GitHub-flavored Markdown does not use C-style escapes for escaping backticks inside spans. Instead, GFM uses double, significant whitespaced, backticks.
Two backticks, then a space, then a backtick, then a space, then two more backticks:
`` ` ``
produces:
`
@jonathanneo I was asking about GitHub issue titles. It seems like you can't use fenced code blocks in titles because they have just one line. Or am I missing something?