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The Engineering Question: Can you create breakthrough technology (vs. incremental improvement)?
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The Timing Question: Is now the right time to start this particular business?
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The Monopoly Question: Are you starting with a big share of a small market?
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The People Question: Do you have the right team?
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The Distribution Question: Do you have a way to not just create but deliver your product?
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The Durability Question: Will your market position be defensible 10 and 20 years into the future?
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The Secret Question: Have you identified a unique opportunity that others don't see?
via Zero to One: Notes on Startups, or How to Build the Future by Peter Thiel