Why don't you exploit functools.partial with sqlalchemy.Column

partialcolumns.py

from functools import partial
from sqlalchemy.dialects.mysql import (
    BIGINT, SMALLINT, TINYINT, INTEGER, DECIMAL,
    VARCHAR, TIMESTAMP, DATETIME)
from sqlalchemy.sql.expression import func
from sqlalchemy import Column, Index, MetaData, Table

auto_pk=dict(autoincrement=True, primary_key=True)

UINT5Column = partial(
    Column, type_=SMALLINT(5, unsigned=True))
UINT3Column = partial(
    Column, type_=TINYINT(3, unsigned=True))
STR45Column = partial(Column, type_=VARCHAR(45))

ActorId = partial(UINT5Column, name='actor_id')
AddressId = partial(UINT5Column, name='address_id')
CityId = partial(UINT5Column, name='city_id')
CategoryId = partial(UINT3Column, name='category_id')
CountryId = partial(UINT5Column, name='country_id')
CustomerId = partial(UINT5Column, name='customer_id')
StoreId = partial(UINT3Column, name='store_id')
FilmId = partial(UINT5Column, name='film_id')

LastUpdate = partial(
    Column, name='last_update', type_=TIMESTAMP,
    default=func.now(), onupdate=func.now(),
)

FirstName = partial(STR45Column, name='first_name')
LastName = partial(STR45Column, name='last_name')

actor_table = Table(
    'actor', MetaData(),
    ActorId(**auto_pk),
    FirstName(),
    LastName(),
    LastUpdate(),
    Index('idx_actor_last_name', 'last_name'),
)

address_table = Table(
    'address', MetaData(),
    AddressId(**auto_pk),
    Column('address', VARCHAR(50)),
    Column('address2', VARCHAR(50), nullable=True),
    Column('district', VARCHAR(20)),
    CityId(),
    Column('postal_code', VARCHAR(10), nullable=True),
    Column('phone', VARCHAR(20)),
    LastUpdate(),
    Index('idx_fk_city_id', 'city_id'),
    # Index('idx_location', 'location'),
)

category_table = Table(
    'category', MetaData(),
    CategoryId(**auto_pk),
    Column('name', VARCHAR(25)),
    FirstName(),
    LastName(index=True),
    LastUpdate(),
)

city_table = Table(
    'city', MetaData(),
    CityId(**auto_pk),
    CountryId(),
    LastUpdate(),
    Index('idx_fk_country_id', 'country_id')
)

country_table = Table(
    'country', MetaData(),
    CountryId(**auto_pk),
    Column('country', VARCHAR(50)),
    LastUpdate(),
)

customer_table = Table(
    'customer', MetaData(),
    CustomerId(**auto_pk),
    StoreId(),
    Column('first_name', VARCHAR(45)),
)

film_table = Table(
    'film', MetaData(),
    FilmId(**auto_pk),
    Column('title', VARCHAR(255)),
)

# ... blah blah blah ...