Book summary: Finally Focussed by Dr. James Greenblatt MD.

guide.txt

Book: Finally Focussed by Dr. James Greenblatt MD.
Checkout: https://examine.com/ , no ads, non-industry affliated review of supplements backed by research
Checkout: https://consumerlab.com , no ads, non-industry affliated review of supplements backed by research

Nutrient Reference Value(NRV): are used to express the nutritional value of a food product as a percentage of the daily recommended intake for an average adult. It is by the European Food Safety Authority.

A. Magnesium/vitamin b6 guide.
1. Mg(glycinate,citrate,gluconate,l-threonate, but NOT oxide). Under 6yrs: 10mg daily in liquid form.
   Liquid ionic magnesium from New beginnings co.
   Natural calm by Natural vitality co.
   Pure encapsulations co.
   Mg supplements from most companies are reliable.
2. Vitamin B6. 7-12yrs: 25mg daily.
3. Nuts, pumpkin seeds & dark chocolate.
4. Works in 2-3months.
5. Side effect: loose stools(mainly with Mg oxide; don't use MgO).
   If it happens decrease dose, or switch to a slow acting form of Mg.
6. Wellkid Immune Chewable that are listed as been for 4-12 year olds(https://www.vitabiotics.com/products/wellkid-immune-chewable) lists the following as the NRV:
   Magnesium: 375mg
   Vitamin B6: 1.4mg
   Zinc: 10mg
   EPA/DHA: unknown
   Vitamin D: 5µg
7. Kenya:
   (a) https://westerncosmetics.com/products/magnesium-citrate
       LifeExtension, Magnesium(Citrate)100mg: KES 2,795
       MgCitrate 100mg per serving
   (b) https://westerncosmetics.com/products/childrens-multivitamin-formula
       LifeExtension Children's Formula Life Extension Mix: KES 6,813
       For children 4-8 years.
       Vit A: 1050mcg
       Vit C: 120mg
       Vit D(as D3): 10mcg
       Vit E: 20mg
       Vit B1: 3mg
       Vit B3: 20mg
       Vit B6: 2mg
       Mg(oxide): 50mg
       Zinc(zinc bisglycinate): 10mg
       Marigold extract: 11.2mg
    (c) Magnesium RDA for 4yr old is 130mg. "Specifically our Magnesium L-Threonate contains 94mg of Magnesium, which is within the daily recommended guidelines for kids aged 4-8 years old of 130mg daily, or 9-13 years old of 240mg" - https://www.ourkidsasd.com/products/magnesium-l-threonate
    (d) RDA is 130mg for 4-8yr olds. With Tolerable Upper Intake Levels at 110mg. The UL is lower than RDA bcoz RDA includes from all sources, whereas UL is only for supplements;  https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/  
        "Too much magnesium from FOOD does not pose a health risk in healthy individuals because the kidneys eliminate excess amounts in the urine. High doses from supplements can cause nausea & abdominal cramping" - https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#h19

B. OPC(oligomeric proanthocyanidins) guide.
   Plant extracts(pine bark extract, green tea extract, blueberry extract, grape extract, monterey bark extract).
   Its type of polyphenol
1. 2pills/day.
   CurcumaSorb Mind by Pure encapsulations co.
   OPC-3 by Isotonix.
2. 28gms dark chocolate(> 60% cacao). Or hot chocolate using dark chocolate cocoa powder.
3. Discontinue in 1-3months if no improvement
4. No side effects in his experience. Discontinue if kid develops hives(raised, itchy red bumps on skin).

C. Lithium guide.
1. Li(orotate or citrate, but not aspartate or carbonate(used for pharmaceutical lithium)). 0.5mg(500mcg) per day, liquid form.
   Lithium liquid by Pure encapsulations co.
2. Discontinue in 3 months if no change.
3. Found in drinking water an soil.
4. No side effects(from nutritional lithium) in his experience.
5. Inadvisable if kid has underlying thyroid issue, since pharmaceutical lithium can hurt lithium.
   But he is against carbonate(pharmaceutical lithium), and says he wouldn't hesitate to give nutritional lithium even if his kid has thyroid issue.

