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Gut dysbiosis in severe mental illness and chronic fatigue: a novel trans-diagnostic construct? A systematic review and meta-analysis

Our findings suggest that gut dysbiosis may underlie symptoms of sickness behavior across traditional diagnostic boundaries. Future investigations should validate these findings comparing the performances of the trans-diagnostic vs. categorical approach. This will facilitate treatment breakthrough in an area of unmet clinical need. [...] Animal models showed that gut dysbiosis triggers a chronic low-grade pro-inflammatory status in the host by increasing the permeability of the gut barrier (“leaky gut”) and by facilitating the translocation of bacterial antigens into the bloodstream (“endotoxemia”) (Fig. 1) [5,6,7]. In both animals and experimental models in otherwise healthy subjects, endotoxemia **manifests with a range of flu-like symptoms (fatigue, anhedonia, loss of motivation), which most authors refer to as

Asmageddon /
Last active November 10, 2021 09:52
Sleep Disordered Breathing Questionnaire (25 questions, EN, PL)


Sleep Disordered Breathing is a rarely-diagnosed spectrum of disorders caused by respiratory airflow resistance resulting from allergies/nasal obstruction and/or physically narrow airways due to insufficient jaw development, and less frequently other disorders(septum deviation, adenoid, tonsil, turbinate hypertrophy are usually consequences of insufficient space to develop properly or inflammation)

This causes increased respiratory effort during sleep(and frequently, partial or even full airway collapse) when airway muscles are relaxed, leading to abnormal Autonomous Nervous System modulation which results in destabilization of sleep processes, severely impaired rest quality, and dysregulation of numerous physical and mental functions.

Contrary to popular belief, Obstructive Sleep Apnea is not a standalone syndrome, but rather results from years or decades of damage caused by abnormal sleep, and primary symptoms in most people are psychological and somatic in nature.

This questionnaire is desig


Diet modulates brain network stability, a biomarker for brain aging, in young adults

Large-scale life span neuroimaging datasets show functional communication between brain regions destabilizes with age, typically starting in the late 40s, and that destabilization correlates with poorer cognition and accelerates with insulin resistance. Targeted experiments show that this biomarker for brain aging is reliably modulated with consumption of different fuel sources: Glucose decreases, and ketones increase the stability of brain networks. This effect replicated across both changes to total diet as well as fuel-specific calorie-matched bolus, producing changes in overall brain activity that suggest that network “switching” may reflect the brain’s adaptive response to conserve energy under resource constraint.

[...] irrespective of whether ketosis was achieved with a ketogenic diet or exogenous ketone ester.

[...] suggesting

Asmageddon /
Created July 8, 2021 12:09
Paper Digest: Loneliness Maters

Loneliness Matters: A Theoretical and Empirical Review of Consequences and Mechanisms General info:

As a social species, humans rely on a safe, secure social surround to survive and thrive. Perceptions of social isolation, or loneliness, increase vigilance for threat and heighten feelings of vulnerability while also raising the desire to reconnect. Implicit hypervigilance for social threat alters psychological processes that influence physiological functioning, diminish sleep quality, and increase morbidity and mortality. [...] Loneliness is not simply being alone. Interventions to reduce loneliness and its health consequences may need to take into account its attentional, confirmatory, and memorial biases as well as its social and behavioral effects. [...] Loneliness is a common experience; as many as 80% of those under 18 years of age and 40% of adults over 65 years of age report being lonely at least sometimes [1–3], with levels of l

Asmageddon /
Created October 15, 2019 07:50
How to be kind and helpful to oneself
  1. Always be kind to yourself, and forgive yourself for failures. Even if you screw up badly or feel like you deserve it, not being kind to yourself only hurts you more, it doesn't ever help you, or anyone else, in any way. It's essentially camouflaged self-sabotage. Real attempts to get better don't end up with feeling worse for trying. Appreciate your success in trying to do something for yourself instead.

  2. Focus on noticing when you're starting to sink into intrusive or self-destructive thoughts, and on deflecting them whenever you can. Just think anything else. The opposite of what you're thinking, or generic compliments towards yourself. When you fail, and you will, refer to #1. The point is to slowly work on making your mind less likely to go down those routes, and dissociating your thoughts and actions from negative feelings and thoughts.

  3. Your thoughts and mind as a whole are there to help you succeed, whatever success means. The thoughts that lead to stress and other bad emotions, unless cri

Asmageddon /
Last active July 27, 2020 01:11
Anime worth checking out


Anyway, for a brief list in a very rough order of what I consider best, with stuff near the bottom of the list still being at the very least "Kinda decent".

I strongly apologize for not including links and some of the descriptions being vague, but that's halfway intentional(there are better synopses and reviews out there) and halfway because this already took damn ages.

I've marked every show with single-letter tags:

Asmageddon / scopecolor.lua
Created September 7, 2016 19:59
A buggy scope highlighter for ZeroBrane Studio
local golden_ratio = (1+math.sqrt(5))/2
local offset = 0.05
local function HSVtoRGB(h, s, v)
if s == 0 then
return v,v,v
h = h/60
i = math.floor( h )
f = h - i
rawrequire = require
function require(path)
if string.sub(path, 1,1) == "." then
local root = (debug.getinfo(2, 'S')).source:sub(2);
root = root:gsub("/[^/]*$", ""):gsub("/", ".")
return rawrequire(root .. path)
return rawrequire(path)
// Syntax notes:
// Blah!Int is generic type application, equivalent to C++'s Blah<Int>
// Ptr!Type is a pointer to a Type object
// Type? is Option!Type, e.g. either a Type object, or None
// Semantics notes:
// struct is a C-style struct
// union is a typed union, e.g. union!(A, B) can be either A, or B, but not at the same time
// Type notes:
// Splashmap is a map with multiple key and value types, where keys map to only some of the types
// For example, in Splashmap!((A, A), (A, B), (B, B)):
Asmageddon / gist:a76d7938da3c0564631b
Last active July 4, 2016 20:59
Sandbox for markdown experimentation



a = a + b


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