WordPress multi-tenant directory structure sharing core files for opcode awesomeness, fast deployments, and low disk usage. With inspiration from @weskoop. "=>" indicates a symlink.

gistfile1.txt

sites
  |__ ms.dev
  | |__ content
  | |__ index.php
  | |__ wp => ../../wordpress/stable
  | |__ wp-config.php
  |__ one.dev
  | |__ content
  | |__ index.php
  | |__ wp => ../../wordpress/stable
  | |__ wp-config.php
  |__ two.dev
  | |__ content
  | |__ index.php
  | |__ wp => ../../wordpress/stable
  | |__ wp-config.php
wordpress
  |__ 3.5.2
  |__ 3.6
  |__ stable => 3.6
  |__ wp-config.php