D. Zinc guide.
1. Zinc picolinate. 6-12yrs: 15mg 2times per day.
2. Below 5yrs: no Zinc.
3. Half ADHDs have little zinc and high copper.
4. Low zinc makes kids picky eaters, decrease appetite and makes meat repulsive.
5. Red meat, sea food, chicken has lots of zinc.
6. Works in 3-4months. It is slow acting.
7. Side effect: very rarely, zinc may force copper out of tissues into blood and kid becomes aggressive before getting better.
   If it happens, stop zinc for a few days. Then restart and give once a day instead of twice.
8. Wellkid Immune Chewable that are listed as been for 4-12 year olds(https://www.vitabiotics.com/products/wellkid-immune-chewable) lists the following as the NRV:
   Magnesium: 375mg
   Vitamin B6: 1.4mg
   Zinc: 10mg
   EPA/DHA: unknown
   Vitamin D: 5µg
9. zinc picolinate, zinc citrate, & zinc gluconate were tested. There was no significant change for citrate, gluconate or placebo. There was a change for picolinate. https://pubmed.ncbi.nlm.nih.gov/3630857/
10. absorption of zinc was citrate(61%), gluconate(60%), oxide(49%, 3participants had no absorption of the oxide). https://pubmed.ncbi.nlm.nih.gov/24259556/
11. glycinate(Bisglycinate) > picolinate >oxide > gluconate: https://www.semanticscholar.org/paper/Comparison-of-Four-Commercially-Available-Zinc-for-DiSilvestro-Swan/9434872e96e1791e91da57001148915af677a3a4
12. Kenya:
   (a) https://westerncosmetics.com/products/childrens-multivitamin-formula
       LifeExtension Children's Formula Life Extension Mix: KES 6,813
       For children 4-8 years.
       Vit A: 1050mcg
       Vit C: 120mg
       Vit D(as D3): 10mcg
       Vit E: 20mg
       Vit B1: 3mg
       Vit B3: 20mg
       Vit B6: 2mg
       Mg(oxide): 50mg
       Zinc(zinc bisglycinate): 10mg
       Marigold extract: 11.2mg


E. Probiotic guide.
1. 50billion CFU(colony forming units) capsule, 2-4times per day 30mins after meal for 3months.
2. Afterwards 10-20billion CFU 2times per day 30mins after meal.
3. Lactobacillus is one such good bacteria.
4. Hasn't seen side effects.
5. Kenya:
   (a) https://westerncosmetics.com/products/digestive-enzymes-and-probiotics
       Life extension Super Digestive Enzymes and Probiotics: KES 5,965
       Protease SP
       Bromelain
       Lactase
       Cellulase
       Lipase
       Alpha Galactosidase
       Hemicellulase
       Pectinase
       Protease3.0
       Xylanase
       Lactospore B. coagulans MTCC5856: 1billion cfu
   (b) https://westerncosmetics.com/products/jarro-dophilus-digest-sure
       Jarrow Jarro-Dophilus digest Sure: KES 5,195
       Amylase: Enzyme that breaks down complex carbohydrates (starches) into simpler sugars.
       Protease 4.5/3/6: break down proteins into peptides amino-acids. The numbers refer to the optimal pH range.
       Lipase: breaks down fats (lipids) into fatty acids and glycerol.
       Alpha-galactosidase: breaks down complex sugars, which are found in legumes and can cause digestive discomfort.
       Lactase: breaks down lactose, a sugar found in milk and dairy products, into glucose and galactose.
       Peptidase: breaks down peptides into individual amino acids.
       Bifidobacterium lactis BS-01 & BR-03: Probiotic bacteria that help maintain a healthy gut microbiome.
       Lactobacillus, Lactiplantibacillus & Lacticaseibacillus: Probiotic bacteria that maintain a healthy gut microbiome.
 
F. Dairy/wheat guide.
1. DPP-IV(dpp-4) enzyme to breakdown casein  & gluten.
   Recommends Gluten/Dairy digest 2 capsules per day.
2. Minimize/Eliminate dairy/wheat.

