Copy from Jason Go's answer : https://answers.microsoft.com/en-us/windows/forum/all/reverse-mouse-wheel-scroll/657c4537-f346-4b8b-99f8-9e1f52cd94c2
Hello to all avid readers of Microsoft Community!
I am Jason Go, a developer and a postgrad computer science major. I made a script that will solve this issue the EASIEST and FASTEST way.
To set the scroll direction of your mouse, do the following steps:
Open Windows PowerShell in Administrator Mode
. You can do this by going to Start Menu, type PowerShell, and click Run as Administrator.