGIV,be,monitored,for,those,and,other,potential,complications,of,hemoglobinemia,,,particularly,disseminated,intravascular,coagulation,(,DIC,),. | |
| labels,0,0,0,0,0,0,1,3,0,0,0,0,0,0,0,0,0,8,0,0,5,6,7,0,8,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,1,0,1,0,0 | |
| ==============================, ============================= | |
| ade,muscle weakness | |
| drug,interferon alpha | |
| sequence,To,treat,hepatitis,B,,,interferon,alpha,was,administered,until,the,proximal,muscle,weakness,developed,. | |
| labels,0,0,0,0,0,1,3,0,0,0,0,0,5,7,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0 | |
| ==============================, ============================= | |
| ade,impaired renal function | |
| drug,amphotericin B | |
| sequence,Experience,with,five,patients,in,whom,impaired,renal,function,developed,early,during,amphotericin,B,therapy,is,reported,. | |
| labels,0,0,0,0,0,0,5,6,7,0,0,0,1,3,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity syndrome,hemophagocytic syndrome | |
| drug,Sulfasalazine | |
| sequence,Sulfasalazine-induced,hypersensitivity,syndrome,and,hemophagocytic,syndrome,associated,with,reactivation,of,Epstein-Barr,virus,. | |
| labels,4,5,7,0,5,7,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,increase in the theophylline level | |
| drug,theophylline | |
| sequence,The,noted,increase,in,the,theophylline,level,after,zafirlukast,administration,is,in,contrast,to,the,original,reports,by,the,manufacturer,. | |
| labels,0,0,5,6,6,9,7,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,increase in the theophylline level | |
| drug,zafirlukast | |
| sequence,The,noted,increase,in,the,theophylline,level,after,zafirlukast,administration,is,in,contrast,to,the,original,reports,by,the,manufacturer,. | |
| labels,0,0,5,6,6,9,7,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myocardial infarction | |
| drug,etoposide | |
| sequence,The,occurrence,of,a,myocardial,infarction,is,reported,after,chemotherapy,containing,etoposide,,,in,a,man,with,no,risk,factors,for,coronary,heart,disease,. | |
| labels,0,0,0,0,5,7,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,symptomatic methemoglobinemia | |
| drug,Depakote | |
| sequence,We,report,for,the,first,time,the,development,of,symptomatic,methemoglobinemia,after,an,acute,ingestion,of,divalproex,sodium,(,Depakote,),,,resulting,in,serum,concentrations,10,times,greater,than,the,therapeutic,range,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,1,3,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,symptomatic methemoglobinemia | |
| drug,divalproex sodium | |
| sequence,We,report,for,the,first,time,the,development,of,symptomatic,methemoglobinemia,after,an,acute,ingestion,of,divalproex,sodium,(,Depakote,),,,resulting,in,serum,concentrations,10,times,greater,than,the,therapeutic,range,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,1,3,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe neurotoxicity | |
| drug,vincristine | |
| sequence,Recognizing,early,signs,of,HMSN,,,such,as,areflexia,and,pes,cavus,deformity,,,can,prevent,severe,neurotoxicity,of,polychemotherapy,by,avoiding,vincristine,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperammonemia | |
| drug,Carbamazepine | |
| sequence,Carbamazepine-induced,hyperammonemia,. | |
| labels,4,8,0 | |
| ade_mask,0,1,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis | |
| drug,vasopressin | |
| sequence,These,multiple,overlapping,factors,probably,lead,to,rhabdomyolysis,in,a,minority,of,patients,receiving,vasopressin,infusion,. | |
| labels,0,0,0,0,0,0,0,8,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,complete heart block,CHB | |
| drug,disopyramide phosphate | |
| sequence,A,57-year-old,woman,with,right,bundle,branch,block,+LPH,and,ventricular,premature,contractions,developed,complete,heart,block,(,CHB,),following,administration,of,disopyramide,phosphate,(,Norpace,),. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,8,0,0,0,0,1,3,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,1,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,complete heart block,CHB | |
| drug,Norpace | |
| sequence,A,57-year-old,woman,with,right,bundle,branch,block,+LPH,and,ventricular,premature,contractions,developed,complete,heart,block,(,CHB,),following,administration,of,disopyramide,phosphate,(,Norpace,),. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,8,0,0,0,0,1,3,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,1,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Cryptococcus neoformans fatal sepsis | |
| drug,alemtuzumab | |
| sequence,Cryptococcus,neoformans,fatal,sepsis,in,a,chronic,lymphocytic,leukemia,patient,treated,with,alemtuzumab,:,case,report,and,review,of,the,literature,. | |
| labels,5,6,6,7,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cerebral thrombosis,hemorrhage,coagulation protein deficiencies | |
| drug,L-asparaginase | |
| sequence,Children,with,acute,lymphoblastic,leukemia,(,ALL,),,,treated,with,L-asparaginase,are,at,risk,for,cerebral,thrombosis,or,hemorrhage,because,of,coagulation,protein,deficiencies,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,5,7,0,8,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,anaphylactic reaction | |
| drug,prednisone | |
| sequence,We,describe,the,case,of,a,nonatopic,17-year-old,girl,with,bronchial,asthma,and,aspirin,intolerance,who,developed,a,dramatic,anaphylactic,reaction,to,oral,prednisone,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fasting hypoglycemia | |
| drug,disopyramide | |
| sequence,Clinicians,should,be,aware,of,fasting,hypoglycemia,as,an,unusual,but,potentially,serious,complication,of,disopyramide,therapy,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cutaneous KS lesions | |
| drug,imatinib | |
| sequence,OBJECTIVE,:,We,report,a,case,of,cutaneous,KS,lesions,in,a,patient,affected,by,CML,treated,with,imatinib,. | |
| labels,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,SMON,acrodermatitis enteropathica | |
| drug,clioquinol | |
| sequence,One,type,of,SMON,is,associated,with,acrodermatitis,enteropathica,which,has,a,very,high,frequency,of,occurrence,in,association,with,administration,of,clioquinol,. | |
| labels,0,0,0,8,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,delirious | |
| drug,lithium | |
| sequence,Nine,delirious,patients,suffering,from,lithium,intoxication,were,examined,with,the,Mini-Mental,State,Exam,(,MMS,),to,describe,the,clinical,course,of,the,disorder,. | |
| labels,0,8,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hemodynamic decompensation | |
| drug,verapamil | |
| sequence,However,,,each,infant,demonstrated,hemodynamic,decompensation,shortly,after,verapamil,administration,and,required,cardiopulmonary,resuscitation,. | |
| labels,0,0,0,0,0,5,7,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,marked cholestasis,portal inflammation,bile duct injury,bile duct paucity,ductopenia | |
| drug,clindamycin | |
| sequence,One,patient,who,received,clindamycin,had,liver,biopsy,findings,of,marked,cholestasis,,,portal,inflammation,,,bile,duct,injury,and,bile,duct,paucity,(,ductopenia,),. | |
| labels,0,0,0,0,4,0,0,0,0,0,5,7,0,5,7,0,5,6,7,0,5,6,7,0,8,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,1,1,0,1,1,1,0,0,0,1,0,1,0,0 | |
| ==============================, ============================= | |
| ade,multiorgan failure | |
| drug,lisinopril | |
| sequence,Early,peritoneal,dialysis,has,not,previously,been,reported,for,lisinopril,induced,multiorgan,failure,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,severe lupus erythematosus | |
| drug,CY | |
| sequence,This,case,report,describes,an,adolescent,with,severe,lupus,erythematosus,who,received,cyclophosphamide,(,CY,),paired,with,taste,(,cod,liver,oil,),and,smell,(,rose,perfume,),as,conditioned,stimuli,. | |
| labels,0,0,0,0,0,0,0,5,6,7,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe lupus erythematosus | |
| drug,cyclophosphamide | |
| sequence,This,case,report,describes,an,adolescent,with,severe,lupus,erythematosus,who,received,cyclophosphamide,(,CY,),paired,with,taste,(,cod,liver,oil,),and,smell,(,rose,perfume,),as,conditioned,stimuli,. | |
| labels,0,0,0,0,0,0,0,5,6,7,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myasthenia gravis | |
| drug,statin | |
| sequence,We,report,4,patients,who,developed,symptoms,of,myasthenia,gravis,within,2,weeks,of,starting,treatment,with,a,statin,drug,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Interstitial pneumonitis,alveolar hemorrhage | |
| drug,rituximab | |
| sequence,Interstitial,pneumonitis,and,alveolar,hemorrhage,complicating,use,of,rituximab,:,case,report,and,review,of,the,literature,. | |
| labels,5,7,0,5,7,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Keratitis | |
| drug,methamphetamine | |
| sequence,Keratitis,in,methamphetamine,abusers,. | |
| labels,8,0,4,0,0 | |
| ade_mask,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Severe systemic hypersensitivity reaction | |
| drug,ibuprofen | |
| sequence,Severe,systemic,hypersensitivity,reaction,to,ibuprofen,occurring,after,prolonged,therapy,. | |
| labels,5,6,6,7,0,4,0,0,0,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bilateral corneal edema | |
| drug,amantadine | |
| sequence,RESULTS,:,A,52-year-old,woman,with,Parkinson,disease,who,had,taken,amantadine,for,6,years,had,bilateral,corneal,edema,for,2,months,at,baseline,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,5,6,7,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Thrombotic stroke | |
| drug,porcine factor VIII | |
| sequence,Thrombotic,stroke,associated,with,the,use,of,porcine,factor,VIII,in,a,patient,with,acquired,haemophilia,. | |
| labels,5,7,0,0,0,0,0,1,2,3,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,TD,discomfort | |
| drug,clozapine | |
| sequence,CONCLUSIONS,:,These,results,suggest,that,clozapine,may,cause,TD,;,however,,,the,prevalence,is,low,and,the,severity,is,relatively,mild,,,with,no,or,mild,self-reported,discomfort,. | |
| labels,0,0,0,0,0,0,4,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,hepatic necrosis | |
| drug,Methotrexate | |
| sequence,Methotrexate-induced,hepatic,necrosis,requiring,liver,transplantation,in,a,patient,with,rheumatoid,arthritis,. | |
| labels,4,5,7,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,diffuse papular eruption | |
| drug,methotrexate | |
| sequence,OBJECTIVE,:,To,report,a,case,of,a,diffuse,papular,eruption,following,treatment,of,psoriasis,with,methotrexate,injections,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,upper tract neoplasms | |
| drug,cyclophosphamide | |
| sequence,Other,upper,tract,neoplasms,after,cyclophosphamide,are,reviewed,. | |
| labels,0,5,6,7,0,4,0,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,unusual weight fluctuation | |
| drug,aripiprazole | |
| sequence,The,present,study,describes,a,patient,who,had,unusual,weight,fluctuation,under,corticosteroid,and,psychotropic,treatment,such,as,mianserin,and,aripiprazole,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,unusual weight fluctuation | |
| drug,mianserin | |
| sequence,The,present,study,describes,a,patient,who,had,unusual,weight,fluctuation,under,corticosteroid,and,psychotropic,treatment,such,as,mianserin,and,aripiprazole,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,delirium with psychotic features | |
| drug,Levofloxacin | |
| sequence,Levofloxacin-induced,delirium,with,psychotic,features,. | |
| labels,4,5,6,6,7,0 | |
| ade_mask,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,syndrome of inappropriate antidiuretic hormone,SIADH | |
| drug,Cisplatin | |
| sequence,Cisplatin-induced,syndrome,of,inappropriate,antidiuretic,hormone,(,SIADH,),in,a,patient,with,neuroendocrine,tumor,of,the,cervix,:,a,case,report,and,review,of,the,literature,. | |
| labels,4,5,6,6,6,7,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,increases urate excretion | |
| drug,losartan | |
| sequence,There,is,evidence,that,the,angiotensin,II,receptor,antagonist,,,losartan,,,increases,urate,excretion,by,reducing,reabsorption,of,urate,in,the,renal,proximal,tubule,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nocturnal bingeing,amnesia | |
| drug,Triazolam | |
| sequence,Triazolam-induced,nocturnal,bingeing,with,amnesia,. | |
| labels,4,5,7,0,8,0 | |
| ade_mask,0,1,1,0,1,0 | |
| ==============================, ============================= | |
| ade,Intrahepatic cholestasis,sicca complex | |
| drug,thiabendazole | |
| sequence,Intrahepatic,cholestasis,and,sicca,complex,after,thiabendazole,. | |
| labels,5,7,0,5,7,0,4,0 | |
| ade_mask,1,1,0,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,Epstein-Barr virus (EBV)-associated polyclonal B cell lymphoproliferative disorder | |
| drug,Methotrexate | |
| sequence,Methotrexate,(,MTX,),is,a,commonly,used,second,line,agent,for,RA,,,and,there,have,been,several,recent,reports,of,Epstein-Barr,virus,(,EBV,),-associated,polyclonal,B,cell,lymphoproliferative,disorder,in,MTX-treated,RA,patients,. | |
| labels,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,6,6,6,6,6,7,0,0,0,0,0 | |
| ade_mask,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0,1,1,1,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Epstein-Barr virus (EBV)-associated polyclonal B cell lymphoproliferative disorder | |
| drug,MTX | |
| sequence,Methotrexate,(,MTX,),is,a,commonly,used,second,line,agent,for,RA,,,and,there,have,been,several,recent,reports,of,Epstein-Barr,virus,(,EBV,),-associated,polyclonal,B,cell,lymphoproliferative,disorder,in,MTX-treated,RA,patients,. | |
| labels,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,6,6,6,6,6,7,0,0,0,0,0 | |
| ade_mask,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0,1,1,1,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,weight loss | |
| drug,leflunomide | |
| sequence,RESULTS,:,Five,of,70,patients,who,had,begun,leflunomide,therapy,had,significant,weight,loss,that,could,not,be,linked,to,other,identifiable,etiologies,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thyrotoxicosis,thyrotropin receptor antibody | |
| drug,Amiodarone | |
| sequence,Amiodarone-induced,thyrotoxicosis,associated,with,thyrotropin,receptor,antibody,. | |
| labels,4,8,0,0,5,6,7,0 | |
| ade_mask,0,1,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,Methanol toxicity,severe central nervous system insult,bilateral putaminal injury | |
| drug,Methanol | |
| sequence,Methanol,toxicity,can,cause,severe,central,nervous,system,insult,in,which,a,characteristic,pattern,of,bilateral,putaminal,injury,is,noted,on,brain,imaging,studies,. | |
| labels,9,7,0,0,5,6,6,6,7,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,1,1,1,1,1,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,herpes esophagitis | |
| drug,Cyclosporine A | |
| sequence,With,the,increasing,use,of,Cyclosporine,A,in,transplant,patients,,,the,incidence,of,herpes,esophagitis,may,increase,. | |
| labels,0,0,0,0,0,1,3,0,0,0,0,0,0,0,5,7,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,optic neuropathy | |
| drug,ethambutol | |
| sequence,Since,ethambutol,is,actively,excreted,via,the,renal,system,,,compromise,of,renal,function,such,as,due,to,renal,tuberculosis,may,lead,to,serum,concentration,elevations,of,ethambutol,sufficient,to,produce,optic,neuropathy,. | |
| labels,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Visual system side effects,parasympathetic dysfunction | |
| drug,botulinum toxin type B | |
| sequence,Visual,system,side,effects,caused,by,parasympathetic,dysfunction,after,botulinum,toxin,type,B,injections,. | |
| labels,5,6,6,7,0,0,5,7,0,1,2,2,3,0,0 | |
| ade_mask,1,1,1,1,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,BMTN | |
| drug,RA | |
| sequence,The,occurrence,of,BMTN,in,two,children,treated,with,RA,in,our,unit,is,unlikely,to,be,coincidental,. | |
| labels,0,0,0,8,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,diabetes mellitus,exocrine pancreatic insufficiency | |
| drug,azathioprine | |
| sequence,A,7-year-old,girl,developed,diabetes,mellitus,and,exocrine,pancreatic,insufficiency,after,3.5,years,of,almost,continuous,treatment,with,azathioprine,and,or,prednisone,for,idiopathic,auto-immune,haemolytic,anaemia,. | |
| labels,0,0,0,0,5,7,0,5,6,7,0,0,0,0,0,0,0,0,4,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,diabetes mellitus,exocrine pancreatic insufficiency | |
| drug,prednisone | |
| sequence,A,7-year-old,girl,developed,diabetes,mellitus,and,exocrine,pancreatic,insufficiency,after,3.5,years,of,almost,continuous,treatment,with,azathioprine,and,or,prednisone,for,idiopathic,auto-immune,haemolytic,anaemia,. | |
| labels,0,0,0,0,5,7,0,5,6,7,0,0,0,0,0,0,0,0,4,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Asthma,urticaria | |
| drug,disodium cromoglycate | |
| sequence,Asthma,and,urticaria,during,disodium,cromoglycate,treatment,. | |
| labels,8,0,8,0,1,3,0,0 | |
| ade_mask,1,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute myocardial ischemia | |
| drug,epinephrine | |
| sequence,Acute,myocardial,ischemia,following,accidental,intravenous,administration,of,epinephrine,in,high,concentration,. | |
| labels,5,6,7,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,retinal changes | |
| drug,tamoxifen | |
| sequence,Four,patients,receiving,high-dose,tamoxifen,for,greater,than,1,year,have,demonstrated,similar,retinal,changes,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,dry cough,subfebrile temperatures,dyspnea | |
| drug,gemcitabine | |
| sequence,After,having,received,gemcitabine,on,day,1,of,the,second,course,,,the,patient,developed,dry,cough,,,subfebrile,temperatures,and,dyspnea,within,48,h,. | |
| labels,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,5,7,0,5,7,0,8,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,1,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,theophylline levels had increased to the toxic range | |
| drug,Accolate | |
| sequence,Recently,,,her,serum,theophylline,levels,had,increased,to,the,toxic,range,(,133.2,micromol,L,[,24,microg,mL,],),shortly,after,the,addition,of,zafirlukast,(,Accolate,,,Zeneca,Pharmaceuticals,,,Wilmington,,,Del,),to,her,regimen,. | |
| labels,0,0,0,0,9,6,6,6,6,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,theophylline levels had increased to the toxic range | |
| drug,theophylline | |
| sequence,Recently,,,her,serum,theophylline,levels,had,increased,to,the,toxic,range,(,133.2,micromol,L,[,24,microg,mL,],),shortly,after,the,addition,of,zafirlukast,(,Accolate,,,Zeneca,Pharmaceuticals,,,Wilmington,,,Del,),to,her,regimen,. | |
| labels,0,0,0,0,9,6,6,6,6,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,theophylline levels had increased to the toxic range | |
| drug,zafirlukast | |
| sequence,Recently,,,her,serum,theophylline,levels,had,increased,to,the,toxic,range,(,133.2,micromol,L,[,24,microg,mL,],),shortly,after,the,addition,of,zafirlukast,(,Accolate,,,Zeneca,Pharmaceuticals,,,Wilmington,,,Del,),to,her,regimen,. | |
| labels,0,0,0,0,9,6,6,6,6,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,edema | |
| drug,nabumetone | |
| sequence,She,had,been,taking,nabumetone,for,6,months,,,but,had,discontinued,the,agent,2,weeks,before,admission,due,to,progressive,edema,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Hepatotoxic effects | |
| drug,carnitine | |
| sequence,Hepatotoxic,effects,in,a,child,receiving,valproate,and,carnitine,. | |
| labels,5,7,0,0,0,0,4,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hepatotoxic effects | |
| drug,valproate | |
| sequence,Hepatotoxic,effects,in,a,child,receiving,valproate,and,carnitine,. | |
| labels,5,7,0,0,0,0,4,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,monoclonal gammopathy | |
| drug,diphenylhydantoin | |
| sequence,We,recommended,periodic,examination,of,the,serum,proteins,in,patients,receiving,diphenylhydantoin,in,order,to,detect,development,of,monoclonal,gammopathy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,acute coronary syndromes | |
| drug,rituximab | |
| sequence,We,reviewed,the,records,of,3,patients,with,lymphoproliferative,disorders,who,experienced,acute,coronary,syndromes,associated,with,their,initial,infusion,of,rituximab,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Anaphylaxis | |
| drug,isoniazid | |
| sequence,Anaphylaxis,from,isoniazid,is,a,possible,side,effect,to,this,commonly,prescribed,antibiotic,. | |
| labels,8,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,renal toxicity | |
| drug,interferons | |
| sequence,This,latest,(,third,),report,suggests,that,the,safety,profile,should,be,reexamined,and,at,least,raises,the,question,of,potential,renal,toxicity,of,interferons,in,MS,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,postprandial hyperglycemia,glycosuria | |
| drug,halcinonide | |
| sequence,A,patient,with,psoriasis,is,described,who,had,an,abnormal,response,to,the,glucose,tolerance,test,without,other,evidence,of,diabetes,and,then,developed,postprandial,hyperglycemia,and,glycosuria,during,a,period,of,topical,administration,of,a,corticosteroid,cream,,,halcinonide,cream,0.1,%,,,under,occlusion,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,8,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,aseptic meningitis,hemolytic anemia,hepatitis,orthostatic hypotension | |
| drug,sulfamethoxazole | |
| sequence,PURPOSE,:,The,case,of,a,patient,who,developed,aseptic,meningitis,,,hemolytic,anemia,,,hepatitis,,,and,orthostatic,hypotension,simultaneously,during,treatment,with,trimethoprim-sulfamethoxazole,is,described,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,5,7,0,8,0,0,5,7,0,0,0,0,4,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,1,1,0,1,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,aseptic meningitis,hemolytic anemia,hepatitis,orthostatic hypotension | |
| drug,trimethoprim | |
| sequence,PURPOSE,:,The,case,of,a,patient,who,developed,aseptic,meningitis,,,hemolytic,anemia,,,hepatitis,,,and,orthostatic,hypotension,simultaneously,during,treatment,with,trimethoprim-sulfamethoxazole,is,described,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,5,7,0,8,0,0,5,7,0,0,0,0,4,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,1,1,0,1,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,NMS | |
| drug,amisulpride | |
| sequence,The,epivodes,of,NMS,occured,under,treatment,with,clozapine,,,risperidone,,,and,amisulpride,. | |
| labels,0,0,0,8,0,0,0,0,4,0,4,0,0,4,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,NMS | |
| drug,clozapine | |
| sequence,The,epivodes,of,NMS,occured,under,treatment,with,clozapine,,,risperidone,,,and,amisulpride,. | |
| labels,0,0,0,8,0,0,0,0,4,0,4,0,0,4,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,NMS | |
| drug,risperidone | |
| sequence,The,epivodes,of,NMS,occured,under,treatment,with,clozapine,,,risperidone,,,and,amisulpride,. | |
| labels,0,0,0,8,0,0,0,0,4,0,4,0,0,4,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Inappropriate antidiuretic hormone | |
| drug,adenine arabinoside | |
| sequence,Inappropriate,antidiuretic,hormone,following,adenine,arabinoside,administration,. | |
| labels,5,6,7,0,1,3,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pancytopenia | |
| drug,5-aminosalicylic acid | |
| sequence,We,report,a,case,of,pancytopenia,in,a,23-year-old,man,with,Crohn,'s,disease,who,was,treated,with,5-aminosalicylic,acid,(,Pentasa,;,Nisshin,,,Tokyo,,,Japan,),3.0,g,day,. | |
| labels,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,1,3,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pancytopenia | |
| drug,Pentasa | |
| sequence,We,report,a,case,of,pancytopenia,in,a,23-year-old,man,with,Crohn,'s,disease,who,was,treated,with,5-aminosalicylic,acid,(,Pentasa,;,Nisshin,,,Tokyo,,,Japan,),3.0,g,day,. | |
| labels,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,1,3,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,CML | |
| drug,hydroxyurea | |
| sequence,There,are,no,previous,reports,in,the,literature,about,the,emergence,of,CML,during,treatment,with,hydroxyurea,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute ischaemic event | |
| drug,venlafaxine | |
| sequence,An,acute,ischaemic,event,associated,with,the,use,of,venlafaxine,:,a,case,report,and,proposed,pathophysiological,mechanisms,. | |
| labels,0,5,6,7,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Nonoliguric acute renal failure | |
| drug,captopril | |
| sequence,Nonoliguric,acute,renal,failure,after,captopril,therapy,. | |
| labels,5,6,6,7,0,4,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,production of granulocyte and neutrophil autoantibodies,autoimmune agranulocytosis | |
| drug,infliximab | |
| sequence,These,data,indicated,that,infliximab,possibly,triggered,production,of,granulocyte,and,neutrophil,autoantibodies,with,resultant,autoimmune,agranulocytosis,. | |
| labels,0,0,0,0,4,0,0,5,6,6,6,6,7,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,1,1,1,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,paroxysmal supraventricular tachycardia | |
| drug,cisplatin | |
| sequence,We,report,a,case,of,a,60-year-old,woman,affected,by,squamous,lung,carcinoma,,,who,developed,paroxysmal,supraventricular,tachycardia,during,cisplatin,and,etoposide,combination,chemotherapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,4,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,paroxysmal supraventricular tachycardia | |
| drug,etoposide | |
| sequence,We,report,a,case,of,a,60-year-old,woman,affected,by,squamous,lung,carcinoma,,,who,developed,paroxysmal,supraventricular,tachycardia,during,cisplatin,and,etoposide,combination,chemotherapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,4,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,diarrhoea | |
| drug,spironolactone | |
| sequence,As,these,cases,revealed,,,close,monitoring,of,blood,chemistry,is,mandatory,after,starting,spironolactone,,,and,patients,should,be,advised,to,stop,spironolactone,immediately,if,diarrhoea,develops,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,8,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0 | |
| ==============================, ============================= | |
| ade,acute dissecting thoracic aortic aneurysm | |
| drug,warfarin | |
| sequence,CASE,REPORT,:,A,woman,of,80,years,,,on,long-term,warfarin,therapy,presented,with,an,acute,dissecting,thoracic,aortic,aneurysm,;,on,investigation,the,only,precipitating,factor,found,was,an,international,normalised,ratio,of,4.8,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,5,6,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Angioedema,maculopapular eruptions | |
| drug,carbamazepine | |
| sequence,Angioedema,and,maculopapular,eruptions,associated,with,carbamazepine,administration,. | |
| labels,8,0,5,7,0,0,4,0,0 | |
| ade_mask,1,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute generalized dystonia,brainstem and thalamic lesions | |
| drug,d-penicillamine | |
| sequence,From,these,data,,,acute,generalized,dystonia,with,brainstem,and,thalamic,lesions,may,occur,in,WD,patients,after,an,initial,d-penicillamine,therapy,. | |
| labels,0,0,0,0,5,6,7,0,5,6,6,7,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,1,1,1,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ascites | |
| drug,methotrexate | |
| sequence,A,patient,with,seropositive,rheumatoid,arthritis,developed,ascites,while,taking,weekly,doses,of,methotrexate,(,MTX,),. | |
| labels,0,0,0,0,0,0,0,8,0,0,0,0,0,4,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ascites | |
| drug,MTX | |
| sequence,A,patient,with,seropositive,rheumatoid,arthritis,developed,ascites,while,taking,weekly,doses,of,methotrexate,(,MTX,),. | |
| labels,0,0,0,0,0,0,0,8,0,0,0,0,0,4,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,tardive dyskinesia | |
| drug,sulpiride | |
| sequence,These,cases,indicate,that,sulpiride,can,cause,tardive,dyskinesia,and,that,this,drug,should,be,administered,with,caution,. | |
| labels,0,0,0,0,4,0,0,5,7,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Priapism | |
| drug,olanzapine | |
| sequence,Priapism,associated,with,olanzapine,. | |
| labels,8,0,0,4,0 | |
| ade_mask,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Erythema multiforme bullosum | |
| drug,rifampicin | |
| sequence,Erythema,multiforme,bullosum,due,to,rifampicin,. | |
| labels,5,6,7,0,0,4,0 | |
| ade_mask,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Large cerebral infarction | |
| drug,praziquantel | |
| sequence,Large,cerebral,infarction,during,praziquantel,therapy,in,neurocysticercosis,. | |
| labels,5,6,7,0,4,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anemia,thrombocytopenia | |
| drug,D-Pen | |
| sequence,A,66-year-old,Japanese,woman,with,severe,scleroderma,developed,anemia,and,thrombocytopenia,due,to,D-penicillamine,(,D-Pen,),treatment,,,although,the,leukopenia,was,not,markedly,severe,. | |
| labels,0,0,0,0,0,0,0,0,8,0,8,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anemia,thrombocytopenia | |
| drug,D-penicillamine | |
| sequence,A,66-year-old,Japanese,woman,with,severe,scleroderma,developed,anemia,and,thrombocytopenia,due,to,D-penicillamine,(,D-Pen,),treatment,,,although,the,leukopenia,was,not,markedly,severe,. | |
| labels,0,0,0,0,0,0,0,0,8,0,8,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fulminant hepatitis | |
| drug,ddI | |
| sequence,This,prompted,us,to,suspect,that,ddI,might,be,responsible,for,fulminant,hepatitis,in,all,three,AIDS,patients,. | |
| labels,0,0,0,0,0,0,4,0,0,0,0,5,7,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ischemic colitis,irritable bowel syndrome | |
| drug,tegaserod | |
| sequence,We,describe,the,development,of,ischemic,colitis,in,a,woman,who,was,treated,with,tegaserod,and,review,the,relationship,among,ischemic,colitis,,,tegaserod,use,,,and,irritable,bowel,syndrome,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis | |
| drug,azithromycin | |
| sequence,To,our,knowledge,,,these,cases,are,the,first,published,reports,of,lovastatin-induced,rhabdomyolysis,associated,with,azithromycin,and,clarithromycin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis | |
| drug,clarithromycin | |
| sequence,To,our,knowledge,,,these,cases,are,the,first,published,reports,of,lovastatin-induced,rhabdomyolysis,associated,with,azithromycin,and,clarithromycin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis | |
| drug,lovastatin | |
| sequence,To,our,knowledge,,,these,cases,are,the,first,published,reports,of,lovastatin-induced,rhabdomyolysis,associated,with,azithromycin,and,clarithromycin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bicytopenia | |
| drug,D-Pen | |
| sequence,These,findings,suggest,that,bicytopenia,in,this,patient,was,caused,by,D-Pen,and,may,be,due,to,different,sensitivities,in,the,hematopoietic,lineage,. | |
| labels,0,0,0,0,8,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Panic anxiety | |
| drug,mianserin | |
| sequence,Panic,anxiety,after,abrupt,discontinuation,of,mianserin,. | |
| labels,5,7,0,0,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,impaired memory | |
| drug,atenolol | |
| sequence,His,impaired,memory,was,found,to,be,due,to,the,atenolol,he,was,on,and,he,made,a,complete,recovery,on,withdrawing,the,beta-blocker,. | |
| labels,0,5,7,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pancreatitis | |
| drug,mesalamine | |
| sequence,A,rechallenge,,,performed,in,both,patients,,,confirmed,the,diagnosis,of,mesalamine-induced,pancreatitis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity reactions | |
| drug,cyclosporine | |
| sequence,OBJECTIVE,:,To,investigate,the,mechanisms,involved,in,hypersensitivity,reactions,to,cyclosporine,and,determine,the,feasibility,of,future,cyclosporine,use,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe hypocalcaemia | |
| drug,Zoledronic acid | |
| sequence,Zoledronic,acid-induced,severe,hypocalcaemia,in,a,prostate,cancer,patient,with,extensive,osteoblastic,bone,metastases,. | |
| labels,1,3,5,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,septum-like liver fibrosis,ground-glass hepatocytes | |
| drug,cyanamide | |
| sequence,CONCLUSION,:,In,some,abstainers,who,take,cyanamide,for,several,years,,,thin,septum-like,liver,fibrosis,progresses,along,with,the,emergence,of,ground-glass,hepatocytes,. | |
| labels,0,0,0,0,0,0,0,4,0,0,0,0,0,5,6,7,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,De novo absence status | |
| drug,lorazepam | |
| sequence,De,novo,absence,status,of,late,onset,following,withdrawal,of,lorazepam,:,a,case,report,. | |
| labels,5,6,6,7,0,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,gingival hyperplasia | |
| drug,diphenylhydantoin | |
| sequence,Emphasis,is,given,to,the,differentiation,of,diphenylhydantoin,induced,gingival,hyperplasia,from,the,angiomatous,enlargement,of,the,gingiva,before,any,treatment,is,planned,. | |
| labels,0,0,0,0,0,0,0,4,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute cerebellar syndrome | |
| drug,methotrexate | |
| sequence,Intrathecal,methotrexate-induced,acute,cerebellar,syndrome,. | |
| labels,0,4,5,6,7,0 | |
| ade_mask,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,Ataxia | |
| drug,propafenone | |
| sequence,Ataxia,caused,by,propafenone,has,been,reported,to,the,pharmaceutical,companies,and,drug,monitoring,agencies,,,but,has,not,been,well,described,or,emphasized,in,the,medical,literature,. | |
| labels,8,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,mental, neurological or gastrointestinal symptoms | |
| drug,isoniazid | |
| sequence,Pellagra,should,be,suspected,whenever,tuberculous,patients,under,treatment,with,isoniazid,develop,mental,,,neurological,or,gastrointestinal,symptoms,,,even,in,the,absence,of,typical,pellagra,dermatitis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,0,5,6,6,6,6,7,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cutaneous vasculitis | |
| drug,diltiazem | |
| sequence,Widespread,cutaneous,vasculitis,associated,with,diltiazem,. | |
| labels,0,5,7,0,0,4,0 | |
| ade_mask,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Ecstasy poisoning | |
| drug,Ecstasy | |
| sequence,An,unusual,case,of,Ecstasy,poisoning,. | |
| labels,0,0,0,0,9,7,0 | |
| ade_mask,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,MRI T2 abnormalities,neurotoxicity | |
| drug,cyclosporin | |
| sequence,One,patient,had,MRI,T2,abnormalities,compatible,with,cyclosporin,neurotoxicity,. | |
| labels,0,0,0,5,6,7,0,0,4,8,0 | |
| ade_mask,0,0,0,1,1,1,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Severe neurotoxicity | |
| drug,methyl G: CALGB | |
| sequence,Severe,neurotoxicity,with,methyl,G,:,CALGB,experience,. | |
| labels,5,7,0,1,2,2,3,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,RD | |
| drug,SDA | |
| sequence,Therefore,,,clinicians,should,pay,close,attention,to,possible,onset,of,RD,in,patients,with,multiple,risk,factors,for,TD,,,even,when,SDA,therapy,is,used,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Fatal eosinophilia myalgia syndrome | |
| drug,tryptophan | |
| sequence,Fatal,eosinophilia,myalgia,syndrome,in,a,marrow,transplant,patient,attributed,to,total,parenteral,nutrition,with,a,solution,containing,tryptophan,. | |
| labels,5,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neutropenic,marrow aplasia | |
| drug,ticlopidine | |
| sequence,The,second,was,an,82-year-old,man,receiving,ticlopidine,for,2,years,when,,,during,a,febrile,episode,,,he,was,found,neutropenic,with,marrow,aplasia,. | |
| labels,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,0 | |
| ==============================, ============================= | |
| ade,ototoxicity | |
| drug,ketorolac | |
| sequence,We,recommend,the,cautious,use,of,ketorolac,in,patients,with,underlying,illnesses,where,NSAID-induced,ototoxicity,could,result,in,adverse,otologic,consequences,. | |
| labels,0,0,0,0,0,0,4,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bleeding symptoms | |
| drug,warfarin | |
| sequence,Despite,the,low,dosage,of,warfarin,,,international,normalized,ratio,(,INR,),was,markedly,elevated,from,1.15,to,11.28,for,only,4,days,,,and,bleeding,symptoms,concurrently,developed,. | |
| labels,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatotoxicity | |
| drug,Phenobarbital | |
| sequence,Phenobarbital,hepatotoxicity,in,an,8-month-old,infant,. | |
| labels,4,8,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Eye movement disorders | |
| drug,cyclosporin | |
| sequence,Eye,movement,disorders,in,bone,marrow,transplant,patients,on,cyclosporin,and,ganciclovir,. | |
| labels,5,6,7,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Eye movement disorders | |
| drug,ganciclovir | |
| sequence,Eye,movement,disorders,in,bone,marrow,transplant,patients,on,cyclosporin,and,ganciclovir,. | |
| labels,5,6,7,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Multiple sclerosis-like disease | |
| drug,alpha interferon | |
| sequence,Multiple,sclerosis-like,disease,secondary,to,alpha,interferon,. | |
| labels,5,6,7,0,0,1,3,0 | |
| ade_mask,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypoglycaemia | |
| drug,mefloquine | |
| sequence,We,report,a,case,of,hypoglycaemia,after,mefloquine,therapy,(,1,500,mg,over,two,days,),for,severe,gastrointestinal,cryptosporidiasis,in,a,cachectic,AIDS,patient,with,protracted,diarrhoea,. | |
| labels,0,0,0,0,0,8,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,visual field defects,VFDs | |
| drug,tiagabine | |
| sequence,This,case,report,describes,the,development,of,asymptomatic,visual,field,defects,(,VFDs,),in,a,psychiatric,patient,with,bipolar,disorder,receiving,adjunctive,tiagabine,treatment,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,8,0,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Cutaneous eruptions | |
| drug,carbamazepine | |
| sequence,Cutaneous,eruptions,occur,in,3,%,of,individuals,administered,carbamazepine,. | |
| labels,5,7,0,0,0,0,0,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute intermittent porphyria | |
| drug,Diphenylhydantoin | |
| sequence,Diphenylhydantoin,apparently,adversely,affected,both,the,clinical,and,biochemical,parameters,of,the,acute,intermittent,porphyria,. | |
| labels,4,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,opportunistic infections,fungal infections | |
| drug,alemtuzumab | |
| sequence,The,international,literature,regarding,opportunistic,infections,after,immunosuppressive,therapy,with,alemtuzumab,with,particular,attention,on,fungal,infections,has,also,been,reviewed,. | |
| labels,0,0,0,0,5,7,0,0,0,0,4,0,0,0,0,5,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute respiratory distress | |
| drug,dalteparin | |
| sequence,On,day,4,,,following,3,doses,of,dalteparin,,,the,patient,developed,acute,respiratory,distress,attributable,to,a,massive,right,hemothorax,confirmed,by,computed,tomography,pulmonary,angiography,(,CTPA,),and,intercostal,drainage,of,1500,mL,of,frank,blood,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,teratogenic effects | |
| drug,Thalidomide | |
| sequence,Thalidomide,was,withdrawn,from,world,markets,in,1961,following,recognition,of,its,teratogenic,effects,. | |
| labels,4,0,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,hemophagocytic syndrome | |
| drug,sulfasalazine | |
| sequence,This,case,illustrates,that,the,hemophagocytic,syndrome,associated,with,reactivation,of,EBV,can,occur,as,part,of,drug,hypersensitivity,reactions,in,RA,patients,taking,sulfasalazine,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,15-kg weight gain | |
| drug,ibuprofen | |
| sequence,A,15-kg,weight,gain,developed,in,a,patient,during,the,third,week,of,ibuprofen,therapy,. | |
| labels,0,5,6,7,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,IgA deficiency | |
| drug,aurothiomalate | |
| sequence,This,case,demonstrates,the,association,of,selective,IgA,deficiency,with,remission,in,rheumatoid,arthritis,induced,by,fenclofenac,as,well,as,aurothiomalate,and,sulphasalazine,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,4,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,IgA deficiency | |
| drug,fenclofenac | |
| sequence,This,case,demonstrates,the,association,of,selective,IgA,deficiency,with,remission,in,rheumatoid,arthritis,induced,by,fenclofenac,as,well,as,aurothiomalate,and,sulphasalazine,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,4,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,IgA deficiency | |
| drug,sulphasalazine | |
| sequence,This,case,demonstrates,the,association,of,selective,IgA,deficiency,with,remission,in,rheumatoid,arthritis,induced,by,fenclofenac,as,well,as,aurothiomalate,and,sulphasalazine,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,4,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Sweet's syndrome | |
| drug,sargramostim | |
| sequence,We,report,a,case,of,Sweet,'s,syndrome,in,association,with,sargramostim,treatment,following,chemotherapy,for,acute,myelogenous,leukemia,. | |
| labels,0,0,0,0,0,5,6,7,0,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hemolytic-uremic syndrome | |
| drug,bleomycin | |
| sequence,A,62-year-old,woman,who,was,being,treated,for,squamous,cell,carcinoma,of,the,head,and,neck,developed,a,chemotherapy-related,hemolytic-uremic,syndrome,during,the,second,cycle,of,neoadjuvant,chemotherapy,consisting,of,cisplatin,,,bleomycin,,,and,methotrexate,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,4,0,4,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hemolytic-uremic syndrome | |
| drug,cisplatin | |
| sequence,A,62-year-old,woman,who,was,being,treated,for,squamous,cell,carcinoma,of,the,head,and,neck,developed,a,chemotherapy-related,hemolytic-uremic,syndrome,during,the,second,cycle,of,neoadjuvant,chemotherapy,consisting,of,cisplatin,,,bleomycin,,,and,methotrexate,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,4,0,4,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hemolytic-uremic syndrome | |
| drug,methotrexate | |
| sequence,A,62-year-old,woman,who,was,being,treated,for,squamous,cell,carcinoma,of,the,head,and,neck,developed,a,chemotherapy-related,hemolytic-uremic,syndrome,during,the,second,cycle,of,neoadjuvant,chemotherapy,consisting,of,cisplatin,,,bleomycin,,,and,methotrexate,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,4,0,4,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute renal failure | |
| drug,enalapril | |
| sequence,A,35-year-old,nephrotic,man,developed,acute,renal,failure,with,serum,creatinine,to,1543,micromol,l,after,a,month,of,therapy,with,enalapril,. | |
| labels,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cardiac failure | |
| drug,Insulin | |
| sequence,Insulin-induced,cardiac,failure,. | |
| labels,4,5,7,0 | |
| ade_mask,0,1,1,0 | |
| ==============================, ============================= | |
| ade,oculogyric crisis | |
| drug,metoclopramide | |
| sequence,A,case,of,metoclopramide-induced,oculogyric,crisis,in,a,16-year-old,girl,with,cystic,fibrosis,. | |
| labels,0,0,0,4,5,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,type I second-degree AV block | |
| drug,ritodrine | |
| sequence,The,electrocardiogram,(,ECG,),,,which,was,read,as,normal,prior,to,ritodrine,infusion,,,demonstrated,a,type,I,second-degree,AV,block,which,disappeared,upon,discontinuation,of,ritodrine,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,5,6,6,6,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Mammary gigantism | |
| drug,D-penicillamine | |
| sequence,Mammary,gigantism,is,a,rare,complication,of,D-penicillamine,treatment,. | |
| labels,5,7,0,0,0,0,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pancreatitis | |
| drug,meglumine antimoniate | |
| sequence,An,infant,who,developed,pancreatitis,during,meglumine,antimoniate,treatment,for,visceral,leishmaniasis,and,who,was,successfully,treated,with,a,combination,of,allopurinol,and,ketoconazole,is,reported,. | |
| labels,0,0,0,0,8,0,1,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,secretory carcinoma of the endometrium | |
| drug,tamoxifen | |
| sequence,We,believe,that,this,is,the,first,report,of,secretory,carcinoma,of,the,endometrium,associated,with,tamoxifen,use,. | |
| labels,0,0,0,0,0,0,0,0,0,5,6,6,6,7,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,1,1,1,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,glycemia | |
| drug,methylprednisolone | |
| sequence,Reduction,of,methylprednisolone,dosage,rather,than,insulin,therapy,resulted,in,better,control,of,glycemia,. | |
| labels,0,0,4,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,fatal,hepatotoxic effects | |
| drug,valproate | |
| sequence,We,report,on,a,child,with,fatal,valproate-related,hepatotoxic,effects,despite,this,supplementation,. | |
| labels,0,0,0,0,0,0,8,4,5,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,apnea,death,long QT interval syndrome | |
| drug,quinidine | |
| sequence,Intravenous,verapamil,therapy,in,babies,may,cause,apnea,,,hypotension,,,and,bradycardia,;,continued,episodes,of,atrial,flutter,in,a,child,may,cause,sudden,death,;,quinidine,may,be,related,to,the,death,;,children,with,``,familial,seizure,disorders,'',may,in,fact,have,the,long,QT,interval,syndrome,. | |
| labels,0,4,0,0,0,0,0,8,0,8,0,0,8,0,0,0,0,5,7,0,0,0,0,0,5,7,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,apnea,hypotension,bradycardia,atrial flutter,sudden death | |
| drug,verapamil | |
| sequence,Intravenous,verapamil,therapy,in,babies,may,cause,apnea,,,hypotension,,,and,bradycardia,;,continued,episodes,of,atrial,flutter,in,a,child,may,cause,sudden,death,;,quinidine,may,be,related,to,the,death,;,children,with,``,familial,seizure,disorders,'',may,in,fact,have,the,long,QT,interval,syndrome,. | |
| labels,0,4,0,0,0,0,0,8,0,8,0,0,8,0,0,0,0,5,7,0,0,0,0,0,5,7,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,1,0,0,1,0,0,0,0,1,1,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cardiotoxicity | |
| drug,pentamidine | |
| sequence,Clinicians,should,be,vigilant,when,monitoring,for,cardiotoxicity,in,patients,receiving,pentamidine,throughout,the,duration,of,therapy,. | |
| labels,0,0,0,0,0,0,0,8,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thyrotoxic ophthalmopathy | |
| drug,lithium | |
| sequence,Regression,of,thyrotoxic,ophthalmopathy,following,lithium,withdrawal,. | |
| labels,0,0,5,7,0,4,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,radiation recall | |
| drug,Gemcitabine | |
| sequence,Gemcitabine-related,radiation,recall,preferentially,involves,internal,tissue,and,organs,. | |
| labels,4,5,7,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,phenytoin toxicity | |
| drug,phenytoin | |
| sequence,The,wide,use,of,phenytoin,during,the,recent,tuberculosis,epidemic,makes,it,imperative,to,suspect,this,drug,interaction,in,patients,exhibiting,clinical,features,that,might,be,related,to,phenytoin,toxicity,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,angina pectoris | |
| drug,Verapamil | |
| sequence,Verapamil,in,effort-induced,angina,pectoris,in,patients,with,normal,coronary,arteries,. | |
| labels,4,0,0,5,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,UFT-induced scleroderma-like reaction | |
| drug,UFT | |
| sequence,This,is,the,first,report,of,UFT-induced,scleroderma-like,reaction,. | |
| labels,0,0,0,0,0,0,9,6,7,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,neuropathy | |
| drug,gold | |
| sequence,Three,cases,of,gold-related,neuropathy,are,reported,. | |
| labels,0,0,0,4,8,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,Syringotropic hypersensitivity reaction | |
| drug,infliximab | |
| sequence,Syringotropic,hypersensitivity,reaction,associated,with,infliximab,and,leflunomide,combination,therapy,in,a,child,with,psoriatic,arthritis,. | |
| labels,5,6,7,0,0,4,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Syringotropic hypersensitivity reaction | |
| drug,leflunomide | |
| sequence,Syringotropic,hypersensitivity,reaction,associated,with,infliximab,and,leflunomide,combination,therapy,in,a,child,with,psoriatic,arthritis,. | |
| labels,5,6,7,0,0,4,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Arthritis,bursitis | |
| drug,interferon-beta | |
| sequence,Arthritis,and,bursitis,in,multiple,sclerosis,patients,treated,with,interferon-beta,. | |
| labels,8,0,8,0,0,0,0,0,0,4,0 | |
| ade_mask,1,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute ischaemia of the left leg | |
| drug,flunitrazepam | |
| sequence,A,22-year-old,drug-abuser,injected,flunitrazepam,tablets,dissolved,in,tap,water,into,her,left,femoral,artery,and,presented,with,clinical,signs,of,acute,ischaemia,of,the,left,leg,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,1,1,0,1,0,1,0 | |
| ==============================, ============================= | |
| ade,Fatal lung fibrosis | |
| drug,carboplatin | |
| sequence,Fatal,lung,fibrosis,caused,by,paclitaxel,toxicity,has,not,been,reported,In,this,report,,,we,describe,the,case,of,a,62-year-old,woman,who,received,six,cycles,of,paclitaxel,and,carboplatin,as,combination,chemotherapy,for,advanced,ovarian,cancer,. | |
| labels,5,6,7,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Fatal lung fibrosis | |
| drug,paclitaxel | |
| sequence,Fatal,lung,fibrosis,caused,by,paclitaxel,toxicity,has,not,been,reported,In,this,report,,,we,describe,the,case,of,a,62-year-old,woman,who,received,six,cycles,of,paclitaxel,and,carboplatin,as,combination,chemotherapy,for,advanced,ovarian,cancer,. | |
| labels,5,6,7,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bradycardia | |
| drug,Sotalol | |
| sequence,Sotalol-induced,bradycardia,reversed,by,glucagon,. | |
| labels,4,8,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombocytopenia | |
| drug,quinine | |
| sequence,Even,after,a,strict,warning,,,he,took,another,quinine,tablet,that,evening,,,which,triggered,his,fifth,episode,of,severe,thrombocytopenia,,,and,confirmed,the,etiology,of,quinine-induced,thrombocytopenia,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Bradycardia,congestive heart failure | |
| drug,timolol maleate | |
| sequence,Bradycardia,and,congestive,heart,failure,associated,with,ocular,timolol,maleate,. | |
| labels,8,0,5,6,7,0,0,0,1,3,0 | |
| ade_mask,1,0,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myotonia | |
| drug,Pravastatin | |
| sequence,Pravastatin,is,associated,with,myotonia,in,animals,. | |
| labels,4,0,0,0,8,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,Theophylline intoxication,decrease in clearance | |
| drug,viloxazine | |
| sequence,Theophylline,intoxication,following,viloxazine,induced,decrease,in,clearance,. | |
| labels,9,7,0,4,0,5,6,7,0 | |
| ade_mask,1,1,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,Theophylline intoxication | |
| drug,Theophylline | |
| sequence,Theophylline,intoxication,following,viloxazine,induced,decrease,in,clearance,. | |
| labels,9,7,0,4,0,5,6,7,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypotension,unconsciousness | |
| drug,nitrate | |
| sequence,Elderly,patients,for,whom,nitrate,has,been,prescribed,should,be,warned,of,the,occurrence,of,hypotension,,,leading,to,unconsciousness,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,8,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,hyponatremia,hypoosmolality | |
| drug,lorcainide | |
| sequence,Sixteen,of,33,patients,developed,significant,hyponatremia,and,hypoosmolality,during,oral,treatment,with,lorcainide,. | |
| labels,0,0,0,0,0,0,8,0,8,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,febrile agranulocytosis | |
| drug,ticlopidine | |
| sequence,A,case,is,reported,of,an,elderly,woman,who,developed,febrile,agranulocytosis,several,weeks,after,commencing,ticlopidine,but,who,had,a,favorable,outcome,after,cessation,of,that,drug,and,treatment,with,filgastrim,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe dyspnea,worsening pleuritis carcinomatosa,flare-up | |
| drug,goserelin acetate | |
| sequence,Four,days,after,the,initial,injection,of,3.6,mg,of,goserelin,acetate,,,severe,dyspnea,developed,due,to,worsening,pleuritis,carcinomatosa,,,which,was,considered,as,a,flare-up,. | |
| labels,0,0,0,0,0,0,0,0,0,0,1,3,0,5,7,0,0,0,5,6,7,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,1,1,1,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,maculopathy | |
| drug,chloroquine | |
| sequence,CONCLUSIONS,:,Low,dosages,of,quinacrine,used,for,malaria,prophylaxis,can,be,associated,with,a,delayed,,,severe,maculopathy,indistinguishable,from,chloroquine,maculopathy,in,certain,patients,. | |
| labels,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe maculopathy | |
| drug,quinacrine | |
| sequence,CONCLUSIONS,:,Low,dosages,of,quinacrine,used,for,malaria,prophylaxis,can,be,associated,with,a,delayed,,,severe,maculopathy,indistinguishable,from,chloroquine,maculopathy,in,certain,patients,. | |
| labels,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,RS | |
| drug,aspirin | |
| sequence,Physicians,should,be,aware,of,the,potential,for,the,development,of,RS,among,children,who,are,receiving,long-term,aspirin,therapy,for,the,treatment,of,systemic,inflammatory,illnesses,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nail-changes | |
| drug,penicillamine | |
| sequence,Peculiar,nail-changes,in,a,70-year-old,woman,with,rheumatoid,arthritis,occurring,after,approximately,1,year,of,penicillamine,treatment,are,described,. | |
| labels,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombocytopenia | |
| drug,Rifampin | |
| sequence,Rifampin-associated,thrombocytopenia,secondary,to,poor,compliance,. | |
| labels,4,8,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Minimal change nephrotic syndrome | |
| drug,interferon-beta | |
| sequence,Minimal,change,nephrotic,syndrome,developing,during,postoperative,interferon-beta,therapy,for,malignant,melanoma,. | |
| labels,5,6,6,7,0,0,0,4,0,0,0,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Interstitial pneumonia | |
| drug,sorafenib | |
| sequence,Interstitial,pneumonia,probably,associated,with,sorafenib,treatment,:,An,alert,of,an,adverse,event,. | |
| labels,5,7,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,accelerate HIV disease | |
| drug,methotrexate | |
| sequence,The,use,of,methotrexate,(,MTX,),has,been,contraindicated,for,treatment,of,severe,psoriasis,in,HIV,infection,on,the,basis,of,six,previously,reported,cases,in,which,MTX,appeared,to,potentiate,opportunistic,infections,and,accelerate,HIV,disease,. | |
| labels,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0 | |
| ==============================, ============================= | |
| ade,accelerate HIV disease | |
| drug,MTX | |
| sequence,The,use,of,methotrexate,(,MTX,),has,been,contraindicated,for,treatment,of,severe,psoriasis,in,HIV,infection,on,the,basis,of,six,previously,reported,cases,in,which,MTX,appeared,to,potentiate,opportunistic,infections,and,accelerate,HIV,disease,. | |
| labels,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0 | |
| ==============================, ============================= | |
| ade,Bulls-eye maculopathy | |
| drug,quinacrine | |
| sequence,Bulls-eye,maculopathy,associated,with,quinacrine,therapy,for,malaria,. | |
| labels,5,7,0,0,4,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Optic neuropathy | |
| drug,ethambutol | |
| sequence,Optic,neuropathy,in,ethambutol-treated,renal,tuberculosis,. | |
| labels,5,7,0,4,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,renal failure | |
| drug,suramin | |
| sequence,Acute,renal,failure,should,be,recognized,as,a,potential,complication,of,suramin,treatment,. | |
| labels,0,5,7,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,aplastic anemia | |
| drug,gold | |
| sequence,Three,patients,receiving,gold,salt,treatment,for,rheumatoid,arthritis,developed,severe,aplastic,anemia,. | |
| labels,0,0,0,4,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Massive subfascial hematoma | |
| drug,alteplase | |
| sequence,Massive,subfascial,hematoma,after,alteplase,therapy,for,acute,myocardial,infarction,. | |
| labels,5,6,7,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe hypercalcemia | |
| drug,cinacalcet HCl | |
| sequence,In,this,paper,,,we,report,a,case,of,severe,hypercalcemia,of,immobilization,in,a,40-year-old,hemodialyzed,woman,treated,by,cinacalcet,HCl,for,a,severe,HPTH-II,(,PTH,>,1,000,pg,mL,),. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,1,3,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Fever,pulmonary infiltrates,pleural effusion | |
| drug,acyclovir | |
| sequence,Fever,,,pulmonary,infiltrates,,,and,pleural,effusion,following,acyclovir,therapy,for,herpes,zoster,ophthalmicus,. | |
| labels,8,0,5,7,0,0,5,7,0,4,0,0,0,0,0,0 | |
| ade_mask,1,0,1,1,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,skin necrosis | |
| drug,glatiramer acetate | |
| sequence,This,case,is,remarkable,since,1,),ECM,developed,after,subcutaneous,and,not,after,intramuscular,injection,,,2,),the,injection,was,given,by,the,patient,himself,,,and,3,),glatiramer,acetate,can,induce,skin,necrosis,as,a,side,effect,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,3,0,0,5,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,dyskinesia | |
| drug,amoxapine | |
| sequence,Case,report,of,withdrawal,dyskinesia,associated,with,amoxapine,. | |
| labels,0,0,0,0,8,0,0,4,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nitrofurantoin induced lung injury | |
| drug,nitrofurantoin | |
| sequence,We,suggest,that,the,previous,classification,of,nitrofurantoin,induced,lung,injury,into,``,acute,'',and,``,chronic,'',injury,is,an,oversimplification,in,view,of,the,wide,variety,of,pathological,entities,that,have,subsequently,emerged,. | |
| labels,0,0,0,0,0,0,0,9,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cholelithiasis | |
| drug,cyclosporin | |
| sequence,The,use,of,cyclosporin,has,been,associated,with,the,development,of,cholelithiasis,in,transplant,recipients,. | |
| labels,0,0,0,4,0,0,0,0,0,0,0,8,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fluorosis | |
| drug,niflumic acid | |
| sequence,After,ruling,out,a,hydrotelluric,source,of,fluorine,,,the,patient,'s,fluorosis,was,linked,to,chronic,use,of,niflumic,acid,,,following,the,publication,in,1978,of,the,2,previously,reported,cases,affected,by,this,drug,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,1,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,torsades de pointe | |
| drug,amiodarone | |
| sequence,Although,a,lot,of,amiodarone-induced,torsades,de,pointe,have,been,published,,,a,review,of,all,these,cases,and,the,underlying,risk-factors,has,never,been,made,. | |
| labels,0,0,0,0,4,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Subacute cholestatic hepatitis | |
| drug,senna | |
| sequence,Subacute,cholestatic,hepatitis,likely,related,to,the,use,of,senna,for,chronic,constipation,. | |
| labels,5,6,7,0,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute psychosis | |
| drug,levetiracetam | |
| sequence,A,twelve,year-old-girl,with,idiopathic,partial,epilepsy,with,secondary,generalization,,,developed,acute,psychosis,10,days,after,the,administration,of,levetiracetam,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,SIADH | |
| drug,vinorelbine | |
| sequence,CONCLUSIONS,:,Because,of,its,structural,similarity,to,the,other,vinca,alkaloids,,,vinorelbine,is,believed,to,be,responsible,for,SIADH,in,our,patient,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,8,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Pulmonary oedema | |
| drug,hexoprenaline | |
| sequence,Pulmonary,oedema,after,hexoprenaline,administration,in,preterm,labour,. | |
| labels,5,7,0,4,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,exfoliative rash | |
| drug,temozolomide | |
| sequence,Clinicians,should,be,aware,that,an,erythematous,and,exfoliative,rash,may,be,induced,by,temozolomide,,,and,be,familiar,with,the,pharmacologic,and,supportive,measures,necessary,for,its,treatment,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,diabetes | |
| drug,fosinopril | |
| sequence,RESULTS,:,After,4-,to,14-month,period,of,therapy,with,the,combination,of,indapamide,(,2.5,mg,day,),and,fosinopril,(,10,mg,day,),in,three,patients,and,6-month,period,of,monotherapy,with,indapamide,(,2.5,mg,day,),in,one,patient,,,glucose,levels,of,all,patients,increased,and,achieve,criteria,of,diabetes,diagnoses,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0 | |
| ==============================, ============================= | |
| ade,diabetes | |
| drug,indapamide | |
| sequence,RESULTS,:,After,4-,to,14-month,period,of,therapy,with,the,combination,of,indapamide,(,2.5,mg,day,),and,fosinopril,(,10,mg,day,),in,three,patients,and,6-month,period,of,monotherapy,with,indapamide,(,2.5,mg,day,),in,one,patient,,,glucose,levels,of,all,patients,increased,and,achieve,criteria,of,diabetes,diagnoses,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0 | |
