Google Chrome is an acceptably secure, but by default not very private, browser. Google has wired closed-source Chrome and its underlying open-source Chromium base to serve Google's insatiable need for user behaviorial data, and it shows. Here is a list of the changes the Brave browser team make to fix that: Deviations from Chromium (features we disable or remove).
Given that list, there's no way to make closed-source Chrome significantly more private. But the reality is that many of us still need to use Chrome for a variety of reasons, even if only on occasion. The following settings checklist is what I use to mitigate risks to my privacy (and make Chrome more usable overall):
- You and Google > Sync and Google services: disable everything (including "Allow Chrome sign-ins")
- Autofill and passwords > Google Password Manager > Settings: disable