G. Omega3 guide.
1. 1-2gm EPA/DHA daily.
2. Eat fatty fish(salmon, tuna) & sea food.
3. EPA/DHA/GLA(800mg,400mg,100mg) per capsule. 2-3 capsules per day
4. If adhd teenager is depressed/aggresive/uses marijuana, test for cholesterol.
5. NIH puts RDA at 0.9gm for 4-8yr old. 1.6g adults. https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/
6. Kenya:
   (a) https://westerncosmetics.com/products/mega-epa-dha
       Mega EPA-DHA Omega-3: KES 7,495
       EPA(720mg), DHA(480 mg) per serving.
   (b) https://westerncosmetics.com/products/omega-3-epa-dha
       Super Omega-3 EPA-DHA: KES 4,895
       EPA(700mg), DHA(500mg) per serving.

H. Sugar guide.
1. Eliminate sugar beverages
2. Introduce protein rich food to counteract sugar.

https://www.amazon.com/hz/wishlist/ls/2Y4H9N3N2U9XD

Study by CureMark on whether CM-AT(a proprietary enzyme powder developed by Curemark) can help with adhd;

• https://consultqd.clevelandclinic.org/clinical-trial-blum-investigates-biologic-cm-autism
• https://www.youtube.com/watch?v=_a9eU_Xi_MQ
  The exact composition is not publicly available, but it's known to contain chymotrypsin and other similar enzymes.
  And here is lifeExtension talking about chymotrypsin; https://www.lifeextension.com/magazine/2009/1/optimize-digestive-health

1. Methylated forms of vitamin b12(methylcobalamin) may be important for people with autism. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400809/

2. Life extension children’s formula mix uses methylcobalamin; https://www.lifeextension.com/vitamins-supplements/item02199/childrens-formula-life-extension-mix

Your body has to methylate most forms of most B vitamins to use them. 
If this methylation process is interrupted or slowed,
it bottlenecks your usable B vitamin amount no matter how much regular stuff you take. 
But you can just take the already-methylated form instead! If you are autistic or have chronic fatigue, 
definitely check these out. 
(Autism is correlated with MTHFR gene dysfunction among other things, and MTHFR gene dysfunction makes you 
unable to methylate regular forms of B vitamins, in fact in some cases the regular B vitamins going un-methylated 
will actually jam up that process and cause lots of other problems too. At least some fraction of chronic fatigue 
is exactly this problem, a group of biological cycles in your body grinding to a halt because they’re jammed up. 
Potentially this is also part of the health benefit of cutting out bread from your diet, as most bread is fortified with
folic acid for dietary purposes, and folic acid is one potential source of jams.) 
This one has risks, you should actively research the doses and what symptoms to be prepared for

https://news.ycombinator.com/item?id=35339779

There is now sufficient evidence that omega-3 supplementation reduces aggression in children and adults

• https://www.sciencedirect.com/science/article/abs/pii/S1359178924000466

In a double-blind, placebo-controlled study; magnesium L-threonate together with vitamins C & D, 
was tested for its cognitive benefits in 109 healthy Chinese adults aged 18-65 years. 
Subjects were randomly assigned to receive either Magtein or placebo (starch) capsules, at a dose of 2 g/day. 
"The Clinical Memory Test", the standard test commonly used in Chinese hospitals for cognitive evaluation, 
was administered before and 30 days after subjects received the supplement. 
Subjects receiving Magtein showed significant improvements over the control group 
in all five subcategories of "The Clinical Memory Test" as well as the overall memory quotient scores. 
The older participants showed more improvement than younger participants. 
Results indicated significant benefits of Magtein in improving memory and cognition in healthy Chinese adults.

• https://pubmed.ncbi.nlm.nih.gov/36558392/

- A meta-analysis was conducted on 28 RCTs involving 3918 participants.
- Omega-3 modestly but significantly reduces aggression in children and adults.

• https://www.sciencedirect.com/science/article/abs/pii/S1359178924000466