So, I just kicked off with django's standard project layout to get up quickly asap, and created an app named mutantgui. The first thing I did is added the database params for postgres in settings.py(so I can use the awesome pgAdmin tool to examine what mutant is doing exactly), enabled the django admin app, and added south, mutant and our mutantgui app to the INSTALLED_APPS list.
After running python manage.py syncdb, a couple of mutant tables were created, specifically:
Creating table mutant_modeldefinition
Creating table mutant_basedefinition