Avi Flax wrote a very interesting article about Profiling Node Programs on Mac OS X. However, if you manage your Node.js installation with homebrew, you can use the following hints to install the V8 debugger separately and run it using node-profile or coffee-profile.
I'm forking the gist https://gist.github.com/fhemberger/2000999 because the install.sh didn't work for me. so i'm documenting how I did itmanually)#