It took some time to figure out how to override Skewer's defaults, turns out this is what worked, without the hook it was not working.
(add-hook 'js2-mode-hook #'(lambda ()
(spacemacs/set-leader-keys-for-major-mode 'js2-mode
"'" 'nodejs-repl
"ee" 'nodejs-repl-send-last-sexp
"eb" 'nodejs-repl-send-buffer
"er" 'nodejs-repl-send-region)))