Pre_get_posts

functions.php

function preget_home( $query ) {
    if ( $query->is_home() && $query->is_main_query() ) {
        $metaquery = array(
            array(
                'key' => 'select_destaque',
                'value' => array('maior','menor'),
                'compare' => 'NOT IN'
                ),
            array(
                'key' => 'select_destaque_sidebar',
                'value' => array('sim'),
                'compare' => 'NOT IN'
                ),
        );
        $query->set('post_type', array('post', 'videos') );
        $query->set('meta_query', $metaquery );
    }
    if ($query->is_search) {
        $query->set('post_type', array('post', 'videos') );
    }
}

add_action( 'pre_get_posts', 'preget_home' );