Asmageddon

Summary

Sleep Disordered Breathing is a rarely-diagnosed spectrum of disorders caused by respiratory airflow resistance resulting from allergies/nasal obstruction and/or physically narrow airways due to insufficient jaw development, and less frequently other disorders(septum deviation, adenoid, tonsil, turbinate hypertrophy are usually consequences of insufficient space to develop properly or inflammation)

This causes increased respiratory effort during sleep(and frequently, partial or even full airway collapse) when airway muscles are relaxed, leading to abnormal Autonomous Nervous System modulation which results in destabilization of sleep processes, severely impaired rest quality, and dysregulation of numerous physical and mental functions.

Contrary to popular belief, Obstructive Sleep Apnea is not a standalone syndrome, but rather results from years or decades of damage caused by abnormal sleep, and primary symptoms in most people are psychological and somatic in nature.

This questionnaire is desig

Asmageddon

Gut dysbiosis in severe mental illness and chronic fatigue: a novel trans-diagnostic construct? A systematic review and meta-analysis https://www.nature.com/articles/s41380-021-01032-1

Our findings suggest that gut dysbiosis may underlie symptoms of sickness behavior across traditional diagnostic boundaries. Future investigations should validate these findings comparing the performances of the trans-diagnostic vs. categorical approach. This will facilitate treatment breakthrough in an area of unmet clinical need. [...] Animal models showed that gut dysbiosis triggers a chronic low-grade pro-inflammatory status in the host by increasing the permeability of the gut barrier (“leaky gut”) and by facilitating the translocation of bacterial antigens into the bloodstream (“endotoxemia”) (Fig. 1) [5,6,7]. In both animals and experimental models in otherwise healthy subjects, endotoxemia **manifests with a range of flu-like symptoms (fatigue, anhedonia, loss of motivation), which most authors refer to as