| ==============================, ============================= | |
| ade,urinary incontinence,UI | |
| drug,venlafaxine | |
| sequence,The,authors,report,a,case,of,urinary,incontinence,(,UI,),that,occurred,in,a,woman,after,administration,of,venlafaxine,. | |
| labels,0,0,0,0,0,0,5,7,0,8,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lupus-like syndrome | |
| drug,Infliximab | |
| sequence,Infliximab,therapy,may,cause,a,lupus-like,syndrome,that,is,reversible,upon,discontinuing,this,agent,. | |
| labels,4,0,0,0,0,5,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cytotoxic effect | |
| drug,ticlopidine | |
| sequence,When,the,data,of,the,57,patients,are,evaluated,,,a,reversible,direct,cytotoxic,effect,of,ticlopidine,on,the,pluripotent,bipotent,hematopoietic,progenitor,stem,cell,is,proposed,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,atypical cholangitis,liver damage | |
| drug,captopril | |
| sequence,Patients,treated,with,captopril,who,develop,``,atypical,cholangitis,'',should,be,suspected,of,having,captopril-associated,liver,damage,. | |
| labels,0,0,0,4,0,0,0,5,7,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,hepatotoxicity | |
| drug,TMP-SMX | |
| sequence,Use,of,the,Naranjo,adverse,drug,reaction,probability,scale,indicated,a,probable,relationship,(,score,of,5,),between,the,patient,'s,development,of,hepatotoxicity,and,the,TMP-SMX,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,oedema | |
| drug,insulin | |
| sequence,Does,the,use,of,insulin,in,a,patient,with,liver,dysfunction,increase,water,retention,in,the,body,,,i.e,.,cause,insulin,oedema,? | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,pleural effusions | |
| drug,Dasatinib | |
| sequence,Dasatinib-induced,pleural,effusions,:,a,lymphatic,network,disorder,? | |
| labels,4,5,7,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,leukoencephalopathy | |
| drug,Methotrexate | |
| sequence,Methotrexate-induced,leukoencephalopathy,is,treatable,with,high-dose,folinic,acid,:,a,case,report,and,analysis,of,the,literature,. | |
| labels,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ventricular tachycardia,Torsades de Pointes,TdP | |
| drug,garenoxacin | |
| sequence,We,report,an,82-year-old,man,who,developed,ventricular,tachycardia,and,Torsades,de,Pointes,(,TdP,),after,oral,administration,of,garenoxacin,,,a,novel,quinolone,antibiotic,agent,that,differs,from,the,third-generation,quinolones,,,for,pneumonia,. | |
| labels,0,0,0,0,0,0,0,5,7,0,5,6,7,0,8,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,status epilepticus | |
| drug,cisplatin | |
| sequence,We,describe,the,case,of,a,50-year-old,woman,with,advanced,non-small,cell,lung,cancer,who,developed,status,epilepticus,shortly,after,receiving,cisplatin,and,gemcitabine,chemotherapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,4,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,status epilepticus | |
| drug,gemcitabine | |
| sequence,We,describe,the,case,of,a,50-year-old,woman,with,advanced,non-small,cell,lung,cancer,who,developed,status,epilepticus,shortly,after,receiving,cisplatin,and,gemcitabine,chemotherapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,4,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,parasympathetic dysfunction of the visual system | |
| drug,BTX-B | |
| sequence,In,this,study,,,we,report,on,three,individual,patients,who,received,BTX-B,and,who,subsequently,developed,parasympathetic,dysfunction,of,the,visual,system,after,injections,of,BTX-B,at,remote,sites,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,5,6,6,6,6,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute lung injury,diffuse alveolar damage | |
| drug,mefloquine | |
| sequence,This,is,the,second,report,of,acute,lung,injury,and,diffuse,alveolar,damage,caused,by,mefloquine,. | |
| labels,0,0,0,0,0,0,5,6,7,0,5,6,7,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hemolytic uremic syndrome | |
| drug,gemcitabine | |
| sequence,Rituximab-based,therapy,for,gemcitabine-induced,hemolytic,uremic,syndrome,in,a,patient,with,metastatic,pancreatic,adenocarcinoma,:,a,case,report,. | |
| labels,0,0,0,4,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cutaneous ecchymosis,sudden fall in hemoglobin,diffuse subfascial hematoma | |
| drug,alteplase | |
| sequence,The,development,of,cutaneous,ecchymosis,associated,with,a,sudden,fall,in,hemoglobin,after,the,administration,of,alteplase,should,strongly,suggest,the,possibility,of,diffuse,subfascial,hematoma,. | |
| labels,0,0,0,5,7,0,0,0,5,6,6,7,0,0,0,0,4,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,1,1,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,mucocutaneous reactions | |
| drug,gold | |
| sequence,How,low,can,you,go,?,Use,of,very,low,dosage,of,gold,in,patients,with,mucocutaneous,reactions,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,priapism | |
| drug,Prothipendylhydrochloride | |
| sequence,Prothipendylhydrochloride-induced,priapism,:,case,report,. | |
| labels,4,8,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,DRESS syndrome | |
| drug,chlorambucil | |
| sequence,We,report,the,first,case,of,chlorambucil-induced,DRESS,syndrome,in,a,70-year-old,man,recently,diagnosed,with,chronic,lymphocytic,leukaemia,. | |
| labels,0,0,0,0,0,0,4,5,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Symptomatic hypoglycemia | |
| drug,glipizide | |
| sequence,Symptomatic,hypoglycemia,secondary,to,a,glipizide-trimethoprim,sulfamethoxazole,drug,interaction,. | |
| labels,5,7,0,0,0,4,9,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Symptomatic hypoglycemia | |
| drug,sulfamethoxazole | |
| sequence,Symptomatic,hypoglycemia,secondary,to,a,glipizide-trimethoprim,sulfamethoxazole,drug,interaction,. | |
| labels,5,7,0,0,0,4,9,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Symptomatic hypoglycemia | |
| drug,trimethoprim | |
| sequence,Symptomatic,hypoglycemia,secondary,to,a,glipizide-trimethoprim,sulfamethoxazole,drug,interaction,. | |
| labels,5,7,0,0,0,4,9,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pancytopenia,massive plasmocytosis | |
| drug,MMI | |
| sequence,To,our,knowledge,this,is,the,first,report,of,pancytopenia,due,to,MMI,,,where,the,usual,hypoplasia,found,is,replaced,by,massive,plasmocytosis,. | |
| labels,0,0,0,0,0,0,0,0,0,8,0,0,4,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,cardiac toxicity | |
| drug,diphenhydramine | |
| sequence,However,,,because,diphenhydramine,also,exhibits,type,IA,sodium,channel,blockade,,,cardiac,toxicity,is,also,possible,. | |
| labels,0,0,0,4,0,0,0,0,0,0,0,0,5,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,macular edema,retinopathy | |
| drug,interferon | |
| sequence,Clinical,course,of,macular,edema,in,two,cases,of,interferon-associated,retinopathy,observed,by,optical,coherence,tomography,. | |
| labels,0,0,0,5,7,0,0,0,0,4,8,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,vitiligo | |
| drug,interferon alpha 2a | |
| sequence,We,report,a,case,of,vitiligo,that,occurred,during,the,second,month,of,interferon,alpha,2a,therapy,for,chronic,active,hepatitis,C,. | |
| labels,0,0,0,0,0,8,0,0,0,0,0,0,0,1,2,3,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Syncope | |
| drug,nitrate | |
| sequence,Syncope,in,a,65-year-old,woman,after,nitrate,ingestion,. | |
| labels,8,0,0,0,0,0,4,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,interstitial nephritis | |
| drug,ciprofloxacin | |
| sequence,This,article,describes,a,patient,with,suspected,ciprofloxacin-induced,interstitial,nephritis,. | |
| labels,0,0,0,0,0,0,0,4,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Neuropathy | |
| drug,thalidomide | |
| sequence,Neuropathy,is,a,significant,side,effect,of,thalidomide,therapy,,,which,may,limit,its,clinical,use,. | |
| labels,8,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,unilateral hearing loss | |
| drug,desferrioxamine | |
| sequence,CASE,REPORT,:,A,six-year-old,boy,with,transfusion-dependent,beta-thalassaemia,developed,a,unilateral,hearing,loss,shortly,after,commencing,desferrioxamine,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute exacerbations | |
| drug,ampicillin | |
| sequence,Myasthenic,patients,receiving,ampicillin,should,be,closely,monitored,for,possible,acute,exacerbations,. | |
| labels,0,0,0,4,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,lithium intoxication,diabetes insipidus-like syndrome | |
| drug,Lithium | |
| sequence,Lithium,treatment,was,terminated,in,1975,because,of,lithium,intoxication,with,a,diabetes,insipidus-like,syndrome,. | |
| labels,4,0,0,0,0,0,0,0,9,7,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,lithium intoxication,diabetes insipidus-like syndrome | |
| drug,lithium | |
| sequence,Lithium,treatment,was,terminated,in,1975,because,of,lithium,intoxication,with,a,diabetes,insipidus-like,syndrome,. | |
| labels,4,0,0,0,0,0,0,0,9,7,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,Cardiac arrest | |
| drug,sumatriptan | |
| sequence,Cardiac,arrest,following,use,of,sumatriptan,. | |
| labels,5,7,0,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Marked QT prolongation,torsades de pointes,acute ischemia | |
| drug,dofetilide | |
| sequence,Marked,QT,prolongation,and,torsades,de,pointes,secondary,to,acute,ischemia,in,an,elderly,man,taking,dofetilide,for,atrial,fibrillation,:,a,cautionary,tale,. | |
| labels,5,6,7,0,5,6,7,0,0,5,7,0,0,0,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,1,1,1,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,SS,NMS | |
| drug,carbamazepine | |
| sequence,METHOD,:,Case,analysis,of,a,poly-drug,overdose,(,venlafaxine,,,topiramate,,,divalproex,sodium,,,risperidone,,,and,carbamazepine,),presenting,with,mixed,SS,NMS,features,and,whose,clinical,management,suggests,a,practical,algorithm,for,treatment,of,undifferentiated,SS,NMS,in,critical,care,settings,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,4,0,1,3,0,4,0,0,4,0,0,0,0,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,SS,NMS | |
| drug,divalproex sodium | |
| sequence,METHOD,:,Case,analysis,of,a,poly-drug,overdose,(,venlafaxine,,,topiramate,,,divalproex,sodium,,,risperidone,,,and,carbamazepine,),presenting,with,mixed,SS,NMS,features,and,whose,clinical,management,suggests,a,practical,algorithm,for,treatment,of,undifferentiated,SS,NMS,in,critical,care,settings,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,4,0,1,3,0,4,0,0,4,0,0,0,0,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,SS,NMS | |
| drug,risperidone | |
| sequence,METHOD,:,Case,analysis,of,a,poly-drug,overdose,(,venlafaxine,,,topiramate,,,divalproex,sodium,,,risperidone,,,and,carbamazepine,),presenting,with,mixed,SS,NMS,features,and,whose,clinical,management,suggests,a,practical,algorithm,for,treatment,of,undifferentiated,SS,NMS,in,critical,care,settings,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,4,0,1,3,0,4,0,0,4,0,0,0,0,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,SS,NMS | |
| drug,topiramate | |
| sequence,METHOD,:,Case,analysis,of,a,poly-drug,overdose,(,venlafaxine,,,topiramate,,,divalproex,sodium,,,risperidone,,,and,carbamazepine,),presenting,with,mixed,SS,NMS,features,and,whose,clinical,management,suggests,a,practical,algorithm,for,treatment,of,undifferentiated,SS,NMS,in,critical,care,settings,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,4,0,1,3,0,4,0,0,4,0,0,0,0,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,SS,NMS | |
| drug,venlafaxine | |
| sequence,METHOD,:,Case,analysis,of,a,poly-drug,overdose,(,venlafaxine,,,topiramate,,,divalproex,sodium,,,risperidone,,,and,carbamazepine,),presenting,with,mixed,SS,NMS,features,and,whose,clinical,management,suggests,a,practical,algorithm,for,treatment,of,undifferentiated,SS,NMS,in,critical,care,settings,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,4,0,1,3,0,4,0,0,4,0,0,0,0,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,malignant mixed mesodermal tumor | |
| drug,raloxifene | |
| sequence,We,report,a,case,of,a,women,in,whom,a,malignant,mixed,mesodermal,tumor,was,diagnosed,while,she,was,taking,raloxifene,,,which,is,also,a,selective,estrogen,receptor,modulator,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,secondary infection | |
| drug,imiquimod | |
| sequence,He,developed,a,late,secondary,infection,in,some,sites,treated,with,imiquimod,. | |
| labels,0,0,0,0,5,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,proteinuria | |
| drug,gold | |
| sequence,Three,patients,developed,proteinuria,following,gold,therapy,for,rheumatoid,arthritis,. | |
| labels,0,0,0,8,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyponatremia | |
| drug,sibutramine | |
| sequence,We,describe,a,case,of,life-threatening,hyponatremia,associated,with,sibutramine,use,in,an,obese,woman,. | |
| labels,0,0,0,0,0,0,8,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute icteric hepatitis-like illness | |
| drug,gliclazide | |
| sequence,A,60-year-old,woman,with,diabetes,mellitus,(,type,2,),developed,an,acute,icteric,hepatitis-like,illness,6,weeks,after,the,initiation,of,gliclazide,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ovarian endometrioid carcinoma | |
| drug,tamoxifen | |
| sequence,The,association,with,prolonged,unopposed,estrogen-like,stimulation,with,tamoxifen,as,a,possible,factor,in,the,development,of,ovarian,endometrioid,carcinoma,is,discussed,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,5,6,7,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,urological symptoms | |
| drug,ketamine | |
| sequence,Presentation,of,three,palliative,care,patients,who,were,given,ketamine,as,an,analgesic,and,subsequently,developed,significant,and,debilitating,urological,symptoms,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,headache | |
| drug,capecitabine | |
| sequence,We,hypothesize,that,capecitabine-induced,headache,is,vascular,in,nature,. | |
| labels,0,0,0,4,8,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,C. difficile colitis | |
| drug,cisplatin | |
| sequence,Severe,C.,difficile,colitis,occurred,in,2,patients,(,6.1,%,),after,receiving,cisplatin-based,combination,chemotherapy,for,ovarian,malignancies,. | |
| labels,0,5,6,7,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Lethargy,lithium toxicity | |
| drug,lithium | |
| sequence,Lethargy,in,a,newborn,:,lithium,toxicity,or,lab,error,? | |
| labels,8,0,0,0,0,9,7,0,0,0,0 | |
| ade_mask,1,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypertension,arteriosclerotic disease,myocardial infarction | |
| drug,minoxidil | |
| sequence,One,of,the,subjects,who,was,using,extemporaneous,topical,minoxidil,had,hypertension,and,arteriosclerotic,disease,and,the,other,died,of,a,myocardial,infarction,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,8,0,5,7,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,fixed drug eruption | |
| drug,Ceftriaxone | |
| sequence,Ceftriaxone-induced,fixed,drug,eruption,:,first,report,. | |
| labels,4,5,6,7,0,0,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,toxic epidermal necrolysis,TEN | |
| drug,phenolphthalein | |
| sequence,OBJECTIVE,:,To,report,a,case,of,phenolphthalein-induced,toxic,epidermal,necrolysis,(,TEN,),in,a,patient,maintained,on,several,other,medications,more,commonly,known,to,be,associated,with,TEN,. | |
| labels,0,0,0,0,0,0,0,4,5,6,7,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,angioedema | |
| drug,oxcarbazepine | |
| sequence,A,search,of,the,United,States,Food,and,Drug,Administration,'s,Adverse,Event,Reporting,System,identified,nine,cases,of,oxcarbazepine-associated,angioedema,in,pediatric,patients,aged,16,years,and,younger,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fulminant hepatic failure | |
| drug,Disulfiram | |
| sequence,Disulfiram-induced,fulminant,hepatic,failure,in,an,active,duty,soldier,. | |
| labels,4,5,6,7,0,0,0,0,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,teratogenic,fetotoxic,fetal damage | |
| drug,zidovudine | |
| sequence,Currently,the,use,of,zidovudine,is,one,of,the,few,specific,measures,available,,,and,as,a,potentially,teratogenic,and,fetotoxic,agent,,,any,decision,for,its,use,requires,evaluation,of,the,potential,for,fetal,damage,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,acceleration of the ventricular rate | |
| drug,adenosine | |
| sequence,However,,,adenosine,shortens,the,antegrade,refractoriness,of,accessory,atrioventricular,connections,and,may,cause,acceleration,of,the,ventricular,rate,during,atrial,fibrillation,. | |
| labels,0,0,4,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,7,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,1,0,0,0,0,0,0,1,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,abnormal rhythm | |
| drug,propranolol | |
| sequence,The,abnormal,rhythm,disappeared,with,the,withdrawal,of,propranolol,and,when,the,drug,was,restarted,a,2,1,S-A,block,was,seen,. | |
| labels,0,5,7,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,visual loss | |
| drug,ethambutol | |
| sequence,In,addition,,,ethambutol,rarely,causes,visual,loss,during,the,early,period,or,when,given,at,lower,doses,. | |
| labels,0,0,0,4,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,reproductive endocrine disorders | |
| drug,valproate | |
| sequence,OBJECTIVE,:,To,describe,the,development,of,valproate-related,reproductive,endocrine,disorders,in,women,with,epilepsy,. | |
| labels,0,0,0,0,0,0,0,4,5,6,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Phantom limb pain,neurotoxicity | |
| drug,paclitaxel | |
| sequence,Phantom,limb,pain,as,a,manifestation,of,paclitaxel,neurotoxicity,. | |
| labels,5,6,7,0,0,0,0,4,8,0 | |
| ade_mask,1,1,1,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,photosensitivity | |
| drug,mequitazine | |
| sequence,However,,,dermatologists,should,be,cautious,about,a,photosensitivity,reaction,induced,by,mequitazine,or,other,phenothiazine-derivative,drugs,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,urinary calculus | |
| drug,magnesium ammonium phosphate | |
| sequence,In,association,with,this,tocolysis,,,urinary,calculus,of,magnesium,ammonium,phosphate,occurred,at,34,weeks,gestation,. | |
| labels,0,0,0,0,0,0,5,7,0,1,2,3,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,syncope | |
| drug,oxymetazoline | |
| sequence,Are,nasal,decongestants,safer,than,rhinitis,?,A,case,of,oxymetazoline-induced,syncope,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,aspergillus arthritis | |
| drug,fludarabine | |
| sequence,Indolent,aspergillus,arthritis,complicating,fludarabine-based,non-myeloablative,stem,cell,transplantation,. | |
| labels,0,5,7,0,4,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe anasarca,peripheral oedema,ascites,pleural effusion | |
| drug,insulin | |
| sequence,Soon,after,introduction,of,insulin,therapy,,,she,developed,severe,anasarca,,,including,marked,peripheral,oedema,,,ascites,and,pleural,effusion,. | |
| labels,0,0,0,0,4,0,0,0,0,5,7,0,0,0,5,7,0,8,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,1,1,0,1,0,1,1,0 | |
| ==============================, ============================= | |
| ade,lactic acidosis | |
| drug,metformin | |
| sequence,Metformin-associated,lactic,acidosis,(,MALA,),is,a,serious,metabolic,complication,that,occurs,because,of,metformin,accumulation,in,patients,who,become,dehydrated,or,developed,acute,renal,failure,. | |
| labels,4,5,7,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lactic acidosis | |
| drug,Metformin | |
| sequence,Metformin-associated,lactic,acidosis,(,MALA,),is,a,serious,metabolic,complication,that,occurs,because,of,metformin,accumulation,in,patients,who,become,dehydrated,or,developed,acute,renal,failure,. | |
| labels,4,5,7,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neurotoxicity | |
| drug,itraconazole | |
| sequence,Nineteen,cases,of,unusual,enhanced,vincristine,neurotoxicity,related,to,itraconazole,have,been,reported,in,children,. | |
| labels,0,0,0,0,0,4,8,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neurotoxicity | |
| drug,vincristine | |
| sequence,Nineteen,cases,of,unusual,enhanced,vincristine,neurotoxicity,related,to,itraconazole,have,been,reported,in,children,. | |
| labels,0,0,0,0,0,4,8,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,disulfiram-like reaction | |
| drug,cefmenoxime | |
| sequence,This,is,the,first,report,of,a,disulfiram-like,reaction,with,cefmenoxime,. | |
| labels,0,0,0,0,0,0,0,5,7,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,coma | |
| drug,promethazine | |
| sequence,Response,of,a,promethazine-induced,coma,to,flumazenil,. | |
| labels,0,0,0,4,8,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,delirious | |
| drug,alprazolam | |
| sequence,A,case,is,presented,in,which,a,68-year-old,man,became,delirious,after,being,withdrawn,from,a,low,dosage,of,alprazolam,. | |
| labels,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,reversible toxic liver damage | |
| drug,disulfiram | |
| sequence,A,reversible,toxic,liver,damage,was,observed,in,a,non-alcoholic,woman,treated,with,disulfiram,. | |
| labels,0,5,6,6,7,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute pancreatitis | |
| drug,Tigecycline | |
| sequence,Tigecycline-induced,acute,pancreatitis,:,case,report,and,literature,review,. | |
| labels,4,5,7,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,granulocytopenia | |
| drug,Dipyrone | |
| sequence,Dipyrone-induced,granulocytopenia,:,a,case,for,awareness,. | |
| labels,4,8,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,isolated paresthesia,peripheral neuropathy | |
| drug,sulindac | |
| sequence,To,our,knowledge,,,we,describe,the,first,reported,case,of,isolated,paresthesia,and,peripheral,neuropathy,,,without,systemic,involvement,,,secondary,to,sulindac,administration,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,7,0,5,7,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Eosinophilia | |
| drug,clozapine | |
| sequence,Eosinophilia,has,been,encountered,from,0.2,to,61.7,%,in,clozapine-treated,patients,,,mostly,with,a,transient,course,and,spontaneous,remission,. | |
| labels,8,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Cataracts | |
| drug,Decadron | |
| sequence,Cataracts,induced,by,intermittent,Decadron,used,as,an,antiemetic,. | |
| labels,8,0,0,0,4,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sepsis | |
| drug,metamizole | |
| sequence,After,identification,of,the,index,patient,,,additional,inquiry,revealed,that,the,patient,'s,mother,was,hospitalized,previously,for,overwhelming,sepsis,associated,with,metamizole,use,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity syndrome | |
| drug,Carbamazepine | |
| sequence,Carbamazepine,hypersensitivity,syndrome,is,a,rare,,,life-threatening,condition,. | |
| labels,4,5,7,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,life-threatening vincristine neurotoxicity | |
| drug,vincristine | |
| sequence,Early,recognition,of,hereditary,motor,and,sensory,neuropathy,type,1,can,avoid,life-threatening,vincristine,neurotoxicity,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,5,9,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,severe cholestasis | |
| drug,azathioprine | |
| sequence,A,67-year-old,patient,,,with,primary,polymyositis,and,without,previous,evidence,of,liver,disease,,,developed,clinical,and,biochemical,features,of,severe,cholestasis,3,months,after,initiation,of,azathioprine,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hemolytic anemia | |
| drug,Chlorpropamide | |
| sequence,Chlorpropamide-induced,hemolytic,anemia,. | |
| labels,4,5,7,0 | |
| ade_mask,0,1,1,0 | |
| ==============================, ============================= | |
| ade,tumor lysis syndrome | |
| drug,imatinib | |
| sequence,We,herein,described,an,additional,patient,with,BCR-ABL,(,ela2,),positive,acute,lymphoblastic,leukemia,who,developed,tumor,lysis,syndrome,after,10-day,treatment,with,imatinib,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,confusion,abdominal pain,distention | |
| drug,benztropine | |
| sequence,A,33-year-old,man,with,a,history,of,recreational,benztropine,abuse,presented,to,the,emergency,department,with,confusion,,,abdominal,pain,,,and,distention,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,8,0,5,7,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Transtubular potassium gradient (TTKG) also decreased | |
| drug,phosphate | |
| sequence,Transtubular,potassium,gradient,(,TTKG,),also,decreased,and,an,inverse,correlation,was,found,between,TTKG,and,doses,of,phosphate,(,r,=,-0.37,;,p,<,0.02,;,N,=,38,),. | |
| labels,5,6,6,6,6,6,6,7,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neurotoxicity | |
| drug,INH | |
| sequence,OBJECTIVES,:,To,describe,the,presentation,and,treatment,of,acute,isoniazid,(,INH,),neurotoxicity,appearing,at,an,inner-city,municipal,hospital,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,0,4,0,8,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neurotoxicity | |
| drug,isoniazid | |
| sequence,OBJECTIVES,:,To,describe,the,presentation,and,treatment,of,acute,isoniazid,(,INH,),neurotoxicity,appearing,at,an,inner-city,municipal,hospital,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,0,4,0,8,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Imidazoline intoxication | |
| drug,Imidazoline | |
| sequence,Imidazoline,intoxication,in,children,. | |
| labels,9,7,0,0,0 | |
| ade_mask,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,polymyositis,cardiomyopathy | |
| drug,interferon alpha | |
| sequence,In,this,case,,,interferon,alpha,induced,polymyositis,and,cardiomyopathy,is,diagnosed,in,a,33-yr-old,male,patient,with,history,of,chronic,hepatitis,B,. | |
| labels,0,0,0,0,1,3,0,8,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,gingival bleeding,purpura | |
| drug,danazol | |
| sequence,On,the,next,day,,,after,a,total,dose,of,only,600,mg,of,danazol,,,gingival,bleeding,and,purpura,occurred,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,5,7,0,8,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0,0 | |
| ==============================, ============================= | |
| ade,TEN | |
| drug,levofloxacin | |
| sequence,To,our,knowledge,,,this,case,is,the,first,published,report,of,levofloxacin-induced,TEN,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Psychotic disorder | |
| drug,isoniazid | |
| sequence,Psychotic,disorder,associated,with,isoniazid,. | |
| labels,5,7,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Cardiac hypersensitivity,myopericarditis | |
| drug,mesalazine | |
| sequence,Cardiac,hypersensitivity,and,myopericarditis,have,been,reported,during,long-term,treatment,with,mesalazine,. | |
| labels,5,7,0,8,0,0,0,0,0,0,0,4,0 | |
| ade_mask,1,1,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,interfere with tacrolimus metabolism | |
| drug,nefazodone | |
| sequence,Coadministration,of,antidepressant,agents,such,as,nefazodone,,,or,any,other,drug,that,inhibits,the,CYP3A4,isoenzyme,subfamily,,,should,be,anticipated,to,interfere,with,tacrolimus,metabolism,. | |
| labels,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,9,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,interfere with tacrolimus metabolism | |
| drug,tacrolimus | |
| sequence,Coadministration,of,antidepressant,agents,such,as,nefazodone,,,or,any,other,drug,that,inhibits,the,CYP3A4,isoenzyme,subfamily,,,should,be,anticipated,to,interfere,with,tacrolimus,metabolism,. | |
| labels,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,9,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,refractory coronary vasospasm | |
| drug,cocaine | |
| sequence,This,case,report,illustrates,the,use,of,continuous,high-dose,intracoronary,nitroglycerin,infusion,through,a,6,French,coronary,guiding,catheter,in,the,treatment,of,a,patient,with,cocaine-induced,refractory,coronary,vasospasm,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,1,0,1,0 | |
| ==============================, ============================= | |
| ade,Pancreatitis | |
| drug,L-asparaginase | |
| sequence,Pancreatitis,has,been,noted,to,be,a,complication,in,2-16,%,of,patients,undergoing,treatment,with,L-asparaginase,for,a,variety,of,pediatric,neoplasms,. | |
| labels,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,scleroderma | |
| drug,bleomycin | |
| sequence,Although,an,association,between,exposure,to,bleomycin,and,the,development,of,scleroderma,has,been,suspected,,,few,cases,are,reported,. | |
| labels,0,0,0,0,0,0,4,0,0,0,0,8,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Priapism | |
| drug,trazodone | |
| sequence,Priapism,associated,with,trazodone,therapy,:,case,report,. | |
| labels,8,0,0,4,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cardiac arrhythmias | |
| drug,HCQ | |
| sequence,CONCLUSION,:,The,chronic,use,of,HCQ,for,rheumatic,diseases,,,or,as,an,anti-malarial,drug,,,should,be,balanced,against,the,risk,of,developing,potentially,lethal,cardiac,arrhythmias,. | |
| labels,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,mania | |
| drug,Alprazolam | |
| sequence,Alprazolam-induced,mania,:,two,clinical,cases,. | |
| labels,4,8,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Persisent ocular hypertension | |
| drug,ranibizumab | |
| sequence,Persisent,ocular,hypertension,following,intravitreal,ranibizumab,. | |
| labels,5,6,7,0,0,4,0 | |
| ade_mask,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,extrapyramidal symptoms,tardive dyskinesia,TD | |
| drug,Ziprasidone | |
| sequence,Ziprasidone,is,an,atypical,antipsychotic,drug,that,is,believed,to,have,a,low,propensity,for,inducing,extrapyramidal,symptoms,,,including,tardive,dyskinesia,(,TD,),. | |
| labels,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,5,7,0,8,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,1,0,0 | |
| ==============================, ============================= | |
| ade,LABD | |
| drug,carbamazepine | |
| sequence,We,report,a,patient,who,experienced,LABD,shortly,after,starting,carbamazepine,therapy,. | |
| labels,0,0,0,0,0,0,8,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,basilar invagination | |
| drug,phenytoin | |
| sequence,A,case,of,basilar,invagination,which,is,thought,to,have,arisen,from,the,patient,'s,intrauterine,exposure,to,phenytoin,is,presented,. | |
| labels,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,chronic nausea,confusion | |
| drug,morphine | |
| sequence,We,describe,a,patient,who,experienced,chronic,nausea,and,an,episode,of,confusion,while,treated,with,a,small,,,stable,dose,of,oral,morphine,in,the,setting,of,mild,renal,insufficiency,. | |
| labels,0,0,0,0,0,0,5,7,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute cerebellar syndrome | |
| drug,methotrexate | |
| sequence,We,describe,a,patient,who,developed,acute,cerebellar,syndrome,after,prophylactic,intrathecal,methotrexate,administration,and,recovered,spontaneously,. | |
| labels,0,0,0,0,0,0,5,6,7,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,LABD | |
| drug,Vancomycin | |
| sequence,Vancomycin,is,the,most,frequently,implicated,drug,,,but,other,agents,have,been,reported,to,cause,LABD,. | |
| labels,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,bowel injury | |
| drug,chromic phosphate | |
| sequence,Delayed,bowel,injury,is,an,infrequently,observed,complication,of,chromic,phosphate,administration,. | |
| labels,0,5,7,0,0,0,0,0,0,1,3,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neurological manifestations | |
| drug,interferon alpha | |
| sequence,After,a,two-month,interruption,of,interferon,administration,,,natural,interferon,alpha,was,given,but,followed,by,another,episode,of,the,same,neurological,manifestations,. | |
| labels,0,0,0,0,0,0,0,0,0,1,3,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,weakness,atrophy,worsening of the dysesthesia,gait disturbance | |
| drug,5-aminosalicylic acid | |
| sequence,When,SASP,was,changed,to,5-aminosalicylic,acid,(,5-ASA,),,,his,skin,eruptions,were,resolved,,,however,,,he,developed,weakness,and,atrophy,in,his,right,arm,as,well,as,progressive,worsening,of,the,dysesthesia,in,his,legs,and,gait,disturbance,. | |
| labels,0,0,0,0,0,1,3,0,4,0,0,0,0,0,0,0,0,0,0,0,0,8,0,8,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,weakness,atrophy,worsening of the dysesthesia,gait disturbance | |
| drug,5-ASA | |
| sequence,When,SASP,was,changed,to,5-aminosalicylic,acid,(,5-ASA,),,,his,skin,eruptions,were,resolved,,,however,,,he,developed,weakness,and,atrophy,in,his,right,arm,as,well,as,progressive,worsening,of,the,dysesthesia,in,his,legs,and,gait,disturbance,. | |
| labels,0,0,0,0,0,1,3,0,4,0,0,0,0,0,0,0,0,0,0,0,0,8,0,8,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,cornea | |
| drug,amantadine | |
| sequence,Therefore,,,amantadine,was,permanently,discontinued,and,the,cornea,cleared,again,. | |
| labels,0,0,4,0,0,0,0,0,8,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,restlessness,constant pacing,purposeless movements of the feet and legs,marked anxiety | |
| drug,fluoxetine | |
| sequence,The,typical,fluoxetine-induced,symptoms,of,restlessness,,,constant,pacing,,,purposeless,movements,of,the,feet,and,legs,,,and,marked,anxiety,were,indistinguishable,from,those,of,neuroleptic-induced,akathisia,. | |
| labels,0,0,4,0,0,8,0,5,7,0,5,6,6,6,6,6,7,0,0,5,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,1,1,0,1,1,0,1,1,1,1,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Seizure,hyponatremia | |
| drug,desmopressin | |
| sequence,Seizure,with,hyponatremia,in,a,child,prescribed,desmopressin,for,nocturnal,enuresis,. | |
| labels,8,0,8,0,0,0,0,4,0,0,0,0 | |
| ade_mask,1,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ethambutol toxicity,vision loss | |
| drug,ethambutol | |
| sequence,This,case,and,a,review,of,the,literature,show,the,severe,and,unpredictable,nature,of,ethambutol,toxicity,and,its,potential,for,irreversible,vision,loss,despite,careful,ophthalmologic,monitoring,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,7,0,0,0,0,0,5,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Ocular ethambutol toxicity | |
| drug,ethambutol | |
| sequence,Ocular,ethambutol,toxicity,. | |
| labels,5,9,7,0 | |
| ade_mask,1,1,1,0 | |
| ==============================, ============================= | |
| ade,Fanconi syndrome | |
| drug,ifosfamide | |
| sequence,Recognition,of,a,potential,drug-induced,Fanconi,syndrome,is,important,when,managing,pediatric,oncology,patients,previously,treated,with,ifosfamide,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hemolytic uremic syndrome | |
| drug,oxaliplatin | |
| sequence,Hemolytic,uremic,syndrome,following,the,infusion,of,oxaliplatin,:,case,report,. | |
| labels,5,6,7,0,0,0,0,4,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute pulmonary reactions,pulmonary dysfunction | |
| drug,nitrofurantoin | |
| sequence,Acute,pulmonary,reactions,to,nitrofurantoin,are,an,uncommon,side,effect,of,therapy,and,can,cause,minor,or,life-threatening,pulmonary,dysfunction,. | |
| labels,5,6,7,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,skin necrosis | |
| drug,Warfarin | |
| sequence,Warfarin-induced,skin,necrosis,and,heparin-induced,thrombocytopenia,following,mitral,valve,replacement,for,marantic,endocarditis,. | |
| labels,4,5,7,0,4,8,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,skin necrosis,thrombocytopenia | |
| drug,heparin | |
| sequence,Warfarin-induced,skin,necrosis,and,heparin-induced,thrombocytopenia,following,mitral,valve,replacement,for,marantic,endocarditis,. | |
| labels,4,5,7,0,4,8,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe drop in blood pressure | |
| drug,prazosin | |
| sequence,A,small,initial,dose,of,prazosin,ranging,from,0.5,to,1,mg,has,been,recommended,to,avoid,the,first-dose,phenomenon,characterized,by,a,sudden,and,severe,drop,in,blood,pressure,after,the,administration,of,the,first,dose,of,prazosin,. | |
| labels,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,7,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,priapism | |
| drug,olanzapine | |
| sequence,He,had,priapism,following,the,use,of,olanzapine,. | |
| labels,0,0,8,0,0,0,0,4,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute myeloid leukaemia,AML | |
| drug,tamoxifen | |
| sequence,We,report,two,cases,that,developed,acute,myeloid,leukaemia,(,AML,),during,tamoxifen,therapy,for,breast,cancer,. | |
| labels,0,0,0,0,0,0,5,6,7,0,8,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ventricular arrhythmia | |
| drug,Terlipressin | |
| sequence,Terlipressin-induced,ventricular,arrhythmia,. | |
| labels,4,5,7,0 | |
| ade_mask,0,1,1,0 | |
| ==============================, ============================= | |
| ade,life-threatening complications | |
| drug,5-FU | |
| sequence,We,now,report,the,first,known,cancer,patient,who,developed,life-threatening,complications,after,treatment,with,topical,5-FU,and,was,shown,subsequently,to,have,profound,DPD,deficiency,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Nocardia Asteroides brain abscess | |
| drug,cyclosporine | |
| sequence,We,describe,a,renal,transplant,recipient,maintained,on,cyclosporine,and,prednisone,developing,Nocardia,Asteroides,brain,abscess,. | |
| labels,0,0,0,0,0,0,0,0,4,0,4,0,5,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,Nocardia Asteroides brain abscess | |
| drug,prednisone | |
| sequence,We,describe,a,renal,transplant,recipient,maintained,on,cyclosporine,and,prednisone,developing,Nocardia,Asteroides,brain,abscess,. | |
| labels,0,0,0,0,0,0,0,0,4,0,4,0,5,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,Graves hyperthyroidism | |
| drug,IFN | |
| sequence,We,report,a,case,of,Graves,hyperthyroidism,induced,by,long-term,interferon,(,IFN,),therapy,. | |
| labels,0,0,0,0,0,5,7,0,0,0,4,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Graves hyperthyroidism | |
| drug,interferon | |
| sequence,We,report,a,case,of,Graves,hyperthyroidism,induced,by,long-term,interferon,(,IFN,),therapy,. | |
| labels,0,0,0,0,0,5,7,0,0,0,4,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,elevated serum LTG levels | |
| drug,LTG | |
| sequence,Evaluation,revealed,elevated,serum,LTG,levels,and,no,other,etiology,for,encephalopathy,. | |
| labels,0,0,5,6,9,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute generalized exanthematous pustulosis | |
| drug,salazosulfapyridine | |
| sequence,Acute,generalized,exanthematous,pustulosis,induced,by,salazosulfapyridine,in,a,patient,with,ulcerative,colitis,. | |
| labels,5,6,6,7,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,worsening of chronic aphthous ulcers | |
| drug,sirolimus | |
| sequence,CASE,:,We,present,an,11-year,old,male,with,Budd-Chiari,syndrome,who,experienced,profound,worsening,of,chronic,aphthous,ulcers,after,immunosuppressive,therapy,was,changed,from,tacrolimus,to,sirolimus,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,7,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,worsening of chronic aphthous ulcers | |
| drug,tacrolimus | |
| sequence,CASE,:,We,present,an,11-year,old,male,with,Budd-Chiari,syndrome,who,experienced,profound,worsening,of,chronic,aphthous,ulcers,after,immunosuppressive,therapy,was,changed,from,tacrolimus,to,sirolimus,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,7,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anti-natriuresis,increased vascular permeability,insulin insensitivity,hyperinsulinaemia,hypoalbuminaemia | |
| drug,insulin | |
| sequence,We,conjectured,that,the,side,effects,of,insulin,,,such,as,anti-natriuresis,and,increased,vascular,permeability,,,might,be,pronounced,in,the,presence,of,the,hepatic,dysfunction,that,accompanies,insulin,insensitivity,,,hyperinsulinaemia,and,hypoalbuminaemia,. | |
| labels,0,0,0,0,0,0,0,4,0,0,0,8,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,8,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,1,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,0 | |
| ==============================, ============================= | |
| ade,hyponatremia,grand mal seizure | |
| drug,desmopressin | |
| sequence,We,report,a,case,of,hyponatremia,associated,with,a,grand,mal,seizure,in,a,28,month-old,child,after,intra-nasal,desmopressin,administration,for,high,fluid,intake,with,nocturnal,enuresis,. | |
| labels,0,0,0,0,0,8,0,0,0,5,6,7,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Crohn's disease | |
| drug,Copaxone | |
| sequence,CONCLUSIONS,:,Clinicians,should,be,aware,that,Crohn,'s,disease,is,a,potential,novel,adverse,drug,effect,of,Copaxone,. | |
| labels,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute myeloid leukemia | |
| drug,etoposide | |
| sequence,Secondary,acute,myeloid,leukemia,after,etoposide,therapy,for,haemophagocytic,lymphohistiocytosis,. | |
| labels,0,5,6,7,0,4,0,0,0,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,overwhelming hepatic necrosis | |
| drug,MTX | |
| sequence,A,40-year-old,man,with,a,long,standing,history,of,rheumatoid,arthritis,was,treated,with,MTX,over,a,6,month,period,and,developed,an,overwhelming,hepatic,necrosis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,headaches,dizziness,difficulty with speech,weakness,itching on the trunk,maculopapular rash | |
| drug,sulfamethoxazole | |
| sequence,He,had,been,taking,trimethoprim-sulfamethoxazole,for,approximately,eight,days,when,he,revisited,his,family,physician,,,complaining,of,headaches,,,dizziness,,,difficulty,with,speech,,,weakness,,,and,itching,on,the,trunk,of,his,body,and,legs,,,where,a,maculopapular,rash,was,noted,. | |
| labels,0,0,0,0,4,4,0,0,0,0,0,0,0,0,0,0,0,0,8,0,8,0,5,6,7,0,8,0,0,5,6,6,7,0,0,0,0,0,0,0,0,5,7,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,1,1,0,1,0,0,1,1,1,1,0,0,0,0,0,0,0,0,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,headaches,dizziness,difficulty with speech,weakness,itching on the trunk,maculopapular rash | |
| drug,trimethoprim | |
| sequence,He,had,been,taking,trimethoprim-sulfamethoxazole,for,approximately,eight,days,when,he,revisited,his,family,physician,,,complaining,of,headaches,,,dizziness,,,difficulty,with,speech,,,weakness,,,and,itching,on,the,trunk,of,his,body,and,legs,,,where,a,maculopapular,rash,was,noted,. | |
| labels,0,0,0,0,4,4,0,0,0,0,0,0,0,0,0,0,0,0,8,0,8,0,5,6,7,0,8,0,0,5,6,6,7,0,0,0,0,0,0,0,0,5,7,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,1,1,0,1,0,0,1,1,1,1,0,0,0,0,0,0,0,0,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,Lichen planus,acne | |
| drug,gold | |
| sequence,Lichen,planus,and,acne,provoked,by,gold,. | |
| labels,5,7,0,8,0,0,4,0 | |
| ade_mask,1,1,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,tardive dyskinesia | |
| drug,deanol | |
| sequence,A,case,history,of,a,15-year-old,boy,who,developed,incapacitating,tardive,dyskinesia,that,resolved,during,treatment,with,deanol,is,presented,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,metastatic nodules | |
| drug,Bleomycin | |
| sequence,Bleomycin,and,cyclophosphamide,toxicity,simulating,metastatic,nodules,to,the,lungs,in,childhood,cancer,. | |
| labels,4,0,4,0,0,5,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,metastatic nodules | |
| drug,cyclophosphamide | |
| sequence,Bleomycin,and,cyclophosphamide,toxicity,simulating,metastatic,nodules,to,the,lungs,in,childhood,cancer,. | |
| labels,4,0,4,0,0,5,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,gestational diabetes | |
| drug,norethisterone | |
| sequence,In,a,single,practice,during,the,21,years,1971-1991,,,the,incidence,of,gestational,diabetes,in,pregnancies,in,which,norethisterone,was,prescribed,was,32.4,%,(,22,of,69,),in,comparison,with,7.1,%,in,pregnancies,in,which,the,women,did,not,take,norethisterone,(,137,of,1,684,),(,p,<,0.001,),. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Pulmonary fibrosis | |
| drug,CCNU | |
| sequence,Pulmonary,fibrosis,subsequent,to,high,doses,of,CCNU,for,chronic,myeloid,leukemia,. | |
| labels,5,7,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acne | |
| drug,gold | |
| sequence,Acne,provoked,by,gold,seems,not,to,have,been,described,elsewhere,. | |
| labels,8,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,balanced translocation | |
| drug,chlorambucil | |
| sequence,Case,2,demonstrated,after,40,months,on,chlorambucil,the,presence,of,a,balanced,translocation,,,t,(,1,;,5,),(,p36,;,q31,),in,90,%,of,the,cells,. | |
| labels,0,0,0,0,0,0,0,4,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,SJS | |
| drug,nevirapine | |
| sequence,Though,physicians,treating,large,populations,of,patients,with,HIV,are,well,aware,of,this,complication,,,only,one,other,report,of,nevirapine-associated,SJS,has,been,documented,in,the,dermatology,literature,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Anisocoria | |
| drug,scopolamine | |
| sequence,Anisocoria,from,transdermal,scopolamine,. | |
| labels,8,0,0,4,0 | |
| ade_mask,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,premature closure of the ductus arteriosus | |
| drug,indomethacin | |
| sequence,Exposure,of,the,fetus,to,indomethacin,by,administration,of,the,drug,to,the,mother,may,cause,many,side,effects,,,including,premature,closure,of,the,ductus,arteriosus,. | |
| labels,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,7,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,bleeding | |
| drug,Warfarin | |
| sequence,Warfarin-associated,bleeding,complication,saved,life,. | |
| labels,4,8,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,FSGS | |
| drug,Adriamycin | |
| sequence,FSGS,induced,by,Adriamycin,(,Pharmacia,&,Upjohn,,,Columbus,,,OH,),has,been,observed,experimentally,in,rats,. | |
| labels,8,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,marked motor hyperactivity,anarchic discharges of motor unit potentials,tonic grouped discharges,flexor spasms,painful dysesthesia | |
| drug,levodopa | |
| sequence,Videopolysomnographic,and,pharmacokinetic,studies,with,monitoring,of,plasma,levodopa,levels,demonstrated,marked,motor,hyperactivity,during,augmentation,,,with,anarchic,discharges,of,motor,unit,potentials,,,tonic,grouped,discharges,and,flexor,spasms,,,associated,with,painful,dysesthesia,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,5,6,7,0,0,0,0,5,6,6,6,6,7,0,5,6,7,0,5,7,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,1,1,1,0,0,0,0,1,1,0,0,1,1,0,1,1,0,0,1,1,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,scrotal ulcer | |
| drug,ATRA | |
| sequence,We,report,the,development,of,scrotal,ulcer,in,a,patient,with,acute,promyleocytic,leukemia,(,APL,),within,10,days,of,treatment,with,ATRA,at,a,dose,of,40,mg,orally,twice,daily,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Systemic lupus erythematosus | |
| drug,penicillamine | |
| sequence,Systemic,lupus,erythematosus,during,penicillamine,therapy,for,rheumatoid,arthritis,. | |
| labels,5,6,7,0,4,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fatal interaction | |
| drug,minoxidil | |
| sequence,A,case,is,presented,which,illustrates,a,probably,fatal,interaction,between,minoxidil,and,a,coagulation,disorder,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,reduce the gastrointestinal absorption of orally administered levothyroxine sodium | |
| drug,ferrous sulfate | |
| sequence,Recent,studies,have,shown,that,under,experimental,conditions,ferrous,sulfate,may,reduce,the,gastrointestinal,absorption,of,orally,administered,levothyroxine,sodium,in,patients,with,primary,hypothyroidism,. | |
| labels,0,0,0,0,0,0,0,0,1,3,0,5,6,6,6,6,6,6,6,7,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,1,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,interstitial hypoxaemiant pneumonitis | |
| drug,flecainide | |
| sequence,We,describe,a,case,of,interstitial,hypoxaemiant,pneumonitis,probably,related,to,flecainide,in,a,patient,with,the,LEOPARD,syndrome,,,a,rare,congenital,disorder,. | |
| labels,0,0,0,0,0,5,6,7,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,granulomatous reaction,urethral prolapse | |
| drug,calcium hydroxylapatite | |
| sequence,The,authors,present,a,case,report,of,a,granulomatous,reaction,leading,to,urethral,prolapse,,,3,months,after,the,transurethral,injection,of,calcium,hydroxylapatite,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,5,7,0,0,0,0,0,0,0,0,1,3,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ANCA | |
| drug,PTU | |
| sequence,Administration,of,steroid,and,decreasing,the,dose,of,PTU,produced,a,good,clinical,response,and,the,ANCA,disappeared,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,8,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0 | |
| ==============================, ============================= | |
| ade,photo-onycholysis | |
| drug,doxycycline | |
| sequence,We,present,a,case,of,photo-onycholysis,in,a,patient,treated,with,doxycycline,for,acne,vulgaris,. | |
| labels,0,0,0,0,0,8,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,colonic mucosal necrosis | |
| drug,calcium polystryrene sulfonate | |
| sequence,We,report,a,rare,case,of,colonic,mucosal,necrosis,following,Kalimate,(,calcium,polystryrene,sulfonate,),,,an,analogue,of,Kayexalate,without,sorbitol,in,a,34-yr-old,man,. | |
| labels,0,0,0,0,0,0,5,6,7,0,4,0,1,2,3,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,colonic mucosal necrosis | |
| drug,Kalimate | |
| sequence,We,report,a,rare,case,of,colonic,mucosal,necrosis,following,Kalimate,(,calcium,polystryrene,sulfonate,),,,an,analogue,of,Kayexalate,without,sorbitol,in,a,34-yr-old,man,. | |
| labels,0,0,0,0,0,0,5,6,7,0,4,0,1,2,3,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,colonic mucosal necrosis | |
| drug,Kayexalate | |
| sequence,We,report,a,rare,case,of,colonic,mucosal,necrosis,following,Kalimate,(,calcium,polystryrene,sulfonate,),,,an,analogue,of,Kayexalate,without,sorbitol,in,a,34-yr-old,man,. | |
| labels,0,0,0,0,0,0,5,6,7,0,4,0,1,2,3,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,spasm | |
| drug,morphine | |
| sequence,Relief,by,naloxone,of,morphine-induced,spasm,of,the,sphincter,of,Oddi,in,a,post-cholecystectomy,patient,. | |
| labels,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,subcutaneous changes,localized panniculitis | |
| drug,glatiramer acetate | |
| sequence,In,this,article,,,we,describe,another,case,of,subcutaneous,changes,following,repeated,glatiramer,acetate,injection,,,presented,as,localized,panniculitis,in,the,area,around,the,injection,sites,,,in,a,46-year-old,female,patient,who,was,treated,with,glatiramer,acetate,for,18,months,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,0,1,3,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rippling muscle disease,RMD | |
| drug,simvastatin | |
| sequence,We,report,a,53-year-old-man,who,developed,rippling,muscle,disease,(,RMD,),2,months,after,starting,simvastatin,therapy,for,hypercholesterolemia,. | |
| labels,0,0,0,0,0,0,5,6,7,0,8,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ILD | |
| drug,erlotinib | |
| sequence,RESULTS,:,We,recently,experienced,a,case,of,fatal,erlotinib-induced,ILD,,,diagnosed,based,on,clinical,and,radiologic,findings,,,which,occurred,in,a,patient,with,radiation,fibrosis,. | |
| labels,0,0,0,0,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypothermia | |
| drug,risperidone | |
| sequence,This,is,a,case,report,of,subtle,,,mild,hypothermia,in,a,54-year,old,female,patient,receiving,risperidone,for,schizophrenia,. | |
| labels,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,exacerbate psoriasis or trigger off its onset | |
| drug,Recombinant human interferon-alpha | |
| sequence,Recombinant,human,interferon-alpha,has,been,used,in,the,treatment,of,several,cancers,,,but,there,have,been,several,reports,that,it,may,exacerbate,psoriasis,or,trigger,off,its,onset,. | |
| labels,1,2,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,cerebellar syndrome | |
| drug,Phenytoin | |
| sequence,Phenytoin,toxicity,:,an,easily,missed,cause,of,cerebellar,syndrome,. | |
| labels,4,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,catatonic syndrome | |
| drug,disulfiram | |
| sequence,This,is,the,first,report,of,a,catatonic,syndrome,occurring,in,a,patient,receiving,disulfiram,treatment,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Mycobacterium marinum infection | |
| drug,infliximab | |
| sequence,Mycobacterium,marinum,infection,complicating,Crohn,'s,disease,,,treated,with,infliximab,. | |
| labels,5,6,7,0,0,0,0,0,0,0,4,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lupus | |
| drug,infliximab | |
| sequence,This,is,the,first,case,,,to,our,knowledge,,,of,onset,of,prolonged,infliximab-induced,lupus,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,hyperglycemia | |
| drug,olanzapine | |
| sequence,CONCLUSIONS,:,Clinicians,treating,elderly,patients,with,olanzapine,should,be,aware,of,the,potential,for,rapidly,developing,hyperglycemia,and,monitor,such,patients,accordingly,. | |
| labels,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,elevated serum CK concentration | |
| drug,olanzapine | |
| sequence,CASE,SUMMARY,:,A,39-year-old,white,Jewish,schizophrenic,man,treated,with,olanzapine,developed,an,elevated,serum,CK,concentration,with,a,peak,concentration,of,4000,IU,L,(,normal,<,230,),. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,4,0,0,5,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,suicidal overdose deaths | |
| drug,quetiapine | |
| sequence,We,present,three,cases,from,the,Provincial,Toxicology,Center,of,British,Columbia,,,Canada,in,which,suicidal,overdose,deaths,were,associated,with,quetiapine,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatitis | |
| drug,cimetidine | |
| sequence,There,have,been,only,two,reports,of,cimetidine-induced,hepatitis,. | |
| labels,0,0,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,aseptic pleuropericarditis | |
| drug,methotrexate | |
| sequence,A,case,of,aseptic,pleuropericarditis,in,a,patient,with,chronic,plaque,psoriasis,under,methotrexate,therapy,. | |
| labels,0,0,0,5,7,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,scleroderma | |
| drug,bleomycin | |
| sequence,Our,series,of,3,patients,supports,a,causal,connection,between,bleomycin,and,scleroderma,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,piloerection | |
| drug,fluvoxamine maleate | |
| sequence,AIMS,:,To,present,a,case,of,piloerection,after,replacing,fluvoxamine,maleate,with,milnacipran,hydrochloride,,,and,to,analyse,this,effect,based,on,receptor,occupancy,theory,. | |
| labels,0,0,0,0,0,0,0,8,0,0,1,3,0,1,3,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,piloerection | |
| drug,milnacipran hydrochloride | |
| sequence,AIMS,:,To,present,a,case,of,piloerection,after,replacing,fluvoxamine,maleate,with,milnacipran,hydrochloride,,,and,to,analyse,this,effect,based,on,receptor,occupancy,theory,. | |
| labels,0,0,0,0,0,0,0,8,0,0,1,3,0,1,3,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,herpes esophagitis | |
| drug,Cyclosporine A | |
| sequence,We,report,the,first,case,of,herpes,esophagitis,in,a,renal,transplant,patient,treated,with,Cyclosporine,A,while,on,chronic,steroid,therapy,. | |
| labels,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,1,3,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fever | |
| drug,amifostine | |
| sequence,To,our,knowledge,,,this,is,the,first,case,report,that,demonstrates,the,occurrence,of,fever,with,low-dose,amifostine,therapy,without,the,manifestation,of,accompanying,rash,or,hypotension,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypotension | |
| drug,valproate | |
| sequence,Intravenous,valproate,associated,with,significant,hypotension,in,the,treatment,of,status,epilepticus,. | |
| labels,0,4,0,0,0,8,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,eruption,contact dermatitis | |
| drug,sodium bisulfite | |
| sequence,Therefore,,,we,diagnosed,her,eruption,as,contact,dermatitis,due,to,sodium,bisulfite,. | |
| labels,0,0,0,0,0,8,0,5,7,0,0,1,3,0 | |
| ade_mask,0,0,0,0,0,1,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,desquamative skin rash | |
| drug,Temozolomide | |
| sequence,Temozolomide-induced,desquamative,skin,rash,in,a,patient,with,metastatic,melanoma,. | |
| labels,4,5,6,7,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nephrosis | |
| drug,interferon | |
| sequence,SUBSEQUENT,COURSE,:,The,nephrosis,resolved,almost,completely,once,the,interferon,was,stopped,and,after,immunosuppressive,treatment,. | |
| labels,0,0,0,0,8,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Gangrene | |
| drug,bleomycin | |
| sequence,Gangrene,of,the,fingertips,after,bleomycin,and,methotrexate,. | |
| labels,8,0,0,0,0,4,0,4,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Gangrene | |
| drug,methotrexate | |
| sequence,Gangrene,of,the,fingertips,after,bleomycin,and,methotrexate,. | |
| labels,8,0,0,0,0,4,0,4,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,worsened motorically,encephalopathy | |
| drug,risperidone | |
| sequence,Two,of,the,five,patients,who,worsened,motorically,also,developed,encephalopathy,during,risperidone,treatment,;,the,encephalopathy,resolved,when,the,patients,were,switched,to,clozapine,treatment,. | |
| labels,0,0,0,0,0,0,5,7,0,0,8,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,liver damage | |
| drug,methimazole | |
| sequence,The,authors,report,a,further,case,of,methimazole-associated,liver,damage,and,present,a,brief,review,of,eleven,previous,cases,found,in,the,literature,. | |
| labels,0,0,0,0,0,0,0,4,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,NASH | |
| drug,raloxifene | |
| sequence,This,is,the,first,histologically,confirmed,case,of,NASH,that,was,aggravated,by,raloxifene,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute pancreatitis | |
| drug,Ezetimibe | |
| sequence,Ezetimibe-induced,acute,pancreatitis,. | |
| labels,4,5,7,0 | |
| ade_mask,0,1,1,0 | |
| ==============================, ============================= | |
| ade,parkinsonism | |
| drug,Metoclopramide | |
| sequence,Metoclopramide-induced,parkinsonism,is,not,rare,,,and,appropriate,dose,reduction,in,patients,with,renal,failure,will,help,reduce,the,incidence,of,this,morbidity,. | |
| labels,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,restless legs syndrome,RLS,periodic limb movements during sleep,PLMS | |
| drug,olanzapine | |
| sequence,We,report,five,cases,of,restless,legs,syndrome,(,RLS,),and,periodic,limb,movements,during,sleep,(,PLMS,),that,were,probably,associated,with,olanzapine,. | |
| labels,0,0,0,0,0,5,6,7,0,8,0,0,5,6,6,6,7,0,8,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,1,0,0,1,1,1,1,1,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute bilateral phrenic neuropathy | |
| drug,adalimumab | |
| sequence,Acute,bilateral,phrenic,neuropathy,following,treatment,with,adalimumab,. | |
| labels,5,6,6,7,0,0,0,4,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,toxic epidermal necrolysis | |
| drug,ofloxacin | |
| sequence,This,report,rules,out,other,causes,of,toxic,epidermal,necrolysis,and,implicates,ofloxacin,in,what,appears,to,be,an,atypical,presentation,of,drug-induced,toxic,epidermal,necrolysis,. | |
| labels,0,0,0,0,0,0,0,5,6,7,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,retinopathy,macular edema,reduced visual acuity | |
| drug,IFN | |
| sequence,With,the,use,of,optical,coherence,tomography,(,OCT,),,,two,patients,with,IFN-associated,retinopathy,who,had,developed,macular,edema,and,reduced,visual,acuity,during,the,clinical,course,of,IFN,therapy,were,observed,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,5,7,0,5,6,7,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,1,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,interstitial pneumonitis | |
| drug,sirolimus | |
| sequence,Here,,,we,present,a,case,of,sirolimus-associated,interstitial,pneumonitis,in,a,cardiac,transplant,recipient,that,resolved,completely,with,withdrawal,of,the,drug,and,treatment,with,corticosteroids,. | |
| labels,0,0,0,0,0,0,0,4,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Renal failure | |
| drug,dextran-40 | |
| sequence,Renal,failure,associated,with,the,use,of,dextran-40,. | |
| labels,5,7,0,0,0,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,unintended sleep episodes | |
| drug,L-dopa | |
| sequence,A,74-year-old,patient,with,idiopathic,Parkinson,'s,disease,was,evaluated,for,unintended,sleep,episodes,that,occurred,after,long-term,treatment,with,400,mg,day,of,L-dopa,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,histological abnormalities of the glomerulus | |
| drug,IFN-beta | |
| sequence,To,our,knowledge,this,is,the,first,report,that,demonstrates,histological,abnormalities,of,the,glomerulus,associated,with,postoperative,IFN-beta,therapy,for,the,malignant,melanoma,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,6,6,6,7,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypothermia | |
| drug,risperidone | |
