Q: What are the main findings of the article above?
A: The main findings of the article are that a plasma fraction treatment derived from young adult pigs, termed E5, significantly reversed aging in rats according to epigenetic clocks and other biomarkers of aging. The treatment more than halved the epigenetic ages of blood, heart, and liver tissue, and also showed a significant rejuvenation effect in the hypothalamus. Alongside this, the treatment led to improvements in organ function, reduced markers of chronic inflammation and oxidative stress, increased antioxidant levels, and improved cognitive functions in the rats. The study also developed six different epigenetic clocks for rat tissues, two of which can be applied to humans as well.
Q: How clinically significant were the objective improvements observed? Provide an extensive list of measured markers and effect size.
A: The objective improvements observed in the study were clinicall