| sequence,The,diagnosis,of,hypothermia,was,delayed,until,it,was,apparent,for,several,days,but,resolved,with,the,discontinuation,of,risperidone,and,continuation,of,clozapine,. | |
| labels,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperthyroidism | |
| drug,liothyronine | |
| sequence,There,is,a,putative,role,of,liothyronine,administration,in,precipitating,or,activating,hyperthyroidism,. | |
| labels,0,0,0,0,0,0,4,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,fatal pulmonary fibrosis | |
| drug,BCNU | |
| sequence,A,case,is,reported,of,a,child,with,fatal,pulmonary,fibrosis,following,BCNU,therapy,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bilateral optic neuritis,numbness of the lower extremities,bowel and bladder dysfunction | |
| drug,recombinant interferon alpha-2b | |
| sequence,Case,2,,,a,29-year-old,woman,,,developed,bilateral,optic,neuritis,combined,with,numbness,of,the,lower,extremities,as,well,as,bowel,and,bladder,dysfunction,after,a,22-month,use,of,recombinant,interferon,alpha-2b,for,chronic,myelogenous,leukemia,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,5,6,6,6,7,0,0,0,5,6,6,7,0,0,0,0,0,1,2,3,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,1,1,1,1,1,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Anterior lumbosacral radiculopathy | |
| drug,methotrexate | |
| sequence,Anterior,lumbosacral,radiculopathy,after,intrathecal,methotrexate,treatment,. | |
| labels,5,6,7,0,0,4,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,uveitis | |
| drug,rifabutin | |
| sequence,METHODS,RESULTS,:,This,paper,presents,a,new,case,of,rifabutin,uveitis,and,a,review,of,the,various,published,reports,to,date,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,paraesthesia,agitation | |
| drug,olanzapine | |
| sequence,The,fifth,patient,exhibited,paraesthesia,and,agitation,caused,by,olanzapine,that,was,misdiagnosed,as,psychotic,agitation,. | |
| labels,0,0,0,0,8,0,8,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,significant abnormalities | |
| drug,disulfiram | |
| sequence,Nonspecific,but,significant,abnormalities,have,been,described,in,the,infants,of,women,treated,with,disulfiram,in,the,first,trimester,of,their,pregnancies,. | |
| labels,0,0,5,7,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pulmonary toxicity,pneumonitis | |
| drug,MTX | |
| sequence,Although,risk,factors,for,MTX-induced,pulmonary,toxicity,are,poorly,understood,,,the,presence,in,3,out,of,5,of,our,patients,of,pre-existing,lung,disease,,,represented,by,diffuse,interstitial,changes,on,chest,X-ray,,,and,mild,bronchial,asthma,in,two,RA,patients,and,by,pulmonary,silicosis,in,the,patient,with,PsA,may,account,for,a,predisposition,to,the,development,of,MTX,pneumonitis,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,fulminant hepatic failure | |
| drug,ddI | |
| sequence,We,report,two,cases,of,fulminant,hepatic,failure,in,HIV-1-infected,patients,treated,with,didanosine,(,ddI,),. | |
| labels,0,0,0,0,0,5,6,7,0,0,0,0,0,4,0,4,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fulminant hepatic failure | |
| drug,didanosine | |
| sequence,We,report,two,cases,of,fulminant,hepatic,failure,in,HIV-1-infected,patients,treated,with,didanosine,(,ddI,),. | |
| labels,0,0,0,0,0,5,6,7,0,0,0,0,0,4,0,4,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lupus-like syndrome,malar rash,pain,erythema of the cartilage of both ears,tender erythematous,hemorrhagic lesions of the finger tips | |
| drug,vancomycin | |
| sequence,A,patient,receiving,vancomycin,for,a,serious,staphylococcal,infection,had,a,lupus-like,syndrome,characterized,by,a,malar,rash,,,pain,and,erythema,of,the,cartilage,of,both,ears,,,and,tender,erythematous,and,hemorrhagic,lesions,of,the,finger,tips,. | |
| labels,0,0,0,4,0,0,0,0,0,0,0,5,7,0,0,0,5,7,0,8,0,5,6,6,6,0,6,7,0,0,5,7,0,5,6,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,1,1,0,1,0,1,1,1,1,0,1,1,0,0,1,1,0,1,1,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,desmethylclomipramine plasma level increase,8-hydroacy-desmethylclomipramine plasma level decrease | |
| drug,citalopram | |
| sequence,After,the,addition,of,citalopram,,,a,desmethylclomipramine,plasma,level,increase,and,an,8-hydroacy-desmethylclomipramine,plasma,level,decrease,were,observed,. | |
| labels,0,0,0,0,4,0,0,5,6,6,7,0,0,5,6,6,7,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,1,0,0,1,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,nonthrombocytopenic vascular-type palpable purpura | |
| drug,Metoclopramide | |
| sequence,CONCLUSIONS,:,Metoclopramide,may,cause,reversible,nonthrombocytopenic,vascular-type,palpable,purpura,. | |
| labels,0,0,4,0,0,0,5,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,dead | |
| drug,olanzapine | |
| sequence,This,article,describes,the,case,of,a,25-year-old,man,found,dead,at,home,who,had,been,prescribed,olanzapine,for,schizophrenia,. | |
| labels,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Angioedema | |
| drug,carbamazepine | |
| sequence,Angioedema,,,a,rare,side,effect,of,carbamazepine,,,involves,vascular,leakage,in,dermis,and,subcutis,mediated,by,immunoglobulin,E,and,or,bradykinins,. | |
| labels,8,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Vortex keratopathy | |
| drug,atovaquone | |
| sequence,Vortex,keratopathy,associated,with,atovaquone,. | |
| labels,5,7,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,interstitial pneumonitis | |
| drug,Rituximab-CHOP | |
| sequence,Rituximab-CHOP,induced,interstitial,pneumonitis,in,patients,with,disseminated,extranodal,marginal,zone,B,cell,lymphoma,. | |
| labels,4,0,5,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,HBV reactivations | |
| drug,rituximab | |
| sequence,Several,such,HBV,reactivations,were,reported,after,combined,rituximab,and,multiagent,chemotherapy,for,B-cell,lymphomas,. | |
| labels,0,0,5,7,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,drug interaction | |
| drug,theophylline | |
| sequence,A,drug,interaction,between,zafirlukast,and,theophylline,. | |
| labels,0,5,7,0,4,0,4,0 | |
| ade_mask,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,drug interaction | |
| drug,zafirlukast | |
| sequence,A,drug,interaction,between,zafirlukast,and,theophylline,. | |
| labels,0,5,7,0,4,0,4,0 | |
| ade_mask,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Creutzfeldt-Jakob disease | |
| drug,human growth hormone | |
| sequence,A,clinically,atypical,,,neuropathologically,verified,case,of,Creutzfeldt-Jakob,disease,is,described,in,a,32-year-old,New,Zealand,woman,with,idiopathic,hypopituitarism,who,had,been,treated,in,late,adolescence,(,1970,to,1973,),with,human,growth,hormone,processed,from,pooled,cadaveric,pituitary,glands,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,3,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neuroleptic malignant syndrome | |
| drug,Olanzapine | |
| sequence,Olanzapine-associated,neuroleptic,malignant,syndrome,. | |
| labels,4,5,6,7,0 | |
| ade_mask,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,mania | |
| drug,lopinavir | |
| sequence,OBJECTIVE,:,To,describe,a,case,of,exacerbated,mania,potentially,related,to,an,interaction,between,lopinavir,ritonavir,and,valproic,acid,(,VPA,),and,propose,a,mechanism,of,action,for,this,interaction,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,4,4,0,1,3,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,mania | |
| drug,ritonavir | |
| sequence,OBJECTIVE,:,To,describe,a,case,of,exacerbated,mania,potentially,related,to,an,interaction,between,lopinavir,ritonavir,and,valproic,acid,(,VPA,),and,propose,a,mechanism,of,action,for,this,interaction,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,4,4,0,1,3,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,mania | |
| drug,valproic acid | |
| sequence,OBJECTIVE,:,To,describe,a,case,of,exacerbated,mania,potentially,related,to,an,interaction,between,lopinavir,ritonavir,and,valproic,acid,(,VPA,),and,propose,a,mechanism,of,action,for,this,interaction,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,4,4,0,1,3,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,mania | |
| drug,VPA | |
| sequence,OBJECTIVE,:,To,describe,a,case,of,exacerbated,mania,potentially,related,to,an,interaction,between,lopinavir,ritonavir,and,valproic,acid,(,VPA,),and,propose,a,mechanism,of,action,for,this,interaction,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,4,4,0,1,3,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,disseminated salmonellosis | |
| drug,temozolomide | |
| sequence,We,describe,the,first,case,of,disseminated,salmonellosis,in,a,patient,treated,with,temozolomide,. | |
| labels,0,0,0,0,0,0,5,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,squamous metaplasia within endometrial glands | |
| drug,progestin | |
| sequence,OBJECTIVE,:,To,report,the,finding,of,squamous,metaplasia,within,endometrial,glands,occurring,as,a,result,of,progestin,therapy,of,hyperplasia,. | |
| labels,0,0,0,0,0,0,0,5,6,6,6,7,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,stupor | |
| drug,valproate | |
| sequence,The,case,of,a,4-year-old,girl,with,valproate-induced,stupor,and,electroencephalographic,pattern,of,increased,fast,activity,is,reported,. | |
| labels,0,0,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anaphylaxis | |
| drug,methotrexate | |
| sequence,Management,and,successful,desensitization,in,methotrexate-induced,anaphylaxis,. | |
| labels,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,cardiotoxicity | |
| drug,adriamycin | |
| sequence,Complications,of,chemotherapy,for,a,synovial,sarcoma,in,an,eight-year,old,boy,included,cisplatinum,nephrotoxicity,and,adriamycin,cardiotoxicity,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,nephrotoxicity | |
| drug,cisplatinum | |
| sequence,Complications,of,chemotherapy,for,a,synovial,sarcoma,in,an,eight-year,old,boy,included,cisplatinum,nephrotoxicity,and,adriamycin,cardiotoxicity,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Pneumonitis,pleural and pericardial effusion,neuropathy | |
| drug,amiodarone | |
| sequence,Pneumonitis,with,pleural,and,pericardial,effusion,and,neuropathy,during,amiodarone,therapy,. | |
| labels,8,0,5,6,6,7,0,8,0,4,0,0 | |
| ade_mask,1,0,1,1,1,1,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperchloremic metabolic acidosis | |
| drug,cholestyramine | |
| sequence,It,is,presumed,that,her,hyperchloremic,metabolic,acidosis,was,secondary,to,cholestyramine,because,of,the,similarity,to,pediatric,reports,;,the,rapid,and,lasting,response,to,intravenous,sodium,bicarbonate,;,the,absence,of,another,etiology,;,normal,serum,potassium,,,chloride,and,bicarbonate,despite,continued,spironolactone,therapy,after,recovery,. | |
| labels,0,0,0,0,0,5,6,7,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,teratogen | |
| drug,disulfiram | |
| sequence,In,one,case,,,disulfiram,was,the,only,potential,teratogen,exposed,to,the,fetus,. | |
| labels,0,0,0,0,4,0,0,0,0,8,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Progressive pulmonary fibrosis | |
| drug,cyclophosphamide | |
| sequence,Progressive,pulmonary,fibrosis,complicating,cyclophosphamide,therapy,. | |
| labels,5,6,7,0,4,0,0 | |
| ade_mask,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute renal failure | |
| drug,IVIG | |
| sequence,The,exact,mechanism,of,IVIG-associated,acute,renal,failure,remains,unclear,. | |
| labels,0,0,0,0,4,5,6,7,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,seizures | |
| drug,phenytoin | |
| sequence,Paradoxical,seizures,in,phenytoin,toxicity,. | |
| labels,0,8,0,4,0,0 | |
| ade_mask,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Glomerulonephritis,lupus erythematosus | |
| drug,procainamide | |
| sequence,Glomerulonephritis,in,procainamide,induced,lupus,erythematosus,:,report,of,a,case,and,review,of,the,literature,. | |
| labels,8,0,4,0,5,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ototoxicity | |
| drug,quinine | |
| sequence,The,ototoxicity,of,quinine,can,accurately,be,studied,with,ultrahigh,frequency,audiometry,(,up,to,20,kHz,),. | |
| labels,0,8,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Tumor lysis syndrome | |
| drug,cisplatin | |
| sequence,Tumor,lysis,syndrome,after,transcatheter,arterial,infusion,of,cisplatin,and,embolization,therapy,for,liver,metastases,of,melanoma,. | |
| labels,5,6,7,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe hypomagnesemia,electrolyte disorders | |
| drug,foscarnet | |
| sequence,OBJECTIVE,:,To,report,a,case,of,possible,foscarnet-induced,severe,hypomagnesemia,and,other,electrolyte,disorders,. | |
| labels,0,0,0,0,0,0,0,0,4,5,7,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,torsade de pointes,arrhythmia | |
| drug,disopyramide | |
| sequence,Atypical,ventricular,tachycardia,(,torsade,de,pointes,),induced,by,amiodarone,:,arrhythmia,previously,induced,by,quinidine,and,disopyramide,. | |
| labels,5,6,7,0,5,6,7,0,0,0,4,0,8,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,1,1,1,0,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,torsade de pointes,arrhythmia | |
| drug,quinidine | |
| sequence,Atypical,ventricular,tachycardia,(,torsade,de,pointes,),induced,by,amiodarone,:,arrhythmia,previously,induced,by,quinidine,and,disopyramide,. | |
| labels,5,6,7,0,5,6,7,0,0,0,4,0,8,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,1,1,1,0,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Atypical ventricular tachycardia,torsade de pointes | |
| drug,amiodarone | |
| sequence,Atypical,ventricular,tachycardia,(,torsade,de,pointes,),induced,by,amiodarone,:,arrhythmia,previously,induced,by,quinidine,and,disopyramide,. | |
| labels,5,6,7,0,5,6,7,0,0,0,4,0,8,0,0,0,4,0,4,0 | |
| ade_mask,1,1,1,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cutaneous vasculitis | |
| drug,diltiazem | |
| sequence,Two,cases,of,widespread,cutaneous,vasculitis,are,described,in,association,with,diltiazem,,,a,recently,introduced,calcium,antagonist,. | |
| labels,0,0,0,0,5,7,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ototoxicity | |
| drug,azithromycin | |
| sequence,Intravenous,azithromycin-induced,ototoxicity,. | |
| labels,0,4,8,0 | |
| ade_mask,0,0,1,0 | |
| ==============================, ============================= | |
| ade,renal toxicity | |
| drug,tobramycin | |
| sequence,This,pattern,is,suggestive,of,renal,toxicity,due,to,tobramycin,. | |
| labels,0,0,0,0,0,5,7,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity syndrome | |
| drug,Trimethoprim-sulfamethoxazole | |
| sequence,Trimethoprim-sulfamethoxazole-induced,hypersensitivity,syndrome,associated,with,reactivation,of,human,herpesvirus-6,. | |
| labels,4,5,7,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,septicemia,lethal | |
| drug,cyclosporine | |
| sequence,Recurrent,septicemia,with,lethal,outcome,during,and,after,cyclosporine,therapy,in,severe,ulcerative,colitis,. | |
| labels,0,8,0,8,0,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,methemoglobinemia | |
| drug,Benzocaine | |
| sequence,Benzocaine,,,an,ester-type,local,anesthetic,,,was,believed,responsible,for,apparent,methemoglobinemia,in,a,cat,. | |
| labels,4,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,extrapyramidal side effects | |
| drug,fluphenazine decanoate | |
| sequence,Two,patients,with,extrapyramidal,side,effects,after,the,use,of,fluphenazine,decanoate,were,evaluated,by,means,of,IBZM-SPECT,. | |
| labels,0,0,0,5,6,7,0,0,0,0,1,3,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombotic left middle cerebral artery distribution stroke | |
| drug,pFVIII | |
| sequence,We,have,recently,encountered,a,patient,with,acquired,haemophilia,who,developed,a,thrombotic,left,middle,cerebral,artery,distribution,stroke,while,being,treated,with,pFVIII,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,6,7,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Scrotal ulceration | |
| drug,retinoic acid | |
| sequence,Scrotal,ulceration,induced,by,all-trans,retinoic,acid,in,a,patient,with,acute,promyelocytic,leukemia,. | |
| labels,5,7,0,0,0,1,3,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,disseminated histoplasmosis | |
| drug,prednisone | |
| sequence,Patients,from,endemic,areas,referred,to,transplant,centers,may,be,at,high,risk,for,disseminated,histoplasmosis,when,treated,with,long-term,prednisone,for,graft-versus-host,disease,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cough | |
| drug,quinapril | |
| sequence,We,report,a,case,of,cough,following,the,administration,of,quinapril,,,with,complete,resolution,after,changing,to,the,alternative,ACE,inhibitor,fosinopril,in,a,patient,with,essential,hypertension,. | |
| labels,0,0,0,0,0,8,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,subacute neurotoxicity | |
| drug,MTX | |
| sequence,Our,objective,is,to,present,a,retrospective,analysis,of,the,DWI,findings,in,four,patients,who,suffered,subacute,neurotoxicity,after,intrathecal,MTX,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thyrotoxicosis | |
| drug,amiodarone | |
| sequence,We,report,a,case,of,amiodarone-induced,thyrotoxicosis,of,protracted,duration,,,unresponsive,to,conventional,thionamide,therapy,,,with,therapy,limited,by,severe,adverse,drug,reactions,. | |
| labels,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Sideroblastic anemia | |
| drug,linezolid | |
| sequence,Sideroblastic,anemia,due,to,linezolid,in,a,patient,with,a,left,ventricular,assist,device,. | |
| labels,5,7,0,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,clitoral hypertrophy | |
| drug,Norethisterone | |
| sequence,Norethisterone,in,these,69,pregnancies,accounted,for,33.3,%,(,5,of,15,),cases,of,clitoral,hypertrophy,diagnosed,in,100,756,consecutive,births,. | |
| labels,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,carbamazepine toxicity | |
| drug,carbamazepine | |
| sequence,The,patient,was,diagnosed,with,carbamazepine,toxicity,related,to,the,introduction,of,ritonavir,. | |
| labels,0,0,0,0,0,9,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,carbamazepine toxicity | |
| drug,ritonavir | |
| sequence,The,patient,was,diagnosed,with,carbamazepine,toxicity,related,to,the,introduction,of,ritonavir,. | |
| labels,0,0,0,0,0,9,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,toxicity,potentially fatal symptom,retinoic acid syndrome | |
| drug,retinoic acid | |
| sequence,Its,overall,toxicity,is,considerably,less,compared,to,standard,induction,chemotherapy,;,however,,,it,is,associated,with,a,high,incidence,of,a,potentially,fatal,symptom,complex,referred,to,as,``,retinoic,acid,syndrome,.,'',This,report,describes,a,patient,with,APL,who,developed,the,syndrome,a,few,weeks,after,initiating,induction,therapy,with,ATRA,despite,being,treated,for,hyperleukocytosis,. | |
| labels,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,9,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,serotonin syndrome,extrapyramidal movement disorders | |
| drug,metoclopramide | |
| sequence,OBJECTIVE,:,To,report,2,cases,of,serotonin,syndrome,with,serious,extrapyramidal,movement,disorders,occurring,when,metoclopramide,was,coadministered,with,sertraline,or,venlafaxine,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,5,6,7,0,0,4,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,serotonin syndrome,extrapyramidal movement disorders | |
| drug,sertraline | |
| sequence,OBJECTIVE,:,To,report,2,cases,of,serotonin,syndrome,with,serious,extrapyramidal,movement,disorders,occurring,when,metoclopramide,was,coadministered,with,sertraline,or,venlafaxine,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,5,6,7,0,0,4,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,serotonin syndrome,extrapyramidal movement disorders | |
| drug,venlafaxine | |
| sequence,OBJECTIVE,:,To,report,2,cases,of,serotonin,syndrome,with,serious,extrapyramidal,movement,disorders,occurring,when,metoclopramide,was,coadministered,with,sertraline,or,venlafaxine,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,5,6,7,0,0,4,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,MH | |
| drug,cresol | |
| sequence,However,,,other,factors,or,drugs,(,e.g,.,cresol,),are,thought,to,induce,MH,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Posthypoglycemic hyperglycemia,rebound hyperglycemia | |
| drug,insulin | |
| sequence,Posthypoglycemic,hyperglycemia,(,rebound,hyperglycemia,),after,overdosing,of,insulin,was,diagnosed,in,6,cats,with,diabetes,mellitus,. | |
| labels,5,7,0,5,7,0,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,focal myocardial necrosis,acute myocardial infarction | |
| drug,amsacrine | |
| sequence,The,authors,report,a,case,of,focal,myocardial,necrosis,,,presenting,clinically,as,an,acute,myocardial,infarction,during,the,administration,of,the,antineoplastic,drug,,,amsacrine,,,in,a,patient,without,coronary,artery,disease,. | |
| labels,0,0,0,0,0,0,5,6,7,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bilateral ptosis | |
| drug,chloroquine | |
| sequence,This,report,describes,a,case,of,bilateral,ptosis,induced,by,chloroquine,. | |
| labels,0,0,0,0,0,0,5,7,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anuric ARF | |
| drug,mannitol | |
| sequence,This,is,a,report,of,a,case,of,anuric,ARF,after,high-dose,mannitol,infusion,for,treatment,of,narrow-angle,glaucoma,that,readily,responded,to,acute,hemodialysis,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,electrical decrement | |
| drug,Ampicillin | |
| sequence,Ampicillin,increased,the,preexisting,electrical,decrement,in,three,rabbits,with,experimental,autoimmune,myasthenia,gravis,while,the,drug,had,no,deleterious,effects,in,less,affected,or,normal,animals,. | |
| labels,4,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,longitudinal melanonychia,multiple skin cancers | |
| drug,hydroxyurea | |
| sequence,Both,the,longitudinal,melanonychia,and,the,multiple,skin,cancers,first,appeared,after,approximately,6,months,of,hydroxyurea,treatment,. | |
| labels,0,0,5,7,0,0,5,6,7,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,1,1,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,methemoglobinemia | |
| drug,methyl nitrite | |
| sequence,Although,other,nitrites,induce,methemoglobinemia,,,exposure,to,methyl,nitrite,during,phenylpropanolamine,production,appears,to,be,a,new,cause,of,occupational,methemoglobinemia,. | |
| labels,0,0,0,0,8,0,0,0,1,3,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,TEN | |
| drug,Phenolphthalein | |
| sequence,DISCUSSION,:,Phenolphthalein,is,the,active,ingredient,in,several,over-the-counter,laxative,preparations,and,has,only,rarely,been,reported,to,cause,TEN,. | |
| labels,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,severe splenic hemorrhage and rupture | |
| drug,tPA | |
| sequence,A,case,is,described,of,severe,splenic,hemorrhage,and,rupture,which,developed,3,h,after,completion,of,tPA,infusion,for,suspected,acute,myocardial,infarction,. | |
| labels,0,0,0,0,0,5,6,6,6,7,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cardiorespiratory and anaphylactic reactions | |
| drug,miconazole | |
| sequence,Seven,patients,with,hematologic,malignancies,who,were,treated,with,miconazole,for,either,suspected,or,proven,fungal,infections,developed,eight,episodes,of,major,adverse,cardiorespiratory,and,anaphylactic,reactions,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,meningitis | |
| drug,ibuprofen | |
| sequence,We,report,a,case,of,ibuprofen-induced,meningitis,in,an,otherwise,healthy,individual,. | |
| labels,0,0,0,0,0,4,8,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Focal renal cortical necrosis | |
| drug,zomepirac | |
| sequence,Focal,renal,cortical,necrosis,associated,with,zomepirac,. | |
| labels,5,6,6,7,0,0,4,0 | |
| ade_mask,1,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,palmar-plantar erythrodysaesthesia | |
| drug,cytarabine | |
| sequence,Recurrent,palmar-plantar,erythrodysaesthesia,following,high-dose,cytarabine,treatment,for,acute,lymphoblastic,leukemia,. | |
| labels,0,5,7,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neutropenia,agranulocytosis | |
| drug,olanzapine | |
| sequence,First,,,a,review,of,the,literature,produced,41,anecdotic,cases,of,neutropenia,or,agranulocytosis,during,treatment,with,olanzapine,(,Zyprexa,),reported,in,a,total,of,24,publications,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,8,0,8,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neutropenia,agranulocytosis | |
| drug,Zyprexa | |
| sequence,First,,,a,review,of,the,literature,produced,41,anecdotic,cases,of,neutropenia,or,agranulocytosis,during,treatment,with,olanzapine,(,Zyprexa,),reported,in,a,total,of,24,publications,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,8,0,8,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,tics | |
| drug,atomoxetine | |
| sequence,Development,of,tics,in,a,thirteen-year-old,male,following,atomoxetine,use,. | |
| labels,0,0,8,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,grand mal seizures | |
| drug,bleomycin | |
| sequence,A,31-year-old,female,developed,multiple,episodes,of,grand,mal,seizures,after,combination,chemotherapy,with,cisplatin,,,vinblastine,and,bleomycin,for,germ,cell,ovarian,cancer,stage,Ic,. | |
| labels,0,0,0,0,0,0,0,5,6,7,0,0,0,0,4,0,4,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,grand mal seizures | |
| drug,cisplatin | |
| sequence,A,31-year-old,female,developed,multiple,episodes,of,grand,mal,seizures,after,combination,chemotherapy,with,cisplatin,,,vinblastine,and,bleomycin,for,germ,cell,ovarian,cancer,stage,Ic,. | |
| labels,0,0,0,0,0,0,0,5,6,7,0,0,0,0,4,0,4,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,grand mal seizures | |
| drug,vinblastine | |
| sequence,A,31-year-old,female,developed,multiple,episodes,of,grand,mal,seizures,after,combination,chemotherapy,with,cisplatin,,,vinblastine,and,bleomycin,for,germ,cell,ovarian,cancer,stage,Ic,. | |
| labels,0,0,0,0,0,0,0,5,6,7,0,0,0,0,4,0,4,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe AVP | |
| drug,infliximab | |
| sequence,We,report,a,case,of,severe,AVP,three,weeks,following,the,administration,of,infliximab,for,the,treatment,of,Crohn,'s,disease,(,CD,),. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,enuresis | |
| drug,methylphenidate | |
| sequence,This,is,a,case,report,of,possible,association,of,methylphenidate,and,enuresis,in,an,11-year-old,boy,with,attention,deficit,hyperactivity,disorder,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,8,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,interstitial pneumonitis,fibrosis | |
| drug,Cyclophosphamide | |
| sequence,Cyclophosphamide,can,rarely,cause,interstitial,pneumonitis,and,fibrosis,. | |
| labels,4,0,0,0,5,7,0,8,0 | |
| ade_mask,0,0,0,0,1,1,0,1,0 | |
| ==============================, ============================= | |
| ade,magnesium toxicosis | |
| drug,magnesium | |
| sequence,Overdose,of,magnesium,sulfate,in,combination,with,renal,insufficiency,,,hypocalcemia,,,or,compromise,of,intestinal,integrity,may,predispose,horses,to,magnesium,toxicosis,. | |
| labels,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,magnesium toxicosis | |
| drug,magnesium sulfate | |
| sequence,Overdose,of,magnesium,sulfate,in,combination,with,renal,insufficiency,,,hypocalcemia,,,or,compromise,of,intestinal,integrity,may,predispose,horses,to,magnesium,toxicosis,. | |
| labels,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Acute renal failure | |
| drug,lisinopril | |
| sequence,Acute,renal,failure,during,lisinopril,and,losartan,therapy,for,proteinuria,. | |
| labels,5,6,7,0,4,0,4,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute renal failure | |
| drug,losartan | |
| sequence,Acute,renal,failure,during,lisinopril,and,losartan,therapy,for,proteinuria,. | |
| labels,5,6,7,0,4,0,4,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,HUS | |
| drug,gemcitabine | |
| sequence,RESULTS,:,Including,our,own,patient,,,a,total,of,26,cases,of,gemcitabine-associated,HUS,were,identified,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,Upper tract urothelial malignancy | |
| drug,cyclophosphamide | |
| sequence,Upper,tract,urothelial,malignancy,after,cyclophosphamide,therapy,:,a,case,report,and,literature,review,. | |
| labels,5,6,6,7,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anaphylaxis | |
| drug,methotrexate | |
| sequence,Thus,,,we,confirm,that,desensitization,may,be,a,safe,procedure,in,patients,with,cancer,who,experience,methotrexate-induced,anaphylaxis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,cardiac effects,sudden death | |
| drug,halofantrine | |
| sequence,However,,,in,1993,,,a,clinical,study,involving,400,patients,on,the,Thai-Burmese,border,revealed,cardiac,effects,of,antimalarial,treatment,with,halofantrine,,,including,one,sudden,death,after,the,treatment,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0,0,0,5,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,toxic liver damage | |
| drug,nitrofurantoin | |
| sequence,Given,that,discontinuation,of,nitrofurantoin,and,introduction,of,methylprednisolon,therapy,significantly,lowered,liver,enzyme,levels,,,restoring,most,of,them,to,normal,,,we,concluded,that,this,was,probably,the,case,of,toxic,liver,damage,caused,by,nitrofurantoin,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Uveitis | |
| drug,rifabutin | |
| sequence,Uveitis,associated,with,rifabutin,therapy,:,a,clinical,alert,. | |
| labels,8,0,0,4,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neurotoxicity,acute confusional state | |
| drug,5-fluorouracil | |
| sequence,A,35-year-old,woman,presented,with,neurotoxicity,correlated,to,an,i.v,.,regimen,of,5-fluorouracil,as,episodes,of,acute,confusional,state,and,abnormalities,of,symmetrically,restricted,diffusion,in,the,periventricular,white,matter,and,corpus,callosum,. | |
| labels,0,0,0,0,0,8,0,0,0,0,0,0,0,4,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Choanal atresia,athelia,teratogenicity | |
| drug,methimazole | |
| sequence,Choanal,atresia,and,athelia,:,methimazole,teratogenicity,or,a,new,syndrome,? | |
| labels,5,7,0,8,0,4,8,0,0,0,0,0 | |
| ade_mask,1,1,0,1,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,squamous-cell carcinoma | |
| drug,5-FU | |
| sequence,We,report,the,development,of,squamous-cell,carcinoma,within,a,basal-cell,epithelioma,that,was,treated,with,intralesional,injections,of,5-FU,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Camptocormia | |
| drug,sodium valproate | |
| sequence,Camptocormia,,,a,new,side,effect,of,sodium,valproate,. | |
| labels,8,0,0,0,0,0,0,1,3,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,red cell aplasia | |
| drug,co-trimoxazole | |
| sequence,When,co-trimoxazole,was,stopped,the,red,cell,aplasia,resolved,. | |
| labels,0,4,0,0,0,5,6,7,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0 | |
| ==============================, ============================= | |
| ade,acute transverse myelitis | |
| drug,hepatitis B vaccination | |
| sequence,Early-onset,acute,transverse,myelitis,following,hepatitis,B,vaccination,and,respiratory,infection,:,case,report,. | |
| labels,0,5,6,7,0,1,2,3,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatic enzyme disturbances | |
| drug,pegvisomant | |
| sequence,The,hepatic,enzyme,disturbances,normalized,after,discontinuation,of,pegvisomant,. | |
| labels,0,5,6,7,0,0,0,0,4,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,osteochemonecrosis of the jaw | |
| drug,Bisphosphonate | |
| sequence,Bisphosphonate,induced,osteochemonecrosis,of,the,jaw,mimicking,a,tumour,. | |
| labels,4,0,5,6,6,7,0,0,0,0 | |
| ade_mask,0,0,1,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,incontinence | |
| drug,venlafaxine | |
| sequence,This,concerns,2,male,patients,who,experienced,incontinence,while,taking,venlafaxine,. | |
| labels,0,0,0,0,0,0,0,8,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,chromosome damage | |
| drug,Chlorambucil | |
| sequence,Chlorambucil-induced,chromosome,damage,to,human,lymphocytes,is,dose-dependent,and,cumulative,. | |
| labels,4,5,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,AML | |
| drug,chlorambucil | |
| sequence,After,the,chlorambucil,was,discontinued,,,the,wbc,count,began,to,slowly,rise,and,the,patient,developed,clinical,AML,. | |
| labels,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,severe rash | |
| drug,oxcarbazepine | |
| sequence,This,is,an,image,and,brief,case,report,of,a,13-year-old,boy,who,presented,with,severe,rash,and,systemic,symptoms,after,starting,oxcarbazepine,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute myocardial infarction,coronary spasm | |
| drug,L-thyroxine | |
| sequence,Acute,myocardial,infarction,due,to,coronary,spasm,associated,with,L-thyroxine,therapy,. | |
| labels,5,6,7,0,0,5,7,0,0,4,0,0 | |
| ade_mask,1,1,1,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,gastrointestinal bleeding | |
| drug,tolazoline | |
| sequence,Hypoxemia,improved,during,continuous,tolazoline,infusion,,,but,gastrointestinal,bleeding,occurred,. | |
| labels,0,0,0,0,4,0,0,0,5,7,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0 | |
| ==============================, ============================= | |
| ade,diffuse longitudinal melanonychia,multiple squamous cell carcinomas | |
| drug,Hydroxyurea | |
| sequence,Hydroxyurea,associated,with,concomitant,occurrence,of,diffuse,longitudinal,melanonychia,and,multiple,squamous,cell,carcinomas,in,an,elderly,subject,. | |
| labels,4,0,0,0,0,0,5,6,7,0,5,6,6,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,1,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Codeine intoxication | |
| drug,Codeine | |
| sequence,Codeine,intoxication,in,the,neonate,. | |
| labels,9,7,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,life-threatening toxicity | |
| drug,5-FU | |
| sequence,We,conclude,that,the,presence,of,this,metabolic,defect,combined,with,topical,5-FU,(,a,drug,demonstrating,a,narrow,therapeutic,index,),results,in,the,unusual,presentation,of,life-threatening,toxicity,after,treatment,with,a,topical,drug,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anterior subcapsular opacity on the lens | |
| drug,finasteride | |
| sequence,It,was,highly,suspected,that,finasteride,was,associated,with,the,anterior,subcapsular,opacity,on,the,lens,,,and,the,patient,therefore,discontinued,use,of,finasteride,. | |
| labels,0,0,0,0,0,4,0,0,0,0,5,6,6,6,6,7,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Sweet's syndrome | |
| drug,sargramostim | |
| sequence,Sweet,'s,syndrome,associated,with,sargramostim,(,granulocyte-macrophage,colony,stimulating,factor,),treatment,. | |
| labels,5,6,7,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,prolonged hypoglycemia | |
| drug,octreotide | |
| sequence,Herein,,,we,present,a,patient,with,severe,and,prolonged,hypoglycemia,after,long-acting,octreotide,treatment,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cortical venous thrombosis,dural puncture headache | |
| drug,L-asparaginase | |
| sequence,Patients,with,lymphoblastic,lymphoma,who,had,treatment,with,L-asparaginase,and,steroid,are,predisposed,to,the,development,of,cortical,venous,thrombosis,and,may,have,this,syndrome,in,addition,to,a,dural,puncture,headache,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,Drug eruption | |
| drug,azathioprine | |
| sequence,Drug,eruption,caused,by,azathioprine,:,value,of,using,the,drug-induced,lymphocytes,stimulation,test,for,diagnosis,. | |
| labels,5,7,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,PRES | |
| drug,CSA | |
| sequence,We,describe,a,case,of,PRES,in,a,patient,with,collapsing,focal,glomeruloesclerosis,(,collapsing,FGS,),with,complete,recovery,after,withdrawal,of,cyclosporine,(,CSA,),. | |
| labels,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,PRES | |
| drug,cyclosporine | |
| sequence,We,describe,a,case,of,PRES,in,a,patient,with,collapsing,focal,glomeruloesclerosis,(,collapsing,FGS,),with,complete,recovery,after,withdrawal,of,cyclosporine,(,CSA,),. | |
| labels,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,diabetic ketoacidosis | |
| drug,perospirone hydrochloride | |
| sequence,The,risk,of,new-onset,diabetic,ketoacidosis,in,patients,with,diabetic,risk,factors,who,are,taking,perospirone,hydrochloride,or,other,atypical,antipsychotics,should,be,kept,in,mind,. | |
| labels,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,1,3,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ataxia | |
| drug,propafenone | |
| sequence,We,describe,3,elderly,patients,with,moderate,to,severe,ataxia,that,occurred,while,they,were,taking,propafenone,. | |
| labels,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,systemic hypoglycemic reaction,head trauma,confusion | |
| drug,acetohexamide | |
| sequence,In,one,instance,a,systemic,hypoglycemic,reaction,resulting,in,head,trauma,and,confusion,ended,in,an,emegency,hospital,admission,following,the,substitution,of,acetohexamide,for,acetazolamide,. | |
| labels,0,0,0,0,5,6,7,0,0,5,7,0,8,0,0,0,0,0,0,0,0,0,0,4,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,oral mucosa pigmentation | |
| drug,tacrolimus | |
| sequence,We,report,the,first,histopathologically,documented,case,of,oral,mucosa,pigmentation,after,OLP,treatment,with,topical,tacrolimus,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hyponatraemia | |
| drug,carbamazepine | |
| sequence,Hyponatraemia,developed,after,rechallenge,with,controlled,release,carbamazepine,. | |
| labels,8,0,0,0,0,0,0,4,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,status epilepticus | |
| drug,Gabapentin | |
| sequence,Gabapentin,withdrawal,presenting,as,status,epilepticus,. | |
| labels,4,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,heart block | |
| drug,Disopyramide | |
| sequence,Disopyramide-induced,heart,block,. | |
| labels,4,5,7,0 | |
| ade_mask,0,1,1,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis | |
| drug,azithromycin | |
| sequence,Lovastatin-induced,rhabdomyolysis,possibly,associated,with,clarithromycin,and,azithromycin,. | |
| labels,4,8,0,0,0,4,0,4,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis | |
| drug,clarithromycin | |
| sequence,Lovastatin-induced,rhabdomyolysis,possibly,associated,with,clarithromycin,and,azithromycin,. | |
| labels,4,8,0,0,0,4,0,4,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis | |
| drug,Lovastatin | |
| sequence,Lovastatin-induced,rhabdomyolysis,possibly,associated,with,clarithromycin,and,azithromycin,. | |
| labels,4,8,0,0,0,4,0,4,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,delirium | |
| drug,Alprazolam | |
| sequence,Alprazolam,withdrawal,delirium,unresponsive,to,diazepam,:,case,report,. | |
| labels,4,0,8,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anticonvulsant hypersensitivity syndrome | |
| drug,belladonna alkaloids | |
| sequence,We,report,a,case,of,a,previously,healthy,,,postmenopausal,woman,who,developed,anticonvulsant,hypersensitivity,syndrome,while,taking,Bellamine,S,(,belladonna,alkaloids,;,ergotamine,;,phenobarbital,),for,hot,flashes,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,1,3,0,1,3,0,4,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anticonvulsant hypersensitivity syndrome | |
| drug,Bellamine S | |
| sequence,We,report,a,case,of,a,previously,healthy,,,postmenopausal,woman,who,developed,anticonvulsant,hypersensitivity,syndrome,while,taking,Bellamine,S,(,belladonna,alkaloids,;,ergotamine,;,phenobarbital,),for,hot,flashes,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,1,3,0,1,3,0,4,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anticonvulsant hypersensitivity syndrome | |
| drug,ergotamine | |
| sequence,We,report,a,case,of,a,previously,healthy,,,postmenopausal,woman,who,developed,anticonvulsant,hypersensitivity,syndrome,while,taking,Bellamine,S,(,belladonna,alkaloids,;,ergotamine,;,phenobarbital,),for,hot,flashes,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,1,3,0,1,3,0,4,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anticonvulsant hypersensitivity syndrome | |
| drug,phenobarbital | |
| sequence,We,report,a,case,of,a,previously,healthy,,,postmenopausal,woman,who,developed,anticonvulsant,hypersensitivity,syndrome,while,taking,Bellamine,S,(,belladonna,alkaloids,;,ergotamine,;,phenobarbital,),for,hot,flashes,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,1,3,0,1,3,0,4,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cicatrical entropion | |
| drug,dipivefrin | |
| sequence,PURPOSE,:,To,report,patients,who,presented,to,the,oculoplastics,department,for,repair,of,cicatrical,entropion,after,topical,use,of,dipivefrin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Cushing syndrome | |
| drug,triamcinolone | |
| sequence,We,report,the,first,case,of,a,human,immunodeficiency,virus,type,1,(,HIV-1,),-infected,individual,receiving,combination,antiretroviral,therapy,,,which,included,ritonavir,,,who,developed,Cushing,syndrome,with,profound,complications,after,epidural,triamcinolone,injections,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Squamous metaplasia | |
| drug,progestin | |
| sequence,CONCLUSION,:,Squamous,metaplasia,in,these,cases,appears,to,be,a,consequence,of,progestin,therapy,. | |
| labels,0,0,5,7,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,angioedema | |
| drug,losartan | |
| sequence,The,incidence,of,angioedema,secondary,to,losartan,,,an,angiotensin,II,receptor,antagonist,,,is,unknown,. | |
| labels,0,0,0,8,0,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,VOD | |
| drug,azathioprine | |
| sequence,Here,we,describe,another,case,of,VOD,occurring,after,LT,,,but,in,which,the,causative,role,was,played,by,azathioprine,. | |
| labels,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,interstitial pulmonary disease | |
| drug,Ticlopidine | |
| sequence,Ticlopidine-induced,interstitial,pulmonary,disease,:,a,case,report,. | |
| labels,4,5,6,7,0,0,0,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis | |
| drug,sertraline | |
| sequence,DISCUSSION,:,The,Naranjo,probability,scale,indicated,a,probable,relationship,between,sertraline,treatment,and,the,onset,of,rhabdomyolysis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,hepatotoxicity | |
| drug,D-penicillamine | |
| sequence,Two,patients,with,rheumatoid,arthritis,developed,evidence,of,hepatotoxicity,while,receiving,D-penicillamine,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hypersensitivity | |
| drug,zonisamide | |
| sequence,Hypersensitivity,to,zonisamide,was,confirmed,by,the,skin,patch,test,. | |
| labels,8,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,methanol poisoning | |
| drug,methanol | |
| sequence,Theoretical,basal,ganglia,toxicologic,mechanisms,of,methanol,poisoning,are,reviewed,,,and,the,role,of,brain,imaging,studies,will,regard,to,diagnosis,,,prognosis,and,impact,on,management,is,discussed,. | |
| labels,0,0,0,0,0,0,9,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ventricular tachycardia | |
| drug,HCQ | |
| sequence,After,excluding,other,causes,of,long,QT,syndrome,,,the,HCQ,was,suspected,as,the,cause,of,her,ventricular,tachycardia,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Gastro-oesophageal reflux | |
| drug,nifedipine | |
| sequence,Gastro-oesophageal,reflux,associated,with,nifedipine,. | |
| labels,5,7,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypertension,lead-induced hypertension | |
| drug,lead | |
| sequence,It,also,highlights,a,current,major,etiologic,question,,,that,is,,,whether,and,to,what,degree,lead,exposure,contributes,to,the,development,of,hypertension,,,and,raises,the,issue,of,whether,lead-induced,hypertension,constitutes,a,subset,of,hypertension,that,is,especially,amenable,to,therapy,with,dietary,calcium,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,8,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,seizures | |
| drug,Amphotericin B | |
| sequence,Amphotericin,B-induced,seizures,in,a,patient,with,AIDS,. | |
| labels,1,3,8,0,0,0,0,0,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fulminant hepatitis | |
| drug,PTU | |
| sequence,After,an,extensive,review,of,the,literature,,,we,believe,that,this,is,the,first,communication,of,the,successful,use,of,amiodarone,to,control,hyperthyroidism,in,a,patient,with,PTU-induced,fulminant,hepatitis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,behavioral side effects,exacerbation of preexisting maladaptive behaviors | |
| drug,phenobarbital | |
| sequence,This,profile,should,trigger,a,``,red,flag,'',as,to,the,possibility,of,phenobarbital,behavioral,side,effects,or,exacerbation,of,preexisting,maladaptive,behaviors,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,5,6,7,0,5,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,1,0,1,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,cerebellar dysfunction,neurotoxicity | |
| drug,5-fluorouracil | |
| sequence,Two,patients,treated,with,5-fluorouracil,(,5-FU,),for,disseminated,adenocarcinoma,of,the,colon,developed,cerebellar,dysfunction,typical,of,5-FU,neurotoxicity,. | |
| labels,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,5,7,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,cerebellar dysfunction,neurotoxicity | |
| drug,5-FU | |
| sequence,Two,patients,treated,with,5-fluorouracil,(,5-FU,),for,disseminated,adenocarcinoma,of,the,colon,developed,cerebellar,dysfunction,typical,of,5-FU,neurotoxicity,. | |
| labels,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,5,7,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity | |
| drug,Allopurinol | |
| sequence,Allopurinol,hypersensitivity,. | |
| labels,4,8,0 | |
| ade_mask,0,1,0 | |
| ==============================, ============================= | |
| ade,Polyarthritis,hepatitis,anti-native DNA antibodies | |
| drug,ethambutol | |
| sequence,Polyarthritis,,,hepatitis,and,anti-native,DNA,antibodies,after,treatment,with,ethambutol,and,rifampicin,. | |
| labels,8,0,8,0,5,6,7,0,0,0,4,0,4,0 | |
| ade_mask,1,0,1,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Polyarthritis,hepatitis,anti-native DNA antibodies | |
| drug,rifampicin | |
| sequence,Polyarthritis,,,hepatitis,and,anti-native,DNA,antibodies,after,treatment,with,ethambutol,and,rifampicin,. | |
| labels,8,0,8,0,5,6,7,0,0,0,4,0,4,0 | |
| ade_mask,1,0,1,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,phenytoin toxicity | |
| drug,phenytoin | |
| sequence,Slow,acetylators,,,who,comprise,roughly,50,%,of,the,South,African,population,,,are,likely,to,develop,clinical,and,biochemical,features,of,phenytoin,toxicity,when,this,drug,is,given,together,with,antituberculosis,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,7,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hepatotoxicity | |
| drug,paracetamol | |
| sequence,Hepatotoxicity,of,paracetamol,enhanced,by,ingestion,of,alcohol,:,report,of,two,cases,. | |
| labels,8,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lethargic,apneic | |
| drug,brimonidine | |
| sequence,An,11-day-old,infant,became,lethargic,and,apneic,after,a,single,drop,of,brimonidine,. | |
| labels,0,0,0,0,8,0,8,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,1,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,immunosuppression,superinfection | |
| drug,DCF | |
| sequence,Although,myelosuppression,is,mild,,,immunosuppression,and,superinfection,are,potential,hazards,of,treatment,with,DCF,. | |
| labels,0,0,0,0,0,8,0,8,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pemphigus | |
| drug,captopril | |
| sequence,We,report,a,case,of,drug-induced,pemphigus,caused,by,an,angiotensin-converting,enzyme,inhibitor,,,captopril,. | |
| labels,0,0,0,0,0,0,8,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lichenoid eruption | |
| drug,salsalate | |
| sequence,We,describe,a,patient,who,experienced,a,lichenoid,eruption,after,the,initiation,of,salsalate,for,relief,of,arthritic,pain,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Dapsone syndrome | |
| drug,Dapsone | |
| sequence,Dapsone,syndrome,in,cutaneous,lupus,erythematosus,. | |
| labels,9,7,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Optic neuropathy | |
| drug,penicillamine | |
| sequence,Optic,neuropathy,associated,with,penicillamine,therapy,in,a,patient,with,rheumatoid,arthritis,. | |
| labels,5,7,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neutropenia | |
| drug,vancomycin | |
| sequence,CONCLUSIONS,:,For,all,patients,with,vancomycin-induced,neutropenia,,,possible,cross-reactivity,of,teicoplanin,should,be,monitored,. | |
| labels,0,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,stricture of the hepatic flexure region with associated narrowing,submucosal fibrosis of the transverse colon | |
| drug,high-lipase pancreatin | |
| sequence,We,report,a,5-year-old,boy,with,CF,who,had,a,stricture,of,the,hepatic,flexure,region,with,associated,narrowing,due,to,submucosal,fibrosis,of,the,transverse,colon,,,secondary,to,high-lipase,pancreatin,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,6,6,6,7,0,0,5,6,6,6,6,7,0,0,0,1,3,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,1,1,1,1,1,1,0,1,1,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,interstitial pulmonary disease,lymphocytic colitis | |
| drug,ticlopidine | |
| sequence,We,report,a,case,of,interstitial,pulmonary,disease,that,occurred,together,with,lymphocytic,colitis,during,treatment,with,ticlopidine,. | |
| labels,0,0,0,0,0,5,6,7,0,0,0,0,5,7,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sarcoma | |
| drug,cyclophosphamide | |
| sequence,A,patient,is,described,who,developed,a,poorly,differentiated,sarcoma,after,cyclophosphamide,was,used,to,treat,his,rheumatoid,arthritis,. | |
| labels,0,0,0,0,0,0,0,0,0,8,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,serotonin syndrome | |
| drug,clomipramine | |
| sequence,OBJECTIVE,:,To,report,on,the,possible,development,of,serotonin,syndrome,in,a,patient,receiving,clomipramine,after,clozapine,was,withdrawn,from,the,treatment,regimen,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,serotonin syndrome | |
| drug,clozapine | |
| sequence,OBJECTIVE,:,To,report,on,the,possible,development,of,serotonin,syndrome,in,a,patient,receiving,clomipramine,after,clozapine,was,withdrawn,from,the,treatment,regimen,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,vomiting | |
| drug,cisplatin | |
| sequence,Recent,reports,have,shown,that,Decadron,(,dexamethasone,;,Merck,Sharp,&,Dohme,,,West,Point,,,Pa,),has,a,significant,antiemetic,effect,on,cisplatin-induced,vomiting,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,anaphylactic reaction | |
| drug,bacitracin | |
| sequence,We,report,a,case,of,an,11-year-old,boy,who,experienced,an,anaphylactic,reaction,after,administration,of,bacitracin,ointment,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hepatic reactions | |
| drug,cyclofenil | |
| sequence,Hepatic,reactions,to,cyclofenil,. | |
| labels,5,7,0,4,0 | |
| ade_mask,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,anemia | |
| drug,cyclosporine | |
| sequence,This,report,suggests,that,anemia,can,occur,due,to,MMF,,,in,particular,when,it,is,given,with,prednisone,,,a,side,effect,well,documented,in,the,transplantation,literature,when,the,triple,combination,of,MMF,,,cyclosporine,and,prednisone,is,used,. | |
| labels,0,0,0,0,8,0,0,0,0,4,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anemia | |
| drug,MMF | |
| sequence,This,report,suggests,that,anemia,can,occur,due,to,MMF,,,in,particular,when,it,is,given,with,prednisone,,,a,side,effect,well,documented,in,the,transplantation,literature,when,the,triple,combination,of,MMF,,,cyclosporine,and,prednisone,is,used,. | |
| labels,0,0,0,0,8,0,0,0,0,4,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anemia | |
| drug,prednisone | |
| sequence,This,report,suggests,that,anemia,can,occur,due,to,MMF,,,in,particular,when,it,is,given,with,prednisone,,,a,side,effect,well,documented,in,the,transplantation,literature,when,the,triple,combination,of,MMF,,,cyclosporine,and,prednisone,is,used,. | |
| labels,0,0,0,0,8,0,0,0,0,4,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Myocardial ischemia | |
| drug,carmustine | |
| sequence,Myocardial,ischemia,associated,with,high-dose,carmustine,infusion,. | |
| labels,5,7,0,0,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Stevens-Johnson syndrome,toxic epidermal necrolysis,SJS,TEN | |
| drug,TMP-Sx | |
| sequence,We,report,a,case,of,Stevens-Johnson,syndrome,toxic,epidermal,necrolysis,(,SJS,TEN,),secondary,to,trimethoprim-sulfamethoxazole,(,TMP-Sx,),therapy,for,presumed,community-associated,methicillin-resistant,Staphylococcus,aureus,(,CA-MRSA,),infection,. | |
| labels,0,0,0,0,0,5,7,5,6,7,0,8,8,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,1,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Stevens-Johnson syndrome,toxic epidermal necrolysis,SJS,TEN | |
| drug,trimethoprim-sulfamethoxazole | |
| sequence,We,report,a,case,of,Stevens-Johnson,syndrome,toxic,epidermal,necrolysis,(,SJS,TEN,),secondary,to,trimethoprim-sulfamethoxazole,(,TMP-Sx,),therapy,for,presumed,community-associated,methicillin-resistant,Staphylococcus,aureus,(,CA-MRSA,),infection,. | |
| labels,0,0,0,0,0,5,7,5,6,7,0,8,8,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,1,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,skin manifestations | |
| drug,erlotinib | |
| sequence,We,describe,a,case,of,a,man,treated,with,an,EGFR-inhibitor,(,erlotinib,),for,a,cell,lung,cancer,who,developed,skin,manifestations,localized,in,an,uncommon,area,and,with,an,atypical,evolution,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lipoatrophy | |
| drug,human insulin | |
| sequence,CASE,:,We,report,a,case,of,a,woman,with,severe,human,insulin-induced,lipoatrophy,who,has,been,treated,exclusively,with,recombinant,DNA,human,insulin,since,the,onset,of,IDDM,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,1,0,8,0,0,0,0,0,0,1,2,2,3,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lipoatrophy | |
| drug,recombinant DNA human insulin | |
| sequence,CASE,:,We,report,a,case,of,a,woman,with,severe,human,insulin-induced,lipoatrophy,who,has,been,treated,exclusively,with,recombinant,DNA,human,insulin,since,the,onset,of,IDDM,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,1,0,8,0,0,0,0,0,0,1,2,2,3,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,high-grade endometrial stromal sarcoma,intrauterine polypoid growth | |
| drug,tamoxifen | |
| sequence,A,case,of,high-grade,endometrial,stromal,sarcoma,,,confined,into,an,intrauterine,polypoid,growth,,,in,a,woman,with,a,history,of,breast,cancer,who,was,treated,with,adjuvant,tamoxifen,. | |
| labels,0,0,0,5,6,6,7,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,1,1,1,1,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nephropathy | |
| drug,methicillin | |
| sequence,Review,of,the,literature,relating,to,methicillin-induced,nephropathy,suggests,a,hypersensitivity,origin,for,this,disorder,,,but,immunologic,and,ultrastructural,investigation,to,date,has,failed,to,elucidate,pathogenesis,. | |
| labels,0,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,focal segmental glomerulosclerosis | |
| drug,IFNalpha | |
| sequence,The,renal,biopsy,showed,focal,segmental,glomerulosclerosis,,,which,has,only,been,previously,reported,in,two,cases,of,CML,treated,with,IFNalpha,. | |
| labels,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,daytime somnolence | |
| drug,L-dopa | |
| sequence,The,authors,',results,suggest,that,L-dopa,may,cause,daytime,somnolence,in,some,patients,with,Parkinson,'s,disease,. | |
| labels,0,0,0,0,0,0,4,0,0,5,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ifosfamide-induced encephalopathy | |
| drug,ifosfamide | |
| sequence,Methylene,blue,in,the,treatment,and,prevention,of,ifosfamide-induced,encephalopathy,:,report,of,12,cases,and,a,review,of,the,literature,. | |
| labels,0,0,0,0,0,0,0,0,9,7,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Cerebral demyelinating disease | |
| drug,levamisole | |
| sequence,Cerebral,demyelinating,disease,developed,in,a,patient,during,adjuvant,therapy,with,levamisole,for,malignant,melanoma,. | |
| labels,5,6,7,0,0,0,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,squamous cell carcinoma | |
| drug,psoralens | |
| sequence,In,two,patients,with,mycosis,fungoides,,,a,squamous,cell,carcinoma,developed,during,therapy,with,psoralens,plus,long-wave,ultraviolet,radiation,(,PUVA,),. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyponatremia | |
| drug,citalopram | |
| sequence,In,this,case,,,unlike,those,previously,reported,,,hyponatremia,recurred,5,months,after,switching,from,citalopram,to,mirtazapine,,,which,is,believed,to,be,a,safe,antidepressant,. | |
| labels,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyponatremia | |
| drug,mirtazapine | |
| sequence,In,this,case,,,unlike,those,previously,reported,,,hyponatremia,recurred,5,months,after,switching,from,citalopram,to,mirtazapine,,,which,is,believed,to,be,a,safe,antidepressant,. | |
| labels,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Pericardial hemorrhage | |
| drug,acetylsalicylic acid | |
| sequence,Pericardial,hemorrhage,due,to,acetylsalicylic,acid,in,a,patient,with,essential,thrombocythemia,. | |
| labels,5,7,0,0,1,3,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,toxicity | |
| drug,4-hydroxyifosfamide | |
| sequence,The,toxicity,and,plasma,concentrations,of,ifosfamide,,,chloroacetaldehyde,,,and,4-hydroxyifosfamide,were,then,determined,over,24,h,after,a,single,1.6,g,m2,dose,of,ifosfamide,. | |
| labels,0,8,0,0,0,0,4,0,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,toxicity | |
| drug,chloroacetaldehyde | |
| sequence,The,toxicity,and,plasma,concentrations,of,ifosfamide,,,chloroacetaldehyde,,,and,4-hydroxyifosfamide,were,then,determined,over,24,h,after,a,single,1.6,g,m2,dose,of,ifosfamide,. | |
| labels,0,8,0,0,0,0,4,0,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,toxicity | |
| drug,ifosfamide | |
| sequence,The,toxicity,and,plasma,concentrations,of,ifosfamide,,,chloroacetaldehyde,,,and,4-hydroxyifosfamide,were,then,determined,over,24,h,after,a,single,1.6,g,m2,dose,of,ifosfamide,. | |
| labels,0,8,0,0,0,0,4,0,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neurotoxicity | |
| drug,Acyclovir | |
| sequence,Acyclovir,neurotoxicity,:,clinical,experience,and,review,of,the,literature,. | |
| labels,4,8,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pulmonary toxicity | |
| drug,etoposide | |
| sequence,PET,scintigraphy,of,etoposide-induced,pulmonary,toxicity,. | |
| labels,0,0,0,4,5,7,0 | |
| ade_mask,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Telescoped digits of the hands and feet | |
| drug,allopurinol | |
| sequence,Telescoped,digits,of,the,hands,and,feet,developed,in,a,69-year-old,male,with,severe,chronic,tophaceous,gout,during,allopurinol,treatment,. | |
| labels,5,6,6,6,6,6,7,0,0,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,1,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,livedo reticularis | |
| drug,interferon alpha 2b | |
| sequence,We,report,two,patients,who,developed,intense,livedo,reticularis,clearly,related,to,the,administration,of,interferon,alpha,2b,as,an,adjuvant,therapy,for,melanoma,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,1,2,3,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,non-Hodgkin's lymphoma | |
| drug,2-Chloro-deoxyadenosine | |
| sequence,2-Chloro-deoxyadenosine,induces,durable,complete,remission,in,Castleman,'s,disease,but,may,accelerate,its,transformation,to,non-Hodgkin,'s,lymphoma,. | |
| labels,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,1,0 | |
| ==============================, ============================= | |
| ade,cholestatic liver disease | |
| drug,terbinafine | |
| sequence,We,describe,a,case,of,prolonged,terbinafine-induced,cholestatic,liver,disease,. | |
| labels,0,0,0,0,0,0,4,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,SIADH | |
| drug,Desipramine | |
| sequence,Desipramine-associated,SIADH,in,an,elderly,woman,:,case,report,. | |
| labels,4,8,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,maladaptive behaviors | |
| drug,phenobarbital | |
| sequence,Ten,years,of,behavioral,data,are,presented,to,support,the,hypothesis,that,phenobarbital,was,exacerbating,maladaptive,behaviors,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,akathisia,RLS | |
| drug,olanzapine | |
| sequence,The,third,patient,had,been,suffering,from,serious,akathisia,while,on,risperidone,,,and,was,cured,after,switching,to,olanzapine,,,but,thereafter,the,patient,suffered,from,RLS,at,nighttime,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,4,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,8,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,akathisia,RLS | |
| drug,risperidone | |
| sequence,The,third,patient,had,been,suffering,from,serious,akathisia,while,on,risperidone,,,and,was,cured,after,switching,to,olanzapine,,,but,thereafter,the,patient,suffered,from,RLS,at,nighttime,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,4,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,8,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,neurotoxicity | |
| drug,5-fluorouracil | |
| sequence,Reversible,findings,of,restricted,diffusion,in,5-fluorouracil,neurotoxicity,. | |
| labels,0,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Severe Raynaud's phenomenon | |
| drug,yohimbine | |
| sequence,Severe,Raynaud,'s,phenomenon,with,yohimbine,therapy,for,erectile,dysfunction,. | |
| labels,5,6,6,7,0,4,0,0,0,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,impair sexual function | |
| drug,baclofen | |
| sequence,CONCLUSIONS,:,Intrathecal,baclofen,can,impair,sexual,function,and,ejaculation,in,some,patients,. | |
| labels,0,0,0,4,0,5,6,7,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,High-grade atrioventricular block | |
| drug,dipyridamole | |
| sequence,High-grade,atrioventricular,block,during,dipyridamole,stress,testing,. | |
| labels,5,6,7,0,4,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Kaposi's sarcoma | |
| drug,prednisolone | |
| sequence,We,report,a,case,of,drug-induced,Kaposi,'s,sarcoma,(,KS,),on,the,sole,of,the,right,foot,in,a,71-year-old,man,,,treated,for,6,months,with,corticosteroid,therapy,(,prednisolone,25,mg,day,),for,pericardial,effusion,. | |
| labels,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombocytosis | |
| drug,enoxaparin | |
| sequence,However,,,to,our,knowledge,,,in,newborns,there,have,been,no,reported,cases,to,date,of,thrombocytosis,induced,by,enoxaparin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sustained monomorphic ventricular tachycardia | |
| drug,adenosine | |
| sequence,We,present,a,case,of,a,sustained,monomorphic,ventricular,tachycardia,following,adenosine,infusion,. | |
| labels,0,0,0,0,0,0,5,6,6,7,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ascites | |
| drug,MTX | |
| sequence,Upon,discontinuation,of,MTX,,,her,ascites,resolved,,,and,her,arthritis,became,more,active,. | |
| labels,0,0,0,4,0,0,8,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ADR | |
| drug,lamivudine | |
| sequence,ADR,induced,by,drug,treatment,can,be,a,side,effect,of,treatment,with,antipsychotic,drugs,and,other,drugs,;,however,,,there,have,been,no,reports,of,lamivudine-induced,ADR,in,the,English,literature,. | |
| labels,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Proconvulsive | |
| drug,cilastatin | |
| sequence,Proconvulsive,tendency,of,imipenem,cilastatin,is,one,of,its,well-known,side,effects,. | |
| labels,8,0,0,4,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Proconvulsive | |
| drug,imipenem | |
| sequence,Proconvulsive,tendency,of,imipenem,cilastatin,is,one,of,its,well-known,side,effects,. | |
| labels,8,0,0,4,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,seizures | |
| drug,clozapine | |
| sequence,We,describe,a,case,of,clozapine-induced,seizures,in,a,patient,with,treatment-resistant,schizophrenia,. | |
| labels,0,0,0,0,0,4,8,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pulmonary fibrosis | |
| drug,BCNU | |
| sequence,These,novel,findings,may,offer,specific,therapeutic,targets,in,the,treatment,of,BCNU-associated,pulmonary,fibrosis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Cephalexin rash | |
| drug,Cephalexin | |
| sequence,Cephalexin,rash,in,infectious,mononucleosis,. | |
| labels,9,7,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bradycardia | |
| drug,sotalol | |
| sequence,We,present,a,case,of,sotalol-induced,bradycardia,reversed,by,glucagon,. | |
| labels,0,0,0,0,0,4,8,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lichen planus | |
| drug,gold | |
| sequence,A,58-year-old,man,with,rheumatoid,arthritis,developed,lichen,planus,during,treatment,with,gold,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myelotoxicity | |
| drug,6-mercaptopurine | |
| sequence,Pharmacokinetic,determinants,of,6-mercaptopurine,myelotoxicity,and,therapeutic,failure,in,children,with,acute,lymphoblastic,leukemia,. | |
| labels,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,progressive visual loss,loss of consciousness,death | |
| drug,Ara-C | |
| sequence,Despite,a,response,of,the,meningeal,tumor,the,patient,developed,in,the,third,week,of,MTX,treatment,a,progressive,visual,loss,and,loss,of,consciousness,which,worsened,during,subsequent,Ara-C,treatment,and,led,to,death,within,3,weeks,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,5,6,7,0,5,6,7,0,0,0,0,4,0,0,0,0,8,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,progressive visual loss,loss of consciousness,death | |
| drug,MTX | |
| sequence,Despite,a,response,of,the,meningeal,tumor,the,patient,developed,in,the,third,week,of,MTX,treatment,a,progressive,visual,loss,and,loss,of,consciousness,which,worsened,during,subsequent,Ara-C,treatment,and,led,to,death,within,3,weeks,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,5,6,7,0,5,6,7,0,0,0,0,4,0,0,0,0,8,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Headaches | |
| drug,capecitabine | |
| sequence,BACKGROUND,:,Headaches,have,been,reported,as,a,potential,side,effect,of,capecitabine,therapy,. | |
| labels,0,0,8,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fulminant hepatitis | |
| drug,PTU | |
| sequence,We,present,a,20-year-old,woman,with,Basedow-Graves,disease,who,developed,PTU-induced,fulminant,hepatitis,,,which,progressed,to,acute,hepatic,failure,with,grade,III,hepatic,encephalopathy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lung cancer | |
| drug,methotrexate | |
| sequence,In,this,case,,,it,was,suspected,that,a,combination,of,cigarette,smoking,,,pulmonary,fibrosis,,,and,low-dose,methotrexate,therapy,might,have,promoted,the,development,of,lung,cancer,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,mutism | |
| drug,FK506 | |
| sequence,Tacrolimus,(,FK506,),,,an,immunosuppressant,,,has,been,associated,with,mutism,in,adults,after,liver,transplant,. | |
| labels,4,0,4,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,mutism | |
| drug,Tacrolimus | |
| sequence,Tacrolimus,(,FK506,),,,an,immunosuppressant,,,has,been,associated,with,mutism,in,adults,after,liver,transplant,. | |
| labels,4,0,4,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,wide QRS complex dysrhythmia | |
| drug,Propoxyphene | |
| sequence,Propoxyphene-induced,wide,QRS,complex,dysrhythmia,responsive,to,sodium,bicarbonate,--,a,case,report,. | |
| labels,4,5,6,6,7,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,polymyositis | |
| drug,leuprolide acetate | |
| sequence,Drug,induced,polymyositis,secondary,to,leuprolide,acetate,(,Lupron,),therapy,for,prostate,carcinoma,. | |
| labels,0,0,8,0,0,1,3,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,polymyositis | |
| drug,Lupron | |
| sequence,Drug,induced,polymyositis,secondary,to,leuprolide,acetate,(,Lupron,),therapy,for,prostate,carcinoma,. | |
| labels,0,0,8,0,0,1,3,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,endometrial adenocarcinoma,uterine sarcoma | |
| drug,tamoxifen | |
| sequence,In,deciding,if,tamoxifen,therapy,is,warranted,,,all,potentially,life-threatening,adverse,events,associated,with,tamoxifen,should,be,considered,,,including,endometrial,adenocarcinoma,or,uterine,sarcoma,. | |
| labels,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,1,0 | |
| ==============================, ============================= | |
| ade,overanticoagulation | |
| drug,acenocoumarol | |
| sequence,We,report,the,case,of,a,young,healthy,woman,who,presented,an,early,overanticoagulation,when,receiving,acenocoumarol,for,a,first,thromboembolic,episode,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute myeloid leukemia,lung cancer | |
| drug,fludarabine | |
| sequence,Acute,myeloid,leukemia,and,lung,cancer,occurring,in,a,chronic,lymphocytic,leukemia,patient,treated,with,fludarabine,and,autologous,peripheral,blood,stem-cell,transplantation,. | |
| labels,5,6,7,0,5,7,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fever,hemoptysis,pleural friction rub | |
| drug,acyclovir | |
| sequence,Following,the,institution,of,intravenous,therapy,with,acyclovir,,,the,patient,developed,fever,,,hemoptysis,,,and,a,pleural,friction,rub,. | |
| labels,0,0,0,0,0,0,0,4,0,0,0,0,8,0,8,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,pneumonitis,pulmonary infiltrate | |
| drug,Rapamycin | |
| sequence,Rapamycin,sirolimus-induced,pneumonitis,has,been,described,previously,in,renal,transplant,recipients,,,and,this,report,describes,a,stable,heart-lung,transplant,recipient,who,developed,a,pulmonary,infiltrate,that,reversed,after,ceasing,SR,therapy,. | |
| labels,4,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pneumonitis,pulmonary infiltrate | |
| drug,sirolimus | |
| sequence,Rapamycin,sirolimus-induced,pneumonitis,has,been,described,previously,in,renal,transplant,recipients,,,and,this,report,describes,a,stable,heart-lung,transplant,recipient,who,developed,a,pulmonary,infiltrate,that,reversed,after,ceasing,SR,therapy,. | |
| labels,4,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pulmonary infiltrate | |
| drug,SR | |
| sequence,Rapamycin,sirolimus-induced,pneumonitis,has,been,described,previously,in,renal,transplant,recipients,,,and,this,report,describes,a,stable,heart-lung,transplant,recipient,who,developed,a,pulmonary,infiltrate,that,reversed,after,ceasing,SR,therapy,. | |
| labels,4,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute kidney injury,DRESS,DIHS | |
| drug,zonisamide | |
| sequence,This,is,the,first,report,of,acute,kidney,injury,due,to,zonisamide-induced,DRESS,DIHS,. | |
| labels,0,0,0,0,0,0,5,6,7,0,0,4,8,8,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,neurotoxicity | |
| drug,Acyclovir | |
| sequence,Acyclovir-induced,neurotoxicity,:,concentration-side,effect,relationship,in,acyclovir,overdose,. | |
| labels,4,8,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,antineutrophil cytoplasmic antibody | |
| drug,propylthiouracil | |
| sequence,A,teenage,girl,with,crescentic,glomerulonephritis,had,antineutrophil,cytoplasmic,antibody,(,ANCA,),detected,after,she,had,received,propylthiouracil,(,PTU,),for,hyperthyroidism,without,cutaneous,vasculitis,. | |
| labels,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,antineutrophil cytoplasmic antibody | |
| drug,PTU | |
| sequence,A,teenage,girl,with,crescentic,glomerulonephritis,had,antineutrophil,cytoplasmic,antibody,(,ANCA,),detected,after,she,had,received,propylthiouracil,(,PTU,),for,hyperthyroidism,without,cutaneous,vasculitis,. | |
| labels,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pulmonary toxicity | |
| drug,etoposide | |
| sequence,Because,etoposide-induced,pulmonary,toxicity,is,an,uncommon,but,serious,adverse,event,,,clinicians,must,be,vigilant,about,the,possibility,of,it,,,so,that,the,optimal,treatment,can,start,as,soon,as,possible,. | |
| labels,0,4,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,erythroderma | |
| drug,epoprostenol | |
| sequence,Severe,erythroderma,as,a,complication,of,continuous,epoprostenol,therapy,. | |
| labels,0,8,0,0,0,0,0,4,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,recall pneumonitis | |
| drug,Gemcitabine | |
| sequence,CONCLUSION,:,Gemcitabine-induced,recall,pneumonitis,is,a,rarely,reported,phenomenon,and,should,be,taken,into,account,even,after,extended,time,interval,to,the,previous,radiotherapy,. | |
| labels,0,0,4,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,seizures | |
| drug,fluoxetine | |
| sequence,A,case,of,fluoxetine,induced,seizures,,,in,a,person,with,Down,syndrome,,,is,described,. | |
| labels,0,0,0,4,0,8,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute retinal ischemic change,stroke | |
| drug,bevacizumab | |
| sequence,AIM,:,To,report,a,patient,with,diabetic,rubeosis,who,suffered,from,acute,retinal,ischemic,change,and,stroke,after,intravitreal,injection,of,bevacizumab,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,8,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute hypotonia | |
| drug,pyridoxine | |
| sequence,Administration,of,pyridoxine,to,an,infant,after,a,long,period,of,convulsions,was,followed,by,acute,hypotonia,. | |
| labels,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,granulomatous anterior uveitis | |
| drug,Metipranolol | |
| sequence,Metipranolol,associated,granulomatous,anterior,uveitis,:,not,so,uncommon,as,thought,. | |
| labels,4,0,5,6,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Transient cardiac arrhythmias | |
| drug,lopinavir | |
| sequence,Transient,cardiac,arrhythmias,related,to,lopinavir,ritonavir,in,two,patients,with,HIV,infection,. | |
| labels,5,6,7,0,0,4,4,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Transient cardiac arrhythmias | |
| drug,ritonavir | |
| sequence,Transient,cardiac,arrhythmias,related,to,lopinavir,ritonavir,in,two,patients,with,HIV,infection,. | |
| labels,5,6,7,0,0,4,4,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fever,chills,fatigue,night sweats,generalized, pruritic, macular eruption | |
| drug,minocycline | |
| sequence,A,22-year-old,black,man,developed,fever,,,chills,,,fatigue,,,night,sweats,,,tender,lymphadenopathy,,,and,a,generalized,,,pruritic,,,macular,eruption,3,weeks,after,starting,minocycline,therapy,for,acne,. | |
| labels,0,0,0,0,0,8,0,8,0,8,0,5,7,0,0,0,0,0,0,5,6,6,0,6,7,0,0,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,1,0,1,1,0,0,0,0,0,0,1,0,1,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neurological depression | |
| drug,oxymetalzoline | |
| sequence,We,report,here,a,case,of,cardiovascular,and,neurological,depression,induced,by,oxymetalzoline,in,a,toddler,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,movement disorders,tics | |
| drug,carbamazepine | |
| sequence,A,variety,of,movement,disorders,are,known,to,occur,in,association,with,carbamazepine,(,CBZ,),therapy,in,adults,and,children,,,but,development,of,tics,has,been,described,infrequently,and,only,in,patients,with,underlying,Tourette,'s,syndrome,or,other,movement,disorders,. | |
| labels,0,0,0,5,7,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,movement disorders,tics | |
| drug,CBZ | |
| sequence,A,variety,of,movement,disorders,are,known,to,occur,in,association,with,carbamazepine,(,CBZ,),therapy,in,adults,and,children,,,but,development,of,tics,has,been,described,infrequently,and,only,in,patients,with,underlying,Tourette,'s,syndrome,or,other,movement,disorders,. | |
| labels,0,0,0,5,7,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyponatremia,syndrome of inappropriate antidiuretic hormone | |
| drug,desmopressin | |
| sequence,Without,other,causes,for,the,hyponatremia,,,she,was,diagnosed,with,the,syndrome,of,inappropriate,antidiuretic,hormone,,,presumably,caused,by,desmopressin,. | |
| labels,0,0,0,0,0,8,0,0,0,0,0,0,5,6,6,6,7,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,1,1,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Obsessive-compulsive symptoms | |
| drug,risperidone | |
| sequence,Obsessive-compulsive,symptoms,suddenly,emerged,10,days,after,starting,risperidone,and,resolved,within,3,days,of,discontinuation,. | |
| labels,5,7,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,gynecomastia | |
| drug,theophylline | |
| sequence,A,61,year-old,male,patient,developed,gynecomastia,after,starting,theophylline,. | |
| labels,0,0,0,0,0,0,8,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pulmonary hypertension | |
| drug,protamine | |
| sequence,Ketanserin,in,the,treatment,of,protamine-induced,pulmonary,hypertension,. | |
| labels,0,0,0,0,0,4,5,7,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,tardive dyskinesia | |
| drug,Clozapine | |
| sequence,Clozapine-induced,tardive,dyskinesia,in,schizophrenic,patients,taking,clozapine,as,a,first-line,antipsychotic,drug,. | |
| labels,4,5,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypoglycaemia | |
| drug,Mefloquine | |
| sequence,Mefloquine-associated,hypoglycaemia,in,a,cachectic,AIDS,patient,. | |
| labels,4,8,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatotoxicity | |
| drug,imatinib | |
| sequence,A,short,review,on,imatinib-related,hepatotoxicity,is,also,presented,. | |
| labels,0,0,0,0,4,8,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,MI | |
| drug,PCC | |
| sequence,We,have,safely,used,recombinant,factor,VIIa,to,treat,bleeding,in,the,immediate,and,long-term,period,following,PCC-related,MI,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,thrombocytopenia,thrombosis | |
| drug,Heparin | |
| sequence,Heparin-associated,thrombocytopenia,and,thrombosis,is,a,severe,complication,of,systemic,heparin,therapy,. | |
| labels,4,8,0,8,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,1,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombocytopenia,thrombosis | |
| drug,heparin | |
| sequence,Heparin-associated,thrombocytopenia,and,thrombosis,is,a,severe,complication,of,systemic,heparin,therapy,. | |
| labels,4,8,0,8,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,1,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Prominent eye movements during NREM sleep,REM sleep behavior disorder | |
| drug,fluoxetine | |
| sequence,Prominent,eye,movements,during,NREM,sleep,and,REM,sleep,behavior,disorder,associated,with,fluoxetine,treatment,of,depression,and,obsessive-compulsive,disorder,. | |
| labels,5,6,6,6,6,7,0,5,6,6,7,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,1,1,0,1,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Multicentric hepatocellular carcinoma | |
| drug,phosphate diethylstilbestrol | |
| sequence,Multicentric,hepatocellular,carcinoma,following,phosphate,diethylstilbestrol,therapy,for,prostatic,cancer,. | |
| labels,5,6,7,0,1,3,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperammonemia | |
| drug,carbamazepine | |
| sequence,CONCLUSION,:,A,26-year-old,man,with,bipolar,disorder,developed,hyperammonemia,three,weeks,after,initiating,carbamazepine,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,8,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,menstrual cycle disturbances | |
| drug,valproate | |
| sequence,An,evaluation,of,ovarian,structure,and,function,should,be,considered,in,women,of,reproductive,age,being,treated,with,valproate,for,epilepsy,,,especially,if,they,develop,menstrual,cycle,disturbances,during,treatment,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,5,6,7,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity syndrome,fever,headache,nausea,vomiting,lymphadenopathy,hepatitis,hemolysis,leukopenia,mononucleosis | |
| drug,dapsone | |
| sequence,A,dapsone,hypersensitivity,syndrome,,,consisting,of,fever,,,headache,,,nausea,,,vomiting,,,lymphadenopathy,,,hepatitis,,,hemolysis,,,leukopenia,,,and,mononucleosis,,,has,been,described,in,patients,treated,with,the,drug,for,leprosy,. | |
| labels,0,4,5,7,0,0,0,8,0,8,0,8,0,8,0,8,0,8,0,8,0,8,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,0,0,0,1,0,1,0,1,0,1,0,1,0,1,0,1,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,generalized tonic-clonic seizure | |
| drug,naloxone | |
| sequence,A,generalized,tonic-clonic,seizure,occurred,a,few,minutes,after,injection,of,the,morphine,antagonist,naloxone,. | |
| labels,0,5,6,7,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Comeoscleral perforation | |
| drug,mitomycin C | |
| sequence,Comeoscleral,perforation,after,pterygium,excision,and,intraoperative,mitomycin,C,. | |
| labels,5,7,0,0,0,0,0,1,3,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lactic acidosis | |
| drug,lamivudine | |
| sequence,This,is,the,second,report,of,lactic,acidosis,in,a,patient,on,stavudine,and,lamivudine,. | |
| labels,0,0,0,0,0,0,5,7,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lactic acidosis | |
| drug,stavudine | |
| sequence,This,is,the,second,report,of,lactic,acidosis,in,a,patient,on,stavudine,and,lamivudine,. | |
| labels,0,0,0,0,0,0,5,7,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,AIN | |
| drug,pantoprazole | |
| sequence,The,Naranjo,probability,scale,suggests,a,highly,probable,relationship,between,AIN,and,pantoprazole,therapy,in,this,patient,. | |
| labels,0,0,0,0,0,0,0,0,0,0,8,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe arterial thrombotic events | |
| drug,thrombin | |
| sequence,Despite,a,very,low,complication,rate,,,several,severe,arterial,thrombotic,events,have,been,reported,following,thrombin,injection,of,pseudoaneurysms,. | |
| labels,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute pancreatitis | |
| drug,betamethasone | |
| sequence,CASE,REPORT,:,We,report,the,case,of,a,58,year,old,patient,who,,,after,2,days,of,treatment,with,roxithromycin,and,betamethasone,,,manifested,acute,pancreatitis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,acute pancreatitis | |
| drug,roxithromycin | |
| sequence,CASE,REPORT,:,We,report,the,case,of,a,58,year,old,patient,who,,,after,2,days,of,treatment,with,roxithromycin,and,betamethasone,,,manifested,acute,pancreatitis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,diphasic dyskinesias | |
| drug,levo-dopa | |
| sequence,We,report,on,three,observations,of,parkinsonian,patients,with,levo-dopa-induced,diphasic,dyskinesias,,,who,received,subcutaneous,apomorphine,to,reduce,the,duration,of,abnormal,movements,. | |
| labels,0,0,0,0,0,0,0,0,0,4,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombosis | |
| drug,azathioprine | |
| sequence,In,this,report,,,a,patient,who,had,undergone,a,renal,transplantation,as,a,result,of,malignant,hypertension,,,and,who,was,on,immunosuppressive,therapy,consisting,of,cyclosporin,,,prednisone,and,azathioprine,,,developed,thrombosis,of,the,central,retinal,vein,5,years,following,the,transplantation,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,4,0,0,8,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombosis | |
| drug,cyclosporin | |
| sequence,In,this,report,,,a,patient,who,had,undergone,a,renal,transplantation,as,a,result,of,malignant,hypertension,,,and,who,was,on,immunosuppressive,therapy,consisting,of,cyclosporin,,,prednisone,and,azathioprine,,,developed,thrombosis,of,the,central,retinal,vein,5,years,following,the,transplantation,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,4,0,0,8,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombosis | |
| drug,prednisone | |
| sequence,In,this,report,,,a,patient,who,had,undergone,a,renal,transplantation,as,a,result,of,malignant,hypertension,,,and,who,was,on,immunosuppressive,therapy,consisting,of,cyclosporin,,,prednisone,and,azathioprine,,,developed,thrombosis,of,the,central,retinal,vein,5,years,following,the,transplantation,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,4,0,0,8,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,akathisia | |
| drug,Clozapine | |
| sequence,Clozapine-induced,akathisia,in,children,with,schizophrenia,. | |
| labels,4,8,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,endometrial carcinoma,endometriosis | |
| drug,tamoxifen | |
| sequence,The,possible,effects,of,tamoxifen,upon,the,uterus,are,discussed,in,this,article,,,in,view,of,reports,of,tamoxifen,associated,with,endometrial,carcinoma,and,endometriosis,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0 | |
| ==============================, ============================= | |
| ade,vomiting | |
| drug,Pancrease MT 16 | |
| sequence,METHODS,:,Double-blind,,,placebo-controlled,titrated,oral,challenges,with,pancreatic,enzymes,resulted,in,definite,vomiting,within,1,to,1.5,hours,after,challenges,with,Viokase,and,Pancrease,MT,16,,,but,not,with,placebo,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,4,0,1,2,3,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,vomiting | |
| drug,Viokase | |
| sequence,METHODS,:,Double-blind,,,placebo-controlled,titrated,oral,challenges,with,pancreatic,enzymes,resulted,in,definite,vomiting,within,1,to,1.5,hours,after,challenges,with,Viokase,and,Pancrease,MT,16,,,but,not,with,placebo,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,4,0,1,2,3,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombocytopenia | |
| drug,heparin | |
| sequence,Although,heparin-dependent,antibodies,(,HDAs,),typically,manifest,with,thrombocytopenia,as,in,heparin-induced,thrombocytopenia,(,HIT,),,,they,may,also,manifest,with,preserved,platelet,counts,. | |
| labels,0,0,0,0,0,0,0,0,0,8,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neutropenia | |
| drug,olanzapine | |
| sequence,Second,,,we,report,a,case,of,neutropenia,,,which,proved,to,be,fatal,in,a,schizophrenia,patient,receiving,olanzapine,and,thiazide,. | |
| labels,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neutropenia | |
| drug,thiazide | |
| sequence,Second,,,we,report,a,case,of,neutropenia,,,which,proved,to,be,fatal,in,a,schizophrenia,patient,receiving,olanzapine,and,thiazide,. | |
| labels,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombocythemia | |
| drug,interferon alfa | |
| sequence,Development,of,essential,thrombocythemia,in,a,patient,treated,with,interferon,alfa,and,pentostatin,for,hairy,cell,leukemia,. | |
| labels,0,0,0,8,0,0,0,0,0,1,3,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombocythemia | |
| drug,pentostatin | |
| sequence,Development,of,essential,thrombocythemia,in,a,patient,treated,with,interferon,alfa,and,pentostatin,for,hairy,cell,leukemia,. | |
| labels,0,0,0,8,0,0,0,0,0,1,3,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,delirium | |
| drug,oolong tea | |
| sequence,After,abstinence,from,oolong,tea,his,delirium,resolved,. | |
| labels,0,0,0,1,3,0,8,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0 | |
| ==============================, ============================= | |
| ade,Duodenal ulceration | |
| drug,tolazoline | |
| sequence,Duodenal,ulceration,:,a,complication,of,tolazoline,therapy,. | |
| labels,5,7,0,0,0,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute renal failure | |
| drug,acyclovir | |
| sequence,Acute,renal,failure,in,a,child,associated,with,acyclovir,. | |
| labels,5,6,7,0,0,0,0,0,4,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fluctuation of the QT interval | |
| drug,methadone | |
| sequence,Of,particular,interest,in,this,patient,is,the,fluctuation,of,the,QT,interval,at,a,stable,dose,of,methadone,,,suggesting,that,a,single,normal,electrocardiogram,(,ECG,),does,not,guarantee,that,the,patient,is,not,at,risk,of,ventricular,arrhythmias,. | |
| labels,0,0,0,0,0,0,0,0,5,6,6,6,7,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ocular toxicity,conjunctivitis,keratitis | |
| drug,DCF | |
| sequence,The,ocular,toxicity,of,DCF,,,previously,described,as,conjunctivitis,,,appears,to,be,a,keratitis,of,moderate,severity,which,requires,further,study,. | |
| labels,0,5,7,0,4,0,0,0,0,8,0,0,0,0,0,8,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fatal neuromyeloencephalopathy | |
| drug,muzolimine | |
| sequence,We,report,on,7,patients,(,2,women,,,5,men,),with,chronic,renal,failure,,,who,developed,under,a,high,dosage,of,the,new,diuretic,muzolimine,(,range,240,to,1440,mg,per,day,),fatal,neuromyeloencephalopathy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,lipohypertrophy | |
| drug,insulin | |
| sequence,Based,on,the,history,and,clinical,features,,,a,diagnosis,of,insulin-induced,lipohypertrophy,was,made,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,4,8,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,lupus,serositis,pulmonary parenchymal involvement | |
| drug,sulfasalazine | |
| sequence,It,is,suggested,that,the,patient,had,sulfasalazine-induced,lupus,,,which,manifested,with,serositis,and,pulmonary,parenchymal,involvement,in,the,absence,of,joint,symptoms,. | |
| labels,0,0,0,0,0,0,0,4,8,0,0,0,0,8,0,5,6,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,1,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,allergic reactions | |
| drug,Capecitabine | |
| sequence,Capecitabine,was,discontinued,and,the,allergic,reactions,resolved,after,the,woman,took,diphenhydramine,for,1,week,. | |
| labels,4,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,apnea | |
| drug,lamotrigine | |
| sequence,The,Naranjo,probability,scale,indicated,a,probable,relationship,between,apnea,and,exposure,to,lamotrigine,through,breast-feeding,in,this,infant,. | |
| labels,0,0,0,0,0,0,0,0,0,8,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pulmonary side effects | |
| drug,ticlopidine | |
| sequence,So,far,,,few,cases,of,pulmonary,side,effects,caused,by,ticlopidine,have,been,reported,. | |
| labels,0,0,0,0,0,0,5,6,7,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis | |
| drug,ritodrine-hydrochloride | |
| sequence,We,report,here,a,rare,case,of,ritodrine-hydrochloride-induced,rhabdomyolysis,in,a,pregnant,patient,with,myotonic,dystrophy,. | |
| labels,0,0,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,osteonecrosis | |
| drug,dexamethasone | |
| sequence,It,is,very,likely,that,the,dexamethasone,used,in,the,antiemetic,drug,regimen,contributed,to,the,development,of,osteonecrosis,in,these,patients,. | |
| labels,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fever | |
| drug,Cimetidine | |
| sequence,Cimetidine,is,a,rare,cause,of,drug-induced,fever,. | |
| labels,4,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,intracranial bleeding | |
| drug,amprenavir | |
| sequence,We,report,the,occurrence,of,spontaneous,intracranial,bleeding,in,an,human,immunodeficiency,virus,(,HIV,),-infected,adolescent,with,hemophilia,A,who,was,receiving,amprenavir,(,APV,),. | |
| labels,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Central nervous system manifestations | |
| drug,ibuprofen | |
| sequence,Central,nervous,system,manifestations,of,an,ibuprofen,overdose,reversed,by,naloxone,. | |
| labels,5,6,6,7,0,0,4,0,0,0,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hyperammonemia,lethargy | |
| drug,valproic acid | |
| sequence,Hyperammonemia,has,been,described,as,a,complication,of,valproic,acid,therapy,but,may,often,be,overlooked,as,a,cause,of,lethargy,in,the,postictal,patient,who,presents,to,the,emergency,department,. | |
| labels,8,0,0,0,0,0,0,0,1,3,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,agranulocytosis | |
| drug,methimazole | |
| sequence,A,48-year-old,woman,who,was,treated,for,thyrotoxicosis,with,methimazole,developed,agranulocytosis,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Thyroid dysfunction | |
| drug,recombinant alpha interferon | |
| sequence,Thyroid,dysfunction,has,been,reported,in,patients,with,malignant,disease,treated,with,recombinant,alpha,interferon,. | |
| labels,5,7,0,0,0,0,0,0,0,0,0,0,1,2,3,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute pancreatitis,pseudocyst of the pancreas | |
| drug,L-asparaginase | |
| sequence,An,adolescent,male,developed,acute,pancreatitis,and,pseudocyst,of,the,pancreas,16,weeks,after,cessation,of,intramuscular,L-asparaginase,. | |
| labels,0,0,0,0,5,7,0,5,6,6,7,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,1,1,0,1,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,blast crisis | |
| drug,imatinib | |
| sequence,In,addition,to,disease,refractoriness,,,rare,instances,of,disease,progression,from,chronic,phase,to,blast,crisis,during,imatinib,therapy,have,recently,been,anecdotally,reported,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cutaneous leucocytoclastic vasculitis | |
| drug,Amphotericin B | |
| sequence,Amphotericin,B-induced,cutaneous,leucocytoclastic,vasculitis,:,case,report,. | |
| labels,1,3,5,6,7,0,0,0,0 | |
| ade_mask,0,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,iatrogenic hypoglycaemia | |
| drug,quinidine | |
| sequence,Quinine,and,its,isomer,quinidine,are,well-known,causes,of,iatrogenic,hypoglycaemia,,,due,to,excessive,insulin,secretion,. | |
| labels,4,0,0,0,4,0,0,0,0,5,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,iatrogenic hypoglycaemia | |
| drug,Quinine | |
| sequence,Quinine,and,its,isomer,quinidine,are,well-known,causes,of,iatrogenic,hypoglycaemia,,,due,to,excessive,insulin,secretion,. | |
| labels,4,0,0,0,4,0,0,0,0,5,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Dental and gingival pain | |
| drug,niacin | |
| sequence,Dental,and,gingival,pain,as,side,effects,of,niacin,therapy,. | |
| labels,5,6,6,7,0,0,0,0,4,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,allergic contact dermatitis | |
| drug,bisabolol | |
| sequence,Only,two,case,reports,of,adults,with,allergic,contact,dermatitis,to,this,chemical,exist,in,the,literature,,,and,we,describe,three,more,cases,of,children,with,recalcitrant,atopic,dermatitis,found,to,have,potential,allergic,contact,dermatitis,to,bisabolol-,a,component,of,the,Aquaphor,emollient,they,were,using,to,treat,their,atopic,dermatitis,. | |
| labels,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,respiratory insufficiency,lung disease | |
| drug,cyclophosphamide | |
| sequence,The,temporal,sequence,of,the,respiratory,insufficiency,and,the,histopathology,,,when,compared,to,the,previous,examples,in,the,literature,,,suggest,that,cyclophosphamide,was,aetiologically,responsible,for,the,lung,disease,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Fatal agranulocytosis | |
| drug,dapsone | |
| sequence,Fatal,agranulocytosis,in,an,Indian,male,receiving,100mg,of,dapsone,daily,,,hospitalized,for,mid-borderline,leprosy,in,type,I,reaction,with,triple,nerve,paralysis,is,reported,. | |
| labels,5,7,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,IDDM | |
| drug,IFN | |
| sequence,During,and,after,IFN,therapy,we,should,consider,the,possibility,of,occurrence,of,IDDM,as,well,as,other,autoimmune,diseases,and,observe,the,clinical,course,carefully,. | |
| labels,0,0,0,4,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anaphylactoid reactions | |
| drug,cisplatin | |
| sequence,We,observed,5,reactions,in,3,patients,that,appear,to,be,related,to,a,high,dose-infusion,time,ratio,,,indicating,that,dose,and,rate,of,infusion,may,be,important,factors,in,precipitating,anaphylactoid,reactions,with,cisplatin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,4,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,angle-closure glaucoma | |
| drug,mannitol | |
| sequence,Rapid,resolution,of,topiramate-induced,angle-closure,glaucoma,with,methylprednisolone,and,mannitol,. | |
| labels,0,0,0,4,5,7,0,4,0,4,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,angle-closure glaucoma | |
| drug,methylprednisolone | |
| sequence,Rapid,resolution,of,topiramate-induced,angle-closure,glaucoma,with,methylprednisolone,and,mannitol,. | |
| labels,0,0,0,4,5,7,0,4,0,4,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,angle-closure glaucoma | |
| drug,topiramate | |
| sequence,Rapid,resolution,of,topiramate-induced,angle-closure,glaucoma,with,methylprednisolone,and,mannitol,. | |
| labels,0,0,0,4,5,7,0,4,0,4,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anaphylactoid reactions | |
| drug,cisplatin | |
| sequence,CONCLUSIONS,:,We,conclude,that,a,high,dose,combined,with,a,short,infusion,time,increases,the,risk,of,anaphylactoid,reactions,with,the,administration,of,intraperitoneal,cisplatin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity | |
| drug,sulfadiazine | |
| sequence,Severe,sulfadiazine,hypersensitivity,in,a,child,with,reactivated,congenital,toxoplasmic,chorioretinitis,. | |
| labels,0,4,8,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,haemorrhagic side-effects | |
| drug,warfarin | |
| sequence,BACKGROUND,:,The,risk,benefit,ratio,of,warfarin,therapy,changes,in,the,over,75s,,,when,haemorrhagic,side-effects,become,more,common,. | |
| labels,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,5,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,CDI | |
| drug,lithium | |
| sequence,We,report,a,patient,receiving,chronic,lithium,therapy,who,presented,with,a,transient,CDI,occurring,in,the,setting,of,underlying,chronic,NDI,. | |
| labels,0,0,0,0,0,0,4,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,intrahepatic bile stasis | |
| drug,octreotide | |
| sequence,Extra,caution,should,be,taken,in,using,octreotide,or,its,long-acting,analog,in,patients,otherwise,predisposed,to,intrahepatic,bile,stasis,. | |
| labels,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,died | |
| drug,prednisone | |
| sequence,These,cases,were,considered,unusual,in,light,of,the,short,delay,of,their,onset,after,initiation,of,immunosuppressive,therapy,and,their,fulminant,course,:,3,of,these,patients,died,of,PCP,occurring,during,the,first,month,of,treatment,with,prednisone,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Renal toxicities | |
| drug,ciprofloxacin | |
| sequence,Renal,toxicities,have,been,reported,in,less,than,one,percent,of,the,patients,receiving,ciprofloxacin,therapy,. | |
| labels,5,7,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,coma | |
| drug,Valproic acid | |
| sequence,Valproic,acid,induced,coma,is,presented,in,an,adult,patient,without,a,history,of,metabolic,disease,. | |
| labels,1,3,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nodules | |
| drug,methotrexate | |
| sequence,The,nodules,regressed,after,withdrawal,of,methotrexate,therapy,in,one,patient,and,were,arrested,with,the,addition,of,hydroxychloroquine,in,the,other,. | |
| labels,0,8,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bradycardia | |
| drug,Clonidine | |
| sequence,Clonidine-induced,bradycardia,in,patients,with,spinal,cord,injury,. | |
| labels,4,8,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anaphylactic reactions | |
| drug,MTX | |
| sequence,For,patients,who,suffer,from,osteogenic,sarcoma,and,have,anaphylactic,reactions,to,MTX,,,this,desensitization,protocol,will,allow,these,patients,to,continue,with,needed,therapeutic,or,palliative,chemotherapy,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hemolytic anemia,hepatitis,orthostatic hypotension,aseptic meningitis | |
| drug,sulfamethoxazole | |
| sequence,CONCLUSION,:,A,37-year-old,African-,American,man,with,G6PD,deficiency,developed,hemolytic,anemia,,,hepatitis,,,orthostatic,hypotension,,,and,aseptic,meningitis,simultaneously,after,using,trimethoprim-sulfamethoxazole,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,7,0,8,0,5,7,0,0,5,7,0,0,0,4,4 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0,1,1,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hemolytic anemia,hepatitis,orthostatic hypotension,aseptic meningitis | |
| drug,trimethoprim | |
| sequence,CONCLUSION,:,A,37-year-old,African-,American,man,with,G6PD,deficiency,developed,hemolytic,anemia,,,hepatitis,,,orthostatic,hypotension,,,and,aseptic,meningitis,simultaneously,after,using,trimethoprim-sulfamethoxazole,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,7,0,8,0,5,7,0,0,5,7,0,0,0,4,4 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0,1,1,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Itch,skin rash | |
| drug,fluoxetine | |
| sequence,Itch,and,skin,rash,from,chocolate,during,fluoxetine,and,sertraline,treatment,:,case,report,. | |
| labels,8,0,5,7,0,0,0,4,0,4,0,0,0,0,0 | |
| ade_mask,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Itch,skin rash | |
| drug,sertraline | |
| sequence,Itch,and,skin,rash,from,chocolate,during,fluoxetine,and,sertraline,treatment,:,case,report,. | |
| labels,8,0,5,7,0,0,0,4,0,4,0,0,0,0,0 | |
| ade_mask,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Transient asymptomatic bradycardia | |
| drug,5-fluorouracil | |
| sequence,Transient,asymptomatic,bradycardia,in,patients,on,infusional,5-fluorouracil,. | |
| labels,5,6,7,0,0,0,0,4,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,obsessive-compulsive symptoms | |
| drug,risperidone | |
| sequence,CASES,:,``,A,'',was,an,8-year-old,boy,with,attention,deficit,and,chronic,tic,disorder,who,developed,obsessive-compulsive,symptoms,within,2,weeks,of,starting,risperidone,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,erythroderma | |
| drug,dapsone | |
| sequence,A,35-year-old,female,with,borderline,lepromatous,(,BL,),leprosy,who,suffered,from,dapsone-induced,erythroderma,is,reported,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,multiple congenital anomalies,embryopathy | |
| drug,CP | |
| sequence,The,purpose,of,this,report,is,to,document,a,new,case,of,in,utero,CP,exposure,with,multiple,congenital,anomalies,and,to,establish,an,apparent,CP,embryopathy,phenotype,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,5,6,7,0,0,0,0,0,0,8,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,1,0,0 | |
| ==============================, ============================= | |
| ade,symptomatic cardiac failure | |
| drug,doxorubicin | |
| sequence,There,is,a,dose-effect,relationship,between,doxorubicin,and,the,incidence,of,symptomatic,cardiac,failure,. | |
| labels,0,0,0,0,0,0,4,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,acceleration of the heart rate,arrhythmia | |
| drug,adenosine | |
| sequence,A,12,year,old,patient,with,atrial,flutter,is,presented,,,in,whom,intravenous,adenosine,was,followed,by,acceleration,of,the,heart,rate,to,a,potentially,dangerous,arrhythmia,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,5,6,6,6,7,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Serotonin syndrome | |
| drug,citalopram | |
| sequence,Serotonin,syndrome,caused,by,interaction,between,citalopram,and,fentanyl,. | |
| labels,5,7,0,0,0,0,4,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Serotonin syndrome | |
| drug,fentanyl | |
| sequence,Serotonin,syndrome,caused,by,interaction,between,citalopram,and,fentanyl,. | |
| labels,5,7,0,0,0,0,4,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,optic neuropathy | |
| drug,ethambutol | |
| sequence,The,most,commonly,recognized,toxic,effect,of,ethambutol,is,optic,neuropathy,,,which,generally,is,considered,uncommon,and,reversible,in,medical,literature,. | |
| labels,0,0,0,0,0,0,0,4,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,increase affect | |
| drug,risperidone | |
| sequence,The,authors,suggest,that,risperidone,may,increase,affect,in,patients,with,schizophrenia,and,that,some,patients,,,especially,those,with,anxiety,,,may,have,difficulty,managing,the,increase,. | |
| labels,0,0,0,0,4,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Adult respiratory distress syndrome | |
| drug,pegylated interferon alpha-2a | |
| sequence,Adult,respiratory,distress,syndrome,after,treatment,with,pegylated,interferon,alpha-2a,and,ribavirin,. | |
| labels,5,6,6,7,0,0,0,1,2,3,0,4,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Adult respiratory distress syndrome | |
| drug,ribavirin | |
| sequence,Adult,respiratory,distress,syndrome,after,treatment,with,pegylated,interferon,alpha-2a,and,ribavirin,. | |
| labels,5,6,6,7,0,0,0,1,2,3,0,4,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,noncardiogenic pulmonary edema | |
| drug,EO | |
| sequence,However,,,EO-induced,noncardiogenic,pulmonary,edema,has,not,been,reported,in,human,. | |
| labels,0,0,4,5,6,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyponatremia | |
| drug,Carbamazepine | |
| sequence,Carbamazepine-related,hyponatremia,following,cardiopulmonary,bypass,. | |
| labels,4,8,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fat embolism | |
| drug,Intralipid | |
| sequence,Four,cases,of,fat,embolism,are,described,in,infants,receiving,prolonged,intravenous,infusion,of,fat,(,Intralipid,20,%,),. | |
| labels,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Myelodysplasia,acute myeloid leukemia | |
| drug,2-deoxycoformycin | |
| sequence,Myelodysplasia,terminating,in,acute,myeloid,leukemia,in,a,hairy,cell,leukemia,patient,treated,with,2-deoxycoformycin,. | |
| labels,8,0,0,5,6,7,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,1,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,colitis,pseudomembranous colitis | |
| drug,sulfamethoxazole | |
| sequence,Antibiotic-associated,colitis,(,pseudomembranous,colitis,),developed,in,four,patients,with,spinal,cord,injury,and,taking,oral,trimethoprim-sulfamethoxazole,. | |
| labels,0,8,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,4,4 | |
| ade_mask,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,colitis,pseudomembranous colitis | |
| drug,trimethoprim | |
| sequence,Antibiotic-associated,colitis,(,pseudomembranous,colitis,),developed,in,four,patients,with,spinal,cord,injury,and,taking,oral,trimethoprim-sulfamethoxazole,. | |
| labels,0,8,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,4,4 | |
| ade_mask,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Bronchiolitis obliterans organising pneumonia | |
| drug,nitrofurantoin | |
| sequence,Bronchiolitis,obliterans,organising,pneumonia,associated,with,the,use,of,nitrofurantoin,. | |
| labels,5,6,6,7,0,0,0,0,0,4,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,venous thromboembolism | |
| drug,heparin | |
| sequence,Despite,these,antithrombotic,effects,,,the,patient,developed,repeated,venous,thromboembolism,during,treatment,with,low-molecular-weight,heparin,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,seizures | |
| drug,cilastatin | |
| sequence,Incidence,of,seizures,in,pediatric,cancer,patients,treated,with,imipenem,cilastatin,. | |
| labels,0,0,8,0,0,0,0,0,0,4,4,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,seizures | |
| drug,imipenem | |
| sequence,Incidence,of,seizures,in,pediatric,cancer,patients,treated,with,imipenem,cilastatin,. | |
| labels,0,0,8,0,0,0,0,0,0,4,4,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,death | |
| drug,fluoxetine | |
| sequence,This,is,the,first,report,of,a,fluoxetine-related,death,in,a,child,with,a,confirmed,genetic,polymorphism,of,the,CYP2D6,gene,that,results,in,impaired,drug,metabolism,. | |
| labels,0,0,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Prenatal cytomegalovirus (CMV) infection,brain damage | |
| drug,azathioprine | |
| sequence,Prenatal,cytomegalovirus,(,CMV,),infection,associated,with,severe,brain,damage,was,detected,in,an,infant,whose,mother,had,been,treated,with,prednisolone,and,azathioprine,for,systemic,lupus,erythematosus,(,SLE,),. | |
| labels,5,6,6,6,6,7,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Prenatal cytomegalovirus (CMV) infection,brain damage | |
| drug,prednisolone | |
| sequence,Prenatal,cytomegalovirus,(,CMV,),infection,associated,with,severe,brain,damage,was,detected,in,an,infant,whose,mother,had,been,treated,with,prednisolone,and,azathioprine,for,systemic,lupus,erythematosus,(,SLE,),. | |
| labels,5,6,6,6,6,7,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pulmonary toxicity,pulmonary nodules | |
| drug,fludarabine | |
| sequence,This,case,extends,the,spectrum,of,fludarabine,pulmonary,toxicity,to,include,pulmonary,nodules,. | |
| labels,0,0,0,0,0,0,4,5,7,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,interstitial lung disease | |
| drug,sorafenib | |
| sequence,Oncologists,supervising,future,clinical,trials,for,lung,cancer,should,be,alert,to,the,fact,that,sorafenib,can,potentially,induce,serious,interstitial,lung,disease,,,although,this,might,depend,on,racial,differences,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,syringotropic hypersensitivity reaction | |
| drug,infliximab | |
| sequence,A,17-year-old,boy,with,refractory,psoriatic,arthritis,and,alpha-1,antitrypsin,deficiency,who,developed,a,syringotropic,hypersensitivity,reaction,after,9,months,of,therapy,with,infliximab,and,leflunomide,is,described,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,4,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,syringotropic hypersensitivity reaction | |
| drug,leflunomide | |
| sequence,A,17-year-old,boy,with,refractory,psoriatic,arthritis,and,alpha-1,antitrypsin,deficiency,who,developed,a,syringotropic,hypersensitivity,reaction,after,9,months,of,therapy,with,infliximab,and,leflunomide,is,described,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,4,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,osteomalacia | |
| drug,Acetazolamide | |
| sequence,Acetazolamide-accelerated,anticonvulsant,osteomalacia,. | |
| labels,4,0,8,0 | |
| ade_mask,0,0,1,0 | |
| ==============================, ============================= | |
| ade,myoclonus | |
| drug,dobutamine | |
| sequence,PURPOSE,:,The,occurrence,of,myoclonus,associated,with,continuous,i.v,.,infusion,of,dobutamine,in,a,patient,with,end-stage,renal,disease,(,ESRD,),is,described,. | |
| labels,0,0,0,0,0,8,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis | |
| drug,Sertraline | |
| sequence,Sertraline-induced,rhabdomyolysis,in,an,elderly,patient,with,dementia,and,comorbidities,. | |
| labels,4,8,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anaphylactoid reaction | |
| drug,amifostine | |
| sequence,Life-threatening,anaphylactoid,reaction,to,amifostine,used,with,concurrent,chemoradiotherapy,for,nasopharyngeal,cancer,in,a,patient,with,dermatomyositis,:,a,case,report,with,literature,review,. | |
| labels,0,5,7,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,refractory seizures | |
| drug,INH | |
| sequence,Parenteral,pyridoxine,,,the,specific,antidote,for,INH-induced,refractory,seizures,,,should,be,readily,available,in,every,emergency,department,in,the,areas,similarly,experiencing,increasing,trends,of,TB,. | |
| labels,0,0,0,0,0,0,0,4,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,priapism | |
| drug,zuclopenthixol | |
| sequence,The,capacity,of,zuclopenthixol,to,induce,priapism,is,thought,to,be,due,to,its,antagonist,activity,on,alpha-adrenergic,receptors,. | |
| labels,0,0,0,4,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,theophylline intoxication,decrease in theophylline clearance | |
| drug,viloxazine | |
| sequence,A,case,is,reported,of,theophylline,intoxication,due,to,a,dramatic,decrease,in,theophylline,clearance,following,concomitant,administration,of,viloxazine,. | |
| labels,0,0,0,0,0,9,7,0,0,0,0,5,6,6,7,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,1,1,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,theophylline intoxication | |
| drug,theophylline | |
| sequence,A,case,is,reported,of,theophylline,intoxication,due,to,a,dramatic,decrease,in,theophylline,clearance,following,concomitant,administration,of,viloxazine,. | |
| labels,0,0,0,0,0,9,7,0,0,0,0,5,6,6,7,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,CD8+ cutaneous lymphoproliferative disorders | |
| drug,efalizumab | |
| sequence,Herein,,,we,describe,2,patients,who,developed,unusual,CD8+,cutaneous,lymphoproliferative,disorders,after,treatment,with,efalizumab,and,infliximab,. | |
| labels,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,CD8+ cutaneous lymphoproliferative disorders | |
| drug,infliximab | |
| sequence,Herein,,,we,describe,2,patients,who,developed,unusual,CD8+,cutaneous,lymphoproliferative,disorders,after,treatment,with,efalizumab,and,infliximab,. | |
| labels,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,dermatologic toxicities | |
| drug,5-FU | |
| sequence,Exacerbation,of,5-FU,dermatologic,toxicities,in,patients,with,preexisting,conditions,suggests,the,importance,of,aggressive,ocular,prophylaxis,,,using,frequent,ocular,lubrication,and,topical,steroid,preparations,with,concurrent,medical,management,of,pre-existing,dermatologic,conditions,. | |
| labels,0,0,4,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,catatonia syndrome | |
| drug,disulfiram | |
| sequence,The,authors,describe,a,case,of,the,catatonia,syndrome,associated,with,disulfiram,therapy,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myelosuppression | |
| drug,azathioprine | |
| sequence,Thiopurine,methyltransferase,deficiency,occurs,at,a,frequency,of,one,in,300,and,is,associated,with,profound,myelosuppression,after,a,short,course,of,azathioprine,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatic enzyme disturbances,hepatitis | |
| drug,pegvisomant | |
| sequence,After,rechallenge,with,monotherapy,pegvisomant,,,however,,,the,hepatic,enzyme,disturbances,reappeared,within,a,few,weeks,,,indicating,that,most,likely,pegvisomant,alone,and,not,the,long-acting,somatostatin,analog,or,the,combination,of,these,two,drugs,was,responsible,for,this,case,of,drug-induced,hepatitis,. | |
| labels,0,0,0,0,4,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Granulocytopenia,agranulocytosis | |
| drug,clozapine | |
| sequence,Granulocytopenia,and,agranulocytosis,are,considered,among,the,most,dangerous,adverse,effects,of,clozapine,. | |
| labels,8,0,8,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,1,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,decrease in heart rate,paroxsymal increase in blood pressure | |
| drug,propranolol | |
| sequence,IV,propranolol,was,used,as,the,initial,treatment,for,his,hyperadrenergic,state,,,resulting,in,a,decrease,in,heart,rate,but,a,paroxsymal,increase,in,blood,pressure,. | |
| labels,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,5,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,1,0,0,1,1,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Anaphylactoid reaction | |
| drug,methylprednisolone | |
| sequence,Anaphylactoid,reaction,to,methylprednisolone,pulsed,therapy,for,multiple,sclerosis,. | |
| labels,5,7,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Digestive hemorrhage | |
| drug,metformin | |
| sequence,Digestive,hemorrhage,caused,by,a,Meckel,'s,diverticulum,in,a,metformin-treated,patient,:,is,there,any,connection,? | |
| labels,5,7,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fatigue,fever | |
| drug,cyanamide | |
| sequence,Case,3,:,A,29-year-old,female,alcoholic,complained,of,general,fatigue,and,a,slight,fever,after,1.5,years,of,abstinence,with,cyanamide,treatment,. | |
| labels,0,0,0,0,0,0,0,0,0,0,8,0,0,0,8,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bone marrow toxicity | |
| drug,MMF | |
| sequence,The,side,effects,of,MMF,,,such,as,bone,marrow,toxicity,,,have,been,reported,. | |
| labels,0,0,0,0,4,0,0,0,5,6,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,RTA,nephrotoxicity | |
| drug,FK506 | |
| sequence,RTA,is,one,type,of,nephrotoxicity,induced,by,FK506,,,and,it,is,reversible,in,mild,cases,when,appropriately,treated,. | |
| labels,8,0,0,0,0,8,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,serotonin syndrome | |
| drug,mirtazapine | |
| sequence,Severe,serotonin,syndrome,induced,by,mirtazapine,monotherapy,. | |
| labels,0,5,7,0,0,4,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,confusion,agitation,fever,diaphoresis,tachypnea,tachycardia,hypertension | |
| drug,metoclopramide | |
| sequence,After,a,second,dose,of,metoclopramide,,,these,symptoms,recurred,and,were,associated,with,confusion,,,agitation,,,fever,,,diaphoresis,,,tachypnea,,,tachycardia,,,and,hypertension,. | |
| labels,0,0,0,0,0,4,0,0,0,0,0,0,0,0,8,0,8,0,8,0,8,0,8,0,8,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,0,1,0,1,0,1,0,0,1,0 | |
| ==============================, ============================= | |
| ade,cardiac arrest | |
| drug,Amphotericin B | |
| sequence,Amphotericin,B,overdose,in,pediatric,patients,with,associated,cardiac,arrest,. | |
| labels,1,3,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,lead toxicity | |
| drug,lead | |
| sequence,Poorly,controlled,hypertension,in,a,painter,with,chronic,lead,toxicity,. | |
| labels,0,0,0,0,0,0,0,0,9,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Tardive oculogyric crisis | |
| drug,clozapine | |
| sequence,Tardive,oculogyric,crisis,during,treatment,with,clozapine,:,report,of,three,cases,. | |
| labels,5,6,7,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,macular lesion | |
| drug,gentamicin | |
| sequence,We,are,concerned,that,the,macular,lesion,was,a,retinal,toxic,effect,of,gentamicin,because,of,the,recent,description,of,similar,lesions,occurring,after,the,inadvertent,intraocular,injection,of,massive,doses,of,this,drug,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,death | |
| drug,Ambien | |
| sequence,Zolpidem,tissue,concentrations,in,a,multiple,drug,related,death,involving,Ambien,. | |
| labels,4,0,0,0,0,0,0,0,8,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,death | |
| drug,Zolpidem | |
| sequence,Zolpidem,tissue,concentrations,in,a,multiple,drug,related,death,involving,Ambien,. | |
| labels,4,0,0,0,0,0,0,0,8,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,pancreatitis | |
| drug,propofol | |
| sequence,Can,propofol,precipitate,pancreatitis,in,patients,with,Cushing,'s,syndrome,? | |
| labels,0,4,0,8,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute renal failure | |
| drug,gentamicin sulfate | |
| sequence,Five,patients,are,described,in,whom,only,gentamicin,sulfate,appeared,responsible,for,acute,renal,failure,. | |
| labels,0,0,0,0,0,0,0,1,3,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,respiratory dysfunction,abnormal chest x-ray with diffuse interstitial opacities | |
| drug,piritrexim | |
| sequence,We,describe,a,patient,with,transitional,cell,carcinoma,of,the,renal,pelvis,who,developed,respiratory,dysfunction,and,an,abnormal,chest,x-ray,with,diffuse,interstitial,opacities,while,on,chemotherapy,with,piritrexim,,,a,methotrexate,analog,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,5,6,6,6,6,6,7,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,1,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Fatal interstitial lung disease | |
| drug,erlotinib | |
| sequence,Fatal,interstitial,lung,disease,after,erlotinib,administration,in,a,patient,with,radiation,fibrosis,. | |
| labels,5,6,6,7,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,trichiasis | |
| drug,prostaglandin | |
| sequence,A,patient,with,monocular,open-angle,glaucoma,had,trichiasis,,,a,condition,associated,with,the,use,of,a,prostaglandin,analog,. | |
| labels,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Allergic contact dermatitis | |
| drug,benzoin | |
| sequence,Allergic,contact,dermatitis,to,compound,tincture,of,benzoin,. | |
| labels,5,6,7,0,0,0,0,4,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Myoclonic spasms | |
| drug,morphine | |
| sequence,Myoclonic,spasms,following,intrathecal,morphine,. | |
| labels,5,7,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,BMTN | |
| drug,Cis-retinoic acid | |
| sequence,Cis-retinoic,acid,(,RA,),may,further,increase,the,risk,of,developing,BMTN,. | |
| labels,1,3,0,4,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,BMTN | |
| drug,RA | |
| sequence,Cis-retinoic,acid,(,RA,),may,further,increase,the,risk,of,developing,BMTN,. | |
| labels,1,3,0,4,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,LABD | |
| drug,gemcitabine | |
| sequence,CONCLUSIONS,:,We,report,the,first,case,of,gemcitabine-induced,LABD,. | |
| labels,0,0,0,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Pulmonary edema | |
| drug,ritodrine | |
| sequence,Pulmonary,edema,occurred,24,hours,after,intravenous,ritodrine,therapy,and,10,hours,after,subcutaneous,terbutaline,therapy,. | |
| labels,5,7,0,0,0,0,0,4,0,0,0,0,0,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Pulmonary edema | |
| drug,terbutaline | |
| sequence,Pulmonary,edema,occurred,24,hours,after,intravenous,ritodrine,therapy,and,10,hours,after,subcutaneous,terbutaline,therapy,. | |
| labels,5,7,0,0,0,0,0,4,0,0,0,0,0,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute interstitial nephritis | |
| drug,sunitinib | |
| sequence,Biopsy-proven,acute,interstitial,nephritis,associated,with,the,tyrosine,kinase,inhibitor,sunitinib,:,a,class,effect,? | |
| labels,0,5,6,7,0,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,diffuse erythema,pustules,malaise,fever up to 39 degrees C | |
| drug,salazosulfapyridine | |
| sequence,A,26-year-old,Japanese,man,,,who,had,been,receiving,medical,attention,for,ulcerative,colitis,for,one,year,,,presented,with,diffuse,erythema,and,pustules,on,his,face,and,trunk,,,malaise,,,and,fever,up,to,39,degrees,C,one,day,after,the,administration,of,salazosulfapyridine,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,8,0,0,0,0,0,0,8,0,0,5,6,6,6,6,7,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0,0,0,0,0,0,1,0,0,1,1,1,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Skin necrosis | |
| drug,heparin | |
| sequence,Skin,necrosis,is,a,rare,complication,of,subcutaneous,heparin,therapy,that,usually,occurs,at,injection,sites,. | |
| labels,5,7,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acral vascular toxicity | |
| drug,bleomycin | |
| sequence,This,supports,the,well-reported,potential,of,bleomycin,to,trigger,acral,vascular,toxicity,. | |
| labels,0,0,0,0,0,0,4,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity | |
| drug,carboplatin | |
| sequence,Administration,of,cisplatin,in,three,patients,with,carboplatin,hypersensitivity,:,is,skin,testing,useful,? | |
| labels,0,0,0,0,0,0,0,4,8,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,weight loss | |
| drug,leflunomide | |
| sequence,METHODS,:,We,queried,35,rheumatologists,at,the,Robert,Breck,Brigham,Arthritis,Center,to,determine,if,weight,loss,had,occurred,as,an,adverse,event,in,patients,treated,with,leflunomide,between,November,1998,and,January,2000,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Anticonvulsant hypersensitivity syndrome | |
| drug,Bellamine S | |
| sequence,Anticonvulsant,hypersensitivity,syndrome,associated,with,Bellamine,S,,,a,therapy,for,menopausal,symptoms,. | |
| labels,5,6,7,0,0,1,3,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Pneumonitis | |
| drug,MTX | |
| sequence,Pneumonitis,is,emerging,as,one,of,the,most,unpredictable,and,potentially,serious,,,adverse,effects,of,treatment,with,MTX,. | |
| labels,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fatal stroke,arterial spasm | |
| drug,ergotamine | |
| sequence,It,is,suggested,that,the,fatal,stroke,may,have,resulted,from,arterial,spasm,caused,by,ergotamine,overdosage,and,possibly,complicated,by,thrombosis,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,5,7,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,central diabetes insipidus,CDI | |
| drug,lithium | |
| sequence,The,association,of,central,diabetes,insipidus,(,CDI,),with,lithium,use,is,rare,. | |
| labels,0,0,0,5,6,7,0,8,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,1,1,1,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,angioedema | |
| drug,Losartan | |
| sequence,Losartan-induced,angioedema,. | |
| labels,4,8,0 | |
| ade_mask,0,1,0 | |
| ==============================, ============================= | |
| ade,Nephrotic syndrome | |
| drug,interferon-beta-1b | |
| sequence,Nephrotic,syndrome,associated,with,interferon-beta-1b,therapy,for,multiple,sclerosis,. | |
| labels,5,7,0,0,4,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,transient hypomanic symptoms | |
| drug,Trazodone | |
| sequence,Trazodone-induced,transient,hypomanic,symptoms,and,their,management,. | |
| labels,4,5,6,7,0,0,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,agranulocytosis | |
| drug,methimazole | |
| sequence,The,patient,was,given,methimazole,instead,of,propylthiouracil,but,,,10,weeks,later,,,agranulocytosis,again,occurred,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,8,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis | |
| drug,sertraline | |
| sequence,CONCLUSIONS,:,This,patient,'s,rhabdomyolysis,was,probably,induced,by,sertraline,therapy,. | |
| labels,0,0,0,0,0,8,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,benzodiazepine withdrawal symptoms | |
| drug,nefazodone | |
| sequence,A,case,is,presented,of,a,patient,who,experienced,benzodiazepine,withdrawal,symptoms,on,discontinuation,of,nefazodone,,,an,antidepressant,that,inhibits,the,cytochrome,P450,3A4,isoenzyme,. | |
| labels,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Pseudomembranous colitis | |
| drug,sulfamethoxazole | |
| sequence,Pseudomembranous,colitis,readily,occurs,in,at,least,certain,population,groups,receiving,trimethoprim-sulfamethoxazole,. | |
| labels,5,7,0,0,0,0,0,0,0,0,0,4,4 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Pseudomembranous colitis | |
| drug,trimethoprim | |
| sequence,Pseudomembranous,colitis,readily,occurs,in,at,least,certain,population,groups,receiving,trimethoprim-sulfamethoxazole,. | |
| labels,5,7,0,0,0,0,0,0,0,0,0,4,4 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,paradoxical ocular effect | |
| drug,brimonidine | |
| sequence,A,paradoxical,ocular,effect,of,brimonidine,. | |
| labels,0,5,6,7,0,4,0 | |
| ade_mask,0,1,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,cholestatic liver injury | |
| drug,Methimazole | |
| sequence,Methimazole-associated,cholestatic,liver,injury,:,case,report,and,brief,literature,review,. | |
| labels,4,5,6,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute-onset delirium with psychotic features | |
| drug,levofloxacin | |
| sequence,RESULTS,:,A,previously,healthy,42-year-old,woman,presented,with,acute-onset,delirium,with,psychotic,features,as,a,consequence,of,levofloxacin,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,5,6,6,6,7,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,TEN | |
| drug,phenolphthalein | |
| sequence,Clinicians,should,include,phenolphthalein,in,their,list,of,possible,causes,of,drug-induced,TEN,. | |
| labels,0,0,0,4,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Cerebral edema | |
| drug,Gliadel | |
| sequence,Cerebral,edema,associated,with,Gliadel,wafers,:,two,case,studies,. | |
| labels,5,7,0,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Toxicity | |
| drug,chloroquine | |
| sequence,Toxicity,related,to,chloroquine,treatment,of,resistant,vivax,malaria,. | |
| labels,8,0,0,4,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anisocoria | |
| drug,scopolamine | |
| sequence,After,extensive,neurological,work,up,,,we,realized,that,the,anisocoria,was,related,to,the,transdermal,scopolamine,patch,that,we,had,prescribed,for,weaning,off,the,opioid,. | |
| labels,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,harlequin color change | |
| drug,prostaglandin E1 | |
| sequence,The,harlequin,color,change,and,association,with,prostaglandin,E1,. | |
| labels,0,5,6,7,0,0,0,1,3,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sore throat,fever | |
| drug,carbimazole | |
| sequence,A,72-year-old,woman,with,a,history,of,thyrotoxicosis,presented,with,sore,throat,and,fever,two,weeks,after,starting,carbimazole,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,8,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Peripheral nerve dysfunction | |
| drug,cytosine arabinoside | |
| sequence,Peripheral,nerve,dysfunction,is,a,potentially,serious,complication,of,high-dose,cytosine,arabinoside,. | |
| labels,5,6,7,0,0,0,0,0,0,0,1,3,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Progressive interstitial fibrosis | |
| drug,methotrexate | |
| sequence,Progressive,interstitial,fibrosis,with,roentgenographic,honeycombing,developed,in,the,case,of,a,psoriatic,patient,who,had,been,on,a,regimen,of,methotrexate,for,18,years,. | |
| labels,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombotic microangiopathy | |
| drug,quinine | |
| sequence,We,recommend,that,a,TMA,in,association,with,quinine,be,consistently,referred,to,as,quinine-associated,thrombotic,microangiopathy,(,quinine-TMA,),to,better,distinguish,this,entity,from,idiopathic,TTP,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,toxin-positive Clostridium difficile-induced colitis | |
| drug,clindamycin phosphate | |
| sequence,OBJECTIVE,:,To,report,a,case,of,toxin-positive,Clostridium,difficile-induced,colitis,(,CDIC,),after,use,of,clindamycin,phosphate,vaginal,cream,. | |
| labels,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,0,1,3,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lactate elevation | |
| drug,metronidazole | |
| sequence,Proton,MRS,examination,demonstrated,a,persistent,lactate,elevation,during,metronidazole,treatment,. | |
| labels,0,0,0,0,0,0,5,7,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperglycaemic coma,neuroleptic malignant syndrome | |
| drug,Olanzapine | |
| sequence,Olanzapine-induced,hyperglycaemic,coma,and,neuroleptic,malignant,syndrome,:,case,report,and,review,of,literature,. | |
| labels,4,5,7,0,5,6,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ductopenia | |
| drug,clindamycin | |
| sequence,This,is,the,first,description,,,to,our,knowledge,,,of,ductopenia,apparently,caused,by,clindamycin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,increase in the number of apneic events,SaO2 dips | |
| drug,infliximab | |
| sequence,After,infliximab,treatment,,,additional,sleep,studies,revealed,an,increase,in,the,number,of,apneic,events,and,SaO2,dips,suggesting,that,TNFalpha,plays,an,important,role,in,the,pathophysiology,of,sleep,apnea,. | |
| labels,0,4,0,0,0,0,0,0,0,5,6,6,6,6,6,7,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,1,1,1,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,TTP HUS | |
| drug,quinine | |
| sequence,A,previous,study,of,patients,with,``,quinine-associated,TTP,HUS,'',found,that,ADAMTS13,activities,were,not,abnormal,in,12,12,patients,. | |
| labels,0,0,0,0,0,0,0,4,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,gastro-oesophageal reflux | |
| drug,Nifedipine | |
| sequence,Nifedipine,may,induce,,,or,aggravate,,,pre-existing,,,gastro-oesophageal,reflux,. | |
| labels,4,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Kaposi's sarcoma | |
| drug,imatinib mesylate | |
| sequence,Kaposi,'s,sarcoma,in,a,patient,treated,with,imatinib,mesylate,for,chronic,myeloid,leukemia,. | |
| labels,5,6,7,0,0,0,0,0,1,3,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nonconvulsive status epilepticus | |
| drug,morphine | |
| sequence,A,77-year-old,woman,with,no,history,of,epilepsy,presented,a,probable,nonconvulsive,status,epilepticus,while,receiving,continuous,intravenous,morphine,for,back,pain,relating,to,vertebral,metastasis,of,a,malignant,lymphoma,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,diabetes | |
| drug,danazol | |
| sequence,After,discontinuation,of,danazol,the,diabetes,completely,resolved,. | |
| labels,0,0,0,4,0,8,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,Serious adverse events | |
| drug,spironolactone | |
| sequence,Serious,adverse,events,experienced,by,patients,with,chronic,heart,failure,taking,spironolactone,. | |
| labels,5,6,7,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,glaucoma | |
| drug,5-fluorouracil | |
| sequence,We,report,a,case,of,secondary,glaucoma,caused,by,epithelial,downgrowth,in,which,filtration,surgery,was,performed,with,adjunctive,use,of,subconjunctival,5-fluorouracil,. | |
| labels,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,tics | |
| drug,Carbamazepine | |
| sequence,Carbamazepine-induced,tics,. | |
| labels,4,8,0 | |
| ade_mask,0,1,0 | |
| ==============================, ============================= | |
| ade,hyperthyroidism | |
| drug,Interferon-alpha | |
| sequence,Interferon-alpha-induced,hyperthyroidism,:,a,three-stage,evolution,from,silent,thyroiditis,towards,Graves,disease,. | |
| labels,4,8,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thyrotoxicosis | |
| drug,Amiodarone | |
| sequence,Amiodarone,was,discontinued,,,and,thyrotoxicosis,gradually,abated,. | |
| labels,4,0,0,0,0,8,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,multiple abscesses | |
| drug,CHOP | |
| sequence,Three,months,following,splenectomy,,,multiple,abscesses,occurred,in,the,muscles,of,both,thighs,while,the,patient,was,receiving,the,third,course,of,the,CHOP,regimen,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Rhabdomyolysis | |
| drug,vasopressin | |
| sequence,Rhabdomyolysis,associated,with,the,use,of,intravenous,vasopressin,. | |
| labels,8,0,0,0,0,0,0,4,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neurotoxicity | |
| drug,methotrexate | |
| sequence,Clinicians,should,be,aware,of,the,signs,and,symptoms,of,neurotoxicity,during,treatment,,,as,well,as,predisposing,factors,that,put,patients,receiving,methotrexate,at,risk,for,neurotoxic,effects,. | |
| labels,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bradycardia | |
| drug,dexmedetomidine | |
| sequence,We,report,on,three,cases,wherein,treatment,of,dexmedetomidine-induced,bradycardia,with,i.v,.,glycopyrrolate,(,5.0,microg,kg,),not,only,resulting,in,resolution,of,bradycardia,but,also,resulting,in,an,exaggerated,increase,of,arterial,blood,pressure,. | |
| labels,0,0,0,0,0,0,0,0,4,8,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,exaggerated increase of arterial blood pressure | |
| drug,glycopyrrolate | |
| sequence,We,report,on,three,cases,wherein,treatment,of,dexmedetomidine-induced,bradycardia,with,i.v,.,glycopyrrolate,(,5.0,microg,kg,),not,only,resulting,in,resolution,of,bradycardia,but,also,resulting,in,an,exaggerated,increase,of,arterial,blood,pressure,. | |
| labels,0,0,0,0,0,0,0,0,4,8,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,fatal rhabdomyolysis | |
| drug,vasopressin | |
| sequence,A,patient,with,acute,esophageal,variceal,bleeding,developed,fatal,rhabdomyolysis,during,treatment,with,a,continuous,intravenous,infusion,of,vasopressin,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,serositis | |
| drug,Methotrexate | |
| sequence,Methotrexate,may,rarely,provoke,serositis,,,even,with,low,doses,and,after,just,a,few,weeks,of,therapy,. | |
| labels,4,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,no motile sperm | |
| drug,carbamazepine | |
| sequence,The,patient,was,found,to,have,no,motile,sperm,with,a,normal,sperm,count,,,while,taking,a,dose,of,400,mg,day,of,carbamazepine,. | |
| labels,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myocardial infarction,coronary spasm | |
| drug,L-thyroxine | |
| sequence,We,believe,this,is,the,first,report,of,myocardial,infarction,due,to,coronary,spasm,,,demonstrated,by,angiography,associated,with,L-thyroxine,therapy,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,5,7,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neuropathy | |
| drug,Metronidazole | |
| sequence,Metronidazole,neuropathy,. | |
| labels,4,8,0 | |
| ade_mask,0,1,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity myocarditis | |
| drug,clozapine | |
| sequence,The,autopsy,findings,and,a,detailed,medical,history,supported,the,conclusion,that,clozapine-induced,hypersensitivity,myocarditis,was,the,most,likely,cause,of,death,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,5,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Schneiderian first-rank symptoms | |
| drug,fluvoxamine | |
| sequence,Schneiderian,first-rank,symptoms,associated,with,fluvoxamine,treatment,:,a,case,report,. | |
| labels,5,6,7,0,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ciliochoroidal effusion,displacement of the lens-iris diaphragm,anterior chamber shallowing,acute myopia,angle-closure glaucoma | |
| drug,Topiramate | |
| sequence,CONCLUSIONS,:,Topiramate,may,be,associated,with,ciliochoroidal,effusion,with,forward,displacement,of,the,lens-iris,diaphragm,and,anterior,chamber,shallowing,,,resulting,in,acute,myopia,and,angle-closure,glaucoma,. | |
| labels,0,0,4,0,0,0,0,5,7,0,0,5,6,6,6,7,0,5,6,7,0,0,0,5,7,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,1,1,1,1,1,0,1,1,1,0,0,0,1,1,0,1,1,0 | |
| ==============================, ============================= | |
| ade,symptomatic hyponatremia | |
| drug,mirtazapine | |
| sequence,Five,months,after,initiating,mirtazapine,therapy,,,she,developed,symptomatic,hyponatremia,. | |
| labels,0,0,0,0,4,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,pulmonary hypertension | |
| drug,lithium | |
| sequence,This,is,the,first,report,of,pulmonary,hypertension,in,an,adult,patient,during,lithium,therapy,. | |
| labels,0,0,0,0,0,0,5,7,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,renal insufficiency | |
| drug,Ciprofloxacin | |
| sequence,Ciprofloxacin-induced,renal,insufficiency,in,cystic,fibrosis,. | |
| labels,4,5,7,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,chemical cellulitis,ulceration | |
| drug,pentamidine | |
| sequence,This,is,a,report,of,a,renal,transplant,patient,with,Pneumocystis,pneumonia,who,developed,chemical,cellulitis,and,ulceration,following,the,extravasation,of,intravenous,pentamidine,into,the,soft,tissues,of,the,left,hand,and,forearm,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,8,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,osteomyelitis | |
| drug,Infliximab | |
| sequence,Infliximab,and,its,serious,adverse,effects,are,discussed,,,and,other,cases,of,osteomyelitis,with,infliximab,use,are,also,reviewed,. | |
| labels,4,0,0,0,0,0,0,0,0,0,0,0,0,8,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,osteomyelitis | |
| drug,infliximab | |
| sequence,Infliximab,and,its,serious,adverse,effects,are,discussed,,,and,other,cases,of,osteomyelitis,with,infliximab,use,are,also,reviewed,. | |
| labels,4,0,0,0,0,0,0,0,0,0,0,0,0,8,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Cutaneous mycobacterial infection | |
| drug,BCG | |
| sequence,Cutaneous,mycobacterial,infection,post,intravesical,BCG,installation,. | |
| labels,5,6,7,0,0,4,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis | |
| drug,clarithromycin | |
| sequence,We,report,the,first,case,of,rhabdomyolysis,related,to,the,administration,of,clarithromycin,without,concurrent,use,of,other,medications,. | |
| labels,0,0,0,0,0,0,8,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperproduction of TNF-alpha,dedifferentiation of the adipocytes | |
| drug,insulin | |
| sequence,CONCLUSIONS,:,In,our,reported,case,,,a,local,hyperproduction,of,TNF-alpha,from,macrophages,that,was,induced,by,the,injected,insulin,could,explain,the,dedifferentiation,of,the,adipocytes,of,the,subcutaneous,tissue,and,the,reversion,that,was,induced,by,the,local,injection,of,dexamethasone,. | |
| labels,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,4,0,0,0,5,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe hypoglycaemia | |
| drug,mefloquine | |
| sequence,Clinicians,who,manage,cachectic,patients,,,particularly,those,with,protracted,diarrhoea,and,or,receiving,anti-malarial,drugs,including,mefloquine,,,should,be,aware,of,the,risk,of,severe,hypoglycaemia,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,acute cardiomyopathy,pericarditis | |
| drug,methylphenidate | |
| sequence,However,,,acute,cardiomyopathy,and,pericarditis,secondary,to,methylphenidate,use,has,been,rarely,reported,. | |
| labels,0,0,5,7,0,8,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,renal toxicity | |
| drug,methotrexate | |
| sequence,Early,recognition,of,renal,toxicity,of,high-dose,methotrexate,therapy,:,a,case,report,. | |
| labels,0,0,0,5,7,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute hemorrhagic gastritis,AZ intoxication | |
| drug,AZ | |
| sequence,We,experienced,a,case,of,chronic,renal,failure,in,a,patient,suffering,from,acute,hemorrhagic,gastritis,associated,with,AZ,intoxication,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,9,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Atrial fibrillation | |
| drug,methylprednisolone | |
| sequence,Atrial,fibrillation,following,methylprednisolone,pulse,therapy,. | |
| labels,5,7,0,4,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ulcers | |
| drug,piroxicam | |
| sequence,In,this,case,,,discontinuing,piroxicam,,,a,nonsteroidal,anti-inflammatory,drug,,,and,starting,a,palliative,treatment,plan,helped,resolve,a,patient,'s,ulcers,. | |
| labels,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,dyskinesias | |
| drug,apomorphine | |
| sequence,In,two,patients,,,apomorphine,remained,effective,in,the,morning,,,but,increased,the,intensity,of,the,dyskinesias,in,the,afternoon,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,seizures | |
| drug,lorazepam | |
| sequence,A,10-year-old,girl,with,Lennox-Gastaut,syndrome,who,received,intravenous,lorazepam,for,atypical,absence,status,seizures,is,reported,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,0,0,8,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,increased pigmementation of skin | |
| drug,5-fluorouracil | |
| sequence,Markedly,increased,pigmementation,of,skin,immediately,overlying,veins,used,for,multiple,5-fluorouracil,infusions,was,noted,. | |
| labels,0,5,6,6,7,0,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Celiac disease | |
| drug,pegylated interferon | |
| sequence,Celiac,disease,onset,after,pegylated,interferon,and,ribavirin,treatment,of,chronic,hepatitis,C,. | |
| labels,5,7,0,0,1,3,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Celiac disease | |
| drug,ribavirin | |
| sequence,Celiac,disease,onset,after,pegylated,interferon,and,ribavirin,treatment,of,chronic,hepatitis,C,. | |
| labels,5,7,0,0,1,3,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,methemoglobinemia | |
| drug,bupivacaine | |
| sequence,We,report,a,patient,with,chronic,renal,failure,and,ischemic,heart,disease,who,developed,clinically,significant,methemoglobinemia,after,an,axillary,block,with,bupivacaine,and,additional,injection,of,lidocaine,in,the,operative,field,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,4,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,methemoglobinemia | |
| drug,lidocaine | |
| sequence,We,report,a,patient,with,chronic,renal,failure,and,ischemic,heart,disease,who,developed,clinically,significant,methemoglobinemia,after,an,axillary,block,with,bupivacaine,and,additional,injection,of,lidocaine,in,the,operative,field,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,4,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,asterixis,neurotoxicity | |
| drug,CBZ | |
| sequence,We,consider,asterixis,to,be,an,easily,overlooked,sign,of,neurotoxicity,,,which,may,occur,even,at,low,or,moderate,dosage,levels,,,if,certain,drugs,as,lithium,or,clozapine,are,used,in,combination,with,CBZ,. | |
| labels,0,0,8,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,4,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,asterixis,neurotoxicity | |
| drug,clozapine | |
| sequence,We,consider,asterixis,to,be,an,easily,overlooked,sign,of,neurotoxicity,,,which,may,occur,even,at,low,or,moderate,dosage,levels,,,if,certain,drugs,as,lithium,or,clozapine,are,used,in,combination,with,CBZ,. | |
| labels,0,0,8,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,4,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,asterixis,neurotoxicity | |
| drug,lithium | |
| sequence,We,consider,asterixis,to,be,an,easily,overlooked,sign,of,neurotoxicity,,,which,may,occur,even,at,low,or,moderate,dosage,levels,,,if,certain,drugs,as,lithium,or,clozapine,are,used,in,combination,with,CBZ,. | |
| labels,0,0,8,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,4,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Relapse in the external auditory canal of acute promyelocytic leukemia | |
| drug,all-trans retinoic acid | |
| sequence,Relapse,in,the,external,auditory,canal,of,acute,promyelocytic,leukemia,after,treatment,with,all-trans,retinoic,acid,. | |
| labels,5,6,6,6,6,6,6,6,6,7,0,0,0,1,2,3,0 | |
| ade_mask,1,1,1,1,1,1,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute renal failure | |
| drug,methotrexate | |
| sequence,High-dose,methotrexate-associated,acute,renal,failure,may,be,an,avoidable,complication,. | |
| labels,0,4,5,6,7,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ocular motor disturbances,neurotoxicity | |
| drug,5-FU | |
| sequence,The,ocular,motor,disturbances,are,probably,an,expression,of,regional,5-FU,neurotoxicity,primarily,affecting,the,brain,stem,. | |
| labels,0,5,6,7,0,0,0,0,0,0,4,8,0,0,0,0,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,spontaneous nasal septal perforation | |
| drug,bevacizumab | |
| sequence,This,case,describes,a,52-year-old,white,woman,who,developed,a,spontaneous,nasal,septal,perforation,after,given,the,antiangiogenic,drug,,,bevacizumab,,,for,metastatic,ovarian,cancer,treatment,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Secretory endometrial adenocarcinoma | |
| drug,tamoxifen | |
| sequence,Secretory,endometrial,adenocarcinoma,in,a,patient,on,tamoxifen,for,breast,cancer,:,a,report,of,a,case,. | |
| labels,5,6,7,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,increase in INR | |
| drug,5-FU | |
| sequence,However,,,prolongation,of,5-FU,half-life,and,an,increase,in,INR,have,been,reported,with,the,concurrent,use,of,5-FU,and,warfarin,. | |
| labels,0,0,0,0,4,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,increase in INR | |
| drug,warfarin | |
| sequence,However,,,prolongation,of,5-FU,half-life,and,an,increase,in,INR,have,been,reported,with,the,concurrent,use,of,5-FU,and,warfarin,. | |
| labels,0,0,0,0,4,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,portal vein thrombosis | |
| drug,F VIII | |
| sequence,We,report,on,a,14-year-old,boy,with,severe,haemophilia,A,who,developed,a,portal,vein,thrombosis,during,continuous,infusion,of,F,VIII,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,1,3,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fatality | |
| drug,brompheniramine | |
| sequence,The,case,history,and,toxicological,findings,of,an,infant,fatality,involving,pseudoephedrine,,,brompheniramine,,,and,dextromethorphan,are,presented,. | |
| labels,0,0,0,0,0,0,0,0,0,8,0,4,0,4,0,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fatality | |
| drug,dextromethorphan | |
| sequence,The,case,history,and,toxicological,findings,of,an,infant,fatality,involving,pseudoephedrine,,,brompheniramine,,,and,dextromethorphan,are,presented,. | |
| labels,0,0,0,0,0,0,0,0,0,8,0,4,0,4,0,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fatality | |
| drug,pseudoephedrine | |
| sequence,The,case,history,and,toxicological,findings,of,an,infant,fatality,involving,pseudoephedrine,,,brompheniramine,,,and,dextromethorphan,are,presented,. | |
| labels,0,0,0,0,0,0,0,0,0,8,0,4,0,4,0,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,granulocytopenia | |
| drug,clozapine | |
| sequence,CONCLUSION,:,The,results,suggest,that,olanzapine,may,be,useful,in,treating,patients,with,clozapine-induced,granulocytopenia,without,the,risk,of,recurrence,of,hematologic,side,effects,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,interstitial pneumonitis,high fever | |
| drug,pranlukast | |
| sequence,A,62-year-old,woman,treated,with,pranlukast,for,2,months,developed,interstitial,pneumonitis,with,a,high,fever,. | |
| labels,0,0,0,0,0,4,0,0,0,0,5,7,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Metastatic osteomyelitis | |
| drug,BCG | |
| sequence,Metastatic,osteomyelitis,following,BCG,vaccination,. | |
| labels,5,7,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,QT prolongation,T wave inversion | |
| drug,Pirmenol hydrochloride | |
| sequence,Pirmenol,hydrochloride-induced,QT,prolongation,and,T,wave,inversion,on,electrocardiogram,during,treatment,for,symptomatic,atrial,fibrillation,. | |
| labels,1,3,5,7,0,5,6,7,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,0,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity | |
| drug,Carboplatin | |
| sequence,Carboplatin,hypersensitivity,induced,by,low-dose,paclitaxel,carboplatin,in,multiple,platinum-treated,patients,with,recurrent,ovarian,cancer,. | |
| labels,4,8,0,0,0,4,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity | |
| drug,carboplatin | |
| sequence,Carboplatin,hypersensitivity,induced,by,low-dose,paclitaxel,carboplatin,in,multiple,platinum-treated,patients,with,recurrent,ovarian,cancer,. | |
| labels,4,8,0,0,0,4,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity | |
| drug,paclitaxel | |
| sequence,Carboplatin,hypersensitivity,induced,by,low-dose,paclitaxel,carboplatin,in,multiple,platinum-treated,patients,with,recurrent,ovarian,cancer,. | |
| labels,4,8,0,0,0,4,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Visual changes | |
| drug,amiodarone | |
| sequence,Visual,changes,secondary,to,initiation,of,amiodarone,:,a,case,report,and,review,involving,ocular,management,in,cardiac,polypharmacy,. | |
| labels,5,7,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Bilateral anterior uveitis | |
| drug,clomiphene citrate | |
| sequence,Bilateral,anterior,uveitis,associated,with,clomiphene,citrate,. | |
| labels,5,6,7,0,0,1,3,0 | |
| ade_mask,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,radiation recall | |
| drug,gemcitabine | |
| sequence,CONCLUSIONS,:,This,is,the,second,case,report,that,describes,gemcitabine-induced,radiation,recall,in,rectus,abdominus,muscles,after,gemcitabine-based,radiation,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,5,7,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cholestasis,duct paucity | |
| drug,trimethoprim-sulfamethoxazole | |
| sequence,The,second,patient,,,who,developed,cholestasis,after,receiving,trimethoprim-sulfamethoxazole,,,had,marked,duct,paucity,in,the,liver,biopsy,. | |
| labels,0,0,0,0,0,0,8,0,0,4,0,0,0,5,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Cardiac complications | |
| drug,amphotericin B | |
| sequence,INTERVENTIONS,AND,RESULTS,:,Cardiac,complications,were,observed,in,five,pediatric,patients,who,received,between,4.6,and,40.8,mg,kg,d,of,amphotericin,B,. | |
| labels,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,3,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Septic knee arthritis | |
| drug,hyaluronate | |
| sequence,Septic,knee,arthritis,after,intra-articular,hyaluronate,injection,. | |
| labels,5,6,7,0,0,4,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Cardiac arrest | |
| drug,sulprostone | |
| sequence,Cardiac,arrest,associated,with,sulprostone,use,during,caesarean,section,. | |
| labels,5,7,0,0,4,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,first-rank symptoms | |
| drug,fluvoxamine | |
| sequence,The,patient,,,a,28-year-old,man,suffering,from,panic,disorder,,,developed,several,first-rank,symptoms,during,fluvoxamine,administration,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Akathisia | |
| drug,clozapine | |
| sequence,Akathisia,is,a,relatively,rare,side,effect,with,the,newer,atypical,antipsychotic,agents,,,particularly,clozapine,,,and,is,easily,misdiagnosed,in,children,. | |
| labels,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pulmonary toxicity | |
| drug,piritrexim | |
| sequence,The,pulmonary,toxicity,is,probably,induced,by,piritrexim,. | |
| labels,0,5,7,0,0,0,0,4,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute renal failure | |
| drug,gabapentin | |
| sequence,OBJECTIVE,:,This,case,report,outlines,a,significant,type,of,morbidity,due,to,continued,use,of,gabapentin,during,an,episode,of,acute,renal,failure,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,lupus syndrome | |
| drug,procainamide hydrochloride | |
| sequence,An,elderly,man,with,procainamide,hydrochloride-induced,lupus,syndrome,had,a,circulating,anticoagulant,against,factor,XI,and,a,biologic,false-positive,(,BFP,),test,result,for,syphilis,. | |
| labels,0,0,0,0,1,3,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute generalized exanthematous pustulosis | |
| drug,nimesulide | |
| sequence,Acute,generalized,exanthematous,pustulosis,induced,by,nimesulide,. | |
| labels,5,6,6,7,0,0,4,0 | |
| ade_mask,1,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,monoarthritis | |
| drug,IFN-beta | |
| sequence,The,first,patient,developed,a,monoarthritis,2,weeks,after,initiation,of,IFN-beta,,,which,persisted,during,the,14,months,of,therapy,and,resolved,with,discontinuation,of,the,medication,. | |
| labels,0,0,0,0,0,8,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Severe adenovirus pneumonia,AVP | |
| drug,infliximab | |
| sequence,Severe,adenovirus,pneumonia,(,AVP,),following,infliximab,infusion,for,the,treatment,of,Crohn,'s,disease,. | |
| labels,5,6,7,0,8,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypereosinophilia | |
| drug,zafirlukast | |
| sequence,We,present,a,case,of,hypereosinophilia,related,to,zafirlukast,therapy,. | |
| labels,0,0,0,0,0,8,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute non-lymphocytic leukemia | |
| drug,dihydroxybusulfan | |
| sequence,Acute,non-lymphocytic,leukemia,occurred,in,eight,women,following,long-term,treatment,with,Treosulfan,(,=,dihydroxybusulfan,),for,ovarian,carcinoma,. | |
| labels,5,6,7,0,0,0,0,0,0,0,0,4,0,0,4,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute non-lymphocytic leukemia | |
| drug,Treosulfan | |
| sequence,Acute,non-lymphocytic,leukemia,occurred,in,eight,women,following,long-term,treatment,with,Treosulfan,(,=,dihydroxybusulfan,),for,ovarian,carcinoma,. | |
| labels,5,6,7,0,0,0,0,0,0,0,0,4,0,0,4,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nonconvulsive status epilepticus,NCSE | |
| drug,ifosfamide | |
| sequence,OBJECTIVE,:,To,report,2,cases,of,nonconvulsive,status,epilepticus,(,NCSE,),following,infusion,of,ifosfamide,. | |
| labels,0,0,0,0,0,0,0,5,6,7,0,8,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,gastrointestinal or intracranial bleeding | |
| drug,tissue plasminogen activator | |
| sequence,Thrombolytic,therapy,with,tissue,plasminogen,activator,(,tPA,),for,acute,myocardial,infarction,may,result,in,major,bleeding,complications,such,as,gastrointestinal,or,intracranial,bleeding,. | |
| labels,0,0,0,1,2,3,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,1,1,0,0 | |
| ==============================, ============================= | |
| ade,gastrointestinal or intracranial bleeding | |
| drug,tPA | |
| sequence,Thrombolytic,therapy,with,tissue,plasminogen,activator,(,tPA,),for,acute,myocardial,infarction,may,result,in,major,bleeding,complications,such,as,gastrointestinal,or,intracranial,bleeding,. | |
| labels,0,0,0,1,2,3,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,1,1,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity reaction | |
| drug,gentamicin | |
| sequence,Because,of,a,hypersensitivity,reaction,,,initial,therapy,with,penicillin,G,and,gentamicin,was,stopped,and,substituted,with,cefazolin,. | |
| labels,0,0,0,5,7,0,0,0,0,1,3,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity reaction | |
| drug,penicillin G | |
| sequence,Because,of,a,hypersensitivity,reaction,,,initial,therapy,with,penicillin,G,and,gentamicin,was,stopped,and,substituted,with,cefazolin,. | |
| labels,0,0,0,5,7,0,0,0,0,1,3,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,generalized cutaneous sclerosis | |
| drug,aminotriazole | |
| sequence,We,report,a,case,of,generalized,cutaneous,sclerosis,associated,with,muscle,and,oesophageal,involvement,in,a,patient,exposed,to,herbicides,containing,bromocil,,,diuron,and,aminotriazole,. | |
| labels,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,generalized cutaneous sclerosis | |
| drug,bromocil | |
| sequence,We,report,a,case,of,generalized,cutaneous,sclerosis,associated,with,muscle,and,oesophageal,involvement,in,a,patient,exposed,to,herbicides,containing,bromocil,,,diuron,and,aminotriazole,. | |
| labels,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,generalized cutaneous sclerosis | |
| drug,diuron | |
| sequence,We,report,a,case,of,generalized,cutaneous,sclerosis,associated,with,muscle,and,oesophageal,involvement,in,a,patient,exposed,to,herbicides,containing,bromocil,,,diuron,and,aminotriazole,. | |
| labels,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fulminant hepatic failure | |
| drug,disulfiram | |
| sequence,This,case,describes,fulminant,hepatic,failure,in,a,patient,taking,disulfiram,with,no,previous,liver,disease,and,report,of,being,compliant,with,alcohol,abstinence,. | |
| labels,0,0,0,5,6,7,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,stroke | |
| drug,phenylpropanolamine | |
| sequence,Since,1979,,,over,30,published,case,reports,have,documented,the,relationship,between,phenylpropanolamine,and,stroke,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,sclerosing peritonitis | |
| drug,practolol | |
| sequence,Diagnosis,:,practolol,induced,sclerosing,peritonitis,. | |
| labels,0,0,4,0,5,7,0 | |
| ade_mask,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,pneumonitis | |
| drug,Methotrexate | |
| sequence,Methotrexate,pneumonitis,in,nonsurgical,treatment,of,ectopic,pregnancy,. | |
| labels,4,8,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Nonsustained polymorphous ventricular tachycardia | |
| drug,amiodarone | |
| sequence,Nonsustained,polymorphous,ventricular,tachycardia,during,amiodarone,therapy,for,atrial,fibrillation,complicating,cardiomyopathy,. | |
| labels,5,6,6,7,0,4,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hemorrhage,cerebral vascular malformation | |
| drug,Pseudoephedrine | |
| sequence,Pseudoephedrine-induced,hemorrhage,associated,with,a,cerebral,vascular,malformation,. | |
| labels,4,8,0,0,0,5,6,7,0 | |
| ade_mask,0,1,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,thrombocytopenia | |
| drug,heparin | |
| sequence,We,report,a,patient,who,developed,heparin,associated,thrombocytopenia,during,continuous,arteriovenous,haemofiltration,and,discuss,its,implications,and,alternative,anticoagulant,treatment,. | |
| labels,0,0,0,0,0,0,4,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bronchospasm | |
| drug,propranolol | |
| sequence,Three,patients,with,no,history,of,asthma,or,allergy,developed,bronchospasm,while,taking,propranolol,for,hypertension,. | |
| labels,0,0,0,0,0,0,0,0,0,0,8,0,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anterior ischemic optic neuropathy | |
| drug,interferon alfa | |
| sequence,OBJECTIVE,:,To,report,the,occurrence,of,anterior,ischemic,optic,neuropathy,as,a,complication,of,treatment,with,interferon,alfa,and,to,consider,the,possible,underlying,mechanisms,for,this,association,. | |
| labels,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,0,1,3,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,eating disorder | |
| drug,triazolam | |
| sequence,A,combination,of,behavioural,and,cognitive,adverse,effects,is,illustrated,in,this,case,report,of,a,recurrent,triazolam-induced,eating,disorder,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,polymorphic ventricular tachycardia | |
| drug,levofloxacin | |
| sequence,We,report,the,first,case,of,polymorphic,ventricular,tachycardia,with,normal,QT,interval,associated,with,the,oral,use,of,levofloxacin,in,the,absence,of,other,etiologies,known,to,cause,these,arrhythmias,. | |
| labels,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,gastrointestinal adverse reactions | |
| drug,Ibuprofen | |
| sequence,Ibuprofen,rarely,causes,lower,gastrointestinal,adverse,reactions,but,has,been,implicated,in,systemic,and,local,side,effects,in,patients,with,lupus,. | |
| labels,4,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cholestatic hepatitis | |
| drug,senna | |
| sequence,We,report,a,case,of,senna-induced,cholestatic,hepatitis,which,was,not,diagnosed,at,presentation,. | |
| labels,0,0,0,0,0,4,5,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,interstitial lung disease | |
| drug,trastuzumab | |
| sequence,Life-threatening,interstitial,lung,disease,associated,with,trastuzumab,:,case,report,. | |
| labels,0,5,6,7,0,0,4,0,0,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperkalemia | |
| drug,ACTH | |
| sequence,Two,infants,developed,hyperkalemia,shortly,after,cessation,of,prolonged,ACTH,therapy,for,infantile,spasms,. | |
| labels,0,0,0,8,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatic angiosarcoma | |
| drug,cyclophosphamide | |
| sequence,We,propose,that,cyclophosphamide,be,added,to,the,list,of,exposures,potentially,associated,with,hepatic,angiosarcoma,. | |
| labels,0,0,0,4,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Creutzfeldt-Jakob disease | |
| drug,human growth hormone | |
| sequence,A,new,case,of,Creutzfeldt-Jakob,disease,associated,with,human,growth,hormone,therapy,in,New,Zealand,. | |
| labels,0,0,0,0,5,7,0,0,1,2,3,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,difficulty walking,marked pain,loss of proprioception | |
| drug,taxol | |
| sequence,We,describe,a,case,of,advanced,ovarian,carcinoma,who,developed,difficulty,walking,because,of,marked,pain,in,the,lower,extremities,and,loss,of,proprioception,25,days,after,treatment,with,weekly,taxol,(,80,mg,m,(,2,),x3,),. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,0,5,7,0,0,0,0,0,5,6,7,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,parkinsonism | |
| drug,metoclopramide | |
| sequence,We,have,reported,six,cases,of,metoclopramide-induced,parkinsonism,seen,in,consultation,over,a,two-year,period,. | |
| labels,0,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,mild cognitive impairment | |
| drug,propafenone | |
| sequence,CASE,SUMMARY,:,An,80-year-old,white,female,,,followed,up,at,the,Memory,Clinic,for,mild,cognitive,impairment,,,had,been,taking,propafenone,900,mg,d,for,>,10,years,for,paroxysmal,atrial,fibrillation,without,adverse,effects,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sub-acute neurotoxicity | |
| drug,methotrexate | |
| sequence,Conventional,and,diffusion-weighted,MRI,findings,of,methotrexate,related,sub-acute,neurotoxicity,. | |
| labels,0,0,0,0,0,0,4,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,reversible hearing loss | |
| drug,quinine | |
| sequence,The,case,of,a,29-year-old,man,suffering,from,falciparum,malaria,disease,who,got,a,reversible,hearing,loss,from,quinine,therapy,is,presented,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe hypercalcemia,vitamin D poisoning | |
| drug,vitamin D | |
| sequence,We,report,the,use,of,pamidronate,for,acute,,,severe,hypercalcemia,secondary,to,iatrogenic,vitamin,D,poisoning,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,0,0,9,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,hypoglycaemia | |
| drug,insulin | |
| sequence,Assessment,of,cortisol,response,was,by,insulin-induced,hypoglycaemia,in,three,cases,,,by,short,tetracosactrin,test,in,two,,,and,by,low-dose,tetracosactrin,and,24-hour,urinary,cortisol,creatinine,ratio,in,one,. | |
| labels,0,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,increase of INR | |
| drug,5-FU | |
| sequence,CONCLUSIONS,:,This,case,describes,the,clinically,significant,increase,of,INR,in,an,elderly,patient,after,adding,a,chemotherapy,regimen,of,levamisole,and,5-FU,to,a,previous,regimen,of,warfarin,alone,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,increase of INR | |
| drug,levamisole | |
| sequence,CONCLUSIONS,:,This,case,describes,the,clinically,significant,increase,of,INR,in,an,elderly,patient,after,adding,a,chemotherapy,regimen,of,levamisole,and,5-FU,to,a,previous,regimen,of,warfarin,alone,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,increase of INR | |
| drug,warfarin | |
| sequence,CONCLUSIONS,:,This,case,describes,the,clinically,significant,increase,of,INR,in,an,elderly,patient,after,adding,a,chemotherapy,regimen,of,levamisole,and,5-FU,to,a,previous,regimen,of,warfarin,alone,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,abdominal right lower quadrant pain,cecal lymphoma | |
| drug,cyclophosphamide | |
| sequence,Five,and,one-half,years,after,the,diagnosis,of,myeloma,,,while,in,remission,on,cyclophosphamide,therapy,,,the,patient,experienced,severe,abdominal,right,lower,quadrant,pain,due,to,a,large,cecal,lymphoma,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,5,6,6,6,7,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,vortex keratopathy | |
| drug,atovaquone | |
| sequence,RESULTS,:,Similar,to,previous,findings,of,drug-induced,vortex,keratopathy,,,atovaquone,vortex,keratopathy,is,presumably,caused,by,its,lipophilic,properties,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,renal insufficiency | |
| drug,rifampicin | |
| sequence,A,literature,review,revealed,83,other,reported,cases,of,rifampicin-induced,renal,insufficiency,. | |
| labels,0,0,0,0,0,0,0,0,0,4,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Abnormalities of the pupil,amblyopia | |
| drug,quinine | |
| sequence,Abnormalities,of,the,pupil,and,visual-evoked,potential,in,quinine,amblyopia,. | |
| labels,5,6,6,7,0,0,0,0,4,8,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Methemoglobinemia | |
| drug,dapsone | |
| sequence,Methemoglobinemia,is,another,common,finding,among,patients,receiving,dapsone,therapy,,,but,rarely,does,it,result,in,prominent,symptoms,other,than,transient,pallor,. | |
| labels,8,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,vagina bleeding | |
| drug,Acetic acid | |
| sequence,CONCLUSION,:,Acetic,acid,is,corrosive,and,may,cause,vagina,bleeding,. | |
| labels,0,0,1,3,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,torsades de pointes | |
| drug,amiodarone | |
| sequence,We,report,a,case,of,recurrent,torsades,de,pointes,following,treatment,with,pentavalent,antimonial,drugs,and,amiodarone,. | |
| labels,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,unilateral acute angle-closure glaucoma | |
| drug,scopolamine | |
| sequence,A,58-year-old,woman,developed,unilateral,acute,angle-closure,glaucoma,four,days,after,the,application,of,a,patch,of,transdermal,scopolamine,delivery,system,(,TRANSDERM-V,),. | |
| labels,0,0,0,0,5,6,6,7,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,wide complex dysrhythmia | |
| drug,Propoxyphene | |
| sequence,Propoxyphene-induced,wide,complex,dysrhythmia,responsive,to,sodium,bicarbonate,therapy,has,not,been,previously,reported,in,the,literature,. | |
| labels,4,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,noncardiogenic pulmonary edema | |
| drug,EO | |
| sequence,We,report,a,case,of,noncardiogenic,pulmonary,edema,developed,after,therapeutic,trial,of,EO,as,sclerosing,agent,for,esophageal,varix,. | |
| labels,0,0,0,0,0,5,6,7,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,necrotizing fasciitis,myonecrosis | |
| drug,sodium warfarin | |
| sequence,This,case,study,describes,an,atypical,case,of,refractory,,,sodium,warfarin-induced,necrotizing,fasciitis,and,myonecrosis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,1,3,5,7,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0 | |
| ==============================, ============================= | |
| ade,psoriasis-like skin reaction | |
| drug,SASP | |
| sequence,Presented,is,a,case,story,of,a,woman,with,classical,rheumatoid,arthritis,,,who,during,introduction,of,sulphasalazine,(,SASP,),therapy,developed,a,severe,and,lasting,psoriasis-like,skin,reaction,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,psoriasis-like skin reaction | |
| drug,sulphasalazine | |
| sequence,Presented,is,a,case,story,of,a,woman,with,classical,rheumatoid,arthritis,,,who,during,introduction,of,sulphasalazine,(,SASP,),therapy,developed,a,severe,and,lasting,psoriasis-like,skin,reaction,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,meningitis | |
| drug,Ibuprofen | |
| sequence,Ibuprofen-induced,meningitis,:,detection,of,intrathecal,IgG,synthesis,and,immune,complexes,. | |
| labels,4,8,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hemorrhagic vasculitis | |
| drug,Ciprofloxacin | |
| sequence,Ciprofloxacin-induced,hemorrhagic,vasculitis,is,a,rare,side,effect,. | |
| labels,4,5,7,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute pancreatitis | |
| drug,danazol | |
| sequence,Acute,pancreatitis,associated,with,danazol,treatment,for,endometriosis,. | |
| labels,5,7,0,0,4,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,corneoscleral melting | |
| drug,mitomycin C | |
| sequence,To,the,best,of,our,knowledge,,,corneoscleral,melting,in,the,first,postoperative,week,after,a,single,intraoperative,application,of,mitomycin,C,has,not,been,reported,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,1,3,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,impeded lactogenesis | |
| drug,magnesium sulfate | |
| sequence,No,explanation,for,this,delay,was,found,,,other,than,the,possibility,that,magnesium,sulfate,treatment,impeded,lactogenesis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,1,3,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Autoimmune thyroid disease | |
| drug,IFN-alpha | |
| sequence,Autoimmune,thyroid,disease,is,a,common,side-effect,of,interferon-alpha,(,IFN-alpha,),treatment,of,viral,hepatitis,C,. | |
| labels,5,6,7,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Autoimmune thyroid disease | |
| drug,interferon-alpha | |
| sequence,Autoimmune,thyroid,disease,is,a,common,side-effect,of,interferon-alpha,(,IFN-alpha,),treatment,of,viral,hepatitis,C,. | |
| labels,5,6,7,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatitis | |
| drug,disulfiram | |
| sequence,We,reported,a,case,of,disulfiram-induced,hepatitis,with,unique,clinical,features,and,compared,our,case,with,others,in,the,literature,. | |
| labels,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sensorineural hearing loss,antineutrophil cytoplasmic antibodies | |
| drug,Propylthiouracil | |
| sequence,Propylthiouracil-induced,sensorineural,hearing,loss,associated,with,antineutrophil,cytoplasmic,antibodies,. | |
| labels,4,5,6,7,0,0,5,6,7,0 | |
| ade_mask,0,1,1,1,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,abnormal liver function tests | |
| drug,cyproterone acetate | |
| sequence,Monitoring,of,liver,function,tests,should,be,mandatory,in,patients,receiving,high,doses,of,cyproterone,acetate,;,the,drug,should,be,withdrawn,immediately,if,abnormal,liver,function,tests,are,found,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,3,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0 | |
| ade_mask,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,serum testosterone | |
| drug,valproate | |
| sequence,RESULTS,:,Replacing,valproate,with,lamotrigine,resulted,in,a,decrease,in,serum,testosterone,concentrations,in,all,3,women,. | |
| labels,0,0,0,4,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cognitive dysfunction | |
| drug,IL-2 | |
| sequence,A,case,is,reported,of,a,40,year,old,woman,treated,with,intraventricular,IL-2,for,leptomeningeal,disease,who,developed,progressive,cognitive,dysfunction,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,local cutaneous reactions | |
| drug,pegylated interferon alfa-2b | |
| sequence,We,report,5,patients,(,3,patients,with,chronic,hepatitis,C,treated,with,pegylated,interferon,alfa-2b,in,association,with,oral,ribavirin,and,two,patients,with,chronic,myelocytic,leukemia,),who,developed,local,cutaneous,reactions,at,sites,of,injection,after,the,administration,of,weekly,subcutaneous,injections,of,pegylated,interferon,alfa-2b,at,different,doses,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,3,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,local cutaneous reactions | |
| drug,ribavirin | |
| sequence,We,report,5,patients,(,3,patients,with,chronic,hepatitis,C,treated,with,pegylated,interferon,alfa-2b,in,association,with,oral,ribavirin,and,two,patients,with,chronic,myelocytic,leukemia,),who,developed,local,cutaneous,reactions,at,sites,of,injection,after,the,administration,of,weekly,subcutaneous,injections,of,pegylated,interferon,alfa-2b,at,different,doses,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,3,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bilateral ptosis | |
| drug,vincristine | |
| sequence,Five,days,after,the,fourth,dose,of,vincristine,,,she,presented,with,bilateral,ptosis,. | |
| labels,0,0,0,0,0,0,0,4,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Interference with the cortisol axis | |
| drug,CPH82 | |
| sequence,Interference,with,the,cortisol,axis,by,the,microtubule,antagonist,,,CPH82,. | |
| labels,5,6,6,6,7,0,0,0,0,0,4,0 | |
| ade_mask,1,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Serotonin syndrome | |
| drug,metoclopramide | |
| sequence,Serotonin,syndrome,caused,by,selective,serotonin,reuptake-inhibitors-metoclopramide,interaction,. | |
| labels,5,7,0,0,0,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,psychiatric symptoms | |
| drug,lidocaine | |
| sequence,Awareness,of,this,route,of,intoxication,might,be,important,in,patients,in,whom,neurologic,or,psychiatric,symptoms,develop,while,large,amounts,of,lidocaine,cream,are,being,used,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fever | |
| drug,temozolomide | |
| sequence,According,to,the,Naranjo,adverse,drug,reaction,probability,scale,,,the,likelihood,that,temozolomide,was,responsible,for,the,adverse,drug,reaction,of,fever,was,probable,(,score,of,6,),. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute hepatitis | |
| drug,gliclazide | |
| sequence,We,describe,the,case,of,acute,hepatitis,induced,by,gliclazide,,,a,second,generation,sulfonylurea,. | |
| labels,0,0,0,0,0,5,7,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypotension | |
| drug,verapamil | |
| sequence,The,incidence,of,oral-verapamil-induced,hypotension,in,the,presence,of,concomitant,beta-adrenergic,blockade,by,the,oral,route,is,quite,rare,. | |
| labels,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,polymyositis,dilated cardiomyopathy | |
| drug,interferon alpha | |
| sequence,A,case,of,polymyositis,with,dilated,cardiomyopathy,associated,with,interferon,alpha,treatment,for,hepatitis,B,. | |
| labels,0,0,0,8,0,5,7,0,0,1,3,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity | |
| drug,CBDCA | |
| sequence,Our,report,suggested,that,CBDCA,hypersensitivity,was,correlated,with,the,total,dose,of,previously,administered,platinum,agents,and,that,CBDCA,should,be,excluded,in,patients,who,have,received,multiple,platinum-based,chemotherapy,,,even,in,platinum-sensitive,cases,,,because,CBDCA,hypersensitivity,can,occur,even,with,low-dose,CBDCA,administration,. | |
| labels,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lipohypertrophy | |
| drug,insulin | |
| sequence,Thus,,,the,possible,in,vivo,effects,of,insulin,on,adipocytes,were,clearly,observed,in,this,case,of,insulin-induced,lipohypertrophy,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,hypoglycemia,rebound hyperglycemia | |
| drug,insulin | |
| sequence,Administration,of,excessive,insulin,induced,hypoglycemia,within,4,to,8,hours,,,followed,by,rebound,hyperglycemia,. | |
| labels,0,0,0,4,0,8,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,bleeding | |
| drug,argatroban | |
| sequence,After,39,hours,on,argatroban,,,the,infusion,was,stopped,when,minor,bleeding,was,observed,with,a,concurrent,activated,partial,thromboplastin,time,(,aPTT,),of,100,seconds,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute renal failure | |
| drug,suramin | |
| sequence,Acute,renal,failure,in,a,patient,receiving,treatment,with,suramin,. | |
| labels,5,6,7,0,0,0,0,0,0,4,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Reye-like syndrome,pantothenic acid deficiency | |
| drug,calcium hopantenate | |
| sequence,Evidence,obtained,indicated,that,the,Reye-like,syndrome,might,be,caused,by,calcium,hopantenate,possibly,due,to,the,induction,of,pantothenic,acid,deficiency,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,1,3,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,pneumonitis | |
| drug,Gold | |
| sequence,Gold-induced,pneumonitis,is,a,rare,complication,of,gold,salt,therapy,. | |
| labels,4,8,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cardiomyopathy | |
| drug,ouabain | |
| sequence,One,patient,on,ouabain,also,developed,cardiomyopathy,. | |
| labels,0,0,0,4,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Fatal acute tubular necrosis | |
| drug,formalin | |
| sequence,Fatal,acute,tubular,necrosis,occurred,in,1,patient,in,whom,intravesical,formalin,was,used,to,control,massive,persistent,hemorrhage,from,radiation,cystitis,. | |
| labels,5,6,6,7,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,visual disturbance | |
| drug,rifabutin | |
| sequence,We,suggest,that,objective,evaluation,of,retinal,function,with,electrophysiological,methods,should,be,performed,in,patients,with,visual,disturbance,during,treatment,with,rifabutin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,chloroquine toxicity | |
| drug,chloroquine | |
| sequence,His,fever,resolved,,,but,he,developed,symptoms,consistent,with,those,of,chloroquine,toxicity,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,9,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,severe apnea | |
| drug,lamotrigine | |
| sequence,OBJECTIVE,:,To,report,a,case,of,severe,apnea,in,an,infant,exposed,to,lamotrigine,through,breast-feeding,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,0,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Severe hepatitis | |
| drug,cyproterone acetate | |
| sequence,Severe,hepatitis,caused,by,cyproterone,acetate,. | |
| labels,5,7,0,0,1,3,0 | |
| ade_mask,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,atypical ventricular tachycardia,AVT,torsade de pointes | |
| drug,amiodarone | |
| sequence,A,44-year-old,woman,is,described,in,whom,amiodarone,,,disopyramide,,,and,quinidine,,,administered,alone,separately,,,induced,atypical,ventricular,tachycardia,(,AVT,,,torsade,de,pointes,),. | |
| labels,0,0,0,0,0,0,0,4,0,4,0,0,4,0,0,0,0,0,0,5,6,7,0,8,0,5,6,7,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0,1,1,1,0,0 | |
| ==============================, ============================= | |
| ade,atypical ventricular tachycardia,AVT,torsade de pointes | |
| drug,disopyramide | |
| sequence,A,44-year-old,woman,is,described,in,whom,amiodarone,,,disopyramide,,,and,quinidine,,,administered,alone,separately,,,induced,atypical,ventricular,tachycardia,(,AVT,,,torsade,de,pointes,),. | |
| labels,0,0,0,0,0,0,0,4,0,4,0,0,4,0,0,0,0,0,0,5,6,7,0,8,0,5,6,7,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0,1,1,1,0,0 | |
| ==============================, ============================= | |
| ade,atypical ventricular tachycardia,AVT,torsade de pointes | |
| drug,quinidine | |
| sequence,A,44-year-old,woman,is,described,in,whom,amiodarone,,,disopyramide,,,and,quinidine,,,administered,alone,separately,,,induced,atypical,ventricular,tachycardia,(,AVT,,,torsade,de,pointes,),. | |
| labels,0,0,0,0,0,0,0,4,0,4,0,0,4,0,0,0,0,0,0,5,6,7,0,8,0,5,6,7,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0,1,1,1,0,0 | |
| ==============================, ============================= | |
| ade,altered mental status | |
| drug,valproic acid | |
| sequence,Based,on,our,experience,and,on,previously,published,data,,,serum,ammonia,levels,appear,to,be,indicated,in,all,ED,patients,on,valproic,acid,therapy,who,present,with,altered,mental,status,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,3,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,Thymic enlargement | |
| drug,etanercept | |
| sequence,Thymic,enlargement,in,a,patient,with,juvenile,idiopathic,arthritis,during,etanercept,therapy,. | |
| labels,5,7,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,morbidity | |
| drug,hyperbaric oxygen | |
| sequence,We,describe,2,children,with,cerebral,palsy,who,suffered,significant,morbidity,immediately,after,treatment,with,hyperbaric,oxygen,. | |
| labels,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,1,3,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Recurrent hypotension,seizures | |
| drug,nortriptyline | |
| sequence,Recurrent,hypotension,immediately,after,seizures,in,nortriptyline,overdose,. | |
| labels,5,7,0,0,8,0,4,0,0 | |
| ade_mask,1,1,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Carbamazepine intoxication | |
| drug,Carbamazepine | |
| sequence,After,administration,of,Oxybutynin,concomitantly,with,an,increase,in,the,dose,of,Dantrolene,,,she,presented,the,clinical,symptoms,and,laboratory,finding,of,Carbamazepine,intoxication,. | |
| labels,0,0,0,4,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,9,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Carbamazepine intoxication | |
| drug,Dantrolene | |
| sequence,After,administration,of,Oxybutynin,concomitantly,with,an,increase,in,the,dose,of,Dantrolene,,,she,presented,the,clinical,symptoms,and,laboratory,finding,of,Carbamazepine,intoxication,. | |
| labels,0,0,0,4,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,9,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Carbamazepine intoxication | |
| drug,Oxybutynin | |
| sequence,After,administration,of,Oxybutynin,concomitantly,with,an,increase,in,the,dose,of,Dantrolene,,,she,presented,the,clinical,symptoms,and,laboratory,finding,of,Carbamazepine,intoxication,. | |
| labels,0,0,0,4,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,9,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Hyperkalemia | |
| drug,adrenocorticotropic hormone | |
| sequence,Hyperkalemia,as,a,late,side,effect,of,prolonged,adrenocorticotropic,hormone,therapy,for,infantile,spasms,. | |
| labels,8,0,0,0,0,0,0,0,1,3,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,intertrigo-like eruption | |
| drug,doxorubicin | |
| sequence,An,intertrigo-like,eruption,from,pegylated,liposomal,doxorubicin,. | |
| labels,0,5,7,0,0,0,4,0 | |
| ade_mask,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,renal dysfunction | |
| drug,IFNalpha | |
| sequence,Chronic,myelogenous,leukemia,(,CML,),,,hepatitis,C,,,and,interferon,alpha,(,IFNalpha,),have,all,been,associated,with,renal,dysfunction,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,1,3,0,4,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,renal dysfunction | |
| drug,interferon alpha | |
| sequence,Chronic,myelogenous,leukemia,(,CML,),,,hepatitis,C,,,and,interferon,alpha,(,IFNalpha,),have,all,been,associated,with,renal,dysfunction,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,1,3,0,4,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,gastric-outlet obstruction,antral hyperplasia | |
| drug,prostaglandin E1 | |
| sequence,CONCLUSIONS,:,The,administration,of,prostaglandin,E1,to,neonates,can,cause,gastric-outlet,obstruction,due,to,antral,hyperplasia,. | |
| labels,0,0,0,0,0,1,3,0,0,0,0,5,7,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,hyperammonemia,altered mental status | |
| drug,Valproate | |
| sequence,Valproate-induced,hyperammonemia,as,a,cause,of,altered,mental,status,. | |
| labels,4,8,0,0,0,0,5,6,7,0 | |
| ade_mask,0,1,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,hiccups | |
| drug,aripiprazole | |
| sequence,We,report,a,patient,of,organic,bipolar,affective,disorder,who,developed,hiccups,with,the,atypical,antipsychotic,aripiprazole,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neutropenia | |
| drug,MMF | |
| sequence,Herein,we,report,four,patients,who,underwent,liver,transplantation,and,developed,neutropenia,while,receiving,MMF,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,8,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lung toxicity,lung disease | |
| drug,Fludarabine | |
| sequence,Fludarabine,induced,lung,toxicity,must,be,considered,in,all,patients,who,develop,unexplained,lung,disease,while,receiving,fludarabine,. | |
| labels,4,0,5,7,0,0,0,0,0,0,0,0,0,5,7,0,0,4,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lung disease | |
| drug,fludarabine | |
| sequence,Fludarabine,induced,lung,toxicity,must,be,considered,in,all,patients,who,develop,unexplained,lung,disease,while,receiving,fludarabine,. | |
| labels,4,0,5,7,0,0,0,0,0,0,0,0,0,5,7,0,0,4,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,paradoxical raised IOP | |
| drug,brimonidine | |
| sequence,CONCLUSION,:,Under,certain,circumstances,topical,brimonidine,can,cause,paradoxical,raised,IOP,necessitating,vigilance,in,follow-up,of,patients,on,topical,brimonidine,. | |
| labels,0,0,0,0,0,0,4,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombocytopenia | |
| drug,heparin | |
| sequence,Argatroban,for,heparin-induced,thrombocytopenia,in,hepato-renal,failure,and,CVVHD,. | |
| labels,0,0,4,8,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fulminant hepatic failure | |
| drug,didanosine | |
| sequence,We,report,a,case,of,fulminant,hepatic,failure,associated,with,didanosine,and,masquerading,as,a,surgical,abdomen,and,compare,the,clinical,,,biologic,,,histologic,,,and,ultrastructural,findings,with,reports,described,previously,. | |
| labels,0,0,0,0,0,5,6,7,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,generalized exanthem | |
| drug,enoxaparin | |
| sequence,To,our,knowledge,,,this,is,the,first,case,reported,in,the,English,literature,of,a,generalized,exanthem,due,to,subcutaneous,injection,of,enoxaparin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,leukopenia,skin and hepatic toxicity | |
| drug,nevirapine | |
| sequence,We,report,an,HIV-infected,woman,who,developed,mild,leukopenia,as,the,first,sign,of,a,nevirapine-related,adverse,event,,,which,was,followed,by,skin,and,hepatic,toxicity,associated,with,a,more,severe,leukopenia,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,4,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity syndrome | |
| drug,dapsone | |
| sequence,A,case,report,of,the,hypersensitivity,syndrome,occurring,in,a,patient,being,treated,with,dapsone,for,a,brown,recluse,spider,bite,is,presented,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hair loss | |
| drug,paroxetine | |
| sequence,Hair,loss,associated,with,paroxetine,treatment,:,a,case,report,. | |
| labels,5,7,0,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatitis | |
| drug,diclofenac | |
| sequence,This,patient,,,who,had,a,history,of,osteoarthritis,,,had,severe,hepatitis,5,weeks,after,being,started,on,diclofenac,for,increasing,pain,in,the,joints,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Severe hepatocellular dysfunction | |
| drug,cyproterone acetate | |
| sequence,Severe,hepatocellular,dysfunction,following,cyproterone,acetate,therapy,. | |
| labels,5,6,7,0,1,3,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anaphylactic reaction | |
| drug,vancomycin | |
| sequence,We,report,a,case,of,a,23-year-old,man,who,developed,a,vancomycin-induced,anaphylactic,reaction,in,the,treatment,of,methicillin-resistant,Staphylococcus,aureus,infection,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,4,5,7,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,peripheral neuropathy,neuropathy,bone marrow depression | |
| drug,linezolid | |
| sequence,However,,,peripheral,neuropathy,and,bone,marrow,depression,led,to,linezolid,withdrawal,in,seven,patients,,,and,neuropathy,may,not,be,fully,reversible,in,all,patients,. | |
| labels,0,0,5,7,0,5,6,7,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neurotoxicity | |
| drug,acyclovir | |
| sequence,We,discuss,our,observations,in,the,cases,of,two,patients,with,acyclovir,neurotoxicity,and,review,the,findings,of,all,previous,reports,in,the,English,language,literature,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Sagittal sinus thrombosis,transient free protein S deficiency | |
| drug,L-asparaginase | |
| sequence,Sagittal,sinus,thrombosis,associated,with,transient,free,protein,S,deficiency,after,L-asparaginase,treatment,:,case,report,and,review,of,the,literature,. | |
| labels,5,6,7,0,0,5,6,6,6,7,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neutropenia | |
| drug,penicillin | |
| sequence,Typically,,,drug-induced,neutropenia,occurs,in,a,patient,receiving,a,semisynthetic,penicillin,for,two,weeks,or,more,. | |
| labels,0,0,0,8,0,0,0,0,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,osteonecrosis of the mandible | |
| drug,bisphosphonate | |
| sequence,The,most,serious,dental,side,effect,of,bisphosphonate,treatment,(,particularly,when,it,is,administered,intravenously,),is,,,paradoxically,,,osteonecrosis,of,the,mandible,or,the,maxilla,represented,by,exposed,nonhealing,bone,. | |
| labels,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatitis B infection | |
| drug,adefovir | |
| sequence,Favorable,outcome,of,de,novo,hepatitis,B,infection,after,liver,transplantation,with,lamivudine,and,adefovir,therapy,. | |
| labels,0,0,0,0,0,5,6,7,0,0,0,0,4,0,4,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatitis B infection | |
| drug,lamivudine | |
| sequence,Favorable,outcome,of,de,novo,hepatitis,B,infection,after,liver,transplantation,with,lamivudine,and,adefovir,therapy,. | |
| labels,0,0,0,0,0,5,6,7,0,0,0,0,4,0,4,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neoplastic seeding | |
| drug,ethanol | |
| sequence,Long-term,follow-up,after,neoplastic,seeding,complicating,percutaneous,ethanol,injection,for,treatment,of,hepatocellular,carcinoma,. | |
| labels,0,0,0,5,7,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,visual field loss,objective visual field loss | |
| drug,hydroxychloroquine | |
| sequence,CONCLUSIONS,:,SD-OCT,and,AO,detected,abnormalities,that,correlate,topographically,with,visual,field,loss,from,hydroxychloroquine,toxicity,as,demonstrated,by,HVF,10-2,and,may,be,useful,in,the,detection,of,subclinical,abnormalities,that,precede,symptoms,or,objective,visual,field,loss,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,DAT became positive with anti-IgG and anti-C3d antiglobulins | |
| drug,fludarabine | |
| sequence,When,the,patient,was,treated,again,with,fludarabine,nine,months,later,,,the,DAT,became,positive,with,anti-IgG,and,anti-C3d,antiglobulins,after,the,second,course,of,treatment,. | |
| labels,0,0,0,0,0,0,0,4,0,0,0,0,0,5,6,6,6,6,6,6,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,1,1,1,0,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,psychotic disorder | |
| drug,isoniazid | |
| sequence,We,evaluated,a,patient,who,developed,a,psychotic,disorder,after,4,months,of,isoniazid,prophylaxis,for,a,positive,tuberculosis,tine,test,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Trichiasis | |
| drug,prostaglandin | |
| sequence,Trichiasis,associated,with,prostaglandin,analog,use,. | |
| labels,8,0,0,4,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,changes in serotonergic or noradrenergic neurotransmission | |
| drug,IFN-alpha | |
| sequence,While,for,ribavirin,antidepressant,effects,are,not,known,,,we,suppose,that,antidepressants,may,prevent,changes,in,serotonergic,or,noradrenergic,neurotransmission,caused,by,IFN-alpha,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,7,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe back pain,urinary retention | |
| drug,methotrexate | |
| sequence,The,day,after,methotrexate,administration,,,the,patient,complained,of,severe,back,pain,and,urinary,retention,. | |
| labels,0,0,0,4,0,0,0,0,0,0,5,6,7,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,1,0 | |
| ==============================, ============================= | |
| ade,rash | |
| drug,temozolomide | |
| sequence,Due,to,the,severity,of,the,rash,,,temozolomide,was,permanently,discontinued,. | |
| labels,0,0,0,0,0,0,8,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Rosaceiform eruption | |
| drug,erlotinib | |
| sequence,Rosaceiform,eruption,induced,by,erlotinib,. | |
| labels,5,7,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Methemoglobinemia | |
| drug,benzocaine | |
| sequence,Methemoglobinemia,associated,with,dermal,application,of,benzocaine,cream,in,a,cat,. | |
| labels,8,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,dizziness,ataxia,diplopia,somnolence | |
| drug,lacosamide | |
| sequence,Common,adverse,events,(,frequency,10,%,),of,lacosamide,doses,up,to,600,mg,day,include,nonspecific,central,nervous,system,effects,(,e.g.,,,dizziness,,,ataxia,,,diplopia,,,and,somnolence,),. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,8,0,8,0,0,8,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,0,0,1,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity syndrome | |
| drug,carbamazepine | |
| sequence,Four,patients,who,manifested,symptoms,of,the,antiepileptic,drug,(,AED,),hypersensitivity,syndrome,during,therapy,with,carbamazepine,are,reported,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute renal failure,ARF | |
| drug,mannitol | |
| sequence,High-dose,intravenous,mannitol,infusion,in,various,clinical,settings,may,result,in,acute,renal,failure,(,ARF,),. | |
| labels,0,0,4,0,0,0,0,0,0,0,0,5,6,7,0,8,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0,0 | |
| ==============================, ============================= | |
| ade,Horner's syndrome,demyelinating peripheral neuropathy | |
| drug,cytosine arabinoside | |
| sequence,Horner,'s,syndrome,and,demyelinating,peripheral,neuropathy,caused,by,high-dose,cytosine,arabinoside,. | |
| labels,5,6,7,0,5,6,7,0,0,0,1,3,0 | |
| ade_mask,1,1,1,0,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Charles-Bonnet syndrome,CBS | |
| drug,Avastin | |
| sequence,CONCLUSIONS,:,We,report,a,typical,symptoms,of,Charles-Bonnet,syndrome,(,CBS,),in,patients,with,severe,AMD,after,intravitreal,Avastin-injections,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,8,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Cutaneous necrosis | |
| drug,interferon alfa | |
| sequence,Cutaneous,necrosis,as,a,result,of,interferon,alfa,is,an,infrequent,complication,with,unknown,pathogenesis,,,in,which,a,cutaneous,local,immune-mediated,inflammatory,process,might,be,involved,. | |
| labels,5,7,0,0,0,0,1,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,noncardiogenic pulmonary edema | |
| drug,monooctanoin | |
| sequence,We,describe,a,patient,in,whom,noncardiogenic,pulmonary,edema,developed,during,intrabiliary,infusion,of,monooctanoin,. | |
| labels,0,0,0,0,0,0,5,6,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,CD20-negative tumors | |
| drug,Rituximab | |
| sequence,Recently,,,CD20-negative,tumors,have,been,described,after,Rituximab,therapy,. | |
| labels,0,0,5,7,0,0,0,0,4,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neuroleptic malignant syndrome | |
| drug,olanzapine | |
| sequence,Atypical,neuroleptic,malignant,syndrome,associated,with,olanzapine,. | |
| labels,0,5,6,7,0,0,4,0 | |
| ade_mask,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,CNS lymphoma | |
| drug,mycophenolate mofetil | |
| sequence,Primary,CNS,lymphoma,complicating,treatment,of,myasthenia,gravis,with,mycophenolate,mofetil,. | |
| labels,0,5,7,0,0,0,0,0,0,1,3,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,prolonged seizure,serotonin syndrome,focal seizure | |
| drug,lithium | |
| sequence,Since,recent,studies,have,reported,no,negative,interactions,with,concurrent,use,,,we,here,report,three,cases,(,one,case,of,a,prolonged,seizure,,,a,serotonin,syndrome,and,a,focal,seizure,),of,severe,lithium-induced,side,effects,while,patients,underwent,ECT,without,complications,and,lithium,serum,levels,were,still,subtherapeutic,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,5,7,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anaphylactoid reaction | |
| drug,dextrose | |
| sequence,Two,patients,with,extrinsic,asthma,and,coexistent,insulin-dependent,diabetes,mellitus,sustained,an,anaphylactoid,reaction,after,the,intravenous,administration,of,50,%,solution,of,dextrose,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypercalcemia | |
| drug,rhGH | |
| sequence,The,hypercalcemia,responded,to,discontinuation,of,rhGH,and,a,single,dose,of,intravenous,pamidronate,disodium,and,has,not,recurred,in,8,months,of,follow-up,. | |
| labels,0,8,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,enteropathy,life-threatening | |
| drug,Clofazimine | |
| sequence,Clofazimine,enteropathy,caused,by,crystal,deposition,can,be,life-threatening,. | |
| labels,4,8,0,0,0,0,0,0,8,0 | |
| ade_mask,0,1,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,massive cytokines liberation,destruction of CD20 positive cells | |
| drug,rituximab | |
| sequence,The,pathophysiological,mechanisms,remain,unknown,,,although,the,drug,could,act,through,massive,cytokines,liberation,after,destruction,of,CD20,positive,cells,by,rituximab,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,5,6,6,6,7,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,1,1,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,Growth and adrenal suppression | |
| drug,fluticasone propionate | |
| sequence,Growth,and,adrenal,suppression,in,asthmatic,children,treated,with,high-dose,fluticasone,propionate,. | |
| labels,5,6,6,7,0,0,0,0,0,0,1,3,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anterior spinal artery syndrome | |
| drug,phenol-glycerine | |
| sequence,We,have,seen,a,case,of,terminal,malignant,melanoma,in,which,clinical,manifestations,,,indicative,of,anterior,spinal,artery,syndrome,,,developed,following,the,injection,of,0.3,ml,of,10,%,phenol-glycerine,into,the,cervical,subarachnoid,space,at,the,C4,--,C5,level,for,the,control,of,severe,right,arm,pain,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Rebound hyperglycemia | |
| drug,protamine hagedorn | |
| sequence,Rebound,hyperglycemia,was,observed,with,both,intermediate,(,neutral,protamine,hagedorn,),and,long-acting,(,protamine,zinc,iletin,),insulins,,,and,the,range,of,insulin,doses,at,which,the,disorder,developed,overlapped,previously,determined,therapeutic,doses,for,these,insulins,in,the,cat,. | |
| labels,5,7,0,0,0,0,0,0,0,1,3,0,0,0,0,1,2,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Rebound hyperglycemia | |
| drug,protamine zinc iletin | |
| sequence,Rebound,hyperglycemia,was,observed,with,both,intermediate,(,neutral,protamine,hagedorn,),and,long-acting,(,protamine,zinc,iletin,),insulins,,,and,the,range,of,insulin,doses,at,which,the,disorder,developed,overlapped,previously,determined,therapeutic,doses,for,these,insulins,in,the,cat,. | |
| labels,5,7,0,0,0,0,0,0,0,1,3,0,0,0,0,1,2,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,accelerated nodulosis | |
| drug,methotrexate | |
| sequence,We,describe,two,patients,with,rheumatoid,factor-positive,,,polyarticular-onset,juvenile,rheumatoid,arthritis,in,whom,accelerated,nodulosis,developed,during,methotrexate,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lipohypertrophy | |
| drug,Insulin | |
| sequence,Insulin-induced,lipohypertrophy,:,report,of,a,case,with,histopathology,. | |
| labels,4,8,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Severe acidosis | |
| drug,metformin | |
| sequence,Severe,acidosis,in,patients,taking,metformin,--,rapid,reversal,and,survival,despite,high,APACHE,score,. | |
| labels,5,7,0,0,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,decrease in the D-dimers,slight decrease in peripheral blood leukocytes | |
| drug,arsenic trioxide | |
| sequence,During,the,first,days,of,arsenic,trioxide,treatment,a,rapid,decrease,in,the,D-dimers,was,seen,(,normal,values,reached,until,day,7,),,,together,with,a,slight,decrease,in,peripheral,blood,leukocytes,. | |
| labels,0,0,0,0,0,1,3,0,0,0,5,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,7,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,Loperamide poisoning | |
| drug,Loperamide | |
| sequence,Loperamide,poisoning,in,the,dog,. | |
| labels,9,7,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,arterial thrombosis | |
| drug,thrombin | |
| sequence,We,report,a,case,of,successful,surgical,management,of,arterial,thrombosis,after,percutaneous,thrombin,injection,of,a,femoral,artery,pseudoaneurysm,in,a,69-year-old,woman,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,disorientation,temporary amnesia | |
| drug,propranolol | |
| sequence,Comparable,adverse,effects,,,such,as,disorientation,and,temporary,amnesia,,,have,been,reported,in,patients,in,the,analogous,agent,,,propranolol,. | |
| labels,0,0,0,0,0,0,8,0,5,7,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,collapsed | |
| drug,carboplatin | |
| sequence,A,68-year-old,female,patient,with,advanced,ovarian,carcinoma,collapsed,whilst,receiving,a,carboplatin,and,cyclophosphamide,infusion,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,0,4,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,collapsed | |
| drug,cyclophosphamide | |
| sequence,A,68-year-old,female,patient,with,advanced,ovarian,carcinoma,collapsed,whilst,receiving,a,carboplatin,and,cyclophosphamide,infusion,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,0,4,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Paradoxical precipitation of tonic seizures | |
| drug,lorazepam | |
| sequence,Paradoxical,precipitation,of,tonic,seizures,by,lorazepam,in,a,child,with,atypical,absence,seizures,. | |
| labels,5,6,6,6,7,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fever,generalized rigidity,leukocytosis,increased serum transaminase and creatine kinase | |
| drug,lithium | |
| sequence,A,16-year-old,boy,developed,fever,,,generalized,rigidity,,,leukocytosis,,,and,increased,serum,transaminase,and,creatine,kinase,levels,while,receiving,treatment,with,olanzapine,and,lithium,. | |
| labels,0,0,0,0,8,0,5,7,0,8,0,0,5,6,6,6,6,7,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,1,0,1,1,0,1,0,1,1,1,1,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fever,generalized rigidity,leukocytosis,increased serum transaminase and creatine kinase | |
| drug,olanzapine | |
| sequence,A,16-year-old,boy,developed,fever,,,generalized,rigidity,,,leukocytosis,,,and,increased,serum,transaminase,and,creatine,kinase,levels,while,receiving,treatment,with,olanzapine,and,lithium,. | |
| labels,0,0,0,0,8,0,5,7,0,8,0,0,5,6,6,6,6,7,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,1,0,1,1,0,1,0,1,1,1,1,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperpigmentation | |
| drug,bleomycin | |
| sequence,We,report,a,case,of,hyperpigmentation,due,to,bleomycin,treatment,in,a,patient,with,acquired,immune,deficiency,syndrome,(,AIDS,),. | |
| labels,0,0,0,0,0,8,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neuropathy | |
| drug,gold | |
| sequence,Clinical,and,morphological,features,of,gold,neuropathy,. | |
| labels,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,encephalopathy | |
| drug,methotrexate | |
| sequence,An,episode,of,subacute,encephalopathy,after,the,infusion,of,a,moderate,dose,of,methotrexate,(,1500,mg,m2,),(,MTX,),is,reported,in,a,young,adult,with,metastastic,gastric,cancer,. | |
| labels,0,0,0,0,8,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Psoriasis | |
| drug,imiquimod | |
| sequence,Psoriasis,triggered,by,toll-like,receptor,7,agonist,imiquimod,in,the,presence,of,dermal,plasmacytoid,dendritic,cell,precursors,. | |
| labels,8,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pruritic bullous eruption | |
| drug,prednisone | |
| sequence,A,14-year-old,girl,with,newly,diagnosed,SLE,developed,a,pruritic,bullous,eruption,while,on,prednisone,. | |
| labels,0,0,0,0,0,0,0,0,0,5,6,7,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Colitis,disseminated cryptococcosis | |
| drug,infliximab | |
| sequence,Colitis,as,a,manifestation,of,infliximab-associated,disseminated,cryptococcosis,. | |
| labels,8,0,0,0,0,4,5,7,0 | |
| ade_mask,1,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,variation in muscle fiber size,vacuolated fibers,myopathy | |
| drug,colchicine | |
| sequence,Muscle,biopsy,revealed,variation,in,muscle,fiber,size,and,few,vacuolated,fibers,which,were,features,of,colchicine-induced,myopathy,. | |
| labels,0,0,0,5,6,6,6,7,0,0,5,7,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,1,1,1,1,1,0,0,1,1,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,tardive dyskinesia | |
| drug,risperidone | |
| sequence,This,report,presents,a,potential,case,of,risperidone-induced,tardive,dyskinesia,. | |
| labels,0,0,0,0,0,0,0,4,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,tardive seizures | |
| drug,cefotiam | |
| sequence,Thus,,,tardive,seizures,in,our,cases,are,thought,to,be,related,to,piperacillin,and,cefotiam,. | |
| labels,0,0,5,7,0,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,tardive seizures | |
| drug,piperacillin | |
| sequence,Thus,,,tardive,seizures,in,our,cases,are,thought,to,be,related,to,piperacillin,and,cefotiam,. | |
| labels,0,0,5,7,0,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,mild nitritoid symptoms,pain,T10-T12 dermatomes | |
| drug,gold sodium thiomalate | |
| sequence,The,first,patient,developed,mild,nitritoid,symptoms,and,pain,in,a,band-like,distribution,,,corresponding,to,T10-T12,dermatomes,,,shortly,after,gold,sodium,thiomalate,(,GSTM,),injection,. | |
| labels,0,0,0,0,5,6,7,0,8,0,0,0,0,0,0,0,5,7,0,0,0,1,2,3,0,4,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,0,1,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,mild nitritoid symptoms,pain,T10-T12 dermatomes | |
| drug,GSTM | |
| sequence,The,first,patient,developed,mild,nitritoid,symptoms,and,pain,in,a,band-like,distribution,,,corresponding,to,T10-T12,dermatomes,,,shortly,after,gold,sodium,thiomalate,(,GSTM,),injection,. | |
| labels,0,0,0,0,5,6,7,0,8,0,0,0,0,0,0,0,5,7,0,0,0,1,2,3,0,4,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,0,1,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,coagulopathy | |
| drug,cephalosporin | |
| sequence,Nevertheless,,,the,coagulopathy,seemed,to,be,most,closely,associated,with,the,administration,of,the,cephalosporin,. | |
| labels,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hepatotoxicity | |
| drug,methylprednisolone | |
| sequence,Hepatotoxicity,after,high-dose,methylprednisolone,for,demyelinating,disease,. | |
| labels,8,0,0,4,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute hepatitis | |
| drug,Gliclazide | |
| sequence,Gliclazide-induced,acute,hepatitis,. | |
| labels,4,5,7,0 | |
| ade_mask,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Putaminal infarct,methanol intoxication | |
| drug,methanol | |
| sequence,Putaminal,infarct,in,methanol,intoxication,:,case,report,and,role,of,brain,imaging,studies,. | |
| labels,5,7,0,9,7,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Osteonecrosis | |
| drug,dexamethasone | |
| sequence,Osteonecrosis,is,a,serious,side,effect,of,antiemetic,treatment,with,dexamethasone,and,this,serious,complication,should,be,incorporated,in,the,current,guidelines,. | |
| labels,8,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,staphylococcus aureus sepsis | |
| drug,CyA | |
| sequence,However,,,recurrent,staphylococcus,aureus,sepsis,developed,during,CyA,therapy,. | |
| labels,0,0,0,5,6,7,0,0,4,0,0 | |
| ade_mask,0,0,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sprue-like syndrome | |
| drug,Methotrexate | |
| sequence,Methotrexate,induced,sprue-like,syndrome,. | |
| labels,4,0,5,7,0 | |
| ade_mask,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,agranulocytosis | |
| drug,dapsone | |
| sequence,Various,case,reports,concerning,dapsone-induced,agranulocytosis,are,reviewed,. | |
| labels,0,0,0,0,4,8,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,Horner's syndrome,severe demyelinating peripheral neuropathy,death | |
| drug,cytosine arabinoside | |
| sequence,We,describe,a,patient,with,acute,leukemia,who,developed,Horner,'s,syndrome,and,a,severe,demyelinating,peripheral,neuropathy,leading,to,death,after,receiving,high-dose,cytosine,arabinoside,. | |
| labels,0,0,0,0,0,0,0,0,0,5,6,7,0,0,5,6,6,7,0,0,8,0,0,0,1,3,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,0,0,1,1,1,1,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperglycemia | |
| drug,asparaginase | |
| sequence,Attenuation,of,asparaginase-induced,hyperglycemia,after,substitution,of,the,Erwinia,carotovora,for,the,Escherichia,coli,enzyme,preparation,. | |
| labels,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,drug-drug interaction | |
| drug,theophylline | |
| sequence,We,present,the,first,case,(,to,our,knowledge,),of,a,potentially,serious,drug-drug,interaction,between,zafirlukast,and,theophylline,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,drug-drug interaction | |
| drug,zafirlukast | |
| sequence,We,present,the,first,case,(,to,our,knowledge,),of,a,potentially,serious,drug-drug,interaction,between,zafirlukast,and,theophylline,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,renal impairment | |
| drug,gabapentin | |
| sequence,CONCLUSION,:,All,doctors,need,to,be,aware,of,the,need,to,review,the,indications,for,gabapentin,use,during,periods,of,acute,illness,,,especially,with,regard,to,renal,impairment,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,hypertrophic obstructive cardiomyopathy | |
| drug,dexamethasone | |
| sequence,Effect,of,beta-blockade,on,symptomatic,dexamethasone-induced,hypertrophic,obstructive,cardiomyopathy,in,premature,infants,:,three,case,reports,and,literature,review,. | |
| labels,0,0,0,0,0,4,5,6,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Stevens-Johnson syndrome | |
| drug,prednisolone | |
| sequence,Stevens-Johnson,syndrome,in,a,boy,with,nephrotic,syndrome,during,prednisolone,therapy,. | |
| labels,5,7,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rosaceiform eruption | |
| drug,erlotinib | |
| sequence,The,aim,of,this,paper,is,to,report,the,case,of,rosaceiform,eruption,induced,by,erlotinib,in,an,81-year-old-man,and,to,discuss,the,pathogenetic,role,of,Demodex,folliculorum,mites,,,found,in,the,present,patient,,,using,skin,scraping,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatotoxicity | |
| drug,methotrexate | |
| sequence,In,all,three,cases,,,autopsy,revealed,gross,and,microscopic,features,indistinguishable,from,those,seen,in,the,Hamman-Rich,syndrome,,,and,methotrexate,hepatotoxicity,was,present,in,one,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,psychiatric side effects | |
| drug,IFN-alpha | |
| sequence,Treatment,of,chronic,hepatitis,C,with,interferon,alpha,(,IFN-alpha,),is,relatively,contraindicated,in,patients,with,psychiatric,disorders,because,of,possible,severe,psychiatric,side,effects,. | |
| labels,0,0,0,0,0,0,1,3,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,psychiatric side effects | |
| drug,interferon alpha | |
| sequence,Treatment,of,chronic,hepatitis,C,with,interferon,alpha,(,IFN-alpha,),is,relatively,contraindicated,in,patients,with,psychiatric,disorders,because,of,possible,severe,psychiatric,side,effects,. | |
| labels,0,0,0,0,0,0,1,3,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Acute lung injury | |
| drug,5-fluorouracil | |
| sequence,Acute,lung,injury,associated,with,5-fluorouracil,and,oxaliplatinum,combined,chemotherapy,. | |
| labels,5,6,7,0,0,4,0,4,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute lung injury | |
| drug,oxaliplatinum | |
| sequence,Acute,lung,injury,associated,with,5-fluorouracil,and,oxaliplatinum,combined,chemotherapy,. | |
| labels,5,6,7,0,0,4,0,4,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,multiple comedones,ruptured epidermoid cysts | |
| drug,imiquimod | |
| sequence,The,multiple,comedones,and,ruptured,epidermoid,cysts,are,newly,reported,adverse,effects,of,imiquimod,therapy,. | |
| labels,0,5,7,0,5,6,7,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,1,1,0,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,densification of trabecular bone | |
| drug,niflumic acid | |
| sequence,The,fluorine,contained,in,niflumic,acid,induced,a,marked,densification,of,trabecular,bone,in,all,3,cases,. | |
| labels,0,0,0,0,1,3,0,0,0,5,6,6,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,dacryolith | |
| drug,adrenaline | |
| sequence,Histological,examination,of,the,dacryolith,suggested,its,derivation,from,breakdown,products,of,adrenaline,. | |
| labels,0,0,0,0,8,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypoxemia,hypotension | |
| drug,nimodipine | |
| sequence,Easily,reversible,hypoxemia,and,hypotension,induced,by,nimodipine,. | |
| labels,0,0,8,0,8,0,0,4,0 | |
| ade_mask,0,0,1,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,proteinuria | |
| drug,temsirolimus | |
| sequence,A,58-year-old,man,with,advanced,renal,cell,carcinoma,developed,grade,3,proteinuria,(,8.5,g,24,h,),without,microscopic,hematuria,or,renal,insufficiency,five,days,after,temsirolimus,infusion,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,LPD | |
| drug,MTX | |
| sequence,Increased,awareness,is,needed,on,the,possible,occurrence,of,LPD,resembling,gastric,cancer,in,rheumatoid,arthritis,patients,treated,with,MTX,. | |
| labels,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Encephalopathy,seizures | |
| drug,alum | |
| sequence,Encephalopathy,and,seizures,induced,by,intravesical,alum,irrigations,. | |
| labels,8,0,8,0,0,0,4,0,0 | |
| ade_mask,1,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,B-cell lymphoma | |
| drug,razoxane | |
| sequence,A,woman,with,a,20-year,history,of,acral,pustular,psoriasis,of,Hallopeau,and,recurrent,pustular,lesions,of,the,forearms,and,lower,legs,,,developed,a,B-cell,lymphoma,of,the,lip,following,4,1,2,years,of,treatment,with,razoxane,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,increased calcium-release | |
| drug,dihydrotachysterol | |
| sequence,Immobilization,,,while,Paget,'s,bone,disease,was,present,,,and,perhaps,enhanced,activation,of,dihydrotachysterol,by,rifampicin,,,could,have,led,to,increased,calcium-release,into,the,circulation,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,5,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,reaction to the drug became more toxic | |
| drug,theophylline | |
| sequence,Attempts,were,made,to,stop,and,then,restart,the,theophylline,therapy,at,progressively,lower,doses,;,however,,,with,each,attempt,,,the,patient,'s,reaction,to,the,drug,became,more,toxic,,,with,serum,theophylline,levels,ranging,between,99.9,and,149.9,micromol,L,(,18,and,27,microg,mL,),. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute leukaemia | |
| drug,tamoxifen | |
| sequence,Acute,leukaemia,during,tamoxifen,therapy,. | |
| labels,5,7,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neutropenia,agranulocytosis | |
| drug,clozapine | |
| sequence,It,carries,a,well-known,risk,of,neutropenia,and,agranulocytosis,,,which,necessitates,the,immediate,discontinuation,of,clozapine,. | |
| labels,0,0,0,0,0,0,8,0,8,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,muscle weakness | |
| drug,colchicine | |
| sequence,The,concomitant,use,,,however,,,of,colchicine,and,statin,has,been,associated,with,the,rapid,onset,of,muscle,weakness,. | |
| labels,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,muscle weakness | |
| drug,statin | |
| sequence,The,concomitant,use,,,however,,,of,colchicine,and,statin,has,been,associated,with,the,rapid,onset,of,muscle,weakness,. | |
| labels,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,ductopenia,cholangiopathy | |
| drug,itraconazole | |
| sequence,Beginning,ductopenia,was,present,in,two,,,suggesting,that,itraconazole,might,be,responsible,for,the,occurrence,of,prolonged,drug-induced,cholangiopathy,. | |
| labels,0,8,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,urinary incontinence | |
| drug,Venlafaxine | |
| sequence,Venlafaxine-induced,urinary,incontinence,resolved,after,switching,to,sertraline,. | |
| labels,4,5,7,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,death | |
| drug,quetiapine | |
| sequence,In,all,cases,,,drugs,in,addition,to,quetiapine,were,detected,,,but,in,cases,#,1,and,#,2,,,the,cause,of,death,was,considered,to,be,a,quetiapine,overdose,and,the,other,drugs,were,not,considered,to,be,contributory,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fever | |
| drug,diltiazem | |
| sequence,Drug-induced,fever,due,to,diltiazem,. | |
| labels,0,8,0,0,4,0 | |
| ade_mask,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,interstitial nephritis | |
| drug,ciprofloxacin | |
| sequence,Suspected,ciprofloxacin-induced,interstitial,nephritis,. | |
| labels,0,4,5,7,0 | |
| ade_mask,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Livedo reticularis | |
| drug,interferon alpha | |
| sequence,Livedo,reticularis,associated,with,interferon,alpha,therapy,in,two,melanoma,patients,. | |
| labels,5,7,0,0,1,3,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,TEN,SJS | |
| drug,lamotrigine | |
| sequence,To,date,,,eight,cases,of,TEN,and,one,of,SJS,related,to,lamotrigine,administration,have,been,reported,in,the,literature,. | |
| labels,0,0,0,0,0,0,8,0,0,0,8,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,systemic allergic reaction | |
| drug,aprotinin | |
| sequence,We,highlight,two,instances,of,systemic,allergic,reaction,,,and,discuss,the,potential,side,effects,of,local,aprotinin,injections,in,the,orthopaedic,setting,as,well,as,the,evidence,base,for,its,use,. | |
| labels,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Accelerated nodulosis | |
| drug,methotrexate | |
| sequence,Accelerated,nodulosis,during,methotrexate,therapy,for,juvenile,rheumatoid,arthritis,. | |
| labels,5,7,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,coagulopathy | |
| drug,Quinine | |
| sequence,Quinine,induced,coagulopathy,--,a,near,fatal,experience,. | |
| labels,4,0,8,0,0,0,0,0,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute renal failure,hyperkalemia | |
| drug,aliskiren | |
| sequence,We,report,the,first,case,of,acute,renal,failure,with,hyperkalemia,associated,with,the,recently,marketed,direct,renin,inhibitor,aliskiren,. | |
| labels,0,0,0,0,0,0,5,6,7,0,8,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Reversible heart failure | |
| drug,etanercept | |
| sequence,Reversible,heart,failure,in,a,patient,receiving,etanercept,for,ankylosing,spondylitis,. | |
| labels,5,6,7,0,0,0,0,4,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Priapism | |
| drug,zuclopenthixol | |
| sequence,Priapism,associated,with,zuclopenthixol,. | |
| labels,8,0,0,4,0 | |
| ade_mask,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neurologic deterioration | |
| drug,D-penicillamine | |
| sequence,We,describe,a,patient,with,Wilson,'s,disease,who,presented,with,neurologic,disease,,,was,treated,with,D-penicillamine,,,and,suffered,sudden,neurologic,deterioration,coincident,with,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,5,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,toxic symptoms,drowsiness,dizziness,ataxia | |
| drug,carbamazepine | |
| sequence,During,clarithromycin,coadministration,,,four,out,of,the,seven,patients,developed,moderate-to-severe,toxic,symptoms,of,carbamazepine,,,such,as,drowsiness,,,dizziness,,,and,ataxia,,,which,resolved,within,5,days,after,clarithromycin,discontinuation,. | |
| labels,0,4,0,0,0,0,0,0,0,0,0,0,5,7,0,4,0,0,0,8,0,8,0,0,8,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,1,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,toxic symptoms,drowsiness,dizziness,ataxia | |
| drug,clarithromycin | |
| sequence,During,clarithromycin,coadministration,,,four,out,of,the,seven,patients,developed,moderate-to-severe,toxic,symptoms,of,carbamazepine,,,such,as,drowsiness,,,dizziness,,,and,ataxia,,,which,resolved,within,5,days,after,clarithromycin,discontinuation,. | |
| labels,0,4,0,0,0,0,0,0,0,0,0,0,5,7,0,4,0,0,0,8,0,8,0,0,8,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,1,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Oesophageal ulceration | |
| drug,emepronium bromide | |
| sequence,Oesophageal,ulceration,due,to,emepronium,bromide,. | |
| labels,5,7,0,0,1,3,0 | |
| ade_mask,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pneumonitis | |
| drug,Celiprolol | |
| sequence,Celiprolol,pneumonitis,. | |
| labels,4,8,0 | |
| ade_mask,0,1,0 | |
| ==============================, ============================= | |
| ade,Restless legs syndrome | |
| drug,IFN alpha | |
| sequence,Restless,legs,syndrome,may,thus,be,an,adverse,effect,of,IFN,alpha,treatment,. | |
| labels,5,6,7,0,0,0,0,0,0,0,1,3,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe myelopathy | |
| drug,doxorubicin | |
| sequence,RESULTS,:,Evidence,of,neurological,improvement,and,rehabilitation,potential,after,severe,myelopathy,due,to,intrathecal,injection,of,doxorubicin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,dyskinesia | |
| drug,levodopa | |
| sequence,Prior,to,surgery,,,levodopa,induced,dyskinesia,had,improved,(,<,or,=,50,%,),under,treatment,with,amantadine,(,400,mg,day,,,po,),in,all,three,patients,. | |
| labels,0,0,0,0,4,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cataract | |
| drug,Propecia | |
| sequence,To,the,best,of,the,authors,knowledge,,,this,is,the,first,reported,case,of,Propecia-associated,cataract,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,sub-conjunctival haematoma | |
| drug,warfarin | |
| sequence,An,unusual,presentation,of,spontaneous,sub-conjunctival,haematoma,in,a,patient,receiving,warfarin,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,irritating cough | |
| drug,quinapril | |
| sequence,CASE,SUMMARY,:,A,68-year-old,woman,developed,a,dry,,,irritating,cough,within,one,month,of,starting,quinapril,therapy,for,the,treatment,of,essential,hypertension,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity reaction,diffuse urticaria,facial swelling,cough,chest tightness | |
| drug,MTX | |
| sequence,He,had,an,immediate,hypersensitivity,reaction,during,the,initiation,of,the,MTX,infusion,with,diffuse,urticaria,,,facial,swelling,,,cough,,,and,chest,tightness,. | |
| labels,0,0,0,0,5,7,0,0,0,0,0,4,0,0,5,7,0,5,7,0,8,0,0,5,7,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,1,1,0,1,1,0,1,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Pneumocystis carinii pneumonia | |
| drug,methotrexate | |
| sequence,Pneumocystis,carinii,pneumonia,as,a,complication,of,methotrexate,treatment,of,asthma,. | |
| labels,5,6,7,0,0,0,0,4,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Tubulointerstitial nephritis | |
| drug,pranlukast | |
| sequence,Tubulointerstitial,nephritis,induced,by,the,leukotriene,receptor,antagonist,pranlukast,. | |
| labels,5,7,0,0,0,0,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,psychosis | |
| drug,efavirenz | |
| sequence,We,report,(,to,our,knowledge,,,for,the,first,time,in,a,child,),the,emergence,of,psychosis,in,a,12-year,old,white,girl,with,an,increased,efavirenz,concentration,and,heterozygous,gene,polymorphism,of,the,CYP2B6-G516T,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,FVS | |
| drug,valproic acid | |
| sequence,The,authors,describe,three,families,in,whom,the,occurrence,of,FVS,in,all,the,siblings,strongly,suggests,hereditary,susceptibility,to,valproic,acid-induced,adverse,outcome,. | |
| labels,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,1,3,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,erosion of a psoriatic plaque | |
| drug,methotrexate | |
| sequence,A,43-year-old,white,man,developed,a,shallow,erosion,of,a,psoriatic,plaque,after,chronic,administration,of,methotrexate,. | |
| labels,0,0,0,0,0,0,0,5,6,6,6,7,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,0,1,1,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nausea,shortness of breath,azotemia,hyperkalemia | |
| drug,immunoglobulin | |
| sequence,We,report,the,case,of,an,87-year-old,white,woman,with,myasthenia,gravis,who,presented,with,nausea,,,shortness,of,breath,,,azotemia,,,and,hyperkalemia,shortly,after,completing,a,course,of,intravenous,immunoglobulin,(,IVIG,),. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,5,6,7,0,8,0,0,8,0,0,0,0,0,0,0,4,0,4,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nausea,shortness of breath,azotemia,hyperkalemia | |
| drug,IVIG | |
| sequence,We,report,the,case,of,an,87-year-old,white,woman,with,myasthenia,gravis,who,presented,with,nausea,,,shortness,of,breath,,,azotemia,,,and,hyperkalemia,shortly,after,completing,a,course,of,intravenous,immunoglobulin,(,IVIG,),. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,5,6,7,0,8,0,0,8,0,0,0,0,0,0,0,4,0,4,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,liver injury | |
| drug,troglitazone | |
| sequence,However,,,as,illustrated,by,these,and,other,cases,reported,to,date,,,the,onset,of,troglitazone-induced,liver,injury,is,insidious,and,temporally,variable,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,5,7,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lithium toxicity | |
| drug,acyclovir | |
| sequence,Until,additional,data,are,available,,,if,intravenous,acyclovir,is,administered,concurrently,with,lithium,,,we,recommend,closely,monitoring,patients,for,signs,of,lithium,toxicity,and,measuring,serum,lithium,levels,every,second,or,third,day,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,0,4,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lithium toxicity | |
| drug,lithium | |
| sequence,Until,additional,data,are,available,,,if,intravenous,acyclovir,is,administered,concurrently,with,lithium,,,we,recommend,closely,monitoring,patients,for,signs,of,lithium,toxicity,and,measuring,serum,lithium,levels,every,second,or,third,day,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,0,4,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fulminant microangiopathic hemolytic anemia,thrombocytopenia | |
| drug,sulfamethoxazole | |
| sequence,The,patient,presented,with,fulminant,microangiopathic,hemolytic,anemia,and,thrombocytopenia,within,48,hr,of,initiating,therapy,with,trimethoprim-sulfamethoxazole,. | |
| labels,0,0,0,0,5,6,6,7,0,8,0,0,0,0,0,0,0,4,4 | |
| ade_mask,0,0,0,0,1,1,1,1,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fulminant microangiopathic hemolytic anemia,thrombocytopenia | |
| drug,trimethoprim | |
| sequence,The,patient,presented,with,fulminant,microangiopathic,hemolytic,anemia,and,thrombocytopenia,within,48,hr,of,initiating,therapy,with,trimethoprim-sulfamethoxazole,. | |
| labels,0,0,0,0,5,6,6,7,0,8,0,0,0,0,0,0,0,4,4 | |
| ade_mask,0,0,0,0,1,1,1,1,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Cough | |
| drug,quinapril | |
| sequence,Cough,induced,by,quinapril,with,resolution,after,changing,to,fosinopril,. | |
| labels,8,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ARDS,severe pulmonary symptoms | |
| drug,rituximab | |
| sequence,ARDS,is,rarely,associated,with,rituximab,infusion,for,lympho-proliferative,disorders,,,but,it,should,be,considered,by,those,administering,rituximab,,,especially,when,a,patient,develops,severe,pulmonary,symptoms,soon,after,infusion,. | |
| labels,8,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Cushing's syndrome | |
| drug,TCA | |
| sequence,Caution,is,,,therefore,,,needed,to,prevent,undesired,accumulation,of,TCA,that,may,lead,to,protracted,Cushing,'s,syndrome,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,inappropriate secretion of antidiuretic hormone | |
| drug,vinblastine | |
| sequence,We,report,on,a,patient,with,an,embryonal,teratocarcinoma,of,the,testicle,who,had,the,syndrome,of,inappropriate,secretion,of,antidiuretic,hormone,after,receiving,a,high,dose,of,vinblastine,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,7,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,1,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ulcer | |
| drug,ATRA | |
| sequence,The,ulcer,did,not,respond,to,antibiotic,treatment,and,healed,shortly,after,withholding,ATRA,. | |
| labels,0,8,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,retinopathy | |
| drug,hydroxychloroquine | |
| sequence,Normalization,of,generalized,retinal,function,and,progression,of,maculopathy,after,cessation,of,therapy,in,a,case,of,severe,hydroxychloroquine,retinopathy,with,19,years,follow-up,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute weakness | |
| drug,colchicine | |
| sequence,We,report,a,case,of,a,patient,with,mild,chronic,renal,insufficiency,who,had,been,taking,simvastatin,for,over,a,year,and,developed,acute,weakness,within,3,weeks,after,the,start,of,treatment,with,colchicine,for,acute,gouty,bursitis,. | |
| labels,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,4,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,mild chronic renal insufficiency,acute weakness | |
| drug,simvastatin | |
| sequence,We,report,a,case,of,a,patient,with,mild,chronic,renal,insufficiency,who,had,been,taking,simvastatin,for,over,a,year,and,developed,acute,weakness,within,3,weeks,after,the,start,of,treatment,with,colchicine,for,acute,gouty,bursitis,. | |
| labels,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,4,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,aplastic anaemia,liver failure | |
| drug,Flucloxacillin | |
| sequence,Flucloxacillin-induced,aplastic,anaemia,and,liver,failure,. | |
| labels,4,5,7,0,5,7,0 | |
| ade_mask,0,1,1,0,1,1,0 | |
| ==============================, ============================= | |
| ade,pneumonitis | |
| drug,sirolimus | |
| sequence,Two,cases,of,sirolimus-associated,pneumonitis,have,been,reported,after,cardiac,transplantation,. | |
| labels,0,0,0,4,8,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neuroleptic malignant syndrome | |
| drug,Fluphenazine | |
| sequence,Fluphenazine-induced,neuroleptic,malignant,syndrome,in,a,schizophrenic,patient,. | |
| labels,4,5,6,7,0,0,0,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,multiple nodules in the liver | |
| drug,PDES | |
| sequence,This,paper,reports,an,autopsy,case,of,a,78-year-old,male,with,multiple,nodules,in,the,liver,developed,after,long-termed,administration,of,phosphate,diethylstilbestrol,(,PDES,),for,prostatic,cancer,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,7,0,0,0,0,0,1,3,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,multiple nodules in the liver | |
| drug,phosphate diethylstilbestrol | |
| sequence,This,paper,reports,an,autopsy,case,of,a,78-year-old,male,with,multiple,nodules,in,the,liver,developed,after,long-termed,administration,of,phosphate,diethylstilbestrol,(,PDES,),for,prostatic,cancer,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,7,0,0,0,0,0,1,3,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,tachycardia | |
| drug,procainamide | |
| sequence,Escape,atrial,complexes,,,which,occurred,following,junctional,premature,complexes,,,failed,to,initiate,tachycardia,in,the,control,state,but,tachycardia,was,always,reinitiated,by,an,identical,escape,sequence,after,procainamide,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bronchiolitis obliterans with organizing pneumonia | |
| drug,rituximab | |
| sequence,We,describe,a,case,of,an,NHL,patient,who,received,rituximab,and,developed,symptomatic,,,biopsy-proven,multinodular,bronchiolitis,obliterans,with,organizing,pneumonia,(,BOOP,),. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,5,6,6,6,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Delayed hypersensitivity | |
| drug,flurbiprofen | |
| sequence,Delayed,hypersensitivity,to,flurbiprofen,. | |
| labels,5,7,0,4,0 | |
| ade_mask,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,pulmonary toxicity,widespread reticular pattern,distortion of the lung parenchyma,fibrosis | |
| drug,nitrofurantoin | |
| sequence,We,present,two,cases,of,nitrofurantoin-induced,pulmonary,toxicity,in,which,the,initial,HRCT,showed,a,widespread,reticular,pattern,and,associated,distortion,of,the,lung,parenchyma,,,thought,to,represent,established,fibrosis,. | |
| labels,0,0,0,0,0,4,5,7,0,0,0,0,0,0,0,5,6,7,0,0,5,6,6,6,7,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,1,0,1,1,0,0,1,0,0,0,0,1,1,1,0,0,1,0,0,1,1,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,skin lesions | |
| drug,phenytoin | |
| sequence,All,patients,had,taken,phenytoin,for,variable,time,periods,(,range,16-80,days,;,mean,:,40,),and,were,on,the,medication,when,the,skin,lesions,first,appeared,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,Valproate embryopathy | |
| drug,Valproate | |
| sequence,Valproate,embryopathy,in,three,sets,of,siblings,:,further,proof,of,hereditary,susceptibility,. | |
| labels,9,7,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myopia | |
| drug,metronidazole | |
| sequence,The,second,had,acute,cystitis,and,was,treated,by,sulphonamide,and,the,third,developed,myopia,coincident,with,metronidazole,treatment,for,trichomonas,vaginalis,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,0,0,8,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myopia | |
| drug,sulphonamide | |
| sequence,The,second,had,acute,cystitis,and,was,treated,by,sulphonamide,and,the,third,developed,myopia,coincident,with,metronidazole,treatment,for,trichomonas,vaginalis,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,0,0,8,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,arterial thrombosis | |
| drug,thrombin | |
| sequence,Native,arterial,thrombosis,,,though,recognized,as,a,severe,complication,of,thrombin,injection,,,has,not,been,well,described,in,the,literature,. | |
| labels,0,5,7,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombocytosis | |
| drug,ciprofloxacin | |
| sequence,It,is,concluded,that,simultaneous,administration,of,ciprofloxacin,and,tazobactam,piperacillin,may,cause,marked,thrombocytosis,. | |
| labels,0,0,0,0,0,0,0,4,0,4,4,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,thrombocytosis | |
| drug,piperacillin | |
| sequence,It,is,concluded,that,simultaneous,administration,of,ciprofloxacin,and,tazobactam,piperacillin,may,cause,marked,thrombocytosis,. | |
| labels,0,0,0,0,0,0,0,4,0,4,4,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,thrombocytosis | |
| drug,tazobactam | |
| sequence,It,is,concluded,that,simultaneous,administration,of,ciprofloxacin,and,tazobactam,piperacillin,may,cause,marked,thrombocytosis,. | |
| labels,0,0,0,0,0,0,0,4,0,4,4,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,pulmonary toxicity | |
| drug,etoposide | |
| sequence,A,patient,with,chronic,myelomonocytic,leukemia,developed,drug-induced,pulmonary,toxicity,after,using,low,dose,oral,etoposide,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,precipitating psychosis | |
| drug,amantadine | |
| sequence,Despite,a,postulated,dopaminergic,mechanism,,,there,seems,to,have,been,only,one,previous,report,of,amantadine,'s,precipitating,psychosis,in,a,schizophrenic,patient,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,5,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,polycystic changes,gained weight,amenorrhea | |
| drug,valproate | |
| sequence,The,polycystic,changes,disappeared,from,the,ovaries,in,2,of,the,women,after,valproate,therapy,was,discontinued,,,and,the,2,women,who,had,gained,weight,and,developed,amenorrhea,while,being,treated,with,valproate,lost,weight,and,resumed,menstruating,after,the,change,in,medication,. | |
| labels,0,5,7,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,5,7,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatic and renal failure | |
| drug,argatroban | |
| sequence,OBJECTIVE,:,To,report,a,case,of,significant,hepatic,and,renal,failure,with,the,use,of,argatroban,in,a,patient,with,heparin-induced,thrombocytopenia,(,HIT,),requiring,continuous,veno-veno,hemodialysis,(,CVVHD,),. | |
| labels,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,4,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombocytopenia | |
| drug,heparin | |
| sequence,OBJECTIVE,:,To,report,a,case,of,significant,hepatic,and,renal,failure,with,the,use,of,argatroban,in,a,patient,with,heparin-induced,thrombocytopenia,(,HIT,),requiring,continuous,veno-veno,hemodialysis,(,CVVHD,),. | |
| labels,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,4,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,IOP elevation | |
| drug,Brimonidine | |
| sequence,RESULTS,:,Brimonidine,was,observed,to,cause,IOP,elevation,,,confirmed,on,rechallenge,,,scoring,8,(,strong,probability,),on,an,adverse,drug,reaction,probability,score,. | |
| labels,0,0,4,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,diabetes | |
| drug,indapamide | |
| sequence,After,3-,to,13-month,period,of,therapy,without,indapamide,,,glucose,levels,of,all,patients,decreased,and,diabetes,disappeared,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,8,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0 | |
| ==============================, ============================= | |
| ade,duodenal ulceration,intestinal perforation | |
| drug,Tolazoline | |
| sequence,Two,patients,who,were,receiving,Tolazoline,by,infusion,developed,duodenal,ulceration,and,subsequent,intestinal,perforation,. | |
| labels,0,0,0,0,0,4,0,0,0,5,7,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,tuberculosis | |
| drug,Efalizumab | |
| sequence,A,case,of,tuberculosis,in,a,patient,on,Efalizumab,and,Etanercept,for,treatment,of,refractory,palmopustular,psoriasis,and,psoriatic,arthritis,. | |
| labels,0,0,0,8,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,tuberculosis | |
| drug,Etanercept | |
| sequence,A,case,of,tuberculosis,in,a,patient,on,Efalizumab,and,Etanercept,for,treatment,of,refractory,palmopustular,psoriasis,and,psoriatic,arthritis,. | |
| labels,0,0,0,8,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Renal injury | |
| drug,anastrozole | |
| sequence,Renal,injury,due,to,anastrozole,has,not,been,published,in,the,English,literature,. | |
| labels,5,7,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,porphyria cutanea tarda | |
| drug,cisplatin | |
| sequence,We,report,a,46-yr-old,woman,with,ovarian,carcinoma,who,developed,porphyria,cutanea,tarda,while,undergoing,treatment,with,cisplatin,and,cyclophosphamide,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,porphyria cutanea tarda | |
| drug,cyclophosphamide | |
| sequence,We,report,a,46-yr-old,woman,with,ovarian,carcinoma,who,developed,porphyria,cutanea,tarda,while,undergoing,treatment,with,cisplatin,and,cyclophosphamide,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,eosinophilia | |
| drug,clozapine | |
| sequence,Successful,challenge,with,clozapine,in,a,history,of,eosinophilia,. | |
| labels,0,0,0,4,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Interstitial lung disease,ILD | |
| drug,gefitinib | |
| sequence,Interstitial,lung,disease,(,ILD,),related,to,therapy,with,the,drug,gefitinib,has,been,well,reported,. | |
| labels,5,6,7,0,8,0,0,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,serotonin syndrome | |
| drug,citalopram | |
| sequence,Based,on,the,Naranjo,probability,scale,,,serotonin,syndrome,was,a,probable,adverse,reaction,associated,with,co-administration,of,citalopram,and,fentanyl,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,serotonin syndrome | |
| drug,fentanyl | |
| sequence,Based,on,the,Naranjo,probability,scale,,,serotonin,syndrome,was,a,probable,adverse,reaction,associated,with,co-administration,of,citalopram,and,fentanyl,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hemodynamic collapse | |
| drug,labetalol | |
| sequence,Hemodynamic,collapse,following,labetalol,administration,in,preeclampsia,. | |
| labels,5,7,0,4,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,inflammatory musculoskeletal manifestations | |
| drug,IFN-beta | |
| sequence,We,present,the,cases,of,two,female,patients,diagnosed,with,relapsing-remitting,multiple,sclerosis,(,RRMS,),who,developed,inflammatory,musculoskeletal,manifestations,,,following,IFN-beta,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hemorrhage | |
| drug,aspirin | |
| sequence,Our,case,is,the,second,one,in,which,hemorrhage,from,a,meningioma,may,have,been,induced,by,aspirin,prophylaxis,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,carcinoma | |
| drug,cyclophosphamide | |
| sequence,The,development,of,erythroid,leukemia,plus,carcinoma,in,these,two,men,suggests,mutagenic,change,secondary,to,cyclophosphamide,therapy,. | |
| labels,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sensorimotor axonal neuropathy | |
| drug,thalidomide | |
| sequence,We,report,four,cases,of,sensorimotor,axonal,neuropathy,in,children,aged,10-15,years,,,treated,with,thalidomide,for,myxopapillary,ependymoma,,,Crohn,'s,disease,and,recurrent,giant,aphthous,ulceration,. | |
| labels,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,TMA | |
| drug,bleomycin | |
| sequence,A,case,report,of,a,patient,with,probable,cisplatin,and,bleomycin-induced,TMA,is,presented,. | |
| labels,0,0,0,0,0,0,0,0,4,0,4,8,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,TMA | |
| drug,cisplatin | |
| sequence,A,case,report,of,a,patient,with,probable,cisplatin,and,bleomycin-induced,TMA,is,presented,. | |
| labels,0,0,0,0,0,0,0,0,4,0,4,8,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,elevated serum ammonia levels | |
| drug,valproic acid | |
| sequence,He,had,also,developed,elevated,serum,ammonia,levels,while,on,valproic,acid,. | |
| labels,0,0,0,0,5,6,6,7,0,0,1,3,0 | |
| ade_mask,0,0,0,0,1,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Transtentorial herniation,intracranial mass lesion | |
| drug,methotrexate | |
| sequence,Transtentorial,herniation,caused,by,an,intracranial,mass,lesion,following,high-dose,methotrexate,. | |
| labels,5,7,0,0,0,5,6,7,0,0,4,0 | |
| ade_mask,1,1,0,0,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Osteomyelitis | |
| drug,infliximab | |
| sequence,Osteomyelitis,occurring,during,infliximab,treatment,of,severe,psoriasis,. | |
| labels,8,0,0,4,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatitis | |
| drug,methyldopa | |
| sequence,A,55-year-old,woman,developed,symptoms,suggestive,of,hepatitis,12,weeks,after,first,receiving,methyldopa,for,hypertension,. | |
| labels,0,0,0,0,0,0,0,8,0,0,0,0,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hirsutism,hypertension,increased blood levels of urea and creatinine,abnormalities in liver function tests | |
| drug,Cyclosporin | |
| sequence,Cyclosporin,side,effects,included,hirsutism,,,hypertension,,,increased,blood,levels,of,urea,and,creatinine,,,and,abnormalities,in,liver,function,tests,. | |
| labels,4,0,0,0,8,0,8,0,5,6,6,6,6,6,7,0,0,5,6,6,6,7,0 | |
| ade_mask,0,0,0,0,1,0,1,0,1,1,1,1,1,1,1,0,0,1,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,acute pancreatitis | |
| drug,amiodarone | |
| sequence,We,report,a,patient,who,developed,acute,pancreatitis,during,amiodarone,therapy,. | |
| labels,0,0,0,0,0,0,5,7,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,livedo reticularis | |
| drug,interferon alpha | |
| sequence,These,cases,highlight,the,occurrence,of,livedo,reticularis,as,an,uncommon,side-effect,of,interferon,alpha,treatment,. | |
| labels,0,0,0,0,0,0,5,7,0,0,0,0,0,1,3,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,renal failure,eosinophilia,skin rash | |
| drug,ampicillin | |
| sequence,The,diagnosis,was,based,on,the,rapid,onset,of,renal,failure,,,presence,of,eosinophilia,,,skin,rash,,,and,characteristic,renal,biopsy,finding,,,following,the,administration,of,ampicillin,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,0,0,8,0,5,7,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cerebrospinal fluid eosinophilia | |
| drug,vancomycin | |
| sequence,Intraventricular,vancomycin-induced,cerebrospinal,fluid,eosinophilia,:,report,of,two,patients,. | |
| labels,0,4,5,6,7,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Macular infarction | |
| drug,gentamicin | |
| sequence,Macular,infarction,after,endophthalmitis,treated,with,vitrectomy,and,intravitreal,gentamicin,. | |
| labels,5,7,0,0,0,0,0,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fever,severe cutaneous involvement,swelling,abdominal pain,transaminitis | |
| drug,pyrimethamine | |
| sequence,A,7-year-old,with,congenital,toxoplasmosis,who,took,pyrimethamine,and,sulfadiazine,for,reactivated,chorioretinitis,developed,fever,,,severe,cutaneous,involvement,,,swelling,,,abdominal,pain,and,transaminitis,,,persisting,weeks,after,withholding,medicines,. | |
| labels,0,0,0,0,0,0,0,4,0,4,0,0,0,0,8,0,5,6,7,0,8,0,5,7,0,8,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,1,0,1,0,1,1,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fever,severe cutaneous involvement,swelling,abdominal pain,transaminitis | |
| drug,sulfadiazine | |
| sequence,A,7-year-old,with,congenital,toxoplasmosis,who,took,pyrimethamine,and,sulfadiazine,for,reactivated,chorioretinitis,developed,fever,,,severe,cutaneous,involvement,,,swelling,,,abdominal,pain,and,transaminitis,,,persisting,weeks,after,withholding,medicines,. | |
| labels,0,0,0,0,0,0,0,4,0,4,0,0,0,0,8,0,5,6,7,0,8,0,5,7,0,8,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,1,0,1,0,1,1,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe hyponatremia | |
| drug,hydrochlorothiazide | |
| sequence,One,patient,developed,severe,hyponatremia,with,serum,Na+,of,108,mEq,L,when,hydrochlorothiazide,was,given,to,control,hypertension,. | |
| labels,0,0,0,5,7,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,skin rash,acute kidney injury,high-grade fever,eosinophilia,liver dysfunction,lymphadenopathy,an increase in antihuman herpesvirus-6 immunoglobulin G titer | |
| drug,zonisamide | |
| sequence,The,current,report,describes,a,man,who,was,prescribed,zonisamide,for,epilepsy,and,subsequently,developed,widespread,skin,rash,,,acute,kidney,injury,,,high-grade,fever,,,eosinophilia,,,liver,dysfunction,,,lymphadenopathy,and,an,increase,in,antihuman,herpesvirus-6,immunoglobulin,G,titer,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,5,7,0,5,6,7,0,5,7,0,8,0,5,7,0,8,0,5,6,6,6,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,1,1,0,1,1,0,1,0,1,1,0,1,0,1,1,1,1,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,Disseminated eruptive giant mollusca contagiosa | |
| drug,efalizumab | |
| sequence,Disseminated,eruptive,giant,mollusca,contagiosa,in,an,adult,psoriasis,patient,during,efalizumab,therapy,. | |
| labels,5,6,6,6,7,0,0,0,0,0,0,4,0,0 | |
| ade_mask,1,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Generalised cutaneous rash | |
| drug,ganciclovir | |
| sequence,Generalised,cutaneous,rash,associated,with,ganciclovir,therapy,has,rarely,been,reported,in,literature,. | |
| labels,5,6,7,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypothyroidism | |
| drug,amiodarone | |
| sequence,This,is,the,first,report,on,the,histopathological,findings,of,thyroid,tissue,from,a,patient,with,amiodarone-induced,hypothyroidism,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Hypersensitivity reactions | |
| drug,cisplatin | |
| sequence,Hypersensitivity,reactions,to,cisplatin,following,multiple,uncomplicated,courses,:,a,report,on,two,cases,. | |
| labels,5,7,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pulmonary hypertension | |
| drug,lithium | |
| sequence,The,authors,presented,a,case,of,pulmonary,hypertension,during,lithium,therapy,,,while,she,has,been,on,lithium,for,6,years,. | |
| labels,0,0,0,0,0,0,5,7,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe enteropathy | |
| drug,clofazimine | |
| sequence,An,11-year-old,boy,developed,a,severe,enteropathy,2,years,after,initiation,of,clofazimine,treatment,for,graft-versus-host,disease,. | |
| labels,0,0,0,0,0,5,7,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Graves hyperthyroidism,transient thyrotoxicosis | |
| drug,interferon | |
| sequence,Graves,hyperthyroidism,following,transient,thyrotoxicosis,during,interferon,therapy,for,chronic,hepatitis,type,C,. | |
| labels,5,7,0,5,7,0,4,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fatal massive pulmonary embolus | |
| drug,streptokinase | |
| sequence,A,fatal,massive,pulmonary,embolus,developed,in,a,patient,treated,with,streptokinase,for,acute,deep,vein,thrombosis,. | |
| labels,0,5,6,6,7,0,0,0,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,osteonecrosis of the skull base | |
| drug,Bisphosphonate | |
| sequence,Bisphosphonate-related,osteonecrosis,of,the,skull,base,. | |
| labels,4,5,6,6,6,7,0 | |
| ade_mask,0,1,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,hemolytic uremic syndrome | |
| drug,Mitomycin-C | |
| sequence,Mitomycin-C,is,used,widely,in,the,treatment,of,malignancies,and,is,associated,with,serious,dose,related,adverse,effects,including,the,occurrence,of,hemolytic,uremic,syndrome,. | |
| labels,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,nephrotic syndrome | |
| drug,interferon beta 1a | |
| sequence,CASE,REPORT,:,We,present,a,case,of,a,28-yr-old,male,who,developed,a,severe,case,of,nephrotic,syndrome,while,being,treated,for,relapsing,remitting,Multiple,Sclerosis,(,RRMS,),with,weekly,injections,of,interferon,beta,1a,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,3,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,leukopenia | |
| drug,olanzapine | |
| sequence,Dose-dependent,olanzapine-associated,leukopenia,:,three,case,reports,. | |
| labels,0,4,8,0,0,0,0,0 | |
| ade_mask,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatolithiasis | |
| drug,octreotide | |
| sequence,We,report,a,case,of,hepatolithiasis,(,intrahepatic,stone,),complicated,by,gram-negative,sepsis,in,a,37,year,old,male,with,acromegaly,being,treated,with,octreotide,. | |
| labels,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,valvular heart disease | |
| drug,benfluorex | |
| sequence,The,authors,describe,a,case,of,valvular,heart,disease,in,a,48-year-old,woman,receiving,benfluorex,(,150,mg,t.i.d,.,for,8,years,),and,leading,to,surgical,mitral,valve,replacement,. | |
| labels,0,0,0,0,0,0,5,6,7,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,weight gain,uncontrolled diabetes | |
| drug,olanzapine | |
| sequence,The,patient,was,enrolled,in,a,weight-loss,clinic,,,and,his,diabetes,medications,were,adjusted.Subsequently,,,olanzapine,was,discontinued,because,of,weight,gain,and,uncontrolled,diabetes,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,5,7,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,1,0,1,0,0 | |
| ==============================, ============================= | |
| ade,neurotoxicity | |
| drug,Ifosfamide | |
| sequence,Ifosfamide-associated,neurotoxicity,was,noted,within,hours,of,drug,administration,and,improved,rapidly,following,hemodialysis,. | |
| labels,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,renal abnormalities | |
| drug,IFNalpha | |
| sequence,Despite,the,underlying,hepatitis,C,,,this,case,represents,renal,abnormalities,consistent,with,IFNalpha,therapy,for,CML,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,IBD | |
| drug,sulfasalazine | |
| sequence,We,discuss,a,variety,of,bronchopulmonary,complications,of,IBD,and,their,association,with,sulfasalazine,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fixed drug eruption | |
| drug,iothalamate | |
| sequence,A,unique,case,of,a,transient,,,nonpigmenting,fixed,drug,eruption,caused,by,the,radiopaque,contrast,medium,iothalamate,is,reported,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Increased libido | |
| drug,fluvoxamine | |
| sequence,Increased,libido,in,a,woman,treated,with,fluvoxamine,:,a,case,report,. | |
| labels,5,7,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe acute 5-FU reactions,neurologic symptoms,encephalopathy,coma | |
| drug,5-FU | |
| sequence,The,principle,treatment,for,DPD-deficient,patients,with,severe,acute,5-FU,reactions,is,supportive,care,;,however,,,the,administration,of,thymidine,potentially,may,reverse,severe,5-FU-induced,neurologic,symptoms,such,as,encephalopathy,and,coma,. | |
| labels,0,0,0,0,0,0,0,5,6,9,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,8,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,0,1,0 | |
| ==============================, ============================= | |
| ade,AVT,syncope | |
| drug,disopyramide | |
| sequence,Two,years,later,,,24,hours,following,an,increase,in,the,dose,of,disopyramide,from,300,to,600,mg,day,,,AVT,with,syncope,occurred,;,isoproterenol,abolished,the,arrhythmia,instantly,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,8,0,8,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,maculopapular eruption | |
| drug,ritonavir | |
| sequence,Early,ritonavir-induced,maculopapular,eruption,. | |
| labels,0,4,5,7,0 | |
| ade_mask,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,acute renal failure | |
| drug,methotrexate | |
| sequence,A,17-year-old,boy,with,acute,lymphoblastic,leukemia,developed,acute,renal,failure,within,48,h,of,an,intravenous,high-dose,methotrexate,(,5,g,m2,),infusion,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,priapism | |
| drug,prothipendylhydrochloride | |
| sequence,We,present,the,first,case,of,a,patient,with,priapism,after,oral,intake,of,the,phenothiazine,prothipendylhydrochloride,. | |
| labels,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,skin lesions | |
| drug,rifampicin | |
| sequence,After,the,patient,discontinued,rifampicin,,,the,skin,lesions,cleared,completely,within,5,weeks,without,any,systemic,medication,. | |
| labels,0,0,0,0,4,0,0,5,7,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Inappropriate antidiuretic hormone secretion | |
| drug,vinblastine | |
| sequence,Inappropriate,antidiuretic,hormone,secretion,after,high,dose,vinblastine,. | |
| labels,5,6,6,7,0,0,0,4,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,disseminated nocardiosis | |
| drug,corticosteroid | |
| sequence,In,this,paper,,,we,report,a,patient,with,primary,anti-phospholipid,syndrome,treated,by,corticosteroid,,,who,developed,disseminated,nocardiosis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,pain,biliary colic | |
| drug,morphine | |
| sequence,We,present,the,case,of,a,patient,who,had,undergone,cholecystectomy,previously,,,but,in,whom,morphine,given,in,the,Emergency,Department,precipitated,pain,consistent,with,biliary,colic,;,the,pain,resolved,promptly,after,administration,of,naloxone,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,8,0,0,5,7,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperkalemia | |
| drug,arginine | |
| sequence,Life-threatening,hyperkalemia,induced,by,arginine,. | |
| labels,0,8,0,0,4,0 | |
| ade_mask,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,central blindness | |
| drug,methanol | |
| sequence,An,adult,male,presented,with,central,blindness,after,ingesting,methanol,. | |
| labels,0,0,0,0,0,5,7,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neurotoxicity | |
| drug,acyclovir | |
| sequence,CONCLUSIONS,:,The,observation,that,neurotoxicity,developed,with,a,delay,of,24,to,48,hours,after,acyclovir,peak,serum,concentrations,could,explain,the,wide,range,of,acyclovir,levels,reported,in,similar,cases,. | |
| labels,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,renal failure | |
| drug,Rifampicin | |
| sequence,Rifampicin-induced,renal,failure,. | |
| labels,4,5,7,0 | |
| ade_mask,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Neutrophilic dermatoses | |
| drug,G-CSF | |
| sequence,Neutrophilic,dermatoses,in,two,children,with,idiopathic,neutropenia,:,association,with,granulocyte,colony-stimulating,factor,(,G-CSF,),therapy,. | |
| labels,5,7,0,0,0,0,0,0,0,0,0,1,2,3,0,4,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Neutrophilic dermatoses | |
| drug,granulocyte colony-stimulating factor | |
| sequence,Neutrophilic,dermatoses,in,two,children,with,idiopathic,neutropenia,:,association,with,granulocyte,colony-stimulating,factor,(,G-CSF,),therapy,. | |
| labels,5,7,0,0,0,0,0,0,0,0,0,1,2,3,0,4,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,withdrawal syndrome | |
| drug,Baclofen | |
| sequence,Baclofen,withdrawal,syndrome,resulting,from,underdosing,of,oral,baclofen,should,be,considered,as,a,potential,source,of,prolonged,fever,in,the,intensive,care,unit,. | |
| labels,4,5,7,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,withdrawal syndrome | |
| drug,baclofen | |
| sequence,Baclofen,withdrawal,syndrome,resulting,from,underdosing,of,oral,baclofen,should,be,considered,as,a,potential,source,of,prolonged,fever,in,the,intensive,care,unit,. | |
| labels,4,5,7,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Exfoliative dermatitis | |
| drug,tobramycin sulfate | |
| sequence,Exfoliative,dermatitis,secondary,to,tobramycin,sulfate,. | |
| labels,5,7,0,0,1,3,0 | |
| ade_mask,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pulmonary damage | |
| drug,bleomycin | |
| sequence,Autopsy,findings,were,consistent,with,bleomycin,and,oxygen-induced,pulmonary,damage,. | |
| labels,0,0,0,0,0,4,0,4,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,pulmonary damage | |
| drug,oxygen | |
| sequence,Autopsy,findings,were,consistent,with,bleomycin,and,oxygen-induced,pulmonary,damage,. | |
| labels,0,0,0,0,0,4,0,4,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,hypercalcemia,acute vitamin D poisoning | |
| drug,vitamin D | |
| sequence,Pamidronate,therapy,should,be,considered,in,patients,with,hypercalcemia,secondary,to,acute,vitamin,D,poisoning,. | |
| labels,0,0,0,0,0,0,0,0,8,0,0,5,9,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,colchicine intoxication | |
| drug,colchicine | |
| sequence,CONCLUSION,:,To,the,best,of,our,knowledge,,,this,is,the,first,time,colchicine,intoxication,in,this,age,group,has,been,described,in,the,English,literature,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,7,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hematochezia | |
| drug,warfarin | |
| sequence,A,62-year-old,Caucasian,man,with,atrial,fibrillation,who,was,taking,warfarin,reported,an,episode,of,hematochezia,;,his,international,normalized,ratio,(,INR,),was,1.74,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,brown discolouration of the fingernails | |
| drug,0.1% tretinoin cream | |
| sequence,A,33-year-old,male,presented,with,brown,discolouration,of,the,fingernails,following,the,application,of,4,%,hydroquinone,in,sorbolene,cream,and,0.1,%,tretinoin,cream,to,the,face,intermittently,for,9,months,. | |
| labels,0,0,0,0,0,5,6,6,6,7,0,0,0,0,1,2,2,2,2,3,0,1,2,2,3,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,brown discolouration of the fingernails | |
| drug,4% hydroquinone in sorbolene cream | |
| sequence,A,33-year-old,male,presented,with,brown,discolouration,of,the,fingernails,following,the,application,of,4,%,hydroquinone,in,sorbolene,cream,and,0.1,%,tretinoin,cream,to,the,face,intermittently,for,9,months,. | |
| labels,0,0,0,0,0,5,6,6,6,7,0,0,0,0,1,2,2,2,2,3,0,1,2,2,3,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Severe visual loss | |
| drug,vincristine | |
| sequence,Severe,visual,loss,after,a,single,dose,of,vincristine,in,a,patient,with,spinal,cord,astrocytoma,. | |
| labels,5,6,7,0,0,0,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatic dysfunction,impaired macrophage migration | |
| drug,cimetidine | |
| sequence,The,case,of,an,adult,who,developed,both,hepatic,dysfunction,and,an,impaired,macrophage,migration,after,exposure,to,cimetidine,is,discussed,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,5,6,7,0,0,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,respiratory depression | |
| drug,morphine | |
| sequence,We,report,a,case,of,long,lasting,respiratory,depression,after,intravenous,administration,of,morphine,to,a,7,year,old,girl,with,haemolytic,uraemic,syndrome,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,optic neuropathy,ocular toxicity | |
| drug,isoniazid | |
| sequence,A,well-recognized,complication,of,ethambutol,use,is,optic,neuropathy,,,but,the,potential,ocular,toxicity,of,isoniazid,is,often,overlooked,. | |
| labels,0,0,0,0,4,0,0,5,7,0,0,0,0,5,7,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,optic neuropathy,ocular toxicity | |
| drug,ethambutol | |
| sequence,A,well-recognized,complication,of,ethambutol,use,is,optic,neuropathy,,,but,the,potential,ocular,toxicity,of,isoniazid,is,often,overlooked,. | |
| labels,0,0,0,0,4,0,0,5,7,0,0,0,0,5,7,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,mild neurotoxicity,fatal encephalopathy | |
| drug,methotrexate | |
| sequence,This,patient,rapidly,progressed,from,mild,neurotoxicity,to,fatal,encephalopathy,after,one,dose,of,intrathecal,methotrexate,during,his,third,cycle,of,chemotherapy,. | |
| labels,0,0,0,0,0,5,7,0,5,7,0,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity syndrome | |
| drug,dapsone | |
| sequence,It,may,cause,a,severe,adverse,drug,reaction,with,multiorgan,involvement,known,as,dapsone,hypersensitivity,syndrome,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Uveitis | |
| drug,clarithromycin | |
| sequence,Uveitis,during,treatment,of,disseminated,Mycobacterium,avium-intracellulare,complex,infection,with,the,combination,of,rifabutin,,,clarithromycin,and,ethambutol,. | |
| labels,8,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,4,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Uveitis | |
| drug,ethambutol | |
| sequence,Uveitis,during,treatment,of,disseminated,Mycobacterium,avium-intracellulare,complex,infection,with,the,combination,of,rifabutin,,,clarithromycin,and,ethambutol,. | |
| labels,8,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,4,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Uveitis | |
| drug,rifabutin | |
| sequence,Uveitis,during,treatment,of,disseminated,Mycobacterium,avium-intracellulare,complex,infection,with,the,combination,of,rifabutin,,,clarithromycin,and,ethambutol,. | |
| labels,8,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,4,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,angio-oedema,hypotensive shock | |
| drug,irbesartan | |
| sequence,A,51-year,old,physically,fit,woman,experienced,angio-oedema,and,hypotensive,shock,after,irbesartan,ingestion,requiring,noradrenaline,infusion,. | |
| labels,0,0,0,0,0,0,0,8,0,5,7,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,worsening respiratory distress,fever | |
| drug,5-ASA | |
| sequence,A,49-year-old,man,with,Crohn,'s,disease,treated,with,prednisone,and,mesalamine,(,5-ASA,),developed,worsening,respiratory,distress,and,fever,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,4,0,4,0,0,5,6,7,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0 | |
| ==============================, ============================= | |
| ade,worsening respiratory distress,fever | |
| drug,mesalamine | |
| sequence,A,49-year-old,man,with,Crohn,'s,disease,treated,with,prednisone,and,mesalamine,(,5-ASA,),developed,worsening,respiratory,distress,and,fever,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,4,0,4,0,0,5,6,7,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0 | |
| ==============================, ============================= | |
| ade,worsening respiratory distress,fever | |
| drug,prednisone | |
| sequence,A,49-year-old,man,with,Crohn,'s,disease,treated,with,prednisone,and,mesalamine,(,5-ASA,),developed,worsening,respiratory,distress,and,fever,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,4,0,4,0,0,5,6,7,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0 | |
| ==============================, ============================= | |
| ade,myoclonic muscle spasms | |
| drug,dobutamine | |
| sequence,CONCLUSION,:,A,patient,with,CHF,and,ESRD,developed,myoclonic,muscle,spasms,after,receiving,dobutamine,by,continuous,i.v,.,infusion,. | |
| labels,0,0,0,0,0,0,0,0,0,5,6,7,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hemorrhagic stroke | |
| drug,Prazosin | |
| sequence,Prazosin-induced,first-dose,phenomenon,possibly,associated,with,hemorrhagic,stroke,:,a,report,of,three,cases,. | |
| labels,4,0,0,0,0,0,5,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,glomerulopathy | |
| drug,Temsirolimus | |
| sequence,Temsirolimus-induced,glomerulopathy,. | |
| labels,4,8,0 | |
| ade_mask,0,1,0 | |
| ==============================, ============================= | |
| ade,myopathy | |
| drug,Colchicine | |
| sequence,CONCLUSIONS,:,Colchicine-induced,myopathy,should,be,excluded,in,patients,with,FMF,who,present,with,generalized,muscle,weakness,. | |
| labels,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myeloproliferative disorder | |
| drug,hydroxyurea | |
| sequence,Based,on,the,Naranjo,algorithm,,,the,adverse,reaction,observed,was,probably,related,to,the,hydroxyurea,treatment,(,score,=,6,),;,however,,,the,hydroxyurea,chemotherapy,could,not,be,discontinued,because,of,the,myeloproliferative,disorder,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Neurological side effects | |
| drug,gold | |
| sequence,Neurological,side,effects,in,two,patients,receiving,gold,injections,for,rheumatoid,arthritis,. | |
| labels,5,6,7,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,bacterial peritonitis | |
| drug,vasopressin | |
| sequence,Spontaneous,bacterial,peritonitis,induced,by,intraarterial,vasopressin,therapy,. | |
| labels,0,5,7,0,0,0,4,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,100 mg m2,palmar pruritus,urticaria,edema | |
| drug,cisplatin | |
| sequence,During,her,third,cycle,,,she,again,received,cisplatin,100,mg,m2,over,30,minutes,and,developed,palmar,pruritus,,,urticaria,,,and,edema,. | |
| labels,0,0,0,0,0,0,0,0,4,5,6,7,0,0,0,0,0,5,7,0,8,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,1,1,0,1,0,0,1,0 | |
| ==============================, ============================= | |
| ade,endoscopic lesions | |
| drug,meloxicam | |
| sequence,Symptoms,and,endoscopic,lesions,quickly,regressed,within,1,week,of,meloxicam,withdrawal,. | |
| labels,0,0,5,7,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute renal failure,hyperkalemia,hyperuricemia | |
| drug,sorafenib | |
| sequence,However,,,he,developed,acute,renal,failure,,,hyperkalemia,,,and,hyperuricemia,30,d,after,receiving,the,sorafenib,treatment,. | |
| labels,0,0,0,0,5,6,7,0,8,0,0,8,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,1,1,1,0,1,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,visual field constriction | |
| drug,vigabatrin | |
| sequence,PURPOSE,:,Symptomatic,visual,field,constriction,thought,to,be,associated,with,vigabatrin,has,been,reported,. | |
| labels,0,0,0,5,6,7,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,increased mood symptoms | |
| drug,risperidone | |
| sequence,OBJECTIVE,:,To,our,knowledge,,,this,is,the,first,published,case,report,of,an,adolescent,girl,with,a,mitochondrial,disorder,and,depression,who,displayed,both,new-onset,psychotic,and,increased,mood,symptoms,during,treatment,with,risperidone,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cardiotoxicity | |
| drug,5-fluorouracil | |
| sequence,The,incidence,of,5-fluorouracil,(,5-FU,),-related,cardiotoxicity,seems,to,be,dosage,and,schedule,dependent,. | |
| labels,0,0,0,4,0,4,0,0,8,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cardiotoxicity | |
| drug,5-FU | |
| sequence,The,incidence,of,5-fluorouracil,(,5-FU,),-related,cardiotoxicity,seems,to,be,dosage,and,schedule,dependent,. | |
| labels,0,0,0,4,0,4,0,0,8,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,low-grade fever,cough,dyspnea | |
| drug,sodium aurothiomalate | |
| sequence,A,52-year-old,,,white,female,developed,low-grade,fever,,,cough,,,and,dyspnea,after,8,weeks,treatment,with,sodium,aurothiomalate,for,rheumatoid,arthritis,. | |
| labels,0,0,0,0,0,0,5,7,0,8,0,0,8,0,0,0,0,0,1,3,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,delirium,grand mal seizure,photosensitivity | |
| drug,propranolol | |
| sequence,The,authors,describe,a,woman,with,chronic,schizophrenia,who,experienced,delirium,,,grand,mal,seizure,,,and,photosensitivity,after,the,addition,of,propranolol,to,her,neuroleptic,regimen,. | |
| labels,0,0,0,0,0,0,0,0,0,0,8,0,5,6,7,0,0,8,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,1,1,1,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,gangrene of the extremities,arteriospasm | |
| drug,ergot | |
| sequence,Two,patients,with,imminent,gangrene,of,the,extremities,caused,by,ergot-induced,arteriospasm,underwent,mechanical,dilatation,of,the,arteries,when,conventional,measures,such,as,anticoagulation,,,vasodilation,,,and,sympathetic,blockade,produced,no,improvement,. | |
| labels,0,0,0,0,5,6,6,7,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe cerebral swelling,raised intracranial pressure | |
| drug,sodium valproic acid | |
| sequence,INTRODUCTION,:,We,describe,the,neurointensive,care,(,NIC,),management,of,a,patient,with,severe,cerebral,swelling,and,raised,intracranial,pressure,(,ICP,),after,severe,sodium,valproic,acid,(,VPA,),intoxication,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,5,6,7,0,0,0,0,0,1,2,3,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe cerebral swelling,raised intracranial pressure | |
| drug,VPA | |
| sequence,INTRODUCTION,:,We,describe,the,neurointensive,care,(,NIC,),management,of,a,patient,with,severe,cerebral,swelling,and,raised,intracranial,pressure,(,ICP,),after,severe,sodium,valproic,acid,(,VPA,),intoxication,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,5,6,7,0,0,0,0,0,1,2,3,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,macrophage activation syndrome,methotrexate toxicity | |
| drug,methotrexate | |
| sequence,A,macrophage,activation,syndrome,,,possibly,related,to,methotrexate,toxicity,,,developed,in,a,boy,with,systemic,juvenile,rheumatoid,arthritis,. | |
| labels,0,5,6,7,0,0,0,0,9,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatic injury | |
| drug,thiopurine | |
| sequence,This,case,highlights,the,need,to,monitor,liver,enzymes,in,patients,treated,with,6-TG,and,identifies,the,need,for,additional,research,focused,on,the,mechanism,of,thiopurine-induced,hepatic,injury,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,lichen nitidus | |
| drug,interferon alpha | |
| sequence,It,is,tempting,to,speculate,that,interferon,alpha,may,be,involved,in,the,pathogenesis,of,lichen,nitidus,. | |
| labels,0,0,0,0,0,0,1,3,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,immediate erythema,erythematous macule | |
| drug,mequitazine | |
| sequence,In,addition,,,an,immediate,erythematous,macule,was,observed,on,the,photopatch,test,site,of,mequitazine,directly,after,UV,exposure,which,was,similar,to,the,immediate,erythema,noted,in,chlorpromazine,photoallergy,. | |
| labels,0,0,0,0,5,5,7,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Fibrosis of corpus cavernosum | |
| drug,papaverine | |
| sequence,Fibrosis,of,corpus,cavernosum,after,intracavernous,injection,of,phentolamine,papaverine,. | |
| labels,5,6,6,7,0,0,0,0,4,4,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Fibrosis of corpus cavernosum | |
| drug,phentolamine | |
| sequence,Fibrosis,of,corpus,cavernosum,after,intracavernous,injection,of,phentolamine,papaverine,. | |
| labels,5,6,6,7,0,0,0,0,4,4,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myoclonus | |
| drug,Quetiapine | |
| sequence,Quetiapine-induced,myoclonus,. | |
| labels,4,8,0 | |
| ade_mask,0,1,0 | |
| ==============================, ============================= | |
| ade,thrombocytopenia | |
| drug,heparin | |
| sequence,Heparin-dependent,antibodies,and,thrombosis,without,heparin-induced,thrombocytopenia,. | |
| labels,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,increase serum lithium levels | |
| drug,acyclovir | |
| sequence,Does,acyclovir,increase,serum,lithium,levels,? | |
| labels,0,4,5,6,6,7,0 | |
| ade_mask,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,hepatitis | |
| drug,erlotinib | |
| sequence,Acute,drug,induced,hepatitis,due,to,erlotinib,. | |
| labels,0,0,0,8,0,0,4,0 | |
| ade_mask,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Gastric tumor,endometrial carcinoma,cervical adenocarcinoma | |
| drug,tamoxifen | |
| sequence,Gastric,tumor,,,endometrial,carcinoma,and,cervical,adenocarcinoma,in,situ,were,detected,after,treatment,with,tamoxifen,for,breast,cancer,. | |
| labels,5,7,0,5,7,0,5,7,0,0,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,1,1,0,1,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity,IgE-mediated allergic reactions | |
| drug,cloxacillin | |
| sequence,Several,hypersensitivity,reactions,to,cloxacillin,have,been,reported,,,although,IgE-mediated,allergic,reactions,to,the,drug,are,rare,and,there,is,little,information,about,possible,tolerance,to,other,semisynthetic,penicillins,or,cephalosporins,in,patients,with,cloxacillin,allergy,. | |
| labels,0,8,0,0,4,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyponatremia | |
| drug,vinblastine | |
| sequence,Life-threatening,hyponatremia,caused,by,vinblastine,. | |
| labels,0,8,0,0,4,0 | |
| ade_mask,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,brain injury,disability | |
| drug,IL-2 | |
| sequence,The,potential,for,progressive,brain,injury,and,subsequent,disability,related,to,intraventricular,IL-2,therapy,is,discussed,. | |
| labels,0,0,0,0,5,7,0,0,8,0,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,congestive heart failure | |
| drug,furosemide | |
| sequence,The,patient,was,initially,treated,with,hydration,and,furosemide,but,developed,congestive,heart,failure,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,exogenous lipoid pneumonia,ELP | |
| drug,mineral oil | |
| sequence,We,report,a,case,of,a,child,with,neurodevelopmental,delay,with,chronic,constipation,and,a,history,of,chronic,mineral,oil,ingestion,presenting,as,asymptomatic,exogenous,lipoid,pneumonia,(,ELP,),. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,3,0,0,0,0,5,6,7,0,8,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0,0 | |
| ==============================, ============================= | |
| ade,acute hyponatraemia | |
| drug,cyclophosphamide | |
| sequence,Life-threatening,acute,hyponatraemia,induced,by,low,dose,cyclophosphamide,and,indomethacin,. | |
| labels,0,5,7,0,0,0,0,4,0,4,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute hyponatraemia | |
| drug,indomethacin | |
| sequence,Life-threatening,acute,hyponatraemia,induced,by,low,dose,cyclophosphamide,and,indomethacin,. | |
| labels,0,5,7,0,0,0,0,4,0,4,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lung disease | |
| drug,Nitrofurantoin | |
| sequence,Nitrofurantoin-induced,lung,disease,:,two,cases,demonstrating,resolution,of,apparently,irreversible,CT,abnormalities,. | |
| labels,4,5,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,SJS | |
| drug,nevirapine | |
| sequence,We,describe,2,cases,of,SJS,related,to,nevirapine,use,and,review,the,literature,on,this,newly,recognized,association,. | |
| labels,0,0,0,0,0,8,0,0,4,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Ectropion | |
| drug,5-fluorouracil | |
| sequence,Ectropion,secondary,to,bolus,injection,of,5-fluorouracil,. | |
| labels,8,0,0,0,0,0,4,0 | |
| ade_mask,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,toxic epidermal necrolysis | |
| drug,Ciprofloxacin | |
| sequence,Ciprofloxacin-induced,toxic,epidermal,necrolysis,in,a,patient,with,systemic,lupus,erythematosus,. | |
| labels,4,5,6,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,liver damage,acute and chronic pulmonary reactions,peripheral neuropathy,blood dyscrasias,allergic reactions | |
| drug,Macrodantin | |
| sequence,The,latter,form,(,Macrodantin,),is,reported,to,engender,less,gastrointestinal,intolerance,but,it,can,produce,the,same,adverse,effects,as,the,conventional,form,--,liver,damage,,,acute,and,chronic,pulmonary,reactions,,,peripheral,neuropathy,,,blood,dyscrasias,and,allergic,reactions,--,and,does,so,just,as,rapidly,and,floridly,;,one,such,case,is,reported,here,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,5,6,6,6,7,0,5,7,0,5,7,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,1,1,1,1,0,1,1,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Severe symptomatic hyponatremia | |
| drug,sibutramine | |
| sequence,Severe,symptomatic,hyponatremia,during,sibutramine,therapy,:,a,case,report,. | |
| labels,5,6,7,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Sudden cardiac death,hypersensitivity myocarditis | |
| drug,clozapine | |
| sequence,Sudden,cardiac,death,due,to,hypersensitivity,myocarditis,during,clozapine,treatment,. | |
| labels,5,6,7,0,0,5,7,0,4,0,0 | |
| ade_mask,1,1,1,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe neutropenia | |
| drug,gold | |
| sequence,We,have,successfully,overcome,severe,neutropenia,in,an,RA,patient,treated,with,gold,salts,,,using,granulocyte,colony-stimulating,factor,(,G-CSF,),,,reducing,the,duration,of,neutropenia,and,risk,of,infection,. | |
| labels,0,0,0,0,5,7,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,asthma | |
| drug,aspirin | |
| sequence,Detection,of,activated,eosinophils,in,nasal,polyps,of,an,aspirin-induced,asthma,patient,. | |
| labels,0,0,0,0,0,0,0,0,0,4,8,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0 | |
| ==============================, ============================= | |
| ade,irreversible lethal renal failure,anuria | |
| drug,ifosfamide | |
| sequence,A,sixty-year-old,woman,with,advanced,breast,cancer,,,previously,treated,with,cisplatin,,,developed,an,irreversible,lethal,renal,failure,with,anuria,,,the,day,after,5,g,m2,bolus,ifosfamide,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,8,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Esophageal candidiasis | |
| drug,omeprazole | |
| sequence,Esophageal,candidiasis,following,omeprazole,therapy,:,a,report,of,two,cases,. | |
| labels,5,7,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ocular side effects,hypoalbuminemia,thrombocytopenia | |
| drug,IFN | |
| sequence,Ophthalmologists,should,be,aware,of,the,ocular,side,effects,of,IFN,therapy,and,carefully,monitor,patients,for,the,possible,occurrence,of,hypoalbuminemia,and,thrombocytopenia,. | |
| labels,0,0,0,0,0,0,5,6,7,0,4,0,0,0,0,0,0,0,0,0,0,8,0,8,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0 | |
| ==============================, ============================= | |
| ade,cerebellar toxicity | |
| drug,HDARAC | |
| sequence,Because,the,cerebellar,toxicity,may,be,worsened,by,continuation,of,therapy,after,initial,onset,of,symptoms,,,prompt,termination,of,HDARAC,is,recommended,. | |
| labels,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,transient thyrotoxicosis | |
| drug,Lithium | |
| sequence,Lithium-associated,transient,thyrotoxicosis,in,4,Chinese,women,with,autoimmune,thyroiditis,. | |
| labels,4,5,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe cholestatic jaundice | |
| drug,captopril | |
| sequence,A,patient,with,severe,cholestatic,jaundice,induced,by,captopril,is,presented,. | |
| labels,0,0,0,5,6,7,0,0,4,0,0,0 | |
| ade_mask,0,0,0,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Ocular hypertension | |
| drug,ranibizumab | |
| sequence,Ocular,hypertension,occurred,1,month,after,the,second,ranibizumab,injection,in,patients,1,and,3,,,and,1,month,after,the,first,ranibizumab,in,patient,2,. | |
| labels,5,7,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,coronary vasospasm | |
| drug,Carboplatin | |
| sequence,Carboplatin,hypersensitivity,presenting,as,coronary,vasospasm,-,a,case,report,. | |
| labels,4,0,0,0,5,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,vincristine neurotoxicity | |
| drug,vincristine | |
| sequence,The,disease,predisposes,to,severe,vincristine,neurotoxicity,. | |
| labels,0,0,0,0,0,9,7,0 | |
| ade_mask,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,fatal complication,retinoic acid syndrome | |
| drug,retinoic acid | |
| sequence,Although,retinoic,acid,is,well,tolerated,by,the,majority,of,patients,with,this,disease,,,a,potentially,fatal,complication,of,this,kind,of,treatment,has,been,reported,:,``,the,retinoic,acid,syndrome,'',. | |
| labels,0,1,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0 | |
| ==============================, ============================= | |
| ade,heart rate had decreased | |
| drug,pentamidine | |
| sequence,After,only,the,third,dose,of,pentamidine,,,it,was,noted,that,the,patient,'s,heart,rate,had,decreased,to,48,beats,minute,. | |
| labels,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperglycemia | |
| drug,olanzapine | |
| sequence,There,have,been,numerous,case,reports,of,hyperglycemia,with,olanzapine,in,the,literature,,,but,none,reported,hyperglycemia,within,days,of,initiation,of,the,medication,. | |
| labels,0,0,0,0,0,0,0,8,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity syndrome,cutaneous skin eruptions,hepatotoxicity | |
| drug,TMP-SMX | |
| sequence,Although,this,combination,agent,has,been,associated,with,a,hypersensitivity,syndrome,involving,cutaneous,skin,eruptions,,,pediatric,cases,of,TMP-SMX-induced,hepatotoxicity,are,rare,. | |
| labels,0,0,0,0,0,0,0,0,0,5,7,0,5,6,7,0,0,0,0,4,8,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,1,1,1,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,pulmonary side effects | |
| drug,nitrofurantoin | |
| sequence,Despite,the,known,pulmonary,side,effects,of,nitrofurantoin,,,there,is,no,report,of,this,toxicity,occurring,in,pregnant,patients,. | |
| labels,0,0,0,5,6,7,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Drug rash with eosinophilia and systemic symptoms | |
| drug,chlorambucil | |
| sequence,Drug,rash,with,eosinophilia,and,systemic,symptoms,after,chlorambucil,treatment,in,chronic,lymphocytic,leukaemia,. | |
| labels,5,6,6,6,6,6,7,0,4,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Neisseria mucosa knee arthritis | |
| drug,sodium hyaluronate | |
| sequence,In,the,other,patient,,,a,78-year-old,woman,,,Neisseria,mucosa,knee,arthritis,occurred,after,a,single,sodium,hyaluronate,injection,. | |
| labels,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,1,3,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Thrombocytosis | |
| drug,ciprofloxacin | |
| sequence,Thrombocytosis,under,ciprofloxacin,and,tazobactam,piperacillin,. | |
| labels,8,0,4,0,4,4,0 | |
| ade_mask,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Thrombocytosis | |
| drug,piperacillin | |
| sequence,Thrombocytosis,under,ciprofloxacin,and,tazobactam,piperacillin,. | |
| labels,8,0,4,0,4,4,0 | |
| ade_mask,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Thrombocytosis | |
| drug,tazobactam | |
| sequence,Thrombocytosis,under,ciprofloxacin,and,tazobactam,piperacillin,. | |
| labels,8,0,4,0,4,4,0 | |
| ade_mask,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,interstitial nephritis | |
| drug,Nabumetone | |
| sequence,Nabumetone-associated,interstitial,nephritis,. | |
| labels,4,5,7,0 | |
| ade_mask,0,1,1,0 | |
| ==============================, ============================= | |
| ade,TEN | |
| drug,ampicillin | |
| sequence,We,report,a,third,case,of,a,6-week-old,infant,with,Escherichia,coli,sepsis,who,received,ampicillin,and,other,antibiotics,and,subsequently,developed,TEN,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,acute-onset myopia,angle closure glaucoma | |
| drug,topiramate | |
| sequence,Mechanism,of,topiramate-induced,acute-onset,myopia,and,angle,closure,glaucoma,. | |
| labels,0,0,4,5,7,0,5,6,7,0 | |
| ade_mask,0,0,0,1,1,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,thrombocytopenia | |
| drug,danazol | |
| sequence,We,diagnosed,this,case,as,danazol,induced,thrombocytopenia,. | |
| labels,0,0,0,0,0,4,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,extrapyramidal side effects | |
| drug,olanzapine | |
| sequence,One,should,therefore,be,aware,of,possible,extrapyramidal,side,effects,with,olanzapine,that,are,reduced,compared,to,classical,neuroleptic,drugs,but,not,completely,eliminated,. | |
| labels,0,0,0,0,0,0,0,5,6,7,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neutropenia | |
| drug,teicoplanin | |
| sequence,OBJECTIVE,:,To,report,teicoplanin-related,neutropenia,that,developed,after,an,episode,of,neutropenia,induced,by,vancomycin,therapy,. | |
| labels,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neutropenia | |
| drug,vancomycin | |
| sequence,OBJECTIVE,:,To,report,teicoplanin-related,neutropenia,that,developed,after,an,episode,of,neutropenia,induced,by,vancomycin,therapy,. | |
| labels,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,mutism | |
| drug,FK506 | |
| sequence,Tacrolimus,(,FK506,),-induced,mutism,after,liver,transplant,. | |
| labels,4,0,4,0,0,8,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,mutism | |
| drug,Tacrolimus | |
| sequence,Tacrolimus,(,FK506,),-induced,mutism,after,liver,transplant,. | |
| labels,4,0,4,0,0,8,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatotoxicity | |
| drug,choline magnesium trisalicylate | |
| sequence,A,case,of,a,21-year-old,woman,who,had,developed,mild,hepatotoxicity,while,receiving,choline,magnesium,trisalicylate,therapy,is,described,. | |
| labels,0,0,0,0,0,0,0,0,0,0,8,0,0,1,2,3,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Upper gastrointestinal haemorrhage | |
| drug,aspirin | |
| sequence,Upper,gastrointestinal,haemorrhage,is,a,serious,complication,of,aspirin,and,clopidogrel,(,dual,),anti-platelet,therapy,with,a,high,morbidity,and,mortality,. | |
| labels,5,6,7,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Upper gastrointestinal haemorrhage | |
| drug,clopidogrel | |
| sequence,Upper,gastrointestinal,haemorrhage,is,a,serious,complication,of,aspirin,and,clopidogrel,(,dual,),anti-platelet,therapy,with,a,high,morbidity,and,mortality,. | |
| labels,5,6,7,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,delated cutaneous reactions | |
| drug,captopril | |
| sequence,BACKGROUND,:,reports,on,delated,cutaneous,reactions,to,captopril,have,been,seldom,reported,. | |
| labels,0,0,0,0,5,6,7,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,headache | |
| drug,capecitabine | |
| sequence,A,cause-effect,relationship,to,capecitabine,was,suggested,due,to,resolution,of,headache,with,capecitabine,withdrawal,and,reappearance,with,capecitabine,rechallenge,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Reversible leukopenia | |
| drug,ibopamine | |
| sequence,Reversible,leukopenia,was,documented,in,an,81-year-old,woman,treated,with,adjunctive,ibopamine,100,mg,t.i.d,.,for,chronic,congestive,heart,failure,. | |
| labels,5,7,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neutropenic fever | |
| drug,cilastatin | |
| sequence,Eighty-two,patients,with,various,malignancies,who,received,imipenem,cilastatin,143,times,for,neutropenic,fever,between,March,1994,and,October,1999,in,Department,of,Pediatric,Oncology,,,Gazi,University,,,were,identified,. | |
| labels,0,0,0,0,0,0,0,4,4,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neutropenic fever | |
| drug,imipenem | |
| sequence,Eighty-two,patients,with,various,malignancies,who,received,imipenem,cilastatin,143,times,for,neutropenic,fever,between,March,1994,and,October,1999,in,Department,of,Pediatric,Oncology,,,Gazi,University,,,were,identified,. | |
| labels,0,0,0,0,0,0,0,4,4,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,RTA | |
| drug,FK506 | |
| sequence,We,report,a,case,of,RTA,secondary,to,FK506,administration,in,liver,transplantation,. | |
| labels,0,0,0,0,0,8,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatitis | |
| drug,amodiaquine | |
| sequence,This,report,describes,an,unexpected,drug-induced,hepatitis,in,a,previously,healthy,young,woman,exposed,to,2,doses,of,amodiaquine,and,artesunate,. | |
| labels,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatitis | |
| drug,artesunate | |
| sequence,This,report,describes,an,unexpected,drug-induced,hepatitis,in,a,previously,healthy,young,woman,exposed,to,2,doses,of,amodiaquine,and,artesunate,. | |
| labels,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Esophageal candidiasis | |
| drug,omeprazole | |
| sequence,Esophageal,candidiasis,was,diagnosed,at,endoscopy,in,two,patients,receiving,omeprazole,therapy,. | |
| labels,5,7,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,endometrial disorders | |
| drug,tamoxifen | |
| sequence,Since,tamoxifen,therapy,can,induce,endometrial,disorders,,,surveillance,schemes,of,women,taking,tamoxifen,have,been,recommended,. | |
| labels,0,4,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hemolytic uremic syndrome | |
| drug,bleomycin | |
| sequence,Hemolytic,uremic,syndrome,in,a,patient,on,cis-platinum,,,vinblastine,and,bleomycin,. | |
| labels,5,6,7,0,0,0,0,4,0,4,0,4,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hemolytic uremic syndrome | |
| drug,cis-platinum | |
| sequence,Hemolytic,uremic,syndrome,in,a,patient,on,cis-platinum,,,vinblastine,and,bleomycin,. | |
| labels,5,6,7,0,0,0,0,4,0,4,0,4,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hemolytic uremic syndrome | |
| drug,vinblastine | |
| sequence,Hemolytic,uremic,syndrome,in,a,patient,on,cis-platinum,,,vinblastine,and,bleomycin,. | |
| labels,5,6,7,0,0,0,0,4,0,4,0,4,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,agranulocytosis | |
| drug,Metamizole | |
| sequence,Metamizole,,,a,nonsteroidal,antiinflammatory,agent,,,is,prohibited,in,the,United,States,because,of,the,risk,of,agranulocytosis,but,is,widely,used,in,Mexico,and,other,countries,. | |
| labels,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,colonic perforation | |
| drug,calcium polystyrene sulfonate | |
| sequence,Reports,of,colonic,perforation,as,a,result,of,the,administration,of,calcium,polystyrene,sulfonate,and,sorbitol,are,rare,. | |
| labels,0,0,5,7,0,0,0,0,0,0,0,1,2,3,0,4,0,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,colonic perforation | |
| drug,sorbitol | |
| sequence,Reports,of,colonic,perforation,as,a,result,of,the,administration,of,calcium,polystyrene,sulfonate,and,sorbitol,are,rare,. | |
| labels,0,0,5,7,0,0,0,0,0,0,0,1,2,3,0,4,0,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,death | |
| drug,Fluoxetine | |
| sequence,Fluoxetine-related,death,in,a,child,with,cytochrome,P-450,2D6,genetic,deficiency,. | |
| labels,4,8,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neuropsychiatric symptoms,Parkinsonism,akathisia,seizure,depressive disorders | |
| drug,IFN-alpha | |
| sequence,Therapy,with,IFN-alpha,may,be,associated,with,a,number,of,neuropsychiatric,symptoms,,,such,as,Parkinsonism,,,akathisia,,,seizure,,,and,depressive,disorders,. | |
| labels,0,0,4,0,0,0,0,0,0,0,5,7,0,0,0,8,0,8,0,8,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,1,0,1,0,1,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,pulmonary fibrosis | |
| drug,BCNU | |
| sequence,We,further,used,immunohistochemistry,(,IHC,),to,examine,the,relative,role,of,platelet-derived,growth,factor-B,(,PDGF-B,),,,insulin-like,growth,factor,I,(,IGF-I,),,,transforming,growth,factor-beta1,(,TGF-beta1,),and,cyclooxygenase-2,(,COX-2,),in,the,pathogenesis,of,BCNU-related,pulmonary,fibrosis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,withdrawal syndrome | |
| drug,baclofen | |
| sequence,We,report,a,case,of,baclofen,withdrawal,syndrome,resulting,from,oral,baclofen,underdosing,. | |
| labels,0,0,0,0,0,4,5,7,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,serotonin syndrome,SS | |
| drug,mirtazapine | |
| sequence,OBJECTIVE,:,To,document,a,case,of,serotonin,syndrome,(,SS,),associated,with,mirtazapine,monotherapy,,,review,the,previously,reported,cases,of,SS,associated,with,this,tetracyclic,antidepressant,,,and,discuss,the,possible,pathogenic,mechanisms,leading,to,this,serious,adverse,drug,reaction,. | |
| labels,0,0,0,0,0,0,0,5,7,0,8,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,discoloration of nail plate,subungual hyperkeratosis,onycholysis | |
| drug,clofazimine | |
| sequence,Two,cases,of,lepromatous,leprosy,with,erythema,nodosum,leprosum,who,were,on,high,doses,of,clofazimine,,,showed,discoloration,of,nail,plate,,,subungual,hyperkeratosis,and,onycholysis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,5,6,6,7,0,5,7,0,8,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,0,1,1,0,1,0 | |
| ==============================, ============================= | |
| ade,acute bilateral blindness,focal seizure,hypertension | |
| drug,oxybutynin | |
| sequence,We,report,a,4-year-old,girl,who,presented,with,acute,bilateral,blindness,,,a,focal,seizure,and,hypertension,10,days,after,commencing,oxybutynin,to,treat,enuresis,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,5,7,0,8,0,0,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,infection | |
| drug,infliximab | |
| sequence,The,major,side,effect,of,infliximab,is,infection,. | |
| labels,0,0,0,0,0,4,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,acute dizziness | |
| drug,voglibose | |
| sequence,Three,diabetic,cases,of,acute,dizziness,due,to,initial,administration,of,voglibose,. | |
| labels,0,0,0,0,5,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Toxic hepatitis | |
| drug,etretinate | |
| sequence,Toxic,hepatitis,due,to,combination,therapy,with,methotrexate,and,etretinate,in,psoriasis,. | |
| labels,5,7,0,0,0,0,0,4,0,4,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Toxic hepatitis | |
| drug,methotrexate | |
| sequence,Toxic,hepatitis,due,to,combination,therapy,with,methotrexate,and,etretinate,in,psoriasis,. | |
| labels,5,7,0,0,0,0,0,4,0,4,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Retinopathy | |
| drug,pegylated interferon | |
| sequence,Retinopathy,in,hepatitis,C,patients,due,to,combination,therapy,with,pegylated,interferon,and,ribavirin,. | |
| labels,8,0,0,0,0,0,0,0,0,0,1,3,0,4,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Retinopathy | |
| drug,ribavirin | |
| sequence,Retinopathy,in,hepatitis,C,patients,due,to,combination,therapy,with,pegylated,interferon,and,ribavirin,. | |
| labels,8,0,0,0,0,0,0,0,0,0,1,3,0,4,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,crescentic glomerulonephritis | |
| drug,D-penicillamine | |
| sequence,D-penicillamine,induced,crescentic,glomerulonephritis,:,report,and,review,of,the,literature,. | |
| labels,4,0,5,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sensorimotor polyneuropathy | |
| drug,5-ASA | |
| sequence,This,clinical,course,suggests,that,the,sensorimotor,polyneuropathy,may,have,been,caused,by,5-ASA,. | |
| labels,0,0,0,0,0,0,5,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,deterioration in renal function | |
| drug,RA | |
| sequence,It,is,likely,that,RA,contributed,to,the,deterioration,in,renal,function,in,these,patients,. | |
| labels,0,0,0,0,4,0,0,0,5,6,6,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyponatremia | |
| drug,desmopressin | |
| sequence,Within,24,hours,of,fluid,restriction,and,cessation,of,desmopressin,,,her,symptoms,and,hyponatremia,resolved,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,0,0,8,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0 | |
| ==============================, ============================= | |
| ade,TTP | |
| drug,penicillamine | |
| sequence,To,our,knowledge,,,no,prior,cases,of,penicillamine-induced,TTP,in,RA,have,been,reported,. | |
| labels,0,0,0,0,0,0,0,0,4,8,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,leukoencephalopathy,hydrocephalus | |
| drug,methotrexate | |
| sequence,We,report,the,case,histories,of,identical,twin,brothers,who,developed,concordant,acute,lymphoblastic,leukemia,at,the,age,of,4,years,and,who,later,developed,leukoencephalopathy,and,hydrocephalus,related,to,central,nervous,system,prophylaxis,by,,,in,the,first,case,intrathecally,administered,methotrexate,and,,,in,the,second,by,intrathecally,administered,methotrexate,and,cranial,irradiation,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anemia | |
| drug,Enalapril | |
| sequence,Enalapril-induced,anemia,in,two,kidney,transplant,recipients,. | |
| labels,4,8,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Multifocal inflammatory leukoencephalopathy | |
| drug,levamisole | |
| sequence,Multifocal,inflammatory,leukoencephalopathy,associated,with,levamisole,therapy,. | |
| labels,5,6,7,0,0,4,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nephrotic syndrome | |
| drug,macrophage-colony-stimulating factor | |
| sequence,Development,of,nephrotic,syndrome,in,a,patient,with,acute,myeloblastic,leukemia,after,treatment,with,macrophage-colony-stimulating,factor,. | |
| labels,0,0,5,7,0,0,0,0,0,0,0,0,0,0,1,3,0 | |
| ade_mask,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,akathisia | |
| drug,interferon-alpha | |
| sequence,Intravenous,administration,of,levodopa,ameliorated,a,refractory,akathisia,case,induced,by,interferon-alpha,. | |
| labels,0,0,0,0,0,0,0,8,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute tubulointerstitial nephritis | |
| drug,Flurbiprofen | |
| sequence,Flurbiprofen-associated,acute,tubulointerstitial,nephritis,. | |
| labels,4,5,6,7,0 | |
| ade_mask,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,migraine headaches | |
| drug,methysergide | |
| sequence,The,patient,whose,case,is,reviewed,had,migraine,headaches,and,received,methysergide,maleate,for,13,years,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ophthalmic and neurologic findings | |
| drug,VGB | |
| sequence,We,explored,ophthalmic,and,neurologic,findings,in,two,children,who,have,been,exposed,prenatally,to,VGB,. | |
| labels,0,0,5,6,6,7,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Total blindness with a transient tonic pupillary response,denervation supersensitivity,abnormal visual-evoked potentials | |
| drug,quinine sulfate | |
| sequence,Total,blindness,with,a,transient,tonic,pupillary,response,,,denervation,supersensitivity,,,and,abnormal,visual-evoked,potentials,developed,in,a,54-year-old,man,after,the,use,of,quinine,sulfate,for,leg,cramps,. | |
| labels,5,6,6,6,6,6,6,7,0,5,7,0,0,5,6,7,0,0,0,0,0,0,0,0,0,1,3,0,0,0,0 | |
| ade_mask,1,1,1,1,1,1,1,1,0,1,1,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Anhedonic ejaculation | |
| drug,desipramine | |
| sequence,Anhedonic,ejaculation,with,desipramine,. | |
| labels,5,7,0,4,0 | |
| ade_mask,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,developmental delay,craniosynostosis,blepharophimosis,flat nasal bridge,distal limb defects,hypoplastic thumbs,oligodactyly | |
| drug,cyclosposphamide | |
| sequence,The,reported,cases,of,in,utero,exposure,to,cyclosposphamide,shared,the,following,manifestations,with,our,patient,:,growth,deficiency,,,developmental,delay,,,craniosynostosis,,,blepharophimosis,,,flat,nasal,bridge,,,abnormal,ears,,,and,distal,limb,defects,including,hypoplastic,thumbs,and,oligodactyly,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,5,7,0,8,0,8,0,5,6,7,0,0,0,0,0,5,6,7,0,5,7,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0,1,0,1,1,1,0,0,0,0,0,1,1,1,0,1,1,0,1,0 | |
| ==============================, ============================= | |
| ade,caffeine toxicity,injured the muscle cells,potassium depletion,coexisting hyponatremia,rhabdomyolysis | |
| drug,caffeine | |
| sequence,We,hypothesize,that,caffeine,toxicity,injured,the,muscle,cells,,,which,were,fragile,due,to,the,potassium,depletion,induced,by,the,coexisting,hyponatremia,,,to,result,in,unusually,severe,rhabdomyolysis,. | |
| labels,0,0,0,9,7,5,6,6,7,0,0,0,0,0,0,0,5,7,0,0,0,5,7,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,1,1,1,1,1,1,0,0,0,0,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,neurological and cardiovascular toxicity,death | |
| drug,fluoxetine | |
| sequence,We,report,an,unusual,case,of,massive,fluoxetine,ingestion,resulting,in,neurological,and,cardiovascular,toxicity,resulting,in,death,. | |
| labels,0,0,0,0,0,0,0,4,0,0,0,5,6,6,7,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Stroke-like syndrome,vasomotor reaction | |
| drug,gold sodium thiomalate | |
| sequence,Stroke-like,syndrome,after,gold,sodium,thiomalate,induced,vasomotor,reaction,. | |
| labels,5,7,0,1,2,3,0,5,7,0 | |
| ade_mask,1,1,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,central nervous system dysfunction | |
| drug,Propranolol | |
| sequence,Propranolol,:,an,unrecognized,cause,of,central,nervous,system,dysfunction,in,patients,undergoing,cardiopulmonary,bypass,. | |
| labels,4,0,0,0,0,0,5,6,6,7,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatitis,liver injury | |
| drug,IFN beta | |
| sequence,We,report,three,cases,of,IFN,beta,induced,hepatitis,in,MS,and,discuss,the,pathology,findings,and,possible,mechanisms,of,drug-induced,liver,injury,. | |
| labels,0,0,0,0,0,1,3,0,8,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Systemic vasculitis | |
| drug,cladribine | |
| sequence,Systemic,vasculitis,complicating,hairy,cell,leukaemia,treatment,with,cladribine,. | |
| labels,5,7,0,0,0,0,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,peripheral neuropathy | |
| drug,CAP | |
| sequence,During,analysis,of,28,patients,receiving,CAP,with,concomitant,radiation,(,XRT,),for,pancreatic,cancer,(,resected,or,locally,advanced,),,,two,patients,developed,signs,and,symptoms,consistent,with,peripheral,neuropathy,. | |
| labels,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,left homonymous hemianopsia,encephalopathy,partial nondominant parietal lobe syndrome | |
| drug,bleomycin | |
| sequence,A,36-year-old,man,being,treated,with,cisplatinum,,,vinblastine,,,and,bleomycin,for,testicular,carcinoma,developed,a,dense,left,homonymous,hemianopsia,,,encephalopathy,,,and,a,partial,nondominant,parietal,lobe,syndrome,. | |
| labels,0,0,0,0,0,0,4,0,4,0,0,4,0,0,0,0,0,0,5,6,7,0,8,0,0,0,5,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0,0,0,1,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,left homonymous hemianopsia,encephalopathy,partial nondominant parietal lobe syndrome | |
| drug,cisplatinum | |
| sequence,A,36-year-old,man,being,treated,with,cisplatinum,,,vinblastine,,,and,bleomycin,for,testicular,carcinoma,developed,a,dense,left,homonymous,hemianopsia,,,encephalopathy,,,and,a,partial,nondominant,parietal,lobe,syndrome,. | |
| labels,0,0,0,0,0,0,4,0,4,0,0,4,0,0,0,0,0,0,5,6,7,0,8,0,0,0,5,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0,0,0,1,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,left homonymous hemianopsia,encephalopathy,partial nondominant parietal lobe syndrome | |
| drug,vinblastine | |
| sequence,A,36-year-old,man,being,treated,with,cisplatinum,,,vinblastine,,,and,bleomycin,for,testicular,carcinoma,developed,a,dense,left,homonymous,hemianopsia,,,encephalopathy,,,and,a,partial,nondominant,parietal,lobe,syndrome,. | |
| labels,0,0,0,0,0,0,4,0,4,0,0,4,0,0,0,0,0,0,5,6,7,0,8,0,0,0,5,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0,0,0,1,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,symptomatic cerebral vasospasm | |
| drug,sumatriptan | |
| sequence,Administration,of,sumatriptan,in,subarachnoid,haemorrhage,(,SAH,),patients,,,misdiagnosed,as,migraine,patients,,,may,induce,symptomatic,cerebral,vasospasm,with,potentially,dangerous,consequences,. | |
| labels,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sub-conjunctival haematoma,bloody tears | |
| drug,warfarin | |
| sequence,A,65-year-old,man,on,warfarin,therapy,with,a,sudden,spontaneous,onset,of,sub-conjunctival,haematoma,associated,with,bloody,tears,was,assessed,in,the,clinic,following,a,referral,from,an,optometrist,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,5,7,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Dilated cardiomyopathy | |
| drug,adrenaline | |
| sequence,Dilated,cardiomyopathy,associated,with,chronic,overuse,of,an,adrenaline,inhaler,. | |
| labels,5,7,0,0,0,0,0,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thrombocytopenia,massive thrombosis of the inferior vena cava | |
| drug,Heparin | |
| sequence,Heparin-induced,thrombocytopenia,complicated,with,massive,thrombosis,of,the,inferior,vena,cava,after,filter,placement,. | |
| labels,4,8,0,0,5,6,6,6,6,6,7,0,0,0,0 | |
| ade_mask,0,1,0,0,1,1,1,1,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,skeletal fluorosis | |
| drug,niflumic acid | |
| sequence,A,case,of,skeletal,fluorosis,induced,by,prolonged,treatment,with,niflumic,acid,,,a,fast-acting,non-steroid,antiinflammatory,agent,,,is,reported,in,a,35-year-old,woman,suffering,from,rheumatoid,arthritis,and,treated,,,in,addition,,,with,corticosteroids,. | |
| labels,0,0,0,5,7,0,0,0,0,0,1,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,psychosis | |
| drug,ciprofloxacin | |
| sequence,OBJECTIVE,:,To,report,a,case,of,ciprofloxacin-induced,psychosis,and,to,discuss,occurrence,rates,,,risk,factors,,,possible,etiologies,,,preventive,measures,,,and,treatment,courses,for,this,adverse,reaction,. | |
| labels,0,0,0,0,0,0,0,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,abnormal hypersensitivity | |
| drug,warfarin | |
| sequence,Based,on,the,clinical,status,of,the,patient,,,it,was,suspected,that,several,conditions,contributed,to,the,abnormal,hypersensitivity,to,warfarin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,pulmonary disease | |
| drug,calcium stearate | |
| sequence,Therefore,,,we,concluded,that,this,patient,'s,pulmonary,disease,was,caused,by,calcium,stearate,,,an,additive,for,an,antihistaminic,drug,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,0,1,3,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fever,cough | |
| drug,fludarabine | |
| sequence,A,73-year-old,woman,presented,with,fever,and,cough,2,weeks,after,completing,the,third,cycle,of,fludarabine,for,chronic,lymphocytic,leukemia,(,CLL,),. | |
| labels,0,0,0,0,0,8,0,8,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute syphilitic posterior placoid chorioretinitis,ASPPC | |
| drug,IVTA | |
| sequence,BACKGROUND,:,We,describe,the,ophthalmic,features,and,clinical,course,of,two,cases,of,acute,syphilitic,posterior,placoid,chorioretinitis,(,ASPPC,),that,developed,after,intravitreal,triamcinolone,acetonide,(,IVTA,),injection,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,7,0,8,0,0,0,0,0,1,3,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute syphilitic posterior placoid chorioretinitis,ASPPC | |
| drug,triamcinolone acetonide | |
| sequence,BACKGROUND,:,We,describe,the,ophthalmic,features,and,clinical,course,of,two,cases,of,acute,syphilitic,posterior,placoid,chorioretinitis,(,ASPPC,),that,developed,after,intravitreal,triamcinolone,acetonide,(,IVTA,),injection,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,7,0,8,0,0,0,0,0,1,3,0,4,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,platelet count decreased | |
| drug,lansoprazole | |
| sequence,He,was,started,on,oral,lansoprazole,60,mg,twice,daily,and,,,on,hospital,day,2,,,his,platelet,count,decreased,to,102,x,10,(,3,),mm,(,3,),;,on,hospital,day,3,,,the,platelet,count,was,36,x,10,(,3,),mm,(,3,),. | |
| labels,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute myopathy,degeneration of myosin filaments | |
| drug,methylprednisolone | |
| sequence,Acute,myopathy,with,selective,degeneration,of,myosin,filaments,following,status,asthmaticus,treated,with,methylprednisolone,and,vecuronium,. | |
| labels,5,7,0,0,5,6,6,7,0,0,0,0,0,4,0,4,0 | |
| ade_mask,1,1,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute myopathy,degeneration of myosin filaments | |
| drug,vecuronium | |
| sequence,Acute,myopathy,with,selective,degeneration,of,myosin,filaments,following,status,asthmaticus,treated,with,methylprednisolone,and,vecuronium,. | |
| labels,5,7,0,0,5,6,6,7,0,0,0,0,0,4,0,4,0 | |
| ade_mask,1,1,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anaphylactoid reactions | |
| drug,cisplatin | |
| sequence,OBJECTIVE,:,To,report,the,occurrence,of,anaphylactoid,reactions,to,intraperitoneal,cisplatin,in,3,patients,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,stuttering,priapism | |
| drug,Warfarin | |
| sequence,We,report,a,rare,case,of,recurrent,(,stuttering,),priapism,in,a,patient,with,protein,C,deficiency,while,maintained,on,Warfarin,therapy,. | |
| labels,0,0,0,0,0,0,0,0,8,0,8,0,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hair loss | |
| drug,paroxetine | |
| sequence,We,report,on,a,37-year-old,female,who,complained,of,moderate,hair,loss,during,paroxetine,treatment,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,maculopapular rash,angioedema | |
| drug,carbamazepine | |
| sequence,We,report,the,case,of,a,27-year-old,Indian,woman,who,developed,maculopapular,rash,and,angioedema,secondary,to,carbamazepine,administration,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,5,7,0,8,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ventricular arrhythmia,cardiac arrest | |
| drug,bretylium | |
| sequence,Although,transient,increases,in,ectopy,after,bretylium,therapy,have,been,described,,,presumably,due,to,catecholamine,release,,,the,occurrence,of,life-threatening,ventricular,arrhythmia,leading,to,cardiac,arrest,has,not,previously,been,emphasized,. | |
| labels,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,5,7,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,anaphylaxis | |
| drug,metaraminol | |
| sequence,We,present,two,cases,of,anaphylaxis,under,anaesthesia,where,return,of,spontaneous,circulation,was,refractory,to,epinephrine,,,but,occurred,following,the,administration,of,the,alpha-agonist,metaraminol,. | |
| labels,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,corneal ulcers refractory to conventional treatment | |
| drug,colchicine | |
| sequence,The,authors,report,on,two,patients,with,corneal,ulcers,refractory,to,conventional,treatment,while,the,patients,were,undergoing,oral,colchicine,therapy,. | |
| labels,0,0,0,0,0,0,0,5,6,6,6,6,7,0,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Thrombotic thrombocytopenic purpura | |
| drug,penicillamine | |
| sequence,Thrombotic,thrombocytopenic,purpura,during,penicillamine,therapy,in,rheumatoid,arthritis,. | |
| labels,5,6,7,0,4,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Posterior reversible encephalopathy syndrome | |
| drug,methotrexate | |
| sequence,Posterior,reversible,encephalopathy,syndrome,associated,with,methotrexate,neurotoxicity,:,conventional,magnetic,resonance,and,diffusion-weighted,imaging,findings,. | |
| labels,5,6,6,7,0,0,4,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Severe hyperkalemia | |
| drug,prednisone | |
| sequence,Severe,hyperkalemia,occurred,in,a,patient,with,radiation,pneumonitis,and,glaucoma,shortly,after,beginning,prednisone,therapy,. | |
| labels,5,7,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Edema | |
| drug,ibuprofen | |
| sequence,Edema,associated,with,ibuprofen,therapy,. | |
| labels,8,0,0,4,0,0 | |
| ade_mask,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,decrease in both lumbar spine,increase in the incidence of all bone fractures,joint disorders,increase in the cholesterol level | |
| drug,anastrozole | |
| sequence,There,are,major,side,effects,of,anastrozole,including,decrease,in,both,lumbar,spine,and,total,hip,bone,mineral,density,,,increase,in,the,incidence,of,all,bone,fractures,(,especially,fractures,of,spine,,,hip,and,wrist,),,,joint,disorders,and,increase,in,the,cholesterol,level,. | |
| labels,0,0,0,0,0,0,4,0,5,6,6,6,7,0,0,0,0,0,0,0,5,6,6,6,6,6,6,7,0,0,0,0,0,0,0,0,0,0,0,5,7,0,5,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,1,0,0,1,1,1,1,1,0,0,0,1,0,0,0,1,0,1,1,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,bilateral lower leg edema | |
| drug,pioglitazone | |
| sequence,A,75-year-old,man,developed,bilateral,lower,leg,edema,6,months,after,switching,from,troglitazone,to,pioglitazone,. | |
| labels,0,0,0,0,5,6,6,7,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Pulmonary lymphohistiocytic reactions | |
| drug,etanercept | |
| sequence,Pulmonary,lymphohistiocytic,reactions,temporally,related,to,etanercept,therapy,. | |
| labels,5,6,7,0,0,0,4,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatotoxic | |
| drug,itraconazole | |
| sequence,With,itraconazole,,,hepatotoxic,reactions,have,only,very,rarely,been,reported,,,and,histologic,data,are,lacking,. | |
| labels,0,4,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,allergy | |
| drug,MTX | |
| sequence,He,was,later,skin,tested,to,confirm,allergy,to,MTX,. | |
| labels,0,0,0,0,0,0,0,8,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,nail changes | |
| drug,clofazimine | |
| sequence,These,nail,changes,gradually,disappeared,when,the,dose,of,clofazimine,was,reduced,. | |
| labels,0,5,7,0,0,0,0,0,0,4,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperkalaemia,elevation of serum creatinine and blood urea,increased urinary N-acetyl glucosaminase,one patient became unconscious | |
| drug,cotrimoxazole | |
| sequence,A,high,dose,of,cotrimoxazole,induced,hyperkalaemia,with,the,elevation,of,serum,creatinine,and,blood,urea,,,and,increased,urinary,N-acetyl,glucosaminase,after,several,days,of,the,drug,administration,in,these,patients,;,one,patient,became,unconscious,. | |
| labels,0,0,0,0,4,0,8,0,0,5,6,6,6,6,6,7,0,0,5,6,6,7,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0 | |
| ade_mask,0,0,0,1,0,0,1,0,0,1,0,1,1,1,1,1,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,Anaphylactic reaction | |
| drug,recombinant insulin-like growth factor-I | |
| sequence,Anaphylactic,reaction,to,recombinant,insulin-like,growth,factor-I,. | |
| labels,5,7,0,1,2,2,3,0 | |
| ade_mask,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,akathisia | |
| drug,Fluoxetine | |
| sequence,Fluoxetine-induced,akathisia,:,clinical,and,theoretical,implications,. | |
| labels,4,8,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,syndrome of inappropriate antidiuretic hormone,SIADH | |
| drug,vinorelbine | |
| sequence,OBJECTIVE,:,To,describe,onset,of,syndrome,of,inappropriate,antidiuretic,hormone,(,SIADH,),associated,with,vinorelbine,therapy,for,advanced,breast,cancer,. | |
| labels,0,0,0,0,0,0,5,6,6,6,7,0,8,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Gynecomastia | |
| drug,theophylline | |
| sequence,Gynecomastia,associated,with,theophylline,. | |
| labels,8,0,0,4,0 | |
| ade_mask,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acceleration of ventricular response | |
| drug,adenosine | |
| sequence,Acceleration,of,ventricular,response,to,atrial,flutter,after,intravenous,adenosine,. | |
| labels,5,6,6,7,0,0,0,0,0,4,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Severe acidosis | |
| drug,acetazolamide | |
| sequence,Severe,acidosis,from,acetazolamide,in,a,diabetic,patient,. | |
| labels,5,7,0,4,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sexual dysfunction | |
| drug,Fluoxetine | |
| sequence,BACKGROUND,:,Fluoxetine,,,a,highly,specific,serotonin,reuptake,inhibitor,,,has,been,reported,to,cause,sexual,dysfunction,in,a,minority,of,patients,. | |
| labels,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Vitamin K deficiency | |
| drug,Cephalosporins | |
| sequence,Cephalosporins,are,most,likely,associated,with,Vitamin,K,deficiency,. | |
| labels,4,0,0,0,0,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,Massive plasmocytosis,bone marrow toxicity | |
| drug,methimazole | |
| sequence,Massive,plasmocytosis,due,to,methimazole-induced,bone,marrow,toxicity,. | |
| labels,5,7,0,0,4,5,6,7,0 | |
| ade_mask,1,1,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,cardiomyopathy | |
| drug,Adriamycin | |
| sequence,Adriamycin-induced,cardiomyopathy,aggravated,by,cis-platinum,nephrotoxicity,requiring,dialysis,. | |
| labels,4,8,0,0,4,8,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nephrotoxicity | |
| drug,cis-platinum | |
| sequence,Adriamycin-induced,cardiomyopathy,aggravated,by,cis-platinum,nephrotoxicity,requiring,dialysis,. | |
| labels,4,8,0,0,4,8,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,central nervous system toxicity | |
| drug,cytarabine | |
| sequence,Intravenous,cytarabine,and,methotrexate,appear,to,act,synergistically,to,enhance,the,potential,for,central,nervous,system,toxicity,. | |
| labels,0,4,0,4,0,0,0,0,0,0,0,0,0,5,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,central nervous system toxicity | |
| drug,methotrexate | |
| sequence,Intravenous,cytarabine,and,methotrexate,appear,to,act,synergistically,to,enhance,the,potential,for,central,nervous,system,toxicity,. | |
| labels,0,4,0,4,0,0,0,0,0,0,0,0,0,5,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,akathisia,bucco-linguo-masticatory dyskinesia | |
| drug,lithium | |
| sequence,k,bipolar,manic-depressive,patient,,,developed,while,on,lithium,prophylaxis,,,akathisia,at,therapeutic,serum,lithium,levels,and,subsequently,bucco-linguo-masticatory,dyskinesia,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,8,0,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,pneumonitis | |
| drug,Methotrexate | |
| sequence,Methotrexate-induced,pneumonitis,in,patients,with,rheumatoid,arthritis,and,psoriatic,arthritis,:,report,of,five,cases,and,review,of,the,literature,. | |
| labels,4,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,papular eruption | |
| drug,methotrexate | |
| sequence,CONCLUSIONS,:,The,pathogenesis,of,methotrexate-induced,papular,eruption,in,collagen,vascular,diseases,may,suggest,cutaneous,small-vessel,vasculitis,. | |
| labels,0,0,0,0,0,4,5,7,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fatal acute hepatic failure | |
| drug,Imatinib mesylate | |
| sequence,Imatinib,mesylate-related,fatal,acute,hepatic,failure,in,a,patient,with,chronic,myeloid,leukaemia,and,chronic,hepatitis,B,infection,. | |
| labels,1,3,5,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Crohn's disease | |
| drug,etanercept | |
| sequence,New,onset,of,Crohn,'s,disease,during,treatment,of,active,ankylosing,spondylitis,with,etanercept,. | |
| labels,0,0,0,5,6,7,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute pancreatitis | |
| drug,danazol | |
| sequence,The,present,report,describes,the,first,case,of,acute,pancreatitis,associated,with,danazol,treatment,of,endometriosis,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,red blood cell anemia | |
| drug,MMF | |
| sequence,An,apparent,link,is,described,between,the,use,of,MMF,with,prednisone,to,treat,pemphigus,vulgaris,and,the,development,of,red,blood,cell,anemia,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,5,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,red blood cell anemia | |
| drug,prednisone | |
| sequence,An,apparent,link,is,described,between,the,use,of,MMF,with,prednisone,to,treat,pemphigus,vulgaris,and,the,development,of,red,blood,cell,anemia,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,5,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,nitrite toxicity | |
| drug,nitrite | |
| sequence,Acute,nitrite,toxicity,results,from,industrial,exposure,,,accidental,ingestion,(,e.g.,,,abuse,of,organic,nitrites,as,an,aphrodisiac,,,especially,in,the,male,homosexual,population,),,,and,suicidal,ingestion,. | |
| labels,0,9,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Fulminant hepatic failure | |
| drug,bicalutamide | |
| sequence,Fulminant,hepatic,failure,associated,with,bicalutamide,. | |
| labels,5,6,7,0,0,4,0 | |
| ade_mask,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pulmonary infiltrates with eosinophilia | |
| drug,Captopril | |
| sequence,Captopril-induced,pulmonary,infiltrates,with,eosinophilia,in,an,infant,with,congenital,heart,disease,. | |
| labels,4,5,6,6,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fulminant hepatitis | |
| drug,nevirapine | |
| sequence,We,describe,a,detailed,case,of,fulminant,hepatitis,induced,by,nevirapine,(,Viramune,),and,treated,by,liver,transplantation,. | |
| labels,0,0,0,0,0,0,5,7,0,0,4,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fulminant hepatitis | |
| drug,Viramune | |
| sequence,We,describe,a,detailed,case,of,fulminant,hepatitis,induced,by,nevirapine,(,Viramune,),and,treated,by,liver,transplantation,. | |
| labels,0,0,0,0,0,0,5,7,0,0,4,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,seizures | |
| drug,Didanosine | |
| sequence,Didanosine,also,has,a,potential,for,inducing,seizures,. | |
| labels,4,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Hepatotoxicity | |
| drug,itraconazole | |
| sequence,Hepatotoxicity,related,to,itraconazole,:,report,of,three,cases,. | |
| labels,8,0,0,4,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hypokalemia | |
| drug,albuterol | |
| sequence,Hypokalemia,after,normal,doses,of,neubulized,albuterol,(,salbutamol,),. | |
| labels,8,0,0,0,0,0,4,0,4,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hypokalemia | |
| drug,salbutamol | |
| sequence,Hypokalemia,after,normal,doses,of,neubulized,albuterol,(,salbutamol,),. | |
| labels,8,0,0,0,0,0,4,0,4,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lethargy,confusion,drowsiness | |
| drug,cholestyramine II | |
| sequence,After,taking,cholestyramine,II,sachets,twice,daily,for,two,months,she,presented,with,lethargy,,,confusion,and,drowsiness,. | |
| labels,0,0,1,3,0,0,0,0,0,0,0,0,0,8,0,8,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,0 | |
| ==============================, ============================= | |
| ade,Stevens-Johnson syndrome | |
| drug,nevirapine | |
| sequence,Stevens-Johnson,syndrome,caused,by,the,antiretroviral,drug,nevirapine,. | |
| labels,5,7,0,0,0,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,vasculitis | |
| drug,Vancomycin | |
| sequence,Vancomycin-induced,vasculitis,. | |
| labels,4,8,0 | |
| ade_mask,0,1,0 | |
| ==============================, ============================= | |
| ade,endometrial carcinoma | |
| drug,tamoxifen | |
| sequence,In,this,healthy,population,,,the,relative,risk,of,developing,endometrial,carcinoma,in,the,tamoxifen,arm,was,2.54,,,although,when,stratified,by,age,,,in,women,over,50,,,the,risk,grew,to,4.01,. | |
| labels,0,0,0,0,0,0,0,0,0,0,5,7,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,irreversible renal failure,rickets | |
| drug,TDF | |
| sequence,To,our,knowledge,,,these,cases,represent,the,first,reports,of,TDF-associated,irreversible,renal,failure,and,rickets,in,pediatric,patients,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,4,5,6,7,0,8,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,intrahepatic cholestasis | |
| drug,sodium aurothiomalate | |
| sequence,A,patient,with,rheumatoid,arthritis,developed,an,acute,intrahepatic,cholestasis,after,100,mg,of,sodium,aurothiomalate,. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,0,0,1,3,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute hemorrhagic gastritis,AZ intoxication | |
| drug,AZ | |
| sequence,As,far,as,we,know,,,this,is,the,first,case,report,of,acute,hemorrhagic,gastritis,associated,with,AZ,intoxication,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,9,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,neurotoxicity | |
| drug,interleukin-2 | |
| sequence,Delayed,neurotoxicity,of,intraventricular,interleukin-2,:,a,case,report,. | |
| labels,0,8,0,0,4,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,muscle weakness,rhabdomyolysis | |
| drug,colchicine | |
| sequence,Rapid,onset,of,muscle,weakness,(,rhabdomyolysis,),associated,with,the,combined,use,of,simvastatin,and,colchicine,. | |
| labels,0,0,0,5,7,0,8,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,muscle weakness,rhabdomyolysis | |
| drug,simvastatin | |
| sequence,Rapid,onset,of,muscle,weakness,(,rhabdomyolysis,),associated,with,the,combined,use,of,simvastatin,and,colchicine,. | |
| labels,0,0,0,5,7,0,8,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,general malaise | |
| drug,pantoprazole | |
| sequence,After,5,weeks,of,therapy,,,she,stopped,taking,pantoprazole,due,to,general,malaise,. | |
| labels,0,0,0,0,0,0,0,0,0,4,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,acute dermatitis | |
| drug,8MOP | |
| sequence,Of,371,patients,treated,with,8MOP,,,three,(,0.8,%,),developed,an,acute,dermatitis,in,the,PUVA-treated,areas,. | |
| labels,0,0,0,0,0,4,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,heart failure | |
| drug,timolol | |
| sequence,A,case,of,timolol-associated,heart,failure,in,a,73-year,old,white,man,is,reported,. | |
| labels,0,0,0,4,5,7,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,massive proteinuria,acute nephritic syndrome | |
| drug,methicillin | |
| sequence,A,drug,addict,with,staphylococcal,endocarditis,treated,with,methicillin,,,who,developed,massive,proteinuria,and,acute,nephritic,syndrome,is,described,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,5,7,0,5,6,7,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,liver injury | |
| drug,Methyldopa | |
| sequence,Methyldopa-induced,liver,injury,. | |
| labels,4,5,7,0 | |
| ade_mask,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Transient central diabetes insipidus | |
| drug,lithium | |
| sequence,Transient,central,diabetes,insipidus,in,the,setting,of,underlying,chronic,nephrogenic,diabetes,insipidus,associated,with,lithium,use,. | |
| labels,5,6,6,7,0,0,0,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,granulocytopenia,eosinophilia,skin reaction,hepatitis,lymphocyte sensitization | |
| drug,propylthiouracil | |
| sequence,Multiple,complications,of,propylthiouracil,treatment,:,granulocytopenia,,,eosinophilia,,,skin,reaction,and,hepatitis,with,lymphocyte,sensitization,. | |
| labels,0,0,0,4,0,0,8,0,8,0,5,7,0,8,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,1,0,1,0,1,1,0,1,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Hashimoto's disease | |
| drug,interferon-alpha | |
| sequence,Hashimoto,'s,disease,during,interferon-alpha,therapy,in,a,patient,with,pre-treatment,negative,anti-thyroid,autoantibodies,and,with,the,specific,genetic,susceptibility,to,the,thyroid,disease,. | |
| labels,5,6,7,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Philadelphia positive chronic myeloid leukaemia | |
| drug,hydroxyurea | |
| sequence,Emergence,of,Philadelphia,positive,chronic,myeloid,leukaemia,during,treatment,with,hydroxyurea,for,Philadelphia,negative,essential,thrombocythaemia,. | |
| labels,0,0,5,6,6,6,7,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,TRAb TBII without thyroid-stimulating activity,destructive thyroiditis,thyroiditis | |
| drug,amiodarone | |
| sequence,These,in,vitro,findings,and,clinical,course,suggest,that,TRAb,TBII,without,thyroid-stimulating,activity,may,develop,in,patients,with,amiodarone-induced,destructive,thyroiditis,,,as,reported,in,patients,with,destructive,thyroiditis,,,such,as,subacute,and,silent,thyroiditis,. | |
| labels,0,0,0,0,0,0,0,0,0,5,6,6,6,7,0,0,0,0,0,4,5,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,1,1,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,skin necrosis | |
| drug,Glypressin | |
| sequence,AIM,:,To,report,three,cases,of,extensive,skin,necrosis,in,cirrhotic,patients,treated,with,the,vasoconstrictor,agent,terlipressin,(,Glypressin,),. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,4,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,skin necrosis | |
| drug,terlipressin | |
| sequence,AIM,:,To,report,three,cases,of,extensive,skin,necrosis,in,cirrhotic,patients,treated,with,the,vasoconstrictor,agent,terlipressin,(,Glypressin,),. | |
| labels,0,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,4,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,colitis | |
| drug,cisplatin | |
| sequence,Both,patients,were,then,treated,with,a,carboplatin,alternative,to,cisplatin,in,the,following,courses,,,which,resulted,in,neither,a,relapse,of,the,colitis,nor,a,recurrence,of,the,malignancies,up,to,this,time,. | |
| labels,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,systemic lupus erythematosus | |
| drug,interferon-gamma | |
| sequence,Induction,of,systemic,lupus,erythematosus,by,interferon-gamma,in,a,patient,with,rheumatoid,arthritis,. | |
| labels,0,0,5,6,7,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Rupture of a cerebral aneurysm | |
| drug,nifedipine | |
| sequence,Rupture,of,a,cerebral,aneurysm,associated,with,nifedipine,treatment,. | |
| labels,5,6,6,6,7,0,0,4,0,0 | |
| ade_mask,1,1,1,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,deep vein thrombosis | |
| drug,imatinib | |
| sequence,The,possibility,of,deep,vein,thrombosis,caused,by,the,compression,of,the,veins,by,necrotic,tumor,should,be,considered,in,patients,with,abdominal,or,pelvic,metastases,of,GIST,,,including,patients,treated,with,imatinib,. | |
| labels,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,generalised pustular exacerbation,aggravation of the joint condition | |
| drug,cyclosporin A | |
| sequence,We,report,a,50-year-old,male,patient,with,a,15-year,history,of,psoriasis,including,mutilating,psoriatic,arthritis,,,in,whom,the,withdrawal,of,cyclosporin,A,induced,a,generalised,pustular,exacerbation,and,a,aggravation,of,the,joint,condition,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,3,0,0,5,6,7,0,0,5,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,1,1,0,0,1,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,Hypersensitivity pneumonitis-like syndrome | |
| drug,lenalidomide | |
| sequence,Hypersensitivity,pneumonitis-like,syndrome,associated,with,the,use,of,lenalidomide,. | |
| labels,5,6,7,0,0,0,0,0,4,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,toxic encephalopathy,depressed level of consciousness,marked irritability,ataxia | |
| drug,pentobarbital | |
| sequence,A,toxic,encephalopathy,characterized,by,depressed,level,of,consciousness,,,marked,irritability,,,and,ataxia,developed,in,seven,children,,,5,years,of,age,and,younger,,,following,administration,of,an,antiemetic,combination,of,pentobarbital,and,pyrilamine,maleate,. | |
| labels,0,5,7,0,0,5,6,6,7,0,5,7,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,1,3,0 | |
| ade_mask,0,1,1,0,0,1,1,1,1,0,1,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,toxic encephalopathy,depressed level of consciousness,marked irritability,ataxia | |
| drug,pyrilamine maleate | |
| sequence,A,toxic,encephalopathy,characterized,by,depressed,level,of,consciousness,,,marked,irritability,,,and,ataxia,developed,in,seven,children,,,5,years,of,age,and,younger,,,following,administration,of,an,antiemetic,combination,of,pentobarbital,and,pyrilamine,maleate,. | |
| labels,0,5,7,0,0,5,6,6,7,0,5,7,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,1,3,0 | |
| ade_mask,0,1,1,0,0,1,1,1,1,0,1,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,eruption | |
| drug,salsalate | |
| sequence,This,eruption,emerged,after,1,month,of,therapy,with,salsalate,,,persisted,for,as,long,as,salsalate,was,administered,,,and,cleared,within,3,weeks,of,discontinuing,the,medication,. | |
| labels,0,8,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hemolytic-uremic syndrome,HUS | |
| drug,gemcitabine | |
| sequence,BACKGROUND,:,Gemcitabine,has,mild,renal,toxicity,,,but,cases,of,gemcitabine-associated,hemolytic-uremic,syndrome,(,HUS,),have,been,reported,. | |
| labels,0,0,4,0,0,5,7,0,0,0,0,4,5,7,0,8,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,renal toxicity,hemolytic-uremic syndrome,HUS | |
| drug,Gemcitabine | |
| sequence,BACKGROUND,:,Gemcitabine,has,mild,renal,toxicity,,,but,cases,of,gemcitabine-associated,hemolytic-uremic,syndrome,(,HUS,),have,been,reported,. | |
| labels,0,0,4,0,0,5,7,0,0,0,0,4,5,7,0,8,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,1,1,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ulcers,keratitis | |
| drug,methamphetamine | |
| sequence,The,increasing,prevalence,of,methamphetamine,abuse,and,the,severity,of,the,associated,ulcers,should,alert,ophthalmologists,to,the,problem,of,methamphetamine-related,keratitis,. | |
| labels,0,0,0,0,4,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Sudden death | |
| drug,sweet spirits of nitre | |
| sequence,Sudden,death,in,an,infant,from,methemoglobinemia,after,administration,of,``,sweet,spirits,of,nitre,'',. | |
| labels,5,7,0,0,0,0,0,0,0,0,0,1,2,2,3,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hepatotoxicity | |
| drug,IFN beta | |
| sequence,Post,marketing,studies,of,Interferon-beta,(,IFN,beta,),therapy,in,multiple,sclerosis,(,MS,),have,demonstrated,surprisingly,high,rates,of,hepatotoxicity,. | |
| labels,0,0,0,0,4,0,1,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,hepatotoxicity | |
| drug,Interferon-beta | |
| sequence,Post,marketing,studies,of,Interferon-beta,(,IFN,beta,),therapy,in,multiple,sclerosis,(,MS,),have,demonstrated,surprisingly,high,rates,of,hepatotoxicity,. | |
| labels,0,0,0,0,4,0,1,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,low-grade fever,localized pain,myelo-suppression,liver dysfunction | |
| drug,Lp-TAE | |
| sequence,The,main,side-effects,of,Lp-TAE,combined,with,HT,were,low-grade,fever,,,localized,pain,,,myelo-suppression,and,liver,dysfunction,,,but,these,were,transient,and,eventually,disappeared,. | |
| labels,0,0,0,0,4,0,0,0,0,5,7,0,5,7,0,8,0,5,7,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,0,1,1,0,1,0,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Tremor | |
| drug,itraconazole | |
| sequence,Tremor,:,a,newly,described,adverse,event,with,long-term,itraconazole,therapy,. | |
| labels,8,0,0,0,0,0,0,0,0,4,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,decreased vision,retinal damage | |
| drug,rifabutin | |
| sequence,PURPOSE,:,To,describe,the,clinical,and,electrophysiological,findings,in,a,young,boy,with,decreased,vision,possibly,due,to,retinal,damage,by,rifabutin,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,0,5,7,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,1,1,0,0,0 | |
| ==============================, ============================= | |
| ade,bronchospasm | |
| drug,Propranolol | |
| sequence,Propranolol-related,bronchospasm,in,patients,without,history,of,asthma,. | |
| labels,4,8,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,gastric mucosa foveolar hyperplasia | |
| drug,PGE1 | |
| sequence,The,results,of,the,ultrasound,examination,combined,with,clinical,anamnesis,allowed,diagnosis,of,gastric,mucosa,foveolar,hyperplasia,due,to,prolonged,PGE1,therapy,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Diarrhoea,T-CD4+ lymphopenia,bilateral patchy pulmonary infiltrates | |
| drug,5-fluorouracil | |
| sequence,Diarrhoea,,,T-CD4+,lymphopenia,and,bilateral,patchy,pulmonary,infiltrates,developed,in,a,male,60,yrs,of,age,,,who,was,treated,with,oxaliplatinum,and,5-fluorouracil,for,unresectable,rectum,carcinoma,. | |
| labels,8,0,5,7,0,5,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0 | |
| ade_mask,1,0,1,1,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Diarrhoea,T-CD4+ lymphopenia,bilateral patchy pulmonary infiltrates | |
| drug,oxaliplatinum | |
| sequence,Diarrhoea,,,T-CD4+,lymphopenia,and,bilateral,patchy,pulmonary,infiltrates,developed,in,a,male,60,yrs,of,age,,,who,was,treated,with,oxaliplatinum,and,5-fluorouracil,for,unresectable,rectum,carcinoma,. | |
| labels,8,0,5,7,0,5,6,6,7,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0 | |
| ade_mask,1,0,1,1,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,gestational diabetes,diabetes mellitus,impaired glucose tolerance | |
| drug,norethisterone | |
| sequence,However,,,follow-up,revealed,that,gestational,diabetes,when,associated,with,norethisterone,had,a,lesser,risk,of,emerging,diabetes,mellitus,and,impaired,glucose,tolerance,. | |
| labels,0,0,0,0,0,5,7,0,0,0,4,0,0,0,0,0,0,5,7,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,seizures | |
| drug,clozapine | |
| sequence,Following,discontinuation,of,clozapine,,,she,was,rechallenged,and,again,was,observed,to,have,seizures,. | |
| labels,0,0,0,4,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,Fever | |
| drug,furosemide | |
| sequence,Fever,caused,by,the,use,of,furosemide,was,proved,;,the,fever,resolved,after,discontinuation,of,this,medication,and,recurred,after,its,reintroduction,. | |
| labels,8,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,eosinophilia myalgia syndrome | |
| drug,tryptophan | |
| sequence,Thus,,,the,eosinophilia,myalgia,syndrome,can,be,associated,with,parenteral,tryptophan,administration,. | |
| labels,0,0,0,5,6,7,0,0,0,0,0,4,0,0 | |
| ade_mask,0,0,0,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,symptoms resembling Parkinson's disease | |
| drug,chlorpromazine | |
| sequence,Soon,after,its,introduction,in,1952,,,chlorpromazine,was,noted,to,induce,symptoms,resembling,Parkinson,'s,disease,. | |
| labels,0,0,0,0,0,0,0,4,0,0,0,0,5,6,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,ischaemic cerebrovascular accident | |
| drug,streptokinase | |
| sequence,A,58-year,old,patient,is,reported,who,developed,an,ischaemic,cerebrovascular,accident,22,hours,after,successful,thrombolysis,with,streptokinase,for,life-threatening,pulmonary,emboli,. | |
| labels,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cardiotoxicity | |
| drug,adriamycin | |
| sequence,Radiologic,recognition,of,adriamycin,cardiotoxicity,. | |
| labels,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,angio-oedema | |
| drug,VRC | |
| sequence,Here,,,we,report,a,case,of,angio-oedema,associated,with,VRC,therapy,. | |
| labels,0,0,0,0,0,0,0,8,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypersensitivity reaction | |
| drug,cyclosporine | |
| sequence,Fortunately,,,a,hypersensitivity,reaction,to,one,formulation,of,cyclosporine,does,not,preclude,use,of,a,different,formulation,. | |
| labels,0,0,0,5,7,0,0,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hyperphosphatemia | |
| drug,sodium phosphate | |
| sequence,Acute,hyperphosphatemia,caused,by,sodium,phosphate,enema,in,a,patient,with,liver,dysfunction,and,chronic,renal,failure,. | |
| labels,0,8,0,0,1,3,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myocardial infarction,stroke | |
| drug,triptan | |
| sequence,Though,they,are,generally,considered,safe,,,there,have,been,a,few,reports,of,myocardial,infarction,and,stroke,associated,with,triptan,use,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,8,0,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,coronary spasm,cardiac arrest | |
| drug,sulprostone | |
| sequence,We,postulate,that,the,bolus,of,sulprostone,resulted,in,possible,coronary,spasm,that,resulted,in,cardiac,arrest,. | |
| labels,0,0,0,0,0,0,4,0,0,0,5,7,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,upper gastrointestinal bleeding | |
| drug,cimetidine | |
| sequence,Caution,with,use,of,cimetidine,in,tolazoline,induced,upper,gastrointestinal,bleeding,. | |
| labels,0,0,0,0,4,0,4,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,upper gastrointestinal bleeding | |
| drug,tolazoline | |
| sequence,Caution,with,use,of,cimetidine,in,tolazoline,induced,upper,gastrointestinal,bleeding,. | |
| labels,0,0,0,0,4,0,4,0,5,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis | |
| drug,azithromycin | |
| sequence,OBJECTIVE,:,To,describe,two,cases,of,rhabdomyolysis,in,patients,taking,lovastatin,that,were,precipitated,by,the,use,of,the,newer,macrolide,antibiotics,clarithromycin,and,azithromycin,. | |
| labels,0,0,0,0,0,0,0,8,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis | |
| drug,clarithromycin | |
| sequence,OBJECTIVE,:,To,describe,two,cases,of,rhabdomyolysis,in,patients,taking,lovastatin,that,were,precipitated,by,the,use,of,the,newer,macrolide,antibiotics,clarithromycin,and,azithromycin,. | |
| labels,0,0,0,0,0,0,0,8,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis | |
| drug,lovastatin | |
| sequence,OBJECTIVE,:,To,describe,two,cases,of,rhabdomyolysis,in,patients,taking,lovastatin,that,were,precipitated,by,the,use,of,the,newer,macrolide,antibiotics,clarithromycin,and,azithromycin,. | |
| labels,0,0,0,0,0,0,0,8,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Paroxysmal supraventricular tachycardia | |
| drug,cisplatin | |
| sequence,Paroxysmal,supraventricular,tachycardia,during,treatment,with,cisplatin,and,etoposide,combination,. | |
| labels,5,6,7,0,0,0,4,0,4,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Paroxysmal supraventricular tachycardia | |
| drug,etoposide | |
| sequence,Paroxysmal,supraventricular,tachycardia,during,treatment,with,cisplatin,and,etoposide,combination,. | |
| labels,5,6,7,0,0,0,4,0,4,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nonthrombocytopenic palpable purpura | |
| drug,metoclopramide | |
| sequence,OBJECTIVE,:,To,report,a,case,of,reversible,nonthrombocytopenic,palpable,purpura,associated,with,metoclopramide,. | |
| labels,0,0,0,0,0,0,0,0,5,6,7,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,adverse cutaneous reactions | |
| drug,Ritonavir | |
| sequence,Ritonavir,should,be,added,to,the,list,of,drugs,that,can,induce,adverse,cutaneous,reactions,in,HIV,patients,. | |
| labels,4,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,headache,confusion,gray areas | |
| drug,nefazodone | |
| sequence,After,1,week,of,nefazodone,therapy,the,patient,experienced,headache,,,confusion,,,and,``,gray,areas,'',in,her,vision,,,without,abnormal,ophthalmologic,findings,. | |
| labels,0,0,0,0,4,0,0,0,0,8,0,8,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,spinal cord lesion | |
| drug,zolmitriptan | |
| sequence,A,50-year-old,woman,with,a,history,of,migraine,without,aura,,,predominantly,occurring,around,her,menstrual,periods,,,developed,a,spinal,cord,lesion,following,the,use,of,zolmitriptan,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe necrotizing pancreatitis | |
| drug,L-asparaginase | |
| sequence,L-asparaginase-induced,severe,necrotizing,pancreatitis,successfully,treated,with,percutaneous,drainage,. | |
| labels,4,5,6,7,0,0,0,0,0,0 | |
| ade_mask,0,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,neutropenia | |
| drug,captopril | |
| sequence,We,report,two,cases,of,neutropenia,following,captopril,use,in,cardiac,patients,with,trisomy,21,. | |
| labels,0,0,0,0,0,8,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,systemic lupus erythematosus | |
| drug,Carbamazepine | |
| sequence,Carbamazepine-induced,systemic,lupus,erythematosus,. | |
| labels,4,5,6,7,0 | |
| ade_mask,0,1,1,1,0 | |
| ==============================, ============================= | |
| ade,hepatic reactions | |
| drug,cyclofenil | |
| sequence,Thirty,patients,with,hepatic,reactions,to,cyclofenil,,,a,non-steroidal,drug,with,a,stimulating,effect,on,ovulation,,,are,reviewed,. | |
| labels,0,0,0,5,7,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute asthma | |
| drug,verapamil | |
| sequence,Acute,asthma,associated,with,sustained-release,verapamil,. | |
| labels,5,7,0,0,0,4,0 | |
| ade_mask,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,apnoea | |
| drug,Suxamethonium | |
| sequence,Suxamethonium,apnoea,terminated,with,commercial,serumcholinesterase,. | |
| labels,4,8,0,0,0,0,0 | |
| ade_mask,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,HUS | |
| drug,mitomycin C | |
| sequence,HUS,has,been,reported,after,several,anticancer,chemotherapies,and,most,often,after,mitomycin,C-based,chemotherapy,regimens,. | |
| labels,8,0,0,0,0,0,0,0,0,0,0,0,1,3,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,GTBM | |
| drug,Melphalan | |
| sequence,We,present,a,unique,case,of,GTBM,in,a,patient,with,myeloma,following,treatment,with,Melphalan,. | |
| labels,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Vision declined | |
| drug,methylprednisolone | |
| sequence,Vision,declined,after,treatment,with,methylprednisolone,,,after,which,fundus,examination,became,consistent,with,progressive,outer,retinal,necrosis,. | |
| labels,5,7,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,agranulocytosis | |
| drug,dapsone | |
| sequence,A,case,report,of,fatal,dapsone-induced,agranulocytosis,in,an,Indian,mid-borderline,leprosy,patient,. | |
| labels,0,0,0,0,0,4,8,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,blood pressure decreased,syncope,sudden decrease in pulse rate | |
| drug,isosorbide dinitrate | |
| sequence,In,a,postural,challenge,test,after,administration,of,isosorbide,dinitrate,(,5,mg,),,,blood,pressure,decreased,from,120,67,to,65,35,mmHg,,,followed,by,syncope,with,a,sudden,decrease,in,pulse,rate,from,85,to,60,beats,min,. | |
| labels,0,0,0,0,0,0,0,0,1,3,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,0,0,0,8,0,0,5,6,6,6,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,1,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,gangrene,severe Raynaud's phenomenon | |
| drug,bleomycin | |
| sequence,In,this,report,,,one,patient,who,developed,gangrene,after,bleomycin,and,vincristine,vinblastine,chemotherapy,for,AIDS-related,Kaposi,'s,sarcoma,and,another,HIV-infected,patient,who,exhibited,symptoms,of,severe,Raynaud,'s,phenomenon,related,to,the,same,regimen,are,presented,. | |
| labels,0,0,0,0,0,0,0,0,8,0,4,0,4,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,gangrene,severe Raynaud's phenomenon | |
| drug,vinblastine | |
| sequence,In,this,report,,,one,patient,who,developed,gangrene,after,bleomycin,and,vincristine,vinblastine,chemotherapy,for,AIDS-related,Kaposi,'s,sarcoma,and,another,HIV-infected,patient,who,exhibited,symptoms,of,severe,Raynaud,'s,phenomenon,related,to,the,same,regimen,are,presented,. | |
| labels,0,0,0,0,0,0,0,0,8,0,4,0,4,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,gangrene,severe Raynaud's phenomenon | |
| drug,vincristine | |
| sequence,In,this,report,,,one,patient,who,developed,gangrene,after,bleomycin,and,vincristine,vinblastine,chemotherapy,for,AIDS-related,Kaposi,'s,sarcoma,and,another,HIV-infected,patient,who,exhibited,symptoms,of,severe,Raynaud,'s,phenomenon,related,to,the,same,regimen,are,presented,. | |
| labels,0,0,0,0,0,0,0,0,8,0,4,0,4,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,JHR | |
| drug,penicillin | |
| sequence,An,objective,causality,assessment,suggests,that,the,JHR,in,our,patient,was,probably,related,to,penicillin,. | |
| labels,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fever | |
| drug,Temozolomide | |
| sequence,Temozolomide,was,restarted,2,months,later,;,the,patient,again,developed,a,fever,. | |
| labels,4,0,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,leukopenia | |
| drug,carbamazepine | |
| sequence,She,was,receiving,phenytoin,sodium,300,mg,day,;,carbamazepine,200,mg,four,times,daily,had,been,discontinued,four,days,before,admission,because,of,leukopenia,. | |
| labels,0,0,0,1,3,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,leukopenia | |
| drug,phenytoin sodium | |
| sequence,She,was,receiving,phenytoin,sodium,300,mg,day,;,carbamazepine,200,mg,four,times,daily,had,been,discontinued,four,days,before,admission,because,of,leukopenia,. | |
| labels,0,0,0,1,3,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,malignant mixed mesodermal tumor | |
| drug,raloxifene | |
| sequence,CONCLUSION,:,There,may,be,an,association,between,raloxifene,and,the,development,of,malignant,mixed,mesodermal,tumor,. | |
| labels,0,0,0,0,0,0,0,0,4,0,0,0,0,5,6,6,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0 | |
| ==============================, ============================= | |
| ade,hypothyroid | |
| drug,ferrous sulfate | |
| sequence,We,describe,a,patient,who,became,hypothyroid,while,taking,ferrous,sulfate,. | |
| labels,0,0,0,0,0,0,8,0,0,1,3,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hearing impairment,tinnitus | |
| drug,PTU | |
| sequence,The,hearing,impairment,and,tinnitus,were,gradually,reduced,after,PTU,withdrawal,and,corticosteroid,and,azathioprine,treatment,. | |
| labels,0,5,7,0,8,0,0,0,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,diarrhea,stomatitis,mucositis,myelosuppression,neurotoxicity | |
| drug,5-FU | |
| sequence,DATA,SYNTHESIS,:,Genetic,deficiencies,in,DPD,,,the,rate-limiting,enzyme,responsible,for,5-FU,catabolism,,,may,occur,in,3,%,or,more,of,patients,with,cancer,putting,them,at,increased,risk,for,unusually,severe,adverse,reactions,(,e.g.,,,diarrhea,,,stomatitis,,,mucositis,,,myelosuppression,,,neurotoxicity,),to,standard,doses,of,5-FU,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,8,0,8,0,8,0,8,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,0,1,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Hepatotoxicity | |
| drug,D-penicillamine | |
| sequence,Hepatotoxicity,associated,with,use,of,D-penicillamine,in,rheumatoid,arthritis,. | |
| labels,8,0,0,0,0,4,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypothyroidism | |
| drug,amiodarone | |
| sequence,Although,it,is,difficult,to,be,certain,of,the,direct,link,of,amiodarone,on,the,basis,of,a,single,case,,,it,is,reasonable,to,presume,that,this,histopathology,is,associated,with,amiodarone-induced,hypothyroidism,and,that,involution,changes,represent,the,hypofunctional,status,of,this,drug-induced,disorder,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lower average heart rate,lower average mean blood pressure | |
| drug,propranolol | |
| sequence,One,patient,had,a,lower,average,heart,rate,and,two,patients,had,lower,average,mean,blood,pressure,values,during,propranolol,treatment,,,none,of,which,was,clinically,significant,. | |
| labels,0,0,0,0,5,6,6,7,0,0,0,0,5,6,6,6,7,0,0,4,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,1,1,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,hypercalcemia | |
| drug,dihydrotachysterol | |
| sequence,Unaccountable,severe,hypercalcemia,in,a,patient,treated,for,hypoparathyroidism,with,dihydrotachysterol,. | |
| labels,0,0,8,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,visual hallucinations,altered mental status | |
| drug,zonisamide | |
| sequence,Although,visual,hallucinations,have,not,been,reported,as,an,adverse,effect,of,this,agent,,,we,describe,three,patients,who,experienced,complex,visual,hallucinations,and,altered,mental,status,after,zonisamide,treatment,was,begun,or,its,dosage,increased,. | |
| labels,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fulminant hepatitis | |
| drug,nevirapine | |
| sequence,Liver,transplantation,for,fulminant,hepatitis,related,to,nevirapine,therapy,. | |
| labels,0,0,0,5,7,0,0,4,0,0 | |
| ade_mask,0,0,0,1,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Corneal edema | |
| drug,amantadine | |
| sequence,Corneal,edema,recurred,when,the,administration,of,amantadine,was,resumed,. | |
| labels,5,7,0,0,0,0,0,4,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sarcoidosis | |
| drug,interferon alpha 2b | |
| sequence,Development,of,sarcoidosis,during,interferon,alpha,2b,and,ribavirin,combination,therapy,for,chronic,hepatitis,C,--,a,case,report,and,review,of,the,literature,. | |
| labels,0,0,8,0,1,2,3,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,sarcoidosis | |
| drug,ribavirin | |
| sequence,Development,of,sarcoidosis,during,interferon,alpha,2b,and,ribavirin,combination,therapy,for,chronic,hepatitis,C,--,a,case,report,and,review,of,the,literature,. | |
| labels,0,0,8,0,1,2,3,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Acute renal failure | |
| drug,immunoglobulin | |
| sequence,Acute,renal,failure,is,a,rare,complication,following,the,administration,of,intravenous,immunoglobulin,(,IVIG,),. | |
| labels,5,6,7,0,0,0,0,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myocardial infarction | |
| drug,prothrombin complex concentrate | |
| sequence,Recombinant,VIIa,concentrate,in,the,management,of,bleeding,following,prothrombin,complex,concentrate-related,myocardial,infarction,in,patients,with,haemophilia,and,inhibitors,. | |
| labels,0,0,0,0,0,0,0,0,0,1,2,3,5,7,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cholesterol crystal embolization,extrarenal manifestations,atheroembolic acute renal failure | |
| drug,t-PA | |
| sequence,Although,there,is,one,case,report,of,cholesterol,crystal,embolization,following,t-PA,therapy,with,only,extrarenal,manifestations,(,N,Engl,J,Med,321:1270,,,1989,),,,this,is,the,first,reported,case,of,atheroembolic,acute,renal,failure,following,t-PA,therapy,. | |
| labels,0,0,0,0,0,0,0,5,6,7,0,4,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,symptomatic paroxysmal atrial fibrillation | |
| drug,vardenafil | |
| sequence,We,report,a,case,admitted,with,a,first-detected,,,symptomatic,paroxysmal,atrial,fibrillation,in,a,healthy,patient,after,self-medication,with,vardenafil,. | |
| labels,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute hepatitis | |
| drug,amiodarone | |
| sequence,A,patient,with,acute,changes,suggesting,acute,hepatitis,after,parenteral,amiodarone,administration,is,described,. | |
| labels,0,0,0,0,0,0,5,7,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,elevated liver transaminases,nausea,abdominal pain,bone pain,mild neutropenia,mild pruritus | |
| drug,methotrexate | |
| sequence,The,toxic,effects,of,methotrexate,included,elevated,liver,transaminases,(,3,4,),,,nausea,(,2,4,),,,abdominal,pain,(,2,4,),,,bone,pain,(,2,4,),,,mild,neutropenia,(,1,4,),,,and,mild,pruritus,(,1,4,),. | |
| labels,0,0,0,0,4,0,5,6,7,0,0,0,0,0,8,0,0,0,0,0,5,7,0,0,0,0,0,5,7,0,0,0,0,0,5,7,0,0,0,0,0,0,5,7,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,1,1,0,0,0,0,0,1,0,0,0,0,0,1,1,0,0,0,0,0,1,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Iatrogenic Cushing syndrome | |
| drug,triamcinolone | |
| sequence,Iatrogenic,Cushing,syndrome,after,epidural,triamcinolone,injections,in,an,HIV,type,1-infected,patient,receiving,therapy,with,ritonavir-lopinavir,. | |
| labels,5,6,7,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,intracranial bleeding | |
| drug,aspirin | |
| sequence,A,64,year,old,woman,with,previous,history,of,coronary,stenting,five,days,before,was,admitted,in,our,institution,for,intracranial,bleeding,while,receiving,aspirin,and,clopidogrel,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,intracranial bleeding | |
| drug,clopidogrel | |
| sequence,A,64,year,old,woman,with,previous,history,of,coronary,stenting,five,days,before,was,admitted,in,our,institution,for,intracranial,bleeding,while,receiving,aspirin,and,clopidogrel,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,7,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,loss of consciousness | |
| drug,pilsicainide | |
| sequence,A,74-year-old,man,received,oral,administration,of,pilsicainide,,,a,pure,sodium,channel,blocker,with,slow,recovery,kinetics,,,to,convert,paroxysmal,atrial,fibrillation,to,sinus,rhythm,and,developed,loss,of,consciousness,two,days,later,. | |
| labels,0,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cryptococcal meningitis | |
| drug,azathioprine | |
| sequence,This,is,a,case,report,of,fatal,cryptococcal,meningitis,in,a,child,with,systemic,lupus,erythematosus,being,treated,with,prednisolone,and,azathioprine,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,cryptococcal meningitis | |
| drug,prednisolone | |
| sequence,This,is,a,case,report,of,fatal,cryptococcal,meningitis,in,a,child,with,systemic,lupus,erythematosus,being,treated,with,prednisolone,and,azathioprine,. | |
| labels,0,0,0,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,4,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pneumonitis | |
| drug,MTX | |
| sequence,The,presence,of,a,lymphocyte,alveolitis,with,a,predominance,of,CD4+,T,cells,in,3,RA,patients,and,CD8+,T,cells,with,a,concomitant,increase,in,neutrophils,in,another,case,suggests,that,immunologically,mediated,reactions,may,be,one,damage,mechanism,in,MTX-induced,pneumonitis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,theophylline poisoning | |
| drug,theophylline | |
| sequence,A,diagnosis,of,masked,theophylline,poisoning,should,be,considered,in,similar,situations,involving,a,rapid,decrease,of,insulin,requirements,. | |
| labels,0,0,0,0,9,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rash | |
| drug,Aminoglutethimide | |
| sequence,Aminoglutethimide,was,discontinued,until,completion,of,radiotherapy,,,and,the,rash,resolved,. | |
| labels,4,0,0,0,0,0,0,0,0,0,8,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,1,0,0 | |
| ==============================, ============================= | |
| ade,Additive pulmonary toxicity | |
| drug,busulfan | |
| sequence,Additive,pulmonary,toxicity,with,melphalan,and,busulfan,therapy,. | |
| labels,5,6,7,0,4,0,4,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Additive pulmonary toxicity | |
| drug,melphalan | |
| sequence,Additive,pulmonary,toxicity,with,melphalan,and,busulfan,therapy,. | |
| labels,5,6,7,0,4,0,4,0,0 | |
| ade_mask,1,1,1,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,retinopathy | |
| drug,pegylated interferon | |
| sequence,BACKGROUND,:,To,assess,the,nature,,,incidence,,,and,risk,factors,of,retinopathy,associated,with,pegylated,interferon,and,ribavirin,combination,therapy,in,chronic,hepatitis,C,patients,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,1,3,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,retinopathy | |
| drug,ribavirin | |
| sequence,BACKGROUND,:,To,assess,the,nature,,,incidence,,,and,risk,factors,of,retinopathy,associated,with,pegylated,interferon,and,ribavirin,combination,therapy,in,chronic,hepatitis,C,patients,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,1,3,0,4,0,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,visual dysfunction | |
| drug,VGB | |
| sequence,The,knowledge,concerning,VGB-associated,visual,dysfunction,in,pediatric,patients,,,particularly,in,those,who,have,been,exposed,to,VGB,in,utero,is,limited,. | |
| labels,0,0,0,0,5,7,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0 | |
| ade_mask,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,myoclonic jerks | |
| drug,quetiapine | |
| sequence,A,64-year-old,man,with,schizophrenia,developed,myoclonic,jerks,when,given,higher,doses,of,quetiapine,. | |
| labels,0,0,0,0,0,0,5,7,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,multiple watery stools,abdominal cramping | |
| drug,clindamycin | |
| sequence,CASE,SUMMARY,:,A,25-year-old,postpartum,white,woman,developed,multiple,watery,stools,and,abdominal,cramping,on,day,6,of,therapy,with,clindamycin,vaginal,cream,for,bacterial,vaginosis,. | |
| labels,0,0,0,0,0,0,0,0,0,5,6,7,0,5,7,0,0,0,0,0,0,4,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,1,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Jaundice | |
| drug,streptokinase | |
| sequence,Jaundice,induced,by,streptokinase,. | |
| labels,8,0,0,4,0 | |
| ade_mask,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Renal failure | |
| drug,acetazolamide | |
| sequence,Renal,failure,associated,with,acetazolamide,therapy,for,glaucoma,. | |
| labels,5,7,0,0,4,0,0,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,rhabdomyolysis | |
| drug,sertraline | |
| sequence,The,patient,'s,other,comorbidities,and,medications,have,not,been,suggested,as,possible,interactions,with,sertraline,that,can,cause,rhabdomyolysis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,multifocal leukoencephalopathy | |
| drug,capecitabine | |
| sequence,The,authors,report,five,additional,cases,of,capecitabine-induced,multifocal,leukoencephalopathy,. | |
| labels,0,0,0,0,0,0,0,4,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,pulmonary adverse reaction | |
| drug,5-fluorouracil | |
| sequence,It,is,concluded,that,the,aforementioned,pathological,manifestations,were,due,to,chemotherapy,and,included,a,pulmonary,adverse,reaction,,,a,feature,never,previously,associated,with,oxaliplatinum,and,5-fluorouracil,regimens,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,4,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,pulmonary adverse reaction | |
| drug,oxaliplatinum | |
| sequence,It,is,concluded,that,the,aforementioned,pathological,manifestations,were,due,to,chemotherapy,and,included,a,pulmonary,adverse,reaction,,,a,feature,never,previously,associated,with,oxaliplatinum,and,5-fluorouracil,regimens,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,0,4,0,4,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,fatigue,myalgia,leg weakness | |
| drug,colchicine | |
| sequence,A,79-year-old,man,with,ischemic,heart,disease,,,chronic,atrial,fibrillation,,,chronic,renal,failure,,,hypothyroidism,,,and,gout,arthritis,was,hospitalized,because,of,fatigue,,,myalgia,,,and,leg,weakness,,,shortly,after,starting,treatment,with,colchicine,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,8,0,0,5,7,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,lactic acidosis | |
| drug,metformin | |
| sequence,CONCLUSIONS,:,The,increasing,prevalence,of,Type,2,diabetes,and,its,treatment,with,metformin,might,result,in,more,cases,of,lactic,acidosis,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,0,0,5,7,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0 | |
| ==============================, ============================= | |
| ade,ARF,nephrotoxicity | |
| drug,mannitol | |
| sequence,The,literature,is,also,reviewed,for,ARF,associated,with,mannitol,infusion,in,patients,who,received,dialysis,and,those,who,did,not,receive,dialysis,;,and,the,possible,mechanism,(,s,),of,mannitol,nephrotoxicity,are,discussed,. | |
| labels,0,0,0,0,0,0,8,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8,0,0,0 | |
| ade_mask,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0 | |
| ==============================, ============================= | |
| ade,Bowel perforation | |
| drug,chromic phosphate | |
| sequence,Bowel,perforation,associated,with,intraperitoneal,chromic,phosphate,instillation,. | |
| labels,5,7,0,0,0,1,3,0,0 | |
| ade_mask,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,thyrotoxicosis | |
| drug,amiodarone | |
| sequence,A,54-year-old,man,,,treated,with,amiodarone,,,developed,thyrotoxicosis,. | |
| labels,0,0,0,0,0,0,4,0,0,8,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,1,0 | |
| ==============================, ============================= | |
| ade,increased serum thyroid-stimulating hormone | |
| drug,levothyroxine | |
| sequence,CASE,SUMMARIES,:,Two,patients,with,stable,hypothyroidism,experienced,symptoms,of,hypothyroidism,with,increased,serum,thyroid-stimulating,hormone,(,TSH,),concentrations,after,switching,from,1,levothyroxine,product,to,another,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,7,0,0,0,0,0,0,0,0,4,0,0,0,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,Anaphylaxis | |
| drug,diamorphine | |
| sequence,Anaphylaxis,to,intrathecal,diamorphine,. | |
| labels,8,0,0,4,0 | |
| ade_mask,1,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ARDS | |
| drug,gemtuzumab ozogamicin | |
| sequence,ARDS,has,been,associated,with,the,administration,of,other,monoclonal,antibodies,,,such,as,infliximab,,,gemtuzumab,ozogamicin,,,and,OKT3,and,is,believed,to,be,directly,mediated,by,release,of,proinflammatory,cytokines,. | |
| labels,8,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,1,3,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ARDS | |
| drug,infliximab | |
| sequence,ARDS,has,been,associated,with,the,administration,of,other,monoclonal,antibodies,,,such,as,infliximab,,,gemtuzumab,ozogamicin,,,and,OKT3,and,is,believed,to,be,directly,mediated,by,release,of,proinflammatory,cytokines,. | |
| labels,8,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,1,3,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,ARDS | |
| drug,OKT3 | |
| sequence,ARDS,has,been,associated,with,the,administration,of,other,monoclonal,antibodies,,,such,as,infliximab,,,gemtuzumab,ozogamicin,,,and,OKT3,and,is,believed,to,be,directly,mediated,by,release,of,proinflammatory,cytokines,. | |
| labels,8,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,1,3,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ade_mask,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,nodular scleritis,scleritis | |
| drug,Alendronate | |
| sequence,CONCLUSION,:,Alendronate,led,to,nodular,scleritis,and,rechallenge,caused,recurrence,of,scleritis,. | |
| labels,0,0,4,0,0,5,8,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,acute reversible encephalopathy | |
| drug,flecainide | |
| sequence,A,73,year-old,patient,with,Wolff-Parkinson-White,syndrome,and,paroxysmic,supraventricular,tachycardia,developed,an,acute,reversible,encephalopathy,within,15,days,of,initiation,of,flecainide,. | |
| labels,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,7,0,0,0,0,0,0,4,0 | |
| ade_mask,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe unilateral grand mal seizure | |
| drug,2-propylpentanoic acid | |
| sequence,A,7-year-old,boy,developed,a,severe,unilateral,grand,mal,seizure,at,the,age,of,5,years,(,phenobarbitone,therapy,),;,1.5,years,later,valproate,(,2-propylpentanoic,acid,,,VPA,),was,added,to,the,therapy,. | |
| labels,0,0,0,0,0,5,6,6,6,7,0,0,0,0,0,0,0,4,0,0,0,0,0,0,4,0,1,3,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe unilateral grand mal seizure | |
| drug,phenobarbitone | |
| sequence,A,7-year-old,boy,developed,a,severe,unilateral,grand,mal,seizure,at,the,age,of,5,years,(,phenobarbitone,therapy,),;,1.5,years,later,valproate,(,2-propylpentanoic,acid,,,VPA,),was,added,to,the,therapy,. | |
| labels,0,0,0,0,0,5,6,6,6,7,0,0,0,0,0,0,0,4,0,0,0,0,0,0,4,0,1,3,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe unilateral grand mal seizure | |
| drug,valproate | |
| sequence,A,7-year-old,boy,developed,a,severe,unilateral,grand,mal,seizure,at,the,age,of,5,years,(,phenobarbitone,therapy,),;,1.5,years,later,valproate,(,2-propylpentanoic,acid,,,VPA,),was,added,to,the,therapy,. | |
| labels,0,0,0,0,0,5,6,6,6,7,0,0,0,0,0,0,0,4,0,0,0,0,0,0,4,0,1,3,0,4,0,0,0,0,0,0,0 | |
| ade_mask,0,0,0,0,0,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |
| ==============================, ============================= | |
| ade,severe unilateral grand mal seizur |
Sign up for free
to join this conversation on GitHub.
Already have an account?
Sign